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Microbiology
Microbiology Chapter 14
113
Microbiology
Undergraduate 2
03/22/2013

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Term
Epidemiology
Definition
The study of the occurance and spread of disease
Term
Symbiosis
Definition
to live together
Term
Three types of symbiotic relationships
Definition

Mutualism

Commensalism

Parasitism

Term
Mutualism
Definition
Both members benifit
Term
Commensalism
Definition
One member benifits without significantly affecting the other member.
Term
Staphylococcus epidermidis is an example of?
Definition

Commensalism, 

This bacteria may inhibit pathogenic mocrobes from colonizing on our skin.

Term
Parasitism
Definition
The parasite benifits from the host while harming it.
Term
Tuberculosis is an example of?
Definition

Parasitism

which lives in the human lungs

Term
A parasite that causes a disease is called
Definition
pathogen
Term
Axenic
Definition
an environment that is free of microbes
Term
How many bacteria live in the large intestine
Definition
400 - 1000 bacteria
Term
Normal microbiota
Definition
Microbes that colonize the body without causing disease
Term
Normal microbiota is sometimes called
Definition
normal flora
Term
Two types of normal microbiota
Definition

Resident microbiota

Transient microbiota

Term
Resident microbiota
Definition
remain part of the normal microbiota of a person throught life
Term
Most resident microbiota are ?
Definition
commensal, they feed on excreted cellular waste and dead cells without causing harm.
Term
Transient microbiota
Definition
remain in the body for only a few hours, day or months before disappearing.
Term
An example of an axenic environment
Definition
mother's uterus
Term
Most resident microbiota are established during
Definition
the first months of life
Term

Describe three conditions that create opportunities for normal

microbiota to cause disease

Definition
1. Immune suppression 
2. Changes in the normal microbiota (changes in relative abundance of normal microbiota may allow opportunity for a member to thrive and cause disease) 
3. Introduction of normal microbiota into sterile area of body (axenic environment)
Term
Opportunistic pathogens
Definition
Is when microbes may become harmful if the opportunity arises.
Term
Immune supression
Definition

anything that supresses the body's immune system

disease, malnutrition, stress

Term
microbial antagonsim
Definition
is microbial competition, when a new pathogen has to compete against resident pathogens
Term
Three types of reservoirs of infection in humans?
Definition

Animal reservoirs

Human carriers

Nonliving reservoirs

Term
A reservoir of infection is
Definition
the site where pathogens are maintained as a source of infection
Term
sylvatic animal
Definition
wild animal
Term
Diseases that spread naturally from thier usual animal host to humans are called
Definition
zoonoses
Term
Yellow fever, anthrax, bubonic plague and rabies are examples of
Definition
zoonoses
Term
zoonoses infect humans by
Definition

animal waste

eating animals

bloodsucking arthropods

Term
Typical dead end host for zoonotic pathogen
Definition
Humans
Term
Example of nonliving reservoir
Definition

soil

water

food

Term
Contamination
Definition
the presense of microbes in or on the body
Term
Infection
Definition
A successful invasion of the body by a pathogen. An infection may or may not cause disease
Term
Three portals of entry
Definition

Skin

Mucous membranes

Placenta

Term
Parenteral
Definition
not a true portal of entry, step on nail, bug bite
Term
Hair follicles, sweat glands, and burrowing are examples of
Definition
Skin portal
Term
The main portal of entry for pathogen is?
Definition
Muscous membrane, these line all body cavities that are open to the outside world
Term
Conjunctiva
Definition
thin membrane covering the surface of the eyeball
Term
Adhesion
Definition
The process by which microorganisms attache themselves to cells.
Term
Adhesion factors
Definition
specialized structures and attachment proteins
Term
Adhesion disk in protozoa and suckers and hooks in helminths are examples of
Definition
adhesion factors
Term
Ligands
Definition
adhesion factors such as surface lipoproteins and glycoprotein molecules
Term
Ligands bind to ?
Definition
complementary receptors on host cells
Term
Adhesin is?
Definition
A ligand on bacteria
Term
Attachement protein on a virus is called
Definition
Ligand
Term
Adhesins are found on?
Definition
fimbriae, flagella and glycocalyces of many pathogenic bacteria
Term
What determines specificity of pathogens
Definition
interaction of adhesins and receptors with chemicals on host cells
Term
A pathogen can evade the body's immune system and attack more than one type of cell by?
Definition
changing their adhesins, Plasmodium the cause of malaria can do this
Term
Avirulent
Definition
A bacteria or virus that has lost the ability to produce ligands and becomes harmless.
Term
Disease
Definition
Also known as mirbidity, is when a pathogen becomes so harmful it interferes with the normal function of the body.
Term
Infection is?
Definition
infection is the invasion by a pathogen
Term
Symptoms
Definition
are characteristics of a disease than can be felt by the patient only
Term
Signs
Definition
signs are objective manifistations of disease that can be observed.
Term
Syndrome
Definition
A syndrome is a group of symptoms and signs
Term
Congenital disease
Definition
Congenital diseases are diseases that are present at brith, regardless of cause (hereditary, environmental, or infectious)
Term
Etiology
Definition
The study of the cause of a disease
Term
Germ theory of disease
Definition
states that disease is caused by infections of pathogenic microorganisms
Term
Koch's postulates
Definition

1. The suspected agent must be present in every case of the disease.

2. The agent must be isolated and grown in pure culture.

3. The cultured agent must cause the disease when it is inoculated into a healthy host.

4. The same agent must be reisolated from the diseased experimental host.

Term
Pathogenicity
Definition
the ability of a microorganism to cause disease
Term
Virulence
Definition
The degree of pathogenicity to cause disease
Term
Virulence factors
Definition
ability of the pathogen to enter a host, adhere to host cells, gain access to nutrients, and escape detection or removal by the immune system.
Term
ectracellular enzymes, toxins, and antiphagocytic factors are?
Definition
Virulence factors
Term
Pathogenic extracellular enzymes
Definition

Hyaluraonidase digest hyaluronic acid the glue that holds animal cells together.

Collagenase breaks down collagen the body's chief structural protein.

Coagulase causes blood proteins to clot

Kinase digest blood clots

Term
Toxins
Definition
Are chemicals that either harm tissue or trigger host immune responses that cause damage.
Term
Two types of toxins
Definition
exotoxins and endotoxins
Term
Exotoxins
Definition
exotoxins destroy host cells or interfere with host metabolism
Term

Cytotoxin- kill host cells

Neurotoxins - interfere with nerve cell function

Enterotoxins - affect cell lining

are examples of 

Definition
Exotoxins
Term
The body protects itself against exotoxins with
Definition
antitoxins
Term
Antitoxins are
Definition
protective molecules called antibodies that bind and neutralize specific toxins
Term
Toxoid
Definition
are toxins that have been chemically treated to make them  non toxic.
Term
Endotoxin is called
Definition
Lipid A
Term
When a gram negative bacteria divides, dies naturally, or digested by phagocytic cell it releases?
Definition
endotoxin
Term
Lipid A releases a chemical that causes
Definition
fever, inflamation, diarrhea, hemorrhaging, shock, and blood coagulation
Term
Macrophage?
Definition
Is a phagocytic white blood cell
Term
Capsules
Definition
are compsed of chemicals naturally found in the body, as a result they do not tritrigger the immune system.
Term
Some bacteria produce a chemical that prevents the fusion of lysosomes with phagocytic cells known as?
Definition
Antiphagocytic chemicals
Term
Leukocidins
Definition
are chemicals that are capable of destroying phagocytic white blood cells
Term
Five stages after infection
Definition

incubation period

prodromal period

illness

decline

convalescence

Term
Incubation period
Definition
time between infection and the first symptoms
Term
Prodromal period
Definition
short time of mild symptoms
Term
Illness stage
Definition
most severe stage of disease, signs and symptoms are most evident in this stage
Term
Decline period
Definition
the body gradually returns to normal, antibodies are peak during this stage
Term
Convalescence stage
Definition
pateint recovers and tissues are repaired
Term
Earwax, tears, nasal secretions, and saliva are examples of
Definition
Portals of exit
Term
Transmission of disease can occur by?
Definition

contact transmission

vehicle transmission

vector transmission

Term
Contact transmission
Definition
is the spread of pathogens by direct contact, indirect contact, or respiratory droplets.
Term
Indirect contact transmission
Definition
is when pathogens are spread by fomites (inanimate objects)
Term
Contact transmission includes?
Definition

Direct contact

Indirect contact

Droplet transmission

Term
Droplet transmission
Definition
Pathogen exits by exhaling, coughing, or sneezing. if the pathogen travels more than 1 meter it is respiratory tansmission
Term
Vehicle transmission
Definition
is by air, drinking water, food and body fluids
Term
Airborne transmission
Definition
is by respiratory mucous membranes more than 1 meter, sneezing, coughing, AC, sweeping
Term
Vehicle transmissions include
Definition

Airborne

Waterborne

Foodborne

Term
Vector tranmssion
Definition
are animals that transmit disease, either biological or mechanical
Term
Bitting anthropods are ...... vectors
Definition
biological vectors
Term
House flies and cockroaches are
Definition
Mechanical vectors, pathogens passively carried
Term
Acute disease
Definition
A disease that develops rapidly but last a short time
Term
Chornic disease
Definition
A disease that develops slowy and last a long time
Term
Latent disease
Definition
Pathogen remains inactive for a long period
Term
Communicable disease
Definition
a disease that cones from another infected host
Term
Incidence
Definition
number of NEW cases in a population
Term
Prevalence
Definition
total number of cases
Term
Endemic
Definition
a stable incidence in a given population
Term
Sporadic
Definition
a few scattered cases
Term
Epidemic
Definition
A disease occurs more than usual
Term
Pandemic
Definition
An epidemic disease on more than one continent
Term
Descriptive epidemiology
Definition
careful tabulation of disease
Term
Analytical epidemiology
Definition
investigates a disease in detail, probable cause, and mode of transmission
Term
Experimental epidemiology
Definition
testing a hypothesis concerning disease
Term
Noscomial infections
Definition
Are aquired by patients while in health care facility
Term
Exogenous
Definition
a pathogen aquired from a health care facility
Term
Endogenous
Definition
noscomial infection caused by normal microbiota
Term
Iatrogenic infection
Definition
a noscomial infection caused by a medical procedure
Term
Factors influencing noscomial infections
Definition

1. pathogens present in health care facility

2. weakened immune system 

3. transmission of pathogens from other patients

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