Term
| not associated with apoptosis? |
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Definition
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Term
| type of receptor without own kinase domain |
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Definition
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Term
| type of signaling typically acts on targets close to where signal is produced |
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Definition
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Term
| type of signaling acts on cells located at a distance from source generating the signal |
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Definition
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Term
| set of steps in extracellular communication |
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Definition
| synthesis, release, transport, binding, initiation, change, removal |
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Term
| will not trigger apoptosis |
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Definition
| loss of bad/bax signaling |
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Term
| not a common source for dna damage |
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Definition
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Term
| least efficient mechanism of dna repair |
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Definition
| translesion dna synthesis |
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Term
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Definition
-gene changes can result in either increased activation of a gene or decreased activity of a gene
-most cancers are the result of multiple hits |
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Term
| knockdown gene that works by injecting a molecult that targets RNA for degredation |
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Definition
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Term
| knockdown gene that injects a molecult that will block translation |
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Definition
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Term
| 2 cellular targets of caspases and how their destruction impacts cell functin |
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Definition
-IVAF: inhibitar that blocks CAD from breaking down/cleaving DNA is removed and the cells undergo apoptosis
-autoinhibitor domains of proteins: tdomains will be activated where other pro-apoptotic factors could bind and induce apoptosis |
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Term
| explain loss of heterozygosity (LOH) and what type of tumor genes it relates to |
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Definition
| mutational that once a gene is afflicated and has lost its heterozygosity it can become infected and imposed upon by cancer. relates to proto-oncogenes |
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Term
| diff bw proto-oncogene and tumor supressor gene and example of each |
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Definition
-proto-oncogenes result in mutation where there is a gain of function/over production of a gene product. . produce oncoproteins that change transcription
-tumor suppressor genes that result in mutation that has loss of function (suppress tumor formation) enzymes involved in DNA repair |
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Term
| why blood supply so important to tumor mass |
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Definition
| supplies nutrients to cells and allows the mass to develop further |
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Term
| common DNA damaging agents/events and correcting repair mechanism |
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Definition
-UV radiation: cause dimerization of 2 pyrimidines that hinder transcription/translation. phororeactiation by DNA photolase will remove the covalent bond and allow for transcription
-DNA adderacts are caused by oxidating, alcylating agents and carcinhagens that damage DNA physically. removed by nucleotide excision repair to fix sequence for correct transcription |
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Term
| diff bw gradient and relay signaling |
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Definition
-relay: active process where one cell influences another and so on with a signal
-gradient is passive where signal of a specific concentration is elicited so cells nearby recieve a strongger signal than cells further away |
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Term
| 2 things that influence transmission of signal through gradient |
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Definition
-cell-cell interactions/transport mechanisms
-receptors affinity |
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Term
| diff bw agonist and antagonist in relatin to receptor binding and signaling |
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Definition
-agonist: mimic another receptor and its response with the ligand to produce a wanted/nessesary response signaling inside the cell
-antagonist: bind with a ligand but will elicit no response inside cell |
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): paracrine |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): metastasis |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): proto-oncogene |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): angiogenesis |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): depurination |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): polyaromatic hydrocarbon |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): oxidation |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): PARP |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): caspase |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): TGF-beta |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): Bcl-2 |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): gradient |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): endocrine |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): kinase domain |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): DNA adduct |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): p53 mutation |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): ICAD |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): loss of heteozygosity |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): transversion |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): cyt c |
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Definition
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Term
| associated with what process (apoptosis, cell signaling, cancer, dna damage): RNAi |
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Definition
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