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Microbiology
Final Exam part 4
27
Biology
Undergraduate 2
05/06/2011

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Term
What is the blood brain barrier?
Definition
A barrier between the bloodstream and the brain, blocks, drugs, toxins, microorganisms. Inflammatin can yield a more porous barrier
Term
What are meninges?
Definition
Membranes lining brain and spinal cord. Pia, arachnoid and dura
Term
What is the normal flora of the CNS?
Definition
No normal flora!!!
Term
What are the 5 etiologies of bacterial meningitis?
Definition
-Haemophilus
-Streptococcus pneumoniae
-Neisseria sp.
-Listeria sp.
-Group B Streptococcus
Term
How do you detect bacterial meningitis?
Definition
Graim stain/culture of spinal tap
Term
What is the leading cause of bacterial meningitis in adults?
Definition
Streptococcus pneumoniae
Term
How do you get streptococcus pneumoniae meningitis
Definition
Results from spread of bacteria from primary infection.,Pneumoccal pneimonia, Ear infection, sinuse infection.
Term
What type of bacterial meningitis is common among newborns?
Definition
Group B Streptococus
Term
How does someone get get Group B Streptococcus meningitis?
Definition
transfer of fecal/vaginal strep to infant during birth.
Term
How do you treat streptococcal meningitis?
Definition
penicillins
Term
What type of meningitis is common in youth/young adults?
Definition
Meningococcal meningitis
Term
What is the etiology for meningococcal meningitis?
Definition
Neisseria meningitidis, gram neg. diplococcus
Term
How does a meningococcal meningitis infection proceed?
Definition
Begins with cold-like sympotms, advances to meningitis sympotms, skin hemorrhages and in extreme cases death within 24h.
Term
What route does meningococcal meningitis take?
Definition
Respiratory route from asymptomatic human reservoir,sometimes normal flora
Term
What is the treatment for meningococcal meningitis?
Definition
rifampicn and there is a vaccine.
Term
What is the etiology for Haemophilus meningitis?
Definition
Haemophilus influenza serotype b
Term
What is the most common meningitis i young children and why is it becoming rarer?
Definition
Haemophilus, vaccine now available based on capsular polysaccharide.
Term
What is the treatment for Haemophilus meningitis?
Definition
Chloramphenicol or rifampicin.
Term
What is the etiology for Listeriosis?
Definition
Listeria monocytogenes, faculative anaerobic gram positive.
Term
What usually occurs with LIsteriosis?
Definition
foodborne disease causing GI symtoms, meningitis is a complication of this infection, yields miscarriage in pregnant women.
Term
What is the treatment for Listeriosis?
Definition
penicillin
Term
What is Leprosy also known as?
Definition
Hansen's disease
Term
What is the etiology of Leprosy?
Definition
Mycobacterium leprae, acid fase gram positive rod that grows at temps below 37 C
Term
True or False Lepers are not contagious.
Definition
True
Term
What are the two ways leprosy presents itself?
Definition
Tuberculoid- self limiting disease (majority)
Lepromatous-progressive and disfiguring (minority)
Term
Tuberculoid leprosy
Definition
•! Tuberculoid leprosy
–!CMI responses prevent spread of infection past
peripheral nerves
–!Patient has patches of skin having lost sensation
–!Such skin may have bumpy tubercles at periphery
–!Not contagious-ex
Term
Lepromatous leprosy
Definition
-CMI immunity is lacking in some people
-Invasive, deforming as skin and mucous membranes are infected
-Somewhat contagious
-Very rare, even where endemic
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