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Microbiology
GI
11
Science
Graduate
05/09/2008

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Cards

Term
Salmonella enterocolitis
Definition
Natural reservoir: animal/animal products
transmission: contaminated food
systemic disease: yes
 
ID: Enterobacteriaceae, Lactose -, O/H antigens
 
Clinical Manifestations: Inflammatory enterocolitis 
 
Prevention: public health measures, proper food handling
 
high infectious dose (>10^5 orgs) 
Term
Salmonella typhi
Definition
Natural reservoir: human pathogen (carriers)
Contaminated food and water (human carriers)
Systemic disease: yes
 
ID: enterobacteriaceae, lactose -
 
Clinical Manifestations: typhoid fever, fatigue, malaise, etc.
 
Prevention: vaccines, public health measures 
Term
Shigella
Definition
Natural reservoir: human pathogen
Transmission: fecal-oral
Systemic disease: rare
 
ID: Enterobacteriaceae, lactose -, O antigens
 
Clinical manifestations: dysentery
 
Prevention: handwashing
 
low infectious dose (<100 orgs) 
Term
Campylobacter
Definition
Natural reservoir:animal/animal product
Transmission: contaminated food/water
systemic disease: rare
 
ID: not enterobacteriaceae, microaerophilic, GN curved rod
 
Clinical manifestations: inflammatory enterocolitis
 
Prevention: proper food handling 
Term
gastritis
Definition
inflammation of the stomach
Term
enteritis
Definition
inflammation of the small intestines
Term
colitis
Definition
inflammation of the large intestines
Term
Inflammatory vs. non-inflammatory GI infection
Definition
Non-Inflammatory.
-Due to bacterial toxins or virus
-Mid abdomen pain
-Large watery stools
-Normal proctoscopy
 
Inflammatory.
-Due to shigella, salmonella, or camphylobacter
-Lower abdominal pain
-small, mucoid stools with blood/WBCs
-Mucosal damage may be seen in proctoscopy 
Term
Defense mechanisms vs. GI disease
Definition
  1. physical barriers (acidity, mucosal epithelium)
  2. intestinal motility
  3. normal enteric flora
  4. secretory IgA
  5. phagocytic cells
Term
Vibro cholerae
Definition
Natural reservoir: human pathogen
Transmission: ingestion of contaminated food/water or shellfish
 
ID: GNR (curved)
 
Clinical manifestations: rice water stools
 
Prevention: public health measures, vaccine available 
 
Exotoxins A/B: B binds to receptor, A stimulates electrolyte and water efflux through cAMP 
Term
Helobacter pylori
Definition
Natural reservoir: ?
Transmission: ?
 
ID: microaerophillic, urease+, serological antibodies
 
Clinical manifestations: type B gastritis, peptic ulcers, stomach cancer
 
Prevention: ? 
 
Produces urease that causes a less acidic environment in stomach so that it can grow 
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