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Microbiology
Step 1 Review: Random facts
62
Biology
Graduate
12/23/2007

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Cards

Term
For gram (+) membranes, the Thick peptioglycan layer contains _____ & _____
Definition
Lipoteichoic acid & teichoic acid
Term
The Membrane inner leaflet for Gram (+) is ____
Definition
Phophotidylethanolamine
Term
The membrane outer leaflfet for Gram (+) membrane is _____
Definition
Phophotidylglycerol
Term
The inner Membrane leaflet of Gram (-) bacteria is a mix of _____ & _____
Definition
Phosphtidylglycerol & ethanol amine
Term
The inner leaflet of the outer membrane of gram (-) is made of _______
Definition
Phosphtidylethanolamine
Term
The outer membrane of gram (-) bacteria is made up of _____
Definition
LPS
Term
Why is LPS important?
Definition
It's a endotoxin responsible for endotoxic shock & contains o-specific oligosaccride
Term
What 5 things should make you think of Endocarditis
Definition

1.  Fever & murmur

2.  Fever & IV drug users

3.  fever of unexplained origin

4.  Fever & systemic emboli

5.  Fever after valve surgery 

Term
There are 2 types of bacterial endocarditis name them
Definition

Subacute and acute

Term
That's the difference between subacute and acute endocarditis
Definition

Subacute:

 1.  Insidious onset

2.  Symptoms prior to Dx

3.  Preexisting damaged valve

4.  Strep Viridans

 

Acute:

 1.  Acute onset

2.  Normal valve

3.  Staph aureus 

Term
Describe the hemodynamic change in endocarditis
Definition

1.  Blood goes from high pressure into low pressure

2.  Colonly grows in low pressure sink 

Term
How do platelet formation thrombi allow for endocarditis?
Definition
Gives the bacteria something to adhere to
Term
_______ is the most common cause of culture negative endocarditis
Definition
Bartonella
Term
IV drug users are associated w/
Definition
S. aureus
Term
Prosthetic valves are associated w/
Definition
S. epidermidis
Term
Give the symptoms of endocarditis
Definition

1.  Fever

2.  Chills, sweats

3.  Increased WBC

4.  Elevated sedmentation rate

5.  Splenomegaly 

Term

Emboli can lead to

HINT 5  

Definition

1.  Stroke

2.  Skin lesions

3.  Hematuria

4.  Metastatic infection

5.  Spleen infarction 

Term
What is the hallmark of endocarditis
Definition
Murmur
Term
The immune complexes that form from endocarditis are
Definition

1.  Arthritis

2.  Glomerulonephritis 

3.  Vascultis:  petechaie, roth spots

4.  Rheumatoid factor 

Term
Primary peritonitis is usually seen w/
Definition
Cirrhosis & ascities
Term
What are the bacterial causes of primary peritonitis (SBP)
Definition

1.  Enterobacteria spp (e. coli & klebsiella)

2.  S. pneumoniae

3.  S.  Aureus 

Term
What's the patholgy of Primary peritonitis
Definition

1.  Hematogenous & lymphogenic spread

2.  Migration from the gut 

Term
Give the Clincial picture of Primary peritonitis
Definition

1.  Fever

2.  Abdomonial pain (non-palpation)

3.  Abdominal tenderness (palpation) 

Term
How do you diagnosis Primary Peritonitis
Definition

1.  Cell count

Leukocyte > 300 & PMN > 250 

2.  Albumin concentrattion

> or = 1.1 

3.  Gram stain & culture 

 

Term
What's the treatment of Primary Peritionits
Definition
3rd gen. cephalosporin (ceftraxone)
Term
Secondary Peritonitis is caused by
Definition

GI or GU microbes in the peritoneal cavity

(E. coli, Enterococci & Bacteriods fragilis & Strep) 

Term
What's the pathophysiological response to secondary peritonitis
Definition

1.  Local inflammation

2.  Outpouring of fluids

3.  High protein

4.  Large number of WBC cells 

Term
What are the systemic responses of Secondary Peritonitis
Definition

1.  Release of TNF a, IL-1, 6 & INF g

2.  Paralysis of the gut, increase CO, venous dilation 

Term
What are the clinical manifestation of  Secondary Peritonitis
Definition

1.  Severe abdominal pain

2.  Nausea & vomiting

3.  Fever

4.  Tachycardia

5.  Hypotension 

Term
What are the treatments for secondary peritonitis
Definition

1.  Surgery

2.  Drain abscess 

Term
What are the causes of intraperitonal abscesses
Definition

1.  Appendicitis

2.  Diverticulitis

3.  Pancreatitis

4.  Perforated ucler 

Term
What are the symptoms of acute Appendicitis
Definition

1.  Inflammation of the appendix

2.  RLQ pain w/ anorexia, nausea & vomiting

 

Term
What are the symptoms of Diverticulitis
Definition

1.  Herniation of the mucosa

2.  Symptoms same as appendix

vomiting, nausea, anxorea 

Term
Bacterial pneumonia in children is more likely to affect age ___ w/ a abrupt fever of ___
Definition

< 2

39 C + 

Term
Bacterial pneumonia produces a ___ cough and w/ other ____ ____
Definition

wet

not ill 

Term
The Physical exam for bacterial pneumonia looks like?
Definition

1.  They look awful

2.  Rapid breathing

3.  Anatomically confined 

Term
What WBC count for bacterial pneumonia is ____ w/ ______ predominate
Definition

15000 <

Neutrophils 

Term
What's the treatment for bacterial pneumonia
Definition
Amoxicillin
Term
viral pneumonia occurs at ___ age w/ a _______ fever of ____
Definition

1.  any

2.  Grandual

3.  < 39 C 

Term
Do you find other people ill w/ viral pneumonia
Definition
yes
Term
The more mucous membranes involved the more likely it's  ____
Definition
viral pneumonia
Term
A non-productive cough is indicates
Definition
viral pneumonia
Term
The physical exam for viral pneumonia looks like
Definition

1.  Disease is proportional to how the patient looks like

2.  Bilateral wheezing 

Term
The WBC count for viral pneumonia is _____ w/ ______ cells predominate
Definition

1.  15000 >

2.  Mononuclear  

Term
Mycoplasma pneumonia has a ____ onset fever of ____
Definition

1.  abrupt

2.  < 39 C 

Term
Mycoplasma pneumonia presents with
Definition

1.  Abrupt onset of fever

2.  Malaise

3.  Sore throat 

Term
are others ill in a mycoplasma pneumonia infection?
Definition
yes, they have flu like symptoms
Term
A hacking cough is characteristic of
Definition
Mycoplasma
Term
How does the P.E look for mycoplasma
Definition

1.  Degree of illness is nothing

2.  Hear rouse

3.  walking pneumonia 

Term
How does the CXR look for mycoplasma
Definition
Pachy and anatomically confined
Term
What's the treatment for mycoplasma
Definition

1.  Azithromycin for those w/ no teeth

2.  Doxycycline for older 

Term
Sepsis is due to which endotoxin
Definition
LPS
Term
LPS endotoxin binds to _______ complex and triggers signaling pathway
Definition
Toll/CD14
Term
Name the organism that cause URT infections
Definition

1.  Rhinovirus

2.  Parainflu

3.  RSV

4.  Adenovirus

5.  Coronavirus

6.  Influenzae 

Term
Acute Otitis media is more common in
Definition
2 yr >
Term
If a child comes in w/ Otalgia (rubbing ear), fever & is fussy what do they have?
Definition
Otitis media
Term
In a patient w/ Otitis media, the tympanic membrane would look like
Definition

1.  Redy

2.  Bludeing

3.  Immobile 

Term
Name the 2 common causes of Otitis media
Definition

1.  Pneumococcus

2.  H. influ 

Term
How would you treat otitis media?
Definition
Amoxicillin
Term
What are the symptoms of Acute Sinusitis
Definition

1.  Fever

2.  Facial pain

3.  Teeth hurt

 4.  Purlent Rhinorrhea (green)

Term
Name the 2 most common organism for acute sinusitis
Definition

1.  Pneumococcus

2.  H. Inlu 

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