Term
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Definition
- protein coat (capsid)
- nucleic acid core (genome)
- core proteins
- lipid envelope (SOME)- lipid bilayer with inserted proteins
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Term
| What makes a virus different from bacteria, fungi, eukaryotic cells |
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Definition
- obligate intracellular parasites
- filterable
- contain only one kind of nucleic acid
- self assembly, not binary fission
- no ribosomes, respiratory enzymes, cell walls
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Term
| Classification of viruses based on what? |
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Definition
| Genetic material and structure |
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Term
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Definition
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Term
| Different types of nucleic acid genomes you may see in virus |
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Definition
- ss, ds, DNA, RNA
- RNA may be (+), (-), or ambisense (+/-)
- linear or circular
- may be segmented (ex: influenza A)
- may be diploid (ex: HIV)
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Term
| Function of core viral proteins |
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Definition
- carry out functions needed for viral replication
- nonstructural proteins
- function in assembly and replication
- virus encoded enzymes involved in replication (ex: reverse transcriptase)
- histones for genome packing
- tethering proteins linking core to capsid
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Term
| viral capsid: morphology, function |
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Definition
- function- protect genome from nucleases
- morphology
- symmetrical structure with repeating units
- repetitive structure minimizes genome size
- icosahedral or helical symmetry (allows to be made from repeating, ID subunits aka self assemble)
- icosahedral- regular polyhedron with 20 triangular faces and 12 vertices
- helical- hollow tube with a helical surface
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Term
| lipid envelope (origin, contents, effect of damage) |
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Definition
- lipid bilayer derived from host cell membrane
- contains embedded viral proteins involved in host cell recognition/attachment
- damage (ex: detergents) block infection
- ex: herpesvirus, retrovirus
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Term
| Mechanisms of classification for viruses |
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Definition
- type of genetic material
- morphology (capsid structure, enveloped)
- host/tissue tropism (ex: liver)
- susceptibility to physical/chemical agents
- immunologic properties
- pathology (ex: giant cell formation)
- clinical syndrome (ex: pneumonia)
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Term
| examples of dsDNA viruses |
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Definition
- adenoviruses
- herpesviruses
- HSV
- VZV
- CMV (pneumonia, retinitis)
- EBV (mono)
- HHV-6, HHV-8 (roseola, Kaposi's)
- papovaviruses (tumors of skin, mucosa)
- polyomaviruses (neurologic infection)
- poxviruses (smallpox)
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Term
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Definition
| parvoviruses (parvovirus B19) |
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Term
| example of ss/dsDNA virus |
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Definition
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Term
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Definition
- reovirus
- rotavirus (gastroenteritis)
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Term
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Definition
- picornaviruses
- flaviviruses
- hepaciviruses (hep C)
- togavirus (rubella)
- cornaviruses (common cold, sars)
- caliciviruses (gastroenteritis)
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Term
| examples of - strand ssRNA viruses |
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Definition
- orthomyxoviruses (ex: influenza)
- parmyxoviruses (measles, mumps)
- rhabdoviruses (rabies)
- filoviruses (ebola)
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Term
| examples of ambisense RNA viruses |
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Definition
- arenaviruses (Lassa fever)
- bunyaviruses (encephalitis, hemorrhagic fever)
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Term
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Definition
- HIV
- human T cell lymphotrophic viruses
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Term
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Definition
- infectious agents that contain protein coat but no nucleic acid
- associated with transmissible encephalopathies
- may represent corrupted cellular protein
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Term
| Other filterable pathogens |
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Definition
- prions
- non animal viroids
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