Term
|
Definition
trilaminar phospholipid membrane derived from host cell |
|
|
Term
|
Definition
involved in nucleocapsid assembly |
|
|
Term
|
Definition
-ssRNA or -dsDNA virus must carry a RNA-dependent RNA polymerase
associated with or within capsid |
|
|
Term
Epidemiological classification of viruses |
|
Definition
based on transmission route |
|
|
Term
biochemical classification of viruses |
|
Definition
based on structure and composition |
|
|
Term
|
Definition
a) Attachment (basis of specificity)
b) Penetration (receptor-mediated endocytosis and membrane fusion)
c) Uncoating (location and mechanism)
d) Replication (location of viral protein and of viral nucleic acid biosynthesis)
e) Assembly (location)
f) Release (cell lysis vs budding)
|
|
|
Term
DNA-containing viral genomes |
|
Definition
(most replicate within nucleus, synthesize early and late mRNAs, and encode a DNA-dependent DNA polymerase, but not a DNA-dependent RNA
polymerase). Notable exceptions on next slide
|
|
|
Term
|
Definition
i) Papillomaviruses and Polyomaviruses - does not encode a viral DNA-dependent DNA
polymerase
ii) Parvoviruses - does not encode a viral DNA-dependent DNA polymerase; no temporal
control of translation of viral proteins
iii) Poxviruses - core contains a DNA-dependent RNA polymerase, replicates within core and in
cytoplasm
iv) Adenoviruses - no exceptions
v) Herpesviruses - encodes a thymidine kinase, three classes of RNA transcripts - alpha, beta
and gamma transcripts.
vi) Hepadnaviruses - replicates in cytoplasm, contains a reverse transcriptase, DNA genome is
replicated via a RNA intermediate, DNA replication occurs within cores, no temporal
control of translation of viral proteins.
|
|
|
Term
RNA containing viral genomes |
|
Definition
all encode a RNA-dep polymerase; most replicate in cytoplasm and synthesize transcripts at same time |
|
|
Term
RNA-containing viral genomes exceptions/features |
|
Definition
i) Double-stranded RNA viruses - early and late transcripts, replication of genome occurs
within cores using positive-strand RNA as template.
ii) Positive-stranded viruses - genome is synthesized using negative strand viral RNA as a
template; translation results in polyproteins which are cleaved to form RNA polymerases
and viral proteases. Togaviruses synthesize early and late RNA transcripts.
iii) Negative-stranded viruses - nucleocapsid contains a RNA-dependent RNA polymerase
which synthesizes a positive strand RNA for translation and as a template for synthesis of
genome. Orthomyxoviral genomes replicate in nucleus using cellular RNA as primer and
virions assemble in cytoplasm
iv) Retroviruses - nucleocapsid contains a RNA-dependent DNA polymerase and an integrase.
The virion RNA is a template for the synthesis of a DNA copy. The viral double-stranded
DNA integrates into the host's chromosome. Transcription of the integrated viral DNA
results in viral RNA that serves as progeny genomes and is used for translation. Viral
polyproteins are cleaved by viral proteases to form virion proteins including the RNAdependent
DNA polymerase and integrase.
|
|
|
Term
Alpha and Beta Interferon |
|
Definition
(1) Encoded by cellular gene
(2) Transcription occurs upon viral infection, associated with viral nucleic acid replication
(3) Binds to specific receptor proteins on cell membrane, accounting for species specificity
(4) Induction of interferon-inducible proteins by signal transduction and phosphorylation of
cellular transcription factors
(5) Activation and functioning of the interferon inducible enzymes requires viral doublestranded
RNA and ATP
(6) Functions of interferon-inducible 2'-5' adenylate synthetase and of the interferon
inducible protein kinase
|
|
|
Term
|
Definition
Anti-viral inhibits polymerase activity by causing chain termination; nucleoside analog
(derivatives of acyclovir include valacyclovir, penciclovir, famciclovir)
(i) Specifically phosphorylated by herpesvirus thymidine kinase.
(ii) Preferentially inhibits herpesviral DNA-dependent DNA polymerase
|
|
|
Term
|
Definition
nucleoside analog anti-viral inhibits viral polymerase activity by causing chain termination
(i) Used in treatment of cytomegaloviral retinitis in AIDS patients. Specific
inhibition of viral DDDP
(ii)Phosphorylated by CMV protein kinase homologue, then to the triphosphate
form by cellular kinases
|
|
|
Term
|
Definition
anti-viral nucleoside analog inhibits viral polymerase by causing chain termination
(i) Phosphorylated by cellular enzymes
(ii)Inhibits HIV reverse transcriptase
(iii) Other nucleoside analogs that inhibit HIV reverse transcriptase (and in some
cases HBV): dideoxyinosine, dideoxycytidine, lamivudine, emtricitabine, adefovir
|
|
|
Term
Acyclic nucleoside phosphonates |
|
Definition
nucleoside analog anti-viral inhibits viral polymerase via chain termination
(e.g. cidofovir for CMV, tenofovir for HIV and HBV)
|
|
|
Term
Telbivudine and entecavir |
|
Definition
nucleoside analog anti-viral inhibits viral polymerase via chain termination
(i) Phosphorylated by cellular enzymes and inhibits HBV DNA polymerase (for
chronic HBV infection
|
|
|
Term
|
Definition
Causes errors in replication and transcription; nucleoside analog anti-viral
- inhibits respiratory synctial virus; also inhibits nucleoside biosynthesis
and formation of the mRNA 5' guanosine cap
|
|
|
Term
Trifluridine (trifluorothymidine, TFT)
or Idoxyuridine |
|
Definition
nucleoside analog anti-virral causes error in replication and transcription
thymidine analog, phosphorylated by
cellular enzymes, topical administration
|
|
|
Term
non-nucleoside analog anti-virals |
|
Definition
(1) Foscarnet - Binds to the pyrophosphate binding site of the herpesvirus DNA polymerase
and inhibits the viral DNA polymerase activity. Does not require phosphorylation to be
active. Treatment of CMV retinitis in AIDS patients.
(2) Efavirenz, nevirapine, and delavirdine - noncompetitively inhibits HIV-1 reverse
transciptase by binding to the enzyme; does not require phosphorylation to be active
|
|
|
Term
Anti-virals inhibiting uncoating |
|
Definition
Amantadine and Rimantadine (influenza A) |
|
|
Term
anti-virals affecting enzymatic function of viral proteins |
|
Definition
Protease Inhibitors (e.g. saquinavir, indinavir, nelfinavir, ritinavir) - Binds to active site of
the HIV protease inhibiting the cleavage of HIV polyproteins.
ii) Neuraminidase Inhibitors (zanamivir, oseltamivir) - competitive inhibitor of sialic acid
binding, prevents the functioning of neuraminidase and the formation of infectious progeny
virions
|
|
|
Term
Fusion inhibitor anti-viral |
|
Definition
(enfuvirtide): blocks HIV fusion with host cell by binding to gp41 (for HIV in
combination with other drugs)
|
|
|
Term
CCR5 co-receptor antagonist |
|
Definition
maraviroc [Selzentry]): blocks HIV binding to the chemokine receptor CCR5
|
|
|
Term
Integrase inhibitor anti-viral |
|
Definition
(raltegravir [Isentress]): blocks incorporation of HIV DNA into host genome
|
|
|
Term
|
Definition
Characteristics: naked icosahedral capsid (hexon, hexon-associated proteins, fiber [attachment,
hemagglutination] penton base [cytotoxic], core proteins [no enzymes]), genome dsDNA
Replication: in nucleus; early, and late transcripts; release by cell lysis
Pathogenesis: lytic or latent infections; transmission by aerosols, direct contact, fecal/oral; human
reservoir
Infections: acute febrile pharyngitis, atypical pneumonia, acute respiratory disease, pertussis-like
syndrome, pharyngoconjunctival fever, epidemic keratoconjunctivitis, acute hemorrhagic cystitis,
gastroenteritis (diarrhea in infants)
Control/prevention: none
|
|
|
Term
Bunyaviridae (Bunyavirus, Hantavirus) |
|
Definition
(envelope with 2 types of glycoproteins (G1 & G2);
genome composed of 3 neg pol RNA strands (large [L], medium [M], small [S]); L codes for RNS-dep-
RNA pol (found in nucleocapsid), M codes for envelope glycoproteins and a nonstructural protein, S
codes for nucleocapsid and a nonstructural proteinenvelope; replication in cytoplasm; bud into golgi
and released by exocytosis or cell lysis)
|
|
|
Term
|
Definition
(major strains: California encephalitis virus, La Crosse encephalitis virus)
Pathogenesis: Replicates in (transovarian transmission) and transmitted by mosquito (vector); squirrels,
chipmunks major reservoirs
Infections: subclinical, mild febrile disease, meningitis, encephalitis
Control/prevention: control vector
|
|
|
Term
|
Definition
(major strain: Sin Nombre)
Pathogenesis: mice major reservoir (strains are species-specific); transmitted by mouse saliva, urine,
feces
Infections: pulmonary syndrome (pulmonary edema), hemorrhagic fever renal syndrome (not in U.S.)
Control/prevention: control reservoir
|
|
|
Term
|
Definition
Characteristics: enveloped, helical nucleocapsid symmetry; 1 segment pos pol RNA genome; E2 protein
(attachment), E1 protein (matrix for assembly), E3 protein (hemagglutinin on some strains), L protein
(RNA-dependent-RNA polymerase (synthesizes neg pol template RNA; early protein during
replication), N protein (nucleocapsid)
Replication: replication and assembly in cytoplasm; neg pol template strand made from which several
mRNAs and progeny genomes are made; bud into ER for assembly; released through golgi
Pathogenesis: peak late winter through early spring; transmitted by aerosols, hand to hand, object to
hand; infects mostly URT epithelial cells; inflammation and cytokines contribute to pathogenesis.
Reinfections possible
Infections: cold (with pharyngitis), pneumonia, gastroenteritis
Control/prevention: none
SARS-associated Coronavius
causes a spectrum of symptoms from mild to severe lower respiratory
|
|
|
Term
|
Definition
(genus
Flavivirus
; St. Louis Encephalitis virus, Dengue virus, Yellow Fever virus,
Japanese encephalitis virus, West Nile virus)
Characteristics: similar to
Togaviridae
except envelope derived from intracytoplasmic membranes
Replication: similar to
Togaviridae
except all of genome translated into one protein that is processed into
|
|
|
Term
|
Definition
1.
St. Louis Encephalitis
: transmitted by mosquito; bird reservoir; infects reticuloendothelial
tissue, then viremia and dissemination to CNS
2.
Dengue virus:
transmitted by mosquito and vertically to neonate; primate and mosquito
reservoir; infects reticuloendothelial tissue, then viremia (virus circulates in blood cells) with
dissemination to many tissues; inflammatory cytokines associated with pathogenesis and
symptoms.
3.
Yellow Fever virus:
transmitted by mosquito; primate reservoir; pathogenesis similar to Dengue
except hepatitis, nephritis and circulatory failure more prominent.
4.
Japanese encephalitis virus
: transmitted by mosquito; pigs and aquatic birds main reservoir
5.
West Nile virus
: transmitted by mosquito; crows and aquatic birds main reservoir
|
|
|
Term
|
Definition
1.
St. Louis encephalitis virus
: fever & headache, meningitis, encephalitis
2.
Dengue virus
: Dengue fever (self-limited disease), Dengue hemorrhagic fever, Dengue shock
syndrome
3.
Yellow fever virus
: self-limited disease, hemorrhagic form
4.
Japanese encephalitis virus
: asymptomatic or encephalitis
5.
West Nile virus
: same as St. Louis encephalitis virus
Control/prevention: control vector; vaccine for Yellow fever virus and Japanese encephalitis virus
|
|
|
Term
|
Definition
(~ 20 strains) (family
Picornaviridae)
Characteristics: like Enterovirus but more resistant
Replication: like Enterovirus but infects hepatocytes
Pathogenesis: fecal/oral and common-source transmission; humans only significant reservoir; incubation
2-6 wks; portal inflammation and periportal necrosis (mediated by virus and CMI); no carriers or
chronic disease
Infections: Hepatitis (acute)
Control/prevention: block transmission; passive or active immunizations; single vaccine or vaccine for
both HAV and HBV (Twinrix)
|
|
|
Term
|
Definition
(family
Hepadnaviridae)
Characteristics: enveloped; circular partially dsDNA genome; Major antigens: HBsAg (envelope
protein), HBcAg (core/capsid protein), HBeAg (truncated core protein); core has reverstranscriptase
Replication: replicates in hepatocytes; dsDNA synthesis completed in core, DNA to nucleus; following
transcription and translation, RNA pregenome enclosed in progeny core; RNA pregenome serves as
template for synthesis of neg pol DNA strand, then partial synthesis of pos DNA strand; buds into golgi
and released by exocytosis
Pathogenesis: blood, sex, direct contact, transplacental or during birth transmission; portal and periportal
necrosis (mediated mostly by inflammatory infiltrate) that may lead to fibrosis and cirrhosis; estimated
that 1 million are carriers; humans most significant reservoir; incubation 1 to 4 months (avg 8 wks)
Infections: Hepatitis (subclinical; acute, self-limited; chronic persistent; chronic active; cirrhosis;
hepatocellular carcinoma)
Control/prevention: block transmission; passive or active immunizations (see HAV above); α IFN plus
reverse transcriptase inhibitor (adefovir, lamivudine, entecavir, or tenofovir) or telbivudine for chronic
infection
21
|
|
|
Term
|
Definition
(genus
Deltavirus
)
Characteristics: satellite virus that co-infects with HBV; enveloped; circular ssRNA genome; HDVAg is
core protein; requires HBsAg for replication
Replication: replication in hepatocytes completed only in presence of HBV
Pathogenesis: exacerbation of HBV infection
Infections: coinfection with HBV yielding fulminant hepatitis with death (~4%) or recovery with
immunity (~90%); superinfection of HBV carriers yielding fulminant hepatitis with death (~10%), acute
hepatitis with recovery (~10%), or chronic HBV/HDV hepatitis with cirrhosis (~80%)
Control/prevention: block transmission; α IFN
|
|
|
Term
|
Definition
(family
Flaviviridae)
Characteristics: enveloped; pos pol RNA genome; E1 and E2 envelope proteins; genome codes for 2
proteases and a RNA-dep-RNA-pol
Replication: similar to other Flaviviruses; genome encodes for a polyprotein that is cotranslationally
processed into at least 10 proteins; may replicate in cells other than hepatocytes; multiple genetic
variants recovered from single individual
Pathogenesis: transmitted predominantly by blood (transfusions, iv drug use); high percentage (~80%)
of infections become chronic; incubation 2-26 wks (avg 6-12 wks); characterized by inflammation with
fibrosis
Infections: Hepatitis (acute with resolution [~15%], chronic [~85%] that is stable [~80%] or results in
cirrhosis [~20%][stable, progressive with death, or hepatocellular carcinoma])
Control/prevention: block transmission; chronic treated with α IFN or α IFN + ribavirin
|
|
|
Term
|
Definition
(genus
Hepevirus, family Hepeviridae
)
Characteristics: non-enveloped; pos pol ssRNA genome
Pathogenesis: pathogenesis and transmission like HAV; incubation 4-8 wks; infects a number of
mammals but humans probably main reservoir for human strain-associated infection
Infections: Hepatitis (acute) with a high mortality in pregnant women (~20%)
Control/prevention: block transmission
|
|
|
Term
|
Definition
(enveloped [from nucleus], icosahedral capsid, dsDNA genome, no core enzymes,
replication in host nucleus, three phases of protein synthesis: immediate early [alpha proteins], early
[beta proteins], late [gamma proteins]; viral-encoded DNA polymerase [a beta protein] replicates the
genome; viruses released by budding or cell lysis; human reservoir; envelope proteins for attachment,
fusion, and cell trophism)
|
|
|
Term
|
Definition
(Human Herpes virus -1 & -2;
Alphaherpesvirinae
)
Pathogenesis: lytic and latent (in neurons) infections; transmission by saliva, sex, and vesicle fluid;
syncytia and intranuclear inclusions occur
Infections: gingivostomatitis, pharygotonsillitis, vulvovaginitis, skin infections (whitlow, gladiatorum),
eye infections, genital herpes, meningitis, encephalitis, neonatal infection, infection in the
immunocompromised, recurrent infections
Control/prevention: acyclovir, famciclovir, penciclovir,valacyclovir; topical preparations; cesarean
section for overt disease in genital tract
|
|
|
Term
|
Definition
(Human Herpes virus -3)
Pathogenesis: lytic and latent (in neurons) infections; transmission by aerosols (RT droplets) and vesicle
fluid; rarely transplacental; syncytia and intranuclear inclusions occur; infects reticuloendothelial tissue
then mucous membranes and skin following viremia
Infections: chickenpox (varicella), shingles (zoster)
Control/prevention: varicella Ig (VariZIG) and vaccines for varicella and zoster, acyclovir for varicella;
famciclovir or valacyclovir for zoster
|
|
|
Term
Epstein Barr Virus (Herpes virus 4) |
|
Definition
Pathogenesis: cellular receptor is CD21 (CR2), MHCII are coreceptors; productive (EBNA, VCA),
transforming and latent infections (EBNA, LMPs); transmission by intimate contact (saliva); B cell
activation and proliferation (heterophile Abs), 2 phases of lymphocytosis (B cells and Downey cells);
IL-10-like protein inhibits Th1 response
Infections: heterophile positive mononucleosis (complications), lymphoproliferative disease, neoplastic
diseases (Burkitt's lymphoma, Hodgkin's lymphoma, nasopharyngeal carcinoma)
Control/prevention: none
|
|
|
Term
Cytomegalovirus (Herpes virus 5) |
|
Definition
Replication: large nuclear inclusions occur (Owl's eye inclusion bodies); human CMV grows only in
human cells
Pathogenesis: inhibits expression of MHCI proteins; productive and latent (in many cell types)
infections; congenital, perinatal, oral, sexual, blood, and transplants route of transmission
Infections: congenital infection (cytomegalic inclusion disease), perinatal infection, heterophile-negative
mononucleosis, hepatitis, infection in immunocompromised (pneumonia, chorioretinitis,
colitis/esophagitis, CNS)
Control/prevention: ganciclovir, valganciclovir, foscarnet, or cidofovir
|
|
|
Term
Human Herpes virus 6 & 7 (Roseolovirus) |
|
Definition
Pathogenesis: transmitted by saliva; productive and latent infections; infects mononuclear cells;
downregulates MHCI and CD3 expression
Infections: Roseola (6th disease, exanthem subitum) in children; adult infection (lymphadenopathy,
hepatitis, mono-like syndrome); in immunocompromised (pneumonitis, encephalitis, hepatitis); HHV-7
may cause second cases of roseola
Control/prevention: none
|
|
|
Term
Human Herpes Virus 8 (Rhadinovirus) |
|
Definition
Pathogenesis: latent and lytic infections; latency-associated nuclear antigen important in neoplasia and
during latent genome replication
Infections: Kaposi's sarcoma
Control/prevention: none
|
|
|
Term
Influenza virus (family Orthomyxovirus; species influenza A, B, C) |
|
Definition
Characteristics: helical symmetry, enveloped, 7-8 negative polarity ssRNA genome; NA (N) and HA (H)
envelope proteins (antigenic drifts and shifts)
Replication: replicates in nucleus, assembles in cytoplasm; viral RNA-dependent RNA Pol synthesizes
pos pol RNA for translation and templates for genome replication
Pathogenesis: birds and other animals reservoirs for Inf A; human reservoir for B and C; aerosol
transmission; NS1 inhibits antiviral effects of interferons; replication in RT induces desquamation with
loss of ciliated epithelium; cytokines and T cells responses contribute to pathogenesis
Infections: influenza (complications: influenza pneumonia, bacterial pneumonia, myositis, meningitis,
aspirin-associated Reye syndrome), common cold
Control/prevention: vaccines; amantadine, rimantadine, zanamivir, oseltamivir
|
|
|
Term
Marburg and Ebola (family Filoviridae) |
|
Definition
Characteristics: enveloped, helical nucleocapsid symmetry; 1 segment neg pol RNA genome;
filamentous and pleomorphic
Replication: similar to Rabies; genome codes for 7 proteins
Pathogenesis: reservoirs and routes of spread uncertain; probably spread by direct contact or vectors;
massive tissue necrosis and hemorrhage; cytokines contribute to pathogenesis
Infections: hemorrhagic fever
Control/prevention: Possible use of hyperimmune serum
|
|
|
Term
|
Definition
(helical symmetry, enveloped, 2 cirular ssRNA segments as genome; rodent reservoir,
rodent urine transmission)
Lassa virus
: hemorrhagic fever
|
|
|
Term
|
Definition
spongiform encephalopathies associated with the accumulation of insoluble prion proteins
leading to progressive dementia and death (Kuru, Crueutzfeldt-Jakob disease variants, Mad
cow disease)
|
|
|
Term
Human Astrovirus
8 serogroups
family Astroviridae |
|
Definition
Characteristics: non-enveloped, icosahedral nucleocapsid symmetry; 1 segment pos pol ssRNA genome
filamentous and pleomorphic
Replication: similar to Noroviruses
Pathogenesis: fecal/oral transmission; peak in winter; mostly infects children under 3yr but all can be
infected; estimated 4 million cases per yr
Infections: gastroenteritis (nausea and diarrhea)
Control/prevention: block transmission
|
|
|
Term
Norovirus (5 serogroups)
family Caliciviridae |
|
Definition
Characteristics: non-enveloped, icosahedral symmetry; genome pos pol ssRNA
Replication: replicates and assembles in cytoplasm
Pathogenesis: transmitted by fecal/oral, aerosol, common source, human to human; many animal
reservoirs; estimated 20 million cases per year; infects epithelial cells in jejunum and prevents
absorption; peaks in fall and winter; all ages infected
Infections: gastroenteritis (vomiting and diarrhea)
Control/prevention: control transmission
|
|
|
Term
Human Papillomavirus
Family Papillomaviridae |
|
Definition
Characteristics: non-enveloped, icosahedral symmetry; circular dsDNA genome
Replication: in nucleus utilizing host enzymes
Pathogenesis: the most common viral STD; transmission by direct contact (lesions or inanimate objects);
long incubation; latent and productive infections occur; infection induces epithelial acanthosis,
parakeratosis, and hyperkeratosis (inhibits apoptosis); the koilocyte is diagnostic
Infections: Papillomas: cutaneous, head and neck, anogenital; cervical cancer
Control/prevention: vaccine; chemicals, surgery, imiquimod
|
|
|
Term
Polyomavirus
family Polyomaviridae
JC and BK viruses |
|
Definition
Characteristics: similar to the Papillomaviruses
Replication: similar to Papilloma viruses except prefer to replicate in the respiratory and urinary tracts
(JC and BK) and CNS (JC)
Pathogenesis: multiply in respiratory tract then kidney after viremia; latent infection in kidney
Infections: JC: progressive multifocal leukoencephalopathy; BK & JC: UTI in immunosuppressed
Control/prevention: none
|
|
|
Term
|
Definition
Parainfluenza, Mumps, Measles, Respiratory Syncytial, Metapneumovirus
(enveloped [have fusion protein],helical nucleocapsid [NP] symmetry, 1 segment neg pol RNA genome,
RNA polymerase in core, matrix protein, replicate in cytoplasm)
|
|
|
Term
Parainfluenza (HPIV 1,2,3,4A, 4B) |
|
Definition
Characteristics: HN protein (hemagglutinin/neuraminidase for attachment)
Pathogenesis: transmitted by aerosols or direct contact; humans only reservoir; replicates in mucosal
epithelium of URT; immunity short-lived so re-infections common; Th1 response contributes to path;
HPIV-1 and 2 peaks in fall and winter; HPIV-3 all year with peak in spring; HPIV-4 all year
Infections: HPIV-1-3: croup, pneumonia, bronchiolitis/bronchitis; HPIV-1-4: cold, otitis media,
conjunctivitis
Control/prevention: upper airway support
|
|
|
Term
|
Definition
(genus
Rubulavirus)
Characteristics: like Parainfluenza
Pathogenesis: transmitted by aerosols; humans only reservoir; replicates in mucosal epithelium of URT
yielding viremia; infects parotids and submandibular glands; also may infect pancreas, testes, ovaries,
peripheral nerves, eye, inner ear, and CNS; virus occurs in oral secretions and urine
Infections: mumps (parotitis); complications (orchitis, oophoritis, meningitis, encephalitis)
Control/prevention: vaccine
|
|
|
Term
|
Definition
(genus
Morbillivirus
)
Characteristics: H protein for attachment
Pathogenesis: transmitted by aerosols; humans only reservoir; replicates in URT, then reticuloendothelial
tissue yielding viremia; infects conjunctivae, UT, CNS, RT; infection of endothelial cells results in
vasculitis; virus occurs in RT secretions, urine
Infections: Rubeola (measles); complications (encephalitis, pneumonia, giant cell pneumonia in
immunocompromised, subacute sclerosing panencephalitis)
Control/prevention: vaccine
|
|
|
Term
Respiratory Syncytial virus (genus Pneumovirus) |
|
Definition
Pathogenesis: transmitted by aerosols and direct contact (hands); humans only reservoir; replicates in
mucosal epithelium of URT then spreads to LRT; incomplete immunity from infection; pathologic
change associated with syncytia and inflammation-mediated necrosis
Infections: infants and young children: bronchiolitis, pneumonia, tracheobronchitis, croup, otitis media;
older children and adults: cold, pharyngitis, tracheobronchitis, pneumonia
Control/prevention: Ribavirin for certain situations; Palivizumab (humanized Ab to the F glycoprotein)
|
|
|
Term
|
Definition
Characteristics and pathogenesis: like RSV
Infections: bronchiolitis and pneumonia in young children; cough, congestion in older children and
adults
Control/prevention: none
|
|
|
Term
|
Definition
Human Parvovirus (B19)
(genus Erythrovirus)
Characteristics: non-enveloped, icosahedral symmetry; ssDNA genome
Replication: in nucleus
Pathogenesis: aerosol or transplacental routes of infection; infects erythroid precursors; requires
mitotically active cells; humans only reservoir
Infections: Erythema infectiosum (5th disease) in children; mild disease in adults (polyarthritis); fetal
infections and complications (hydrops fetalis); aplastic crisis in those with hemolytic anemias
Control/prevention: none
|
|
|
Term
|
Definition
Enteroviruses, Rhinovirus
(
positive polarity ssRNA genome; non-enveloped,
icosahedral symmetry; capsid proteins mediate adherence; replication in the cytoplasm, one large protein
processed to structural proteins, polymerase, and protease; release by cell lysis; human reservoir)
|
|
|
Term
Enteroviruses (coxsackie A&B, Echovirus, Enterovirus, Poliovirus) |
|
Definition
Pathogenesis: transmitted by fecal oral, direct contact, or aerosols; initial replication in GIT; humans
only reservoir; resistant to low pH, salt, detergents; final target tissue varies with virus (e.g. skin, heart,
CNS)
Infections: Poliovirus (Poliomyelitis), Coxsackie A (acute febrile disease, meningitis, encephalitis, cold
w/ fever, febrile rash {hand, foot and mouth disease, pericarditis, hemorrhagic conjunctivitis,
herpangina), Coxsackie B (acute febrile disease, meningitis, encephalitis, cold w/ fever, myocarditis,
pericarditis, pleurodynia, transplacental infection), Echovirus A (acute febrile disease, meningitis,
encephalitis, cold w/ fever, febrile rashes, diarrhea w/ fever), Enterovirus (hemorrhagic conjunctivitis)
Control/prevention: no treatment; vaccine for
Poliovirus
(IPV now used again in USA, OPV still used in countries with active polio cases)
|
|
|
Term
|
Definition
Pathogenesis: most infections in early fall & late spring; transmitted by direct contact (hand to hand,
object to hand) or aerosols; replication in URT; ICAM-1 host cell receptor; cytokines contribute to
pathogenesis
Infections: cold, lower RT infection, exacerbation of chronic lung and bronchial diseases (e.g. asthma);
recurrent infections
Control/prevention: none
|
|
|
Term
|
Definition
Smallpox, Molluscum contagiosum,
(complex envelope and symmetry; genome is
linear dsDNA; core contains DNA-dependent-RNA pol; replicates and assembles in cytoplasm; release
by cell lysis)
|
|
|
Term
|
Definition
(genus
Orthopoxvirus, species Variola virus)
Pathogenesis: humans only reservoir; transmission by aerosols or direct contact; replicates in
reticuloendothelial tissue then disseminates to skin and mucous membranes
Infections: variola major and minor
Control/prevention: no treatment; vaccine (Vaccinia virus; not available to public)
|
|
|
Term
Molluscum contagiosum virus (Molluscipoxvirus) |
|
Definition
Pathogenesis: transmitted by direct contact including sexual transmission; self-limiting cutaneous
lesions occur (umbilicated nodule with caseous plug)
Infections: Molluscum contagiosum
Control/prevention: no treatment
|
|
|
Term
Rabies virus (family Rhabdoviridae) |
|
Definition
Characteristics: enveloped, helical nucleocapsid symmetry; 1 segment neg pol RNA genome
Replication: replication and assembly in cytoplasm; pos pol template strand made from which progeny
genomes are made; several mRNAs made from neg pol strand
Pathogenesis: zoonotic disease (common reservoirs are bats, foxes, raccons, and skunks); transmission
by bite or scratch or aerosols; virus travels by retrograde axonal transport to CNS then via afferent
neurons to eye, skin, salivary glands
Infections: Rabies encephalitis
Control/prevention: vaccine
|
|
|
Term
|
Definition
Rotavirus, Colorado tick fever virus (non-enveloped, dsRNA genome)
|
|
|
Term
|
Definition
(genus
Rotavirus, serogroups A-E)
Characteristics: 3 capsid layers and inner core; outer capsid composed of VP4 (host attachment); core
contains complete transcription system; genome composed of 11 segments of dsRNA
Replication: transcription occurs in inner core, translation in cytoplasm; genome replicated in progeny
core using pos pol RNA template; buds into ER, release by cell lysis
Pathogenesis: estimated 4 million cases/yr; fecal/oral or human to human transmission (virus survives in
environment); humans probably only reservoir; peak age 6mo-2yr but all ages can be infected; infects
villus cells in small intestine preventing absorption
Infections: gastroenteritis (fever, vomiting, watery diarrhea)
Control/prevention: none
|
|
|
Term
Colorado Tick Fever virus (genus Coltivirus) |
|
Definition
Characteristics: like Rotavirus but outer capsid not as organized (2 capsid layers); genome 12 dsRNA
segments
Replication: like Rotavirus
Pathogenesis: transmitted by wood ticks; small mammals are reservoirs; infects erythroid precursors
Infections: Colorado tick fever (relapsing fever, headache, myalgia)
Control/prevention: control vector and reservoirs
|
|
|
Term
|
Definition
Human immunodeficiency virus 1 & 2, Human T-cell lymphotrophic 1 (enveloped, 2
identical pos pol RNA stands as genome; proviral DNA integrates into host chromosome; core contains
reverse transcriptase, protease, integrase; genome encodes regulator proteins; humans only significant
reservoir; transmitted by sex, blood, perinatal [in utero, at delivery, breast-feeding])
|
|
|
Term
HIV 1 & 2 (genus Lentivirus) |
|
Definition
Characteristics: envelope proteins gp 120, gp 41 for attachment/entry; inner core (Gag protein p24)
Replication: attaches via CD4 and chemokine receptor; envelope fuses, core enters cytoplasm, reverse
transcriptase synthesizes DNA; transcripts and progeny genomes synthesized; assembly and buds
through plasma membrane; core maturation occurs after release
Pathogenesis: chronic infection that induces profound immunosuppression resulting in life-threatening
secondary infections; lymphopenia, reduced T-cell activity, and reduced macrophage activity; incubation
1-6 wks before onset of acute retroviral syndrome; routes of transmission like HBV; Infections: AIDS;
CDC classification: acute (acute retroviral syndrome ["mononucleosis-like"]), chronic (asymptomatic
with persistent generalized lymphadenopathy), final crisis (secondary infections, neurologic disease,
secondary neoplastic disease, unexplained constitutional diseases); presentations peculiar to women or
children
Control/prevention: block transmission; nucleoside RT inhibitors, non-nucleoside RT inhibitors (only for
HIV-1), protease inhibitors, fusion inhibitor, integrase inhibitor, and co-receptoer inhibitor (see antiviral
section)
|
|
|
Term
|
Definition
Rubella virus, Alphaviruses
(enveloped [from cytoplasm], icosahedral symmetry, 1
segment pos pol RNA genome; 2/3 of genome translated into early proteins (protease, RNA-dep-RNA
pol); neg pol strand made for genome template and 26S transcript; 26S translated into precursor protein
that is cleaved by protease into structural proteins
|
|
|
Term
Rubella virus (genus Rubivirus) |
|
Definition
Pathogenesis: aerosol transmission; humans only reservoir; infects URT, then 1st viremia, infection of
reticuloendothelial tissue then second viremia (fetal infection possible) and immune complex-mediated
vascultis (rash)
Infections: Rubella (German measles), congenital rubella syndrome
Control/prevention: vaccine
|
|
|
Term
Alphavirus (Eastern Equine, Western Equine, Venezuelan Equine Encephalitis viruses) |
|
Definition
Pathogenesis: transmitted by mosquito; birds (WEE & EEE), rodents reservoirs (VEE) and possibly also
amphibians and reptiles; infection of reticuloendothelial tissue then viremia and CNS infection;
inflammatory neuronal necrosis
Infections: encephalitis
Control/prevention: control vector; veterinary vaccines
|
|
|
Term
|
Definition
(+ssRNA, mosquito-borne)
Pathogenesis: acute fever (~2 days @ 40
oC), petechial or maculopapular rash, then headaches, insomnia,
photophobia, intense joint pain (resembles Dengue fever), severe prostration lasting several weeks to
several months; infection of endothelial cells and macrophages; cytopathic infection results in
apoptosis of host cell
Diagnosis and treatment: Diagnosis usu. by RT-PCR or by ELISA for anti-CHIKV IgM; currently no
vaccine, and no specific treatment; chloroquine may alleviate arthritis symptoms
In the news: Typically an African and Asian virus, CHIKV underwent a mutation around 2005 that
enabled it to use another species of Aedes mosquito as a vector. This new host has a broader range, and
has resulted in primary CHIKV cases in Europe (Italy) and on Reunion Island (France).
|
|
|
Term
|
Definition
Single cells that reproduce by budding; some can, under special conditions, form elongated cells that stick together and look like hyphae |
|
|
Term
|
Definition
(grow as filaments or hyphae [septate or non-septate] and reproduce with specialized structures that bear the conidia or produce conidia within the filament.)
(1) Dimorphism is an important trait in many pathogenic fungi. It means that at one temperature (usually 25C), the fungus grows as a mold, and at another temperature (usually 37C) the fungus grows as a yeast
|
|
|
Term
Fungi cell wall composition |
|
Definition
Usually composed of a mixture of chitin, glucan,
and mannan. Yeasts usually only have chitin at the bud scar. The cell wall
is a potent immunogen, however the role of Abs in protection is limited.
|
|
|
Term
|
Definition
Plasma membrane (Fungal plasma membranes contain the sterols ergosterol & zymosterol. Ergosterol and enzymes that synthesize it are the major targets of antifungal drugs.)
|
|
|
Term
|
Definition
Conidia-free spores not enclosed by a spore bearing sac
Sporangiospores-formed by successive division within a sac like structure called a sporangium, attached to a stalk called a sporangiophore |
|
|
Term
|
Definition
Arthrospores-block shaped spores formed when a septate hypha fragments at the crosswall
Chlamydospores-thick walled sperical conidium formed by the septate hypha; are resting spores
Blastospores-produced by budding from a parent cell that is a yeast or another conidium
Microconidium and macroconidium-smaller and larger conidia produced by same fungus (micro=short stalk/one celled) |
|
|
Term
|
Definition
(heterotrophic; utilize a variety of carbohydrates [specific for the species]
some are strict aerobes, some facultative anaerobes)
|
|
|
Term
|
Definition
a.Portals of entry (skin, inhalation, GIT, UT, normal flora)
b. Virulence determinants (predisposing condition [reduced CMI, underlying disease]; filament vs. yeasts; components immunosuppress and/or evade
immune system; extracellular enzymes; induction of proinflammatory cytokines; tissue trophism and adherence; allergic reactions)
|
|
|
Term
Fungal disease classification |
|
Definition
Disease Classification
(1) superficial (Pityriasis versicolor, Tinea nigra)
(2) cutaneous (Dermatophytosis)
(3) subcutaneous (Sporotrichosis)
(4) systemic
(a) primary (Coccidioidomycosis, Histoplasmosis,
Blastomycosis, Cryptococcosis)
(b) opportunistic (Candidiasis, Aspergillosis, Mucormycosis
|
|
|
Term
|
Definition
a. Microscopy (cotton blue, KOH, methenamine silver stain, periodic acid-Schiff stain)
b. Culture (slide culture, birdseed agar for
Cryptococcus, dermatophyte test medium, Sabouraud dextrose agar, biochemical tests
c. serum antibody detection; complement fixation test, agar diffusion test, PCR
|
|
|
Term
|
Definition
Polyenes, Azoles, Flucytosine, Griseofulvin, Terbinafine, Echinocandins |
|
|
Term
|
Definition
(Nystatin, Amphotericin B [AmB]; bind ergosterol and cause an increase in membrane permeability; nystatin used topically for oral and vaginal candidiasis; AmB used topically and systemically [colloidal complex in desoxycholate or as a lipid complex]; AmB drug of choice for most disseminated fungal infections)
|
|
|
Term
|
Definition
Azoles (Miconazole, Ketoconazole, Clotrimazole, Itraconazole,Fluconazole, Voriconazole, Posaconazole, Terconazole; inhibit cytochrome P-450 and thus block ergosterol synthesis that results in increased membrane permeability
|
|
|
Term
|
Definition
inhibits DNA synthesis; used systematically in combination with AmB |
|
|
Term
|
Definition
disrupts microtubules; used for dermatophyte infections |
|
|
Term
|
Definition
inhibits squalene epoxidase and thus ergosterol synthesis; used for dermatophyte infections |
|
|
Term
|
Definition
inhibit glucan synthesis, caspogungin, micafungin, anidulafungin |
|
|
Term
Dermatophytes/
agents causeing superficial infections |
|
Definition
(anthropophilic, zoophilic, & geophilic
varieties; routes of transmission usually direct contact with spores or spore-laden hair or skin scales;
pathogenesis: spores adhere to keratinized tissue, germinate, secrete keratinases, and invade and grow;
hair infection may be endothrix or ectothrix pattern; extent of inflammation varies; Th1 response needed
to control)
|
|
|
Term
Dermatophytoses
Tinea Pedis |
|
Definition
(infection of foot and toes; "id reaction" (autoeczematization)
etiology usually
Trichophyton mentagrophytes, T. rubrum,
or less frequently
Epidermophyton floccosum
; treat topical, itraconazole, terbinafine, fluconazole)
|
|
|
Term
Dermatophytoses
Onychomycosis |
|
Definition
(Tinea unguium; infection of nails; etiology like T. pedis; treat with terbinafine, fluconazole, griseofulvin
|
|
|
Term
Dermatophytoses
Tinea corporis and Tinea faciei |
|
Definition
(infection of the skin and face, respectively;
etiology:
Microsporum audouinii, M. canis, M. gypseum, T.rubrum,
T.verrucosum; treat topical, terbinafine, fluconazole, itraconazole
|
|
|
Term
Dermatophytoses
Tinea barbae |
|
Definition
(infection of the beard; etiology:
T. verrucosum, T. mentagrophytes
treat topical, terbinafine, fluconazole, itraconazole)
|
|
|
Term
Dermatophytoses
Tinea cruris |
|
Definition
(infection of the groin; etiology:
T. rubrum, E. floccosum; treat topical, terbinafine, fluconazole, itraconazole
|
|
|
Term
Dermatophytoses
Tinea capitis |
|
Definition
(infection of the scalp; etiology
T. tonsurans
(most common in this country), M. canis, M. audouinii, T. verrucosum; treat griseofulvin, terbinafine, itraconazole
|
|
|
Term
|
Definition
(1)Tinea nigra (infection of the epidermis, usually hands; etiology:
Exophiala werneckii; treat topical, ketoconazole, itraconazole)
(2) Tinea versicolor (infection of the skin, trunk common; etiology:
Malassezia furfur; treat topical selenium sulfide, ketoconazole, fluconazole,
|
|
|
Term
Sporothrix schenckii (sporotrichosis) |
|
Definition
Characteristics: ubiquitous (especially soil and vegetation) dimorphic fungus; at ambient
temps grows as branching septate hyphae with single or clusters of microconidia;
at 37C grows as elongated yeasts
Pathogenesis: traumatic inoculation of skin with conidia or hyphae; inflammation,
induration at site; asending lymphangitis may occur; pulmonary infection initiated
by inhaling conidia
Infections: lymphocutaneous sporotrichosis, pulmonary sporotrichosis, osteoarticular
sporotrichosis, disseminated in AIDS
Control: cutaneous with itraconazole; disseminated with amphotericin B
|
|
|
Term
Coccidioides immitis (coccidioidomycosis) |
|
Definition
Characteristics: found in desert soil (endemic in southern Texas, New Mexico, Arizona,
and California); at ambient temps grows as branching, septate, hyphae that forms
arthrospores; at 37C forms spherules containing endospores
Pathogenesis: ~60% of the infections are asymptomatic; infection initiated by inhalation
of arthrospores; pulmonary symptoms generally mild and are associated with
inflammatory reaction to spherules; may form cavity or nodular granuloma; may
disseminate to skin, bone and joints, and CNS
Infections: primary pulmonary coccidioidomycosis, disseminated coccidioidomycosis,
primary cutaneous coccidioidomycosis
Control: ketoconazole, fluconazole, itraconazole, or amphotericin B for severe infection
|
|
|
Term
|
Definition
(var
capsulatum and var duboisii) (Histoplasmosis)
Characteristics: grows in rich, acidic soil enriched by bird and bat feces (endemic in the
Ohio-Mississippi valleys); at ambient temps grows as branching, septate hyphae
that form microconidia and tuberculate macroconidia; at 37C grows as small, oval
yeasts
Pathogenesis: ~90% of cases asymptomatic or mild influenza-like; inhale microconidia,
ingested by macrophages, undergoes dimorphic transition; disseminates to
reticuloendothelial tissue; a facultative intracellular parasite (in macrophages)
Infections: acute primary pulmonary histoplasmosis, chronic (cavitary) pulmonary
histoplasmosis, progressive disseminated histoplasmosis (acute and chronic),
cutaneous histoplasmosis (African histoplasmosis caused by
H. capsulatum var duboisii)
|
|
|
Term
Blastomyces dermatitidis (Blastomycosis) |
|
Definition
Characteristics: epidemiology similar to
H. capsulatum except endemic area larger;
grows in rich soil contaminated with bird feces or decaying vegetation; at ambient
temps grows as branching, septate hyphae that produce microconidia; at 37C
grows as a thick-walled yeast with large-pore buds
Pathogenesis: ~50% of infections are asymptomatic; inhale microconidia, dimorphic
transition, WI-1 cell wall protein mediates adherence to host cells; yeast cell wall
may be antiphagocytic; tissue damage mediated by inflammatory infiltrate;
lesions may become granulomatous
Infections: primary pulmonary blastomycosis (course may invole complete recovery or
become progressive with or without dissemination), chronic pulmonary
blastomycosis, disseminated blastomycosis, cutaneous blastomycosis
Control: itraconazole or amphotericin B for severe infection
|
|
|
Term
Cryptococcus neoformans (serotypes D and A)
and
C. bacillospora (sero B&C)
cryptococcosis |
|
Definition
Characteristics: sero A has worldwide distribution, found in areas contaminated with
dried bird feces, infects the immunocompromised;
C. bacillospora restricted to
regions with eucalyptus trees, infects the immunocompetent; grows as a yeast at
all temps; prominent polysaccharide capsule; deposits melanin in cell wall when
grown on catecols
Pathogenesis: capsule is antiphagocytic and immunosuppressive; melanin protects from
oxidative damage; small-capsule yeasts inhaled, primary infection established in
lung, disseminates to CNS
Infections: pulmonary cryptococcosis (acute and chronic), disseminated cryptococcosis
(skin, CNS)
Control: fluconazole, amphotericin B, or amphotericin B +flucytosine
|
|
|
Term
|
Definition
(
C. tropicalis, parapsilosis, glabrata) (Candidiasis)
Characteristics (C. alb): grows as yeasts at all temps; at 37C in the presence of inducers
forms germ tubes and eventually hyphae (dimorphic transition); on special media forms
pseudohyphae and chlamydospores; C. albicans causes ~70% of the candidiasis
cases; normal inhabitant of the GIT
Pathogenesis: usually requires predisposing condition to cause infection;
attachment followed by release of proteases and tissue invasion associated with acute
infection; chronic infection often involves formation of granulomas
Infections: oral and vaginal candidiasis, intertriginous candidiasis, paronychia, onychia,
generalized cutaneous, chronic mucocutaneous, esophagitis, gastrointestinal
candidiasis, bronchopulmonary candidiasis, UTI, fungemia, endocarditis,hepatosplenic candidiasis
Control: topical (e.g. nystatin, miconazole), fluconazole, posaconazole, amphotericin B,
amphotericin B + flucytosine, or echinocandin
|
|
|
Term
|
Definition
(A. fumigatus and A. flavus) (Aspergillosis)
Characteristics:
A. fumigatus causes ~90% of the infections; common soil fungus,
worldwide distribution; thin septate hyphae that typically branch at 45 degree
angles; asexual cycle involves formation of conidia on complex conidiophore
Pathogenesis: inhale conidia, germinate, hyphae adhere to extracellular matrix proteins,
secrete enzymes and toxic secondary metabolites, hyphae invade tissue or grow in
cavities; Th1 response induced; immunocompromised at greatest risk
Infections: allergic bronchopulmonary aspergillosis, aspergilloma (fungus ball), invasive
sinusitis, invasive pulmonary aspergillosis, disseminated aspergillosis
Control: voriconazole (drug of choice for invasive disease), amphotericin B, itraconazole,
or echinocandin
|
|
|
Term
Mucormycosis or Zygomycosis |
|
Definition
(
Rhizopus, Absidia, Mucor, Rhizomucor)
Characteristics: ubiquitous soil fungi; grow as irregularly shaped, non-septate hyphae
with right-angle branches; sporangiospores contained in sporangia
Pathogenesis: infections limited to the immunocompromised, diabetics, and trauma;
inhale spores, germinate, invade tissue and blood; results in tissue necrosis,
thrombosis
Infections: rhinocerebral mucomycosis (most in poorly managed diabetics), pulmonary
mucormycosis (neutropenia), cutaneous mucomycosis (trauma)
Control: amphotericin B or posaconazole
|
|
|
Term
pneumocystis jirovecii (formerly P. carinii)
pneumocystosis |
|
Definition
Characteristics: complex sexual cycle, simple asexual cycle involving yeast-like trophic
form
Pathogenesis: transmitted by aerosols; trophozoite or sporozoite infectious form inhaled,
adheres to type I epithelial cells, proliferates, and induces inflammatory exudate
resulting in hypoxemia; immunosuppression required for infection
Infections: pneumonia (disseminates to reticuloendothelial tissue in advance AIDS
patients)
Control: trimethoprim+sulfamethoxazole
|
|
|
Term
|
Definition
(size 2-100
m, cytoplasm often composed of inner endoplasm
[nutrition] and outer ectoplasm[organelles of locomotion])
(1) Rhizopods (amebas; reproduce by binary fission)
(2) Ciliates (reproduce by binary fission)
(3) Flagellates (reproduce by binary fission)
(4) Sporozoans (reproduce sexually [sporogony] and asexually
[shizogony])
(5) Physiology (most fac. anaerobes; heterotrophic; engulf food by
pinocytosis or phagocytosis; some have specific site for ingestion
[the peristome or cytostome]; many can form resistant cysts)
|
|
|
Term
|
Definition
(elongated, bilaterally symmetric, length varies from <1mm to
>1m; body wall covered with cuticle; anterior end may possess suckers,
hooks, teeth, etc. for attachment; all have differentiated organs [primitive
nervous and excretory systems and well developed reproductive systems
(1) Roundworms (nematodes; have cylindrical bodies, tubular
alimentary track, and the sexes are separate)
(2) Tapeworms (cestodes; have flattened bodies; the anterior end
[scolex] has suckers and or hooklets for attachment; reproductive
segments are called proglottids and each contains both male and
female gonads; no digestive tract)
(3) Flukes (trematodes; flat with branching alimentary tracts;
particulate wastes are regurgitated through the mouth; have two
suckers for attachment; most are hermaphroditic [except
S.mansoni))
4) physiology (ingest or absorb body fluids, etc.; usually anaerobic respiration)
|
|
|
Term
Parasite immunity and Diagnosis |
|
Definition
(all aspects of the immune system important; eosinophils directed at
worms; IgE made to many; acquired resistance often absent or incomplete;
effector mechanisms usually directed at surface antigens of the parasite)
3. Diagnosis (direct examination of specimens [microscopy], serology [ELISA, IF,
CF], molecular probes)
|
|
|
Term
Drugs for luminal protozoa
(aemae, flagellates, ciliates) |
|
Definition
(1) Metronidazole and tinidazole
(2) Nitazoxanide (for
Cryptosporidium)
(3) Paromomycin
(4) Iodoquinol
(5) Furazolidone
(6) Pentamidine
(7) Amphotericin B (for
Naegleria and Leishmania)
|
|
|
Term
|
Definition
(1) Chloroquine
(2) Primaquine
(3) Quinine
(4) Quinidine
(5) Mefloquine
(6) Atovaquone/proquanil (malarone)
(7) Doxycycline
(8) Artesunate (for severe malaria; only available from the CDC)
|
|
|
Term
|
Definition
(1) Albendazole
(2) Mebendazole
(3) Pyrantel pamoate
(4) Ivermectin
|
|
|
Term
drugs for flukes and tapeworms |
|
Definition
1) praziquantel
2) Albendazole |
|
|
Term
Miscellaneous parasite drugs |
|
Definition
1) pyrimethamine/sulfadiazine (for Toxoplasma gondii)
2)Trimethoprim/sulfamethoxazole (for Cyclospora cayatamensis) |
|
|
Term
|
Definition
(
P. vivax, P. ovale, P. malariae, P. falciparum
)
Characteristics/life cycle: sporogeny in mosquito (gametocytes, ookinete, oocyst,
sporozoites), schizogony in human (sporozoite, merozoite [liver & RBC],
trophozoite, schizont, gametocyte
Pathogenesis: transmitted by female
Anopheles
; symptoms associated with RBC rupture
and proinflammatory cytokines; anemia associated with depression of marrow
function; RBCs sequestered in spleen
Infections: malaria:
P. vivax
most prevalent worldwide, invades immature RBC, may
cause chronic infection;
P. falciparum
invades any RBC, associated with microvascular disease as a result of mature trophozoite-infected RBC adhering to microvascular endothelium
Control: chloroquine, mefloquine, primaquine, atovaquone/proquanil, quinine
|
|
|
Term
|
Definition
Characteristics/life cycle: schizogony and sporogeny in cat GIT (trophozoites,
merozoites, gametocytes), oocyst released in feces that mature to contain
sporozoites; oocyst ingested by intermediate host (humans), intracellular
schizogony occurs yielding tachyzoites that encyst; cyst produces sporozoites and
bradyzoites that are passed in feces and infect definitive host
Pathogenesis: transmitted by fecal-oral route or from ingesting undercooked infected
meat; various sizes cysts occur in tissue with varying degrees of inflammation
Infections: acute and chronic toxoplasmosis, congenital toxoplasmosis, toxoplasmosis in
the immunocompromised
Control: pyrimethamine + sulfadiazine or clindamycin
|
|
|
Term
|
Definition
Characteristics/life cycle: acid fast oocysts containing 4 sporozoites ingested, sporozoites
released and attach to microvilli in GIT; become schizonts that release merozoites
that become gametes that mate and become oocyst that is released in the feces
Pathogenesis: many animals serve as reservoirs; transmitted by fecal/oral and person to
person; oocyst resistant to chlorination
Infections: Cryptosporidiosis (noninflammatory, watery diarrhea); may be prolonged in
immunocompromised
Control: avoid contaminated water; Nitazoxanide (Alina)
|
|
|
Term
|
Definition
Characteristics/life cycle: like
C. parvum
but oocyts (fluoresce under UV light) contain 2
sporocysts that each contain 2 sporozoites
Pathogenesis: like
C. parvum
except oocyts mature in the environment
Infections: like
C. parvum
Control: trimeth-sulfameth
|
|
|
Term
|
Definition
Characteristics/life cycle: trophozoite with ameboid morphology; forms cyst with
chromatoidal body
Pathogenesis: transmitted by anal sex, fecal/oral, fomites; ingest cyst, gastric acid induces
release of trophozoites, adhere to epithelial cells in colon via galactose-specific
lectin, release pore-forming protein, invade, and multiply; kill epithelial cells
resulting in a loss of fluid uptake and inflammatory diarrhea
Infections: amebiasis (inflammatory diarrhea), may be asymptomatic (carriers), may
disseminate in immunocompromised
Control: metronidazole or tinidazole followed by paromomycin to eliminate cysts
|
|
|
Term
|
Definition
Characteristics/life cycle: flagellate morphology (flagella, axostyle, undulating
membrane); exists only as trophozoite that divides by binary fission
Pathogenesis: transmitted by sexual contact; infects urethra, vagina, prostate; serious
infections involve necrosis and inflammation; men mostly asymtomatic and the
predominant reservoirs
Infections: women: asymptomatic, vaginitis; men: asymtomatic, urethritis, prostatitis
Control: safe sex; metronidazole or tinidazole
|
|
|
Term
|
Definition
Characteristics/life cycle: flagellate morphology (flagella, sucker [adhesive disk], 2
nuclei); trophozoite and cysts occur; trophozoites multiply by longitudinal binary
fission
Pathogenesis: transmitted by fecal/oral or contaminated food or water; ingest cyst,
trophozoites released and attach to epithelial cells in duodenum; attachment
induces inflammation, tissue damage, and reduce absorption
Infections: acute or chronic noninflammatory diarrhea; may be asymptomatic
Control: metronidazole or tinidazole
|
|
|
Term
|
Definition
(
L. tropica, L. mexicana, L. braziliensis, L. major, L. donovani)
Characteristics/life cycle: hemoflagellate morphology of free-living promastigote,
intracellular amastigote
Pathogenesis: numerous animal reservoirs; transmitted by the bite of female sandfly;
promastigote invades reticuloendothelial tissue and becomes the intracellular
amastigote; replicates and invades other tissue, resulting in inflammation and
necrosis
Infections: cutaneous, mucocutaneous, and disseminated (visceral) leishmaniasis
Control: amphotericin B or pentamidine
|
|
|
Term
|
Definition
Characteristics/life cycle: epimastigote in insect gut, trypomastigote free-living in host
(hemoflagellate morphology), amastigote intracellular
Pathogenesis: numerous animal reservoirs; transmitted by feces of reduviid (kissing) bug;
trypomastigote invades tissue, becomes intracellular amastigote that replicates
and lyses cell; trypomastigote released into blood; tissue inflammation and
necrosis
Infections: American trypanosomiasis (Chagas’ disease)
Control: nifurtimox (from the CDC)
|
|
|
Term
Helminths:
Enterobius vermicularis (pinworm) |
|
Definition
Characteristics: nematode morphology (cylindrical body, tubular alimentary tract, separate sexes)
Pathogenesis: humans only reservoir; hand to mouth or fecal/oral transmission; ingest
eggs, hatch, larvae penetrate mucosa of large intestine, mature into different
sexes, mate, female lays eggs in perianal area; eggs induce allergic reaction
Infections: Pinworm disease (Enterobiasis)
Control: mebendazole or albendazole; pyrantel pamoate is an alternative
|
|
|
Term
Trichuris trichuria (whipworm) |
|
Definition
Characteristics: nematode morphology (cylindrical body, tubular alimentary
tract, separate sexes)
Pathogenesis: humans only reservoir; fecal/oral transmission; ingest embyonated egg,
larvae penetrate mucosa of large intestine, sexes mature, mate, female releases
eggs in feces; larvae develop in moist, dark environment; whip penetrates and
damages mucosa; symptoms related to worm burden
Infections: Whipworm disease (Tricuriasis)
Control: mebendazole or albendazole
|
|
|
Term
|
Definition
Characteristics: nematode morphology; worms may reach 1 m in length
Pathogenesis: humans main reservoir; fecal/oral, hand to mouth transmission; ingest
embyonated egg, larvae penetrate duodenal wall, enter blood then lung, grow in
alveoli, coughed up and swallowed, mature in small intestine, mate, female
produces eggs that are passed in feces; larvae in fertilized eggs mature in moist
dark environments; symptoms related to worm burden
Infections: Ascariasis
Control: mebendazole or albendazole; pyrantel pamoate is an alternative
|
|
|
Term
|
Definition
(Ancylostoma duodenale)
(Hookworm)
Characteristics: nematode morphology; 2 larval morphologies (rhabditiform
[free-living], filariform [infective])
Pathogenesis: transmitted by contact with contaminated soil; filariform larvae penetrate
skin, enter blood, then lungs, coughed up, swallowed, attach to mucosa of small
intestine, induces inflammation and necrosis; mate, eggs pass in feces, mature in
soil, rhabditiforn larvae released, free-lining, develop into infective filariform
larvae
Infections: Hookworm disease (hypersensitive pneumonitis, GIT symptoms); cutaneous
larval migrans caused by non-human hookworms
Control: albendazole, mebendazole, or pyrantel pamoate
|
|
|
Term
Strongyloides stercoralis |
|
Definition
Characteristics: like
Necator
Pathogenesis: transmitted by contact with contaminated soil; filariform larvae penetrate
skin, enter blood, then lungs, coughed up, swallowed, mate in small intestine,
males ejected, female burrow into mucosa and produce eggs; hatch liberating
rhabditiform larvae, some pass in feces, some develop into filariform and
continue the infection; pathogenesis dependent on worm burden
Infections: Strongyloidiasis (acute [hypersensitive pneumonitis, GIT asyptomatic to
inflammatory diarrhea], hyperinfection syndrome in immunocompromised)
Control: ivermectin or albendazole
|
|
|
Term
Toxocara canis (and T. cati) |
|
Definition
Characteristics: eggs of non-human ascarid hatch in GIT and undergo limited
development
Pathogenesis: ascarids migrate into tissue; symptoms and pathogenesis related to
migration (eosinophilia and hepatomegaly common)
Infections: Toxocariasis (Visceral larva migrans); Ocular larval migrans associated with
infection by larvae
Control: usually self-limited; albendazole or mebendazole for severe disease
|
|
|
Term
Trichinella spiralis (T. murrelli) |
|
Definition
Characteristics: nematode morphology
Pathogenesis: many reservoirs (
T. spiralis worldwide, T. murrelli in North American
bears); transmitted by eating undercooked meat; ingest cyst, larvae released,
develop in intestinal mucosa of small intestine (intracellular parasites), mature,
mate, females produce larvae that enter the blood, then muscle where the coil and
encyst; pathogenesis depends on worm burden; myositis and vasculitis occur
Infections: Trichinosis (symptoms depend on worm burden and location of cysts)
Control: mebendazole or albendazole stops development of new larvae
|
|
|
Term
Taenia (T. saginata, T. solium) |
|
Definition
Characteristics: cestode morphology and life cycle (proglottids, scolex,
resistant cuticle)
Pathogenesis: pig ingests embryophores, cattle ingest gravid proglottids and embyonated
eggs, larvae liberated in intestine, enter blood then muscle; humans eat undercooked meat containing cysticerci, scolex attaches to mucosa of small intestine, worms mature, eggs and gravid proglottids released in feces; dead end when human ingests
T. solium embryophore (Cysticercosis)
Infections: tapeworm disease (GIT symptoms depend on worm burden); Cysticercosis when T. solium embryophore is ingested
Control: avoid undercooked meat; praziquantel or niclosamide
|
|
|
Term
diphyllobothrium latum
(freshwater fish tapeworm) |
|
Definition
Characteristics: cestode morphology; crustaceans and fish intermediate hosts; prevalent
in cool lake water
Pathogenesis: humans ingest undercooked fish infected with sparganum larvae, attach to
mucosa of small intestine, mature, eggs in feces, eggs released into freshwater
develop into coracidium that infects crustaceans
Infections: Fish tapeworm disease (GIT symptoms depend on worm burden)
Control: praziquantel or niclosamide
|
|
|
Term
Schistosoma mansoni (blood fluke) |
|
Definition
Characteristics: trematode morphology; unlike most trematodes sexes are separate; eggs
have characteristic lateral spine; adults are obligate intravascular parasites; aquatic
snail intermediate host
Pathogenesis: cercaria penetrate skin, enter blood, develop in portal circulation (inferior
mesenteric vein near lower colon), coat themselves with host proteins, mate, eggs
produced; eggs pass into GIT and released in feces
Infections: Schistosomiasis (blood fluke infection; hypersensitive skin reaction at sites of
skin penetration; hepatic and GIT symptoms depend on worm and egg burden)
Control: praziquantel
|
|
|
Term
|
Definition
A.
Echinococcus
Echinococcus
(dog tapeworm; human infection results in cysts in lung and liver)
B.
Babesia
Babesia
(intraerythrocytic protozoan transmitted by same tick that transmits Lyme
disease; malaria-like syndrome)
C.
Naegleria fowleri
Naegleria fowleri
(amebic meningoencephalitis)
D.
Baylisascaris procyonis
Baylisascaris procyonis
(raccoon roundworm; causes visceral, ocular, and neural larval migrans in humans)
|
|
|
Term
|
Definition
A.
Sarcotes scabiei
Sarcotes scabiei
(itch mite; scabies in humans, mange in animals)
B.
Pediculus humanus
Pediculus humanus (body or head louse)
C.
Phthirus pubis
Phthirus pubis (crab louse)
D. Cimex hemipterus (bed bugs)
|
|
|