Term
| which plasma/serum proteins are not synthesized in liver? |
|
Definition
Hemoglobin in rbc's
Ig in plasma |
|
|
Term
| the fluid which seperates from unclotted rbc so it DOES contain FIBRINOGEN |
|
Definition
|
|
Term
| clear yellowish fluid which seperates from plasma after coagulation |
|
Definition
|
|
Term
| appearance of Hg in serum/plasma due to rbc destruction |
|
Definition
|
|
Term
| what do citrate and EDTA bind? |
|
Definition
|
|
Term
| which proteins are not glycosylated? |
|
Definition
|
|
Term
| how are proteins broken down @ end of life? |
|
Definition
| glycosylated proteins have sialic acid which is removed by endothelial neuraminandase which exposes galactose now. Hepatocytes have a receptor for galactose (asialoglycoprotein receptors) which take the rest of protein up and destroy them. |
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|
Term
| albumins/globulins constitute what % of serum proteins? |
|
Definition
|
|
Term
electrophoretic mobility
what kind of protein migrates fastest
what is pH of agarose medium, its effect? |
|
Definition
negatively charged proteins. albumin tends to most negative and so if found closes to ANODE
B) 8.4-8.8 makes most body fluid proteins carry neg charge |
|
|
Term
| charge at anode and cathode |
|
Definition
anode is positive and attracts neg charged protiens
cathode is negative. least neg charged proteins are closer here |
|
|
Term
| which protein has the greatest effect on colloidal osmotic pressure? |
|
Definition
|
|
Term
| what does albumin transport |
|
Definition
non suluble substances ie billirubin and FA's
drugs: Salicylates, barbiturates, sulfonamides, warfarin, penicillin |
|
|
Term
| hypoalbuminemia is associated with what disorders? |
|
Definition
| liver disease, glomerunephritis, nephrosis, starvation and burn patients |
|
|
Term
| hyperalbuminemia is related to what disorders? |
|
Definition
no known pathology for increase albumin synthesis. generally from dehydration.
also excessive stasis during venepuncture: cuff is too tight |
|
|
Term
| during inflamation, what happens to albumin levels in serum? |
|
Definition
|
|
Term
hypolbuminema
a) reduced synthesis
b) altered distrubution
c) increased catabolism
abnormal losses already covered |
|
Definition
a) Il6/stress
b) Increased capillary permeability, decreased lymph clearance
c) Chronic infections/trauma |
|
|
Term
| inherited hypoalbuminemia |
|
Definition
| analbuminemia: no band in albumin region |
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|
Term
Name what proteins bind:
a) retinol
b)thyroid hormones t3 and t4
c) glucocorticoids |
|
Definition
a) prealbumin and thyroxine binding globin
b) pre albumin and retinol binding protein
c) cortisol binding globin or transcortin |
|
|
Term
Alpha 1 anti trypsin
B) De indicates what |
|
Definition
APR
Main Finct: anti protease activity in LUNG: Pulmonary Emphysema
DEC: hepatocellular disease since its synthesized inliver |
|
|
Term
|
Definition
ONTD
DOWN SYNDROME
HEPATOCELLULAR CARCINOMA
tumor marker
|
|
|
Term
|
Definition
Protease Inhib
Used to detect nephrotic syndrome
not apr |
|
|
Term
|
Definition
subunit of HLA
APR
used to detect nephrotic syndrom
renal tube dysfunction |
|
|
Term
|
Definition
is an alpha 2 globin linked to copper levels
low ceruloplasmin --> increased Cu in serum and wilsons disease... keiser fisher syndrome |
|
|
Term
|
Definition
tansport of free Hg to re cells for degradtion
if u find hg in urine then this may be decreased in serum
apr |
|
|
Term
|
Definition
| transport of free heme to liver where it is converted to bilirubin |
|
|
Term
|
Definition
bind Heme, and transport to liver for conversion to bilirubin
seen in anemia
neg apr |
|
|
Term
heparin
citrate
edta
are what? |
|
Definition
|
|
Term
C reactive protein
B)where is it made? |
|
Definition
most sensisitive APR
Binds extracts of pneumococcal cell walls
Gamma Globin
B) not in liver |
|
|
Term
when would you give someone
a)fresh frozen plasma?
b) cryoprecipitate
c) factor 7 concentrate |
|
Definition
a) MULTIPLE clotting disorders, liver cirrhosis
b) Clotting Disorders
c) Hemophilia A |
|
|
Term
when would you give somone
a) 5% albumin
b) 25% albumin |
|
Definition
a) hpovolemic shock
b) cerebral edema |
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