Shared Flashcard Set

Details

Modification of Cell and Tissue Responses to Radiation
Rad Bio for the Senior
20
Health Care
Undergraduate 2
02/25/2013

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Cards

Term
What happens to cell sensitivity response when irradiated
Definition
Nothing, the cell sensitivity only appears to be affected. Cell charatcteristics cannot be changed, they are inherent. Only the outcome is changed
Term
What are the three groups of factors affecting cell outcome
Definition

Physical

Chemical

Biologic

Term
What is the RBE Formula
Definition

RBE = Dose in 250 kVp / to dose of test radiation

 

Measured in Gy

Term

What does RBE tell us

 

Definition
How many times is the test radiation effect than the Xray radiation
Term
What type of shoulder will a survival curve with High Let have
Definition
Narrow, Steep
Term
What type of shoulder with low LET radiation have on a survival curve
Definition
Wide, Shallow
Term
State the law of Bergonie & Tribondeau
Ionizing radiation is more effective against.....
Definition
.... cells that are rapidly dividing, undifferentiated, and have a longer dividing future.
Term

State the Law of Ancel anf Vitemberger....

 

All cells will be......

Definition
Damaged to the same extent for a given dose, but damaged will only be expressed if and when a cell divides
Term

Which of these are radio sensitive

Stem cells

Embryonic tissue

epithelium

bone marrow stem cells

neurons

muscle cells

Definition

stem cells

embryonic tissue

epithelium

bone marrow stem cells

 

Term

Which one of these is a undifferentiated cell

spermatogonia or spermatozoa

Definition
spermatogonia
Term
What are three categories that stem cell populations are divided in to
Definition

Stem

Static

Transit

Term

Which of the three populations will experince these characteristics

 

May or may not divide

cell on the way to one place or another

 

Definition
Transit
Term
What are the five categories that cells are divided into according to the radiosensitivity
Definition

VIM

DIM

MCT

RPM

FPM

Term
What are three categories of assays or examinations used to compare responses of different tissues to radiation
Definition

clonogenic

Specific tissue function

lethality

Term
Is a lethality essay considered clonogenic
Definition
No
Term
What is the most used Assay
Definition
Term
What three things can happen after a cell is exosed to radiation
Definition

Division Delay

Interphase Death

Reproductive Failure

Term
Cell survival curves describe the relationshiop between ________ and __________
Definition
Radiation Dose and Proportion of cells that survive
Term
What are the two types of damage repair
Definition
Sublethal and Potentially lethal
Term
How is RBE calculated on Cell Survival curves
Definition
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