Term
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Definition
reversibility inhibits the growth of bacteria. |
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Term
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Definition
kills the susceptible bacteria. |
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Term
Minimum Inhibitory Concentration (MIC) |
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Definition
lowest concentration of antibiotic that results in inhibition of visible growth (i.e. colonies on a plate or turbidity in broth) under standard conditions. |
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Term
For an antibiotic to be effective... |
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Definition
it must reach either MIC or MBC at the site of the infection. |
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Term
Antibiotic is bactericidal |
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Definition
if MIC and MBC are close in value. |
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Term
Antibiotic is bacteriostatic |
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Definition
if the MBC is much higher than the MIC |
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Term
Minimum bactericidal concentration (MBC) |
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Definition
the lowest concentration of the antibiotic that kills 99.9% of the original inoculum in a given time. |
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Term
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Definition
bacterial strain inhibited by in vitro by a concentration of an antimicrobial agent that is associated with a high likelihood of therapeutic success. |
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Term
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Definition
bacterial stain inhibited in vitro by a concentration of an antimicrobial agent that is associated with a high likelihood of therapeutic failure. |
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Term
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Definition
Bacterial stain inhibited in vitro by a concentration of an antimicrobial agent that is associated with uncertain therapeutic effect. |
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Term
Clinical and Laboratory Standards Institute (2013) |
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Definition
harmonized terminology database. http://login.clsi.org/HTDatabase.cfm |
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Term
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Definition
Pregnancy Cat. D. Not recommended for children under 9 years or for breast feeding mothers. |
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Term
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Definition
not recommended for children under 18 years (except for inhalation antrax)or breast feeding mothers. |
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Term
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Definition
are no recommended for third trimester of pregnancy. |
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Term
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Definition
not recommended at term of pregnancy. |
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Term
Monthly prescribing reference |
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Definition
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Term
Inhibit Cell Wall Synthesis |
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Definition
Beta-lactams Penicillin (+/- Beta lactamase inhibitors) Cephalosporins (3 generations) Monobactams Carbapenems Glycopeptides (Vancomycin, Telovavancin) Fosfomycin (Manurol) |
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Term
Inhibit Protein Synthesis |
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Definition
Aminoglycosides (Gentamycin, Tobramycin, Streptomycin, Kanamycin, Amikacin) Macrolides & Ketolides (Erythromycin, Azithromicin, Clarithromycin, Telithromycin) Lincosamides (Clindomycin Lincomycin) Stretogramins (Synercid) Tetracyclines (Tertracycline, Moncycline, Doxycycline) Glycylcyclines (Tigercycline) Phenicals (Chloromphenicol) Oxazolidinones (Linezolid) Ansamycins (Rifampin) |
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Term
Inhibit Membrane Functions |
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Definition
Leptopeptides (Daptomycin) Polymyxin |
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Term
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Definition
Sulfonamides (Sulfamethoxazole/Trimethaprim, Sulfisoxazole) |
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Term
Inhibit Nucleic Acid Synthesis |
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Definition
Fluoroquinolones (Ciprofloxacin, Levofloxacin, Moxifloxacin, Ofloxacin) Furanes (Nitrofurantoin) |
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