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Microbiology
Classes of Antibodies
6
Biology
Undergraduate 1
11/12/2007

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Term
What are the five classes of Antibodies (Immunoglobins)?
Definition
  1. IgG
  2. IgM (Mega)
  3. IgA
  4. IgD
  5. IgE
Term
What are the seven characteristics of IgG?
Definition
  1. 80% of Igs (most common)
  2. Monomer structure
  3. Crosses placenta
  4. Acts as opsinin
  5. Binds to phagocytes
  6. Activates complement
    • Ab-Ag binding
    • Ednotoxins
  7. Most found in plasma and some in tissue
    • Can cross capillary wall
Term
What are the four characteristics of IgM?
Definition
  1. 10% of Igs.
  2. Pentamer structure
  3. First Ab prduced, first responder
  4. Acts as opsinin when broken into monomers
  5. Binds to phagocytes.
Term
What are the five characteristics of IgA?
Definition
  1. 10% of Igs
  2. Dimer structure
  3. Primarily found in secretions (mucous, saliva, sweat, tears, breast milk to GI of infant)
  4. Protects mucous membrane from invasion
  5. sIgA(secratory) is inactivated by sIgA protease  found in Nisseria Meningitidis.
Term
What are the two characteristics of IgD?
Definition
  1. <1% of Igs
  2. Monomer structure
Term
What are the four characteristics of IgE?
Definition
  1. <1% of Igs
  2. Monomer structure
  3. Attaches to surfaces of mast cells and basophils
  4. Pollen binds to IgE in basophils which then release histamines.
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