Term
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Definition
| Fluid is phospholipid bilayer. Mosaic is peripheral and integral protein |
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Term
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Definition
| Hydrophillic globular head(water loving) and hydrophobic fatty acid tail(water fearing) |
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Term
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Definition
| different chemical properties on each side of the molecule |
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Term
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Definition
| spontaneously form a sheet out of cells |
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Term
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Definition
| Lets us look at parts. Low salt concentration to rupture. Contents flood out, leaving plasma membrane. |
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Term
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Definition
| type of spectroscopy. Whole SDS-PAGE separate into band microsequencing. Identifies specific proteins. See how many proteins are there and the size range of proteins. |
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Term
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Definition
| Find if protein is peripheral or integral. Salt: peripheral off, knocked off. Detergent disrupts lipids, get integral proteins |
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Term
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Definition
| Alpha Helix or Beta Pleated |
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Term
| Primary Protein Structure |
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Definition
| Sequence of a chain of amino acids. |
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Term
| Secondary Protein Structure |
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Definition
| Occurs when the sequence of amino acids are linked by hydrogen bonds. |
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Term
| Tertiary Protein Structure |
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Definition
| Occurs when certain attractions are present between alpha helices and pleated sheets |
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Term
| Quaternary Protein Structure |
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Definition
| A protein consisting of more than one amino acid chain. |
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Term
| Acylation (Post Translational Protein) |
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Definition
| addition of a simple long chain fatty acid to hydrophobic protein allowing protein to associate with membrane-occurs in cytosol (applies to peripheral proteins). Myristic acid and Palmitic acid. |
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Term
| GPI Linkage: Er; Golgi (Post Translational Protein) |
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Definition
| Attaches to a protein to allow/facilitate membrane interaction. Takes off hydrophobic lipid group and adds to protein to encourage interaction with membrane. Signaling molecule. |
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Term
| Pronylation: Addition of a Prsemyl group (Post Translational Protein) |
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Definition
| Farnesyl group. Gernyl-Gernyl. Post translational addition allows non hydrophobic protein to react with hydrophobic bilayer. |
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Term
| Protein-Protein Interactions: SH2 (allows 2 proteins to stick together) (Post Translational Protein) |
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Definition
| Region of protein that are specifically there to interact with other proteins-works like velcro, lets proteins stick together. SH2 domain that, in response to single, becomes exposed/accessible to other proteins in cytosol, making these cytosolic proteins interact with that specific domain to associate them with membrane |
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Term
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Definition
| Spans the whole membrane layer |
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Term
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Definition
| Embedded in membrane either intracellular or extracellular |
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Term
| Fluidity of Plasma Membrane |
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Definition
| Temp is responsible for less movement when cold. Liquid composition: length of fatty acid tails, longer the tail, less fluidity. Cryoprotectants: Setrals (cholesterol). Low concentration: more rigid. High concentration: less rigid, more fluid. |
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Term
| Human Red Blood Cell Membrane (Simplest Membrane) |
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Definition
| Phospholipids: Outerlayer-phosphotidylcholine, sphingomyelin. Innerlayer-phospholipidylethanolamine, phosphotidylserine (-). Glycolipids: lipids stuck on protein, projects out of cell and fans out, specific signaling. Cholesterol: small amounts. |
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Term
| Plasma Membrane Proteins: Lateral and Rotational (spinning around) Diffusion |
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Definition
| Cytoskeleton anchor: direct/indirect. Extracellular matrix: anchor. Tight junction. Lipid raft. |
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Term
| Free Diffusion (no energy required) (Membrane Transport) |
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Definition
| Water and carbon dioxide. Moves down concentration gradient. Unregulated. |
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Term
| Facilitated Diffusion (no energy required) (Membrane Transport) |
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Definition
| With a gradient. With a channel protein: use of protein for specific ion movement. Regulated (gated-opens when signaled through voltage, mechanically, or chemically). |
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Term
| Active Transport (energy required-ATP) (Membrane Transport) |
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Definition
| Against a gradient:establishes ion gradient, overall ion balance. Carrier proteins:facilitates in ion transport by carrying them across membrane |
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Term
| Carrier Mediated Transport (active transport) (Membrane Transport) |
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Definition
| Uniport:movement of single molecule in one direction. Coupled:movement of 2 or more molecules in diff directions. (Antiport:moves 2 molecules opposite, NaK; Symport:moves 2 molecules in same direction). |
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