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-science of small particles, such as powders and granules
-studies size, shape, SA, density/porosity, flow/compact/compress |
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| how does solid differ from liquid |
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Definition
-solids: compacted to density >1, drug is more stable
-liquids: no def. shape, typically homogenous, easier to handle on large manufacturing scale |
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| how does one solid differ from another |
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Definition
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| typical particle size range for pharmaceutical powders |
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| PS impact on dosage forms |
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| dissolution, suspendability, uniformity, penetrability, non-grittiness |
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| mechanical process of reducing the PS and aggregates. sieving, trituration, levigation, pulverization by intervention |
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| once a solid is in solution... |
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Definition
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| why do you want a crystalline structure over amorphous and a base over a salt? |
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Definition
| crystalline is less hygroscopic than amorphous and bases are less hygroscopic than acids |
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