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Molecular Biology Chapter 19
The Eukaryotic Cell Cycle
17
Biology
Graduate
12/06/2012

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Term
During which stage of the cell cycle is the chromosome content of a mammalian liver cell 1n?
Definition
None of the Above
Term
Human genes/proteins that regulate the cell cycle are most easily isolated by
Definition
Complementation of Yeast mutants
Term
Injection of an immature Xenopus oocyte with MPF induces
Definition
Both A and B
meiosis.
oocyte maturation.
Term
All the following statement(s) about destruction of cyclins is (are) true except
Definition
Ubiquitin targets Cdks
Term
Mitotic cyclin levels in early Xenopus embryos are regulated by
Definition
degradation by APC.
Term
Which of the following is a target of the APC?
Definition
cyclin B
Term
Site-directed mutagenesis of Tyr-15 to Phe in cdc2
Definition
results in the wee phenotype
Term
Which of the following S. pombe mutants is larger than normal?
Definition
cdc25-
Term
Exit from mitosis depends upon the degradation of
Definition
cyclin B
Term
The S. cerevisiae homolog of Xenopus MPF is
Definition
Clb1-Cdc28
Term
During G1, prereplication complexes
Definition
bind to ORC
Term
Cyclin D/Cdk4 functions during
Definition
G1.
Term
Which of the following inhibits cyclin A/Cdk2 activity?
Definition
p21CIP
Term
Failure of which cell-cycle checkpoint is most likely to result in nondysjunction?
Definition
chromosome-segregation checkpoint
Term
Chk1is activated by
Definition
ATR
Term
hich of the following is a substrate of Cln3-Cdc28?
Definition
SBF
Term
Which of the following is targeted by the SCF?
Definition
Sic1
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