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Microbiology
Viruses
49
Biology
Undergraduate 1
07/11/2007

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Term
name two viral infections that first instigated curiosity about viruses
Definition
polio and smallpox
Term
who proposed the term virus and developed teh first vaccine for rabies?
Definition
louis pasteur
Term
when did the first relevations about teh unique charactaristics of viruses occur?
Definition
1890s
Term
what was the first virus discovered and in what plant?
also, who was it discovered by?
Definition
tobacco mosaic virus in tobacco-discovered by d. ivanovski and m. beijerinck
Term
what was teh first animal virus discovered? by who?
Definition
one that caused foot and mouth disease in cattle
friedrich loeffler and paul frosch
Term
are viruses cellular?
Definition
no
Term
what types of cells do viruses infect?
Definition
all
Term
what is a good way to describe viruses?
Definition
infectious particles
Term
what are the terms used to deem viruses as alive or dead?
Definition
active or inactive
Term
what are obligate intercellular parasites?
Definition
cannot multiply unless they invad a specific host cell and instruct its genetic and matabolic machinery to make and relase quantities of new viruses
Term
true or false
viruses are able to redirect the metabolism of living cells to reproduce virus particles
Definition
true
Term
true or false: viral replication inside a cel usually causes death or loss of fxn of that cell
Definition
true
Term
explain the size of viruses
Definition
they are ultramicroscopic in size, ranging from 20nm up to 450nm
Term
explain the basic structure of a virus
Definition
a protein shell(capsid) surrounding nucleic acid core
Term
do viruses have machinery for synthesizing proteins?
Definition
no
Term
do viruses have enzymes?
Definition
no
Term
which type of microscope is necessary to view viruses?
Definition
electron microscope
NOT LIGHT
Term
explain negative staining of a virus:
____ layers of opaque _______
what does this ^^^^^ do?
Definition
thin layers of opaque salt
outlines the virus against a dark background
Term
how are internal details of a virus revealed?
what type of staining?
Definition
positive staining
Term
what is the shadowcasting technique and what do its vapors do?
Definition
a proces by which a virus is attached to a surface and showered with metallic vapors then viewed from a certain angle to better view its contours
Term
referring to the molecular structure of the virus; what are teh essential parts it assembles to invade and control a host cell?
Definition
an external coating and a core
Term
what is a capsid?
Definition
it is the protein shell that surrounds the nucleic acid of a virus
Term
what are the nucleic acid and the capsid referred to as combined?
Definition
nucleocapsid
Term
some viruses are more complex and they have an extra addition to their structure
what is this addition?
what is generally inserted into this envelope?
Definition
an envelope-just a flexible membrane

receoptor spikes are usually inserted into it
Term
naked viruses? what do they consist of?
Definition
they have only a nucleocapsid
Term
what is a fully established virus often referred to?
(one that can establish infection in the host cell)
Definition
virion
Term
what are capsids composed of?
and what are these composed of?
Definition
capsomers
which are composed of protein molecules
Term
what are the two different forms capsomers can take?
Definition
helical and icosahedral
Term
helical capsids have capsomers of what shape?
do they look like bracelets?
Definition
rod; yes
Term
naked helical appear as____
Definition
cylinder
Term
ex: of naked virus
Definition
tobacco mosaic
Term
what is an icosahedron?
Definition
a three dimensional 20 sided figure with 12 evenly spaced corners
Term
name two examples of isosahedron viruses
Definition
papillomavirus(naked) and herpes simplex(enveloped)
Term
how does an enveloped virus accquire its envelope?
Definition
when tey are released from the host cell they take a bit of its membrane with them
Term
regarding spikes-how do they form?
Definition
by formin a binding layer etween the envelope and capsid of the virus- glycoproteins remain exposed on the outside
Term
is the envelope more or less supple than the capsid?
Definition
more supple-making the viruses pleomorphic
Term
is the envelope more or less supple than the capsid?
Definition
more supple-making the viruses pleomorphic
Term
why is the outermost part of the cell indispensable?
Definition
it protects the nucleic acid from teh effects of various enqymes and chemicals when the virus is outside the host
Term
complex viruses called poxviruses lack a regular_____
what do they have in its place?
Definition
several layers of lipoproteins and coarse surface fibrils
Term
a complex type of virus, bacteriophages, have a polyhedral shaped head, a ____tail, and ___for attachment to the host cell
Definition
helical; fibers for attachment
Term
sum total of the information carried by an organism:
Definition
genome
Term
genetic info is carried by _________ ______
Definition
nucleic acids
Term
do viruses have nucleic acids(dna and rna)?
Definition
yes
Term
do viruses contain dna AND rna?
Definition
no; either of these but not both
Term
true or false:
the DNA and RNA of viruses is always teh same
Definition
false: viruses exhibit wide variety in how their RNA or DNA is configured
Term
positive sense RNA
Definition
single stranded rna genomes that are ready for mmediate translation into proteins
Term
rna genomes that have to be converted into the proper form to be made into proteins
Definition
negative sense rna
Term
segmented DNA?
Definition
the individual genes eist on separate pieces of RNA
Term
name two enzymes that viruses may have
note: they do not have metabolic enzymes
Definition
polymerase: for dna and rna replication
reerse transcriptase-for synthesizing dna from rna
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