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Microbiology Test 4
Last Call
135
Biology
Undergraduate 2
04/06/2012

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Term
skin- first line defence
Definition
normal flora protective gm+ mainly opportunistsbreak in skin problem natural/artificial
Term
most minor skin infections
Definition
Staphylococcus aureus, Streptococcus pyogenes localized systemic- toxin associated
Term
typical bacteria
Definition
Staphylococcus, Streptococcus, Pseudomonas, Propionibacteria
Term
Staphylococcus
clusters
Definition
S. aureus- most pathogenic
S. epidermis- opportunist/implants
S. saprophyticus-opportunist/ uti
most staphs penicllin G resistant
MRSA- methicillin resistent Staph. aureus
resists all penicillins
generally
catalase pos
coagulase- S. aureus-pos
Others- neg
Term
Staph infections
Definition
Localized
Folliculitis-"pimple",
furuncle-"boil",
carbuncle.
Each deeper and more damage
Term
Systemic( Staph infections)(Systemic)
Definition
Scalded skin syndrome
Toxic shock- fever, vomiting, rash, shock,associated super max tampons
Term
Streptococcus
> 30 species
Definition
5 most important.
esp. S. pyogenes, S. agalactiea, S. pneumonia
Chains
Term
Hemolysins:
Definition
Alpha hemolytic-partial digestion, green brown color on blood agar.
Beta hemolytic- complete digestion, clearing of red color on blood agar.
Gamma reaction- no effect on blood agar, just grows.
Term
Virulence factors
Definition
antiphagocytic: M protein,
erythrogenic toxin,
DNAse, NADase, Streptokinase
Hyaluronidase, leukocidins
Term
S. pyogenes most important
Definition
Erysipelas: high fever, bright red rash
Impetigo: crusted pustules around mouth, especially newborns.
Scarlet fever: rash
Term
Diagnose: Pharyngitis
Swab test
Definition
rapid antigen detection test.
Quick, not sensitive
Term
Growth-Pharyngitis
Definition
Throat swab overnight on blood agar,
look for clearing around colonies (beta hemolysis)

Treatment:
Penicillin, Erythromycin, Clindamycin
Term
Pseudomonas
Definition
Gram neg.,
polar flagella,
aeroic,
blue green pigment-can secrete into media,
grape-like sweet odor
Term
Pseudomonas aeruginosa
Definition
Mainly opportunist:
sick, immunocompromised, burn patients.
Very tough.
Resists almost all antibiotics.
Term
Pseudomonas aeruginosa( May be associated with)
Definition
Numerous exotoxins
Pneumonia in cystic fibrosis, immunocompromised.
Osteomyelitis: via foot wounds- cuts, diabetic ulcers. Goes to bone.
Burn wounds. Can lead to fatal sepsis.
Urinary tract infections.
Especially thru Foley catheters.
Endocarditis in IV drug users.
Term
Pseudomonas aeruginosa(Treatment)
Definition
Several antibiotics at a time.
Combination :
anti-pseudomonal penicillin-piperacillin and aminoglycoside-gentamycin.
Imipenem -broadest antibacterial activity and Aztreonam-magic bullet G- aerobes
Term
Propionibacterium acnes
Definition
Feeds on sebum-hence most problem during puberty.
Causes inflammation, skin scarring
Term
Treatment:(Propionibacterium acnes)
Definition
Cleanse skin- any number of "soaps".
Slow food production- acutane
Term
Viral Skin Diseases
Definition
Warts
human papilloma virus
generally benign skin tumors
spread direct contact
treatment removal freeze
burn electrical acid
Term
varicella-zoster(Viral Skin Diseases)
Definition
part of herpes family
one virus
two diseases
chickenpox
shingles
Term
Chickenpox- varicella
Definition
highly contagious, childhood
virus remains latent in nerve cells
vaccine used to control
odd complication w/ asprin use
Reyes syndrome
vomiting, brain damage
rare now
Term
Shingles- herpes zoster
Definition
reactivation
some trigger
trauma, immunosuppression, ??
painful lesions
rash along sensory nerve
trunk, head, eye
treatment
vaccine
acyclovir -soon after outbreak sysmptoms
shorten/lessen ??
zoster immune globulin
Term
Herpes simplex(Type I)
Definition
cold sores, fever blisters
Term
measles
Definition
respiratory route
characteristic koplik spots in throat
red spots-bluish/white specks center
extremely infectious
sotry- 2hrs after infected child leaves waitng room- cold still infect
can be deadly
kills many n refugee camps
Term
measles(Treatment)
Definition
vaccine MMR
measles, mumps, rubella
seen uptick because of non-vaccination
Term
Fungal diseases(cutaneuous)
Definition
hair, nails, outer layer
Tinea capitis-head, Tinea pedis-foot
ringworm
release keratinase
raised inflammatory ring, healing center
loss hair, flaky skin, crumbly nails
Term
Fungal diseases (subcutaneous)
Definition
underneath outer layer
thru wound
sporotrichosis
cut in skin
soil fungus
roses, sphagnum moss
may spread via lymph system
Term
opportunistic cutaneous
Definition
candidiasis
yeast like fungus
oral cavity- thrush
white coating
groin- diaper rash
vaginitis
Term
Scabies
Definition
burrowing mites
extreme itching
Term
keratitis-(Eyes)
Definition
inflammation of cornea
Term
conjunctiva-(Eyes)
Definition
inflammation of conjunctiva outer coating eyeball, inner eyelid
Staph, Strep, Neiseseria
Term
Trachoma-(Eyes)
Definition
leading cause of preventable blindness
Term
Chlamydia trachomatis-(Eyes)
Definition
infects epithelial cells eye
causes hard pustules inner surface eyelid scratches eye when blink
control-
clean water,
control eye seeking flies
Term
Keratitis
Acanthamoeba-(Eyes)
Definition
esp in contact lens wearers
improperly prepared saline solutions

Nervous system
normally sterile
gain access
trauma
peripheral nerve
bloodstream
lymphatic system
Term
Hemolysins:(Group A)
Definition
Group A, beta hemolytic most problematic due to subsequent infections..
Group A-refers to Lancefield C carbohydrate type (A-S
Term
Pharyngitis
Definition
red swollen tonsils, pharynx, purulent exudate on tonsils, high fever, swollen lymph nodes.rheumatic fever-heart damage.
glomerulonephritis-kidney damage
Term
Pseudomonas aeruginosa(Also Associated With)
Definition
Osteomyelitis: via foot wounds- cuts, diabetic ulcers. Goes to bone.

Burn wounds. Can lead to fatal sepsis.
Urinary tract infections.
Especially thru Foley catheters.
Endocarditis in IV drug users
Term
Herpes simplex(Type II)
Definition
genital sores
clinically same
can swap sites

Latent in nerve cells
trigger
trauma, UV, immunosuppression, ??
treatment
acyclovir
Term
infection of CNS(meningitis)
Definition
headache, nausea, vomiting, stiff neck
convulsions, coma, death
necrosis, clogged bv, edema
spinal tap
cerebrospinal fluid
Term
(meningitis)
Definition
viral less problem
Neisseria meningiditis, 5-40
Streptococcus pneumonia >40
Haemophilus influenzae type B 2mos-5 yrs
need to treat promptly
penicillin G, Ceftriaxone
Term
Listeriosis
Definition
pregnant women
sepsis, bacteremia
fetus/baby, elderly, immunosuppressed
tillbirths, neurological problems- meningitis,
Foodborne
Dairy products
milk
soft cheese
Deli meats
Can grow at refrigerator temp.
Term
Tetanus
Definition
gm +
endospore forming,deep puncture wounds,secretes toxin
neurotoxin
spastic paralysis
contracts not relax
cannot breathe
lockjaw
Term
Tetanus: Treatment
Definition
vaccination DPT
passive immunity
tetanus immune globulin
active immunity
tetanus toxoid vaccine
Term
Botulism
Definition
Clostridium botulinum
similar to tentanus
exotoxin
~90% foodborne
ingest toxin
smoked fish
improper canning vegetables
especially non acid >pH4.7
very potent
colorless, odorless, tasteless
heat sensitive- boiling will inactivate neurotoxin
Term
Botulism(Neurotoxin)
Definition
flaccid paralysis
no release of acetylcholine
never contracts
respiratory failure
"iron lung"
Term
Honey-
Definition
botulism riskfor infants,can survive/grow in intestine
prduce toxin
Term
viral disease(Polio)
Definition
humans only known host
infecting people for long time
ingestion fecal contaminated water
Term
(Polio)Vaccine
Definition
salk- fromalin inactivated mainly used now.

sabin- live attenuated not in use
problem- reversion vaccinated will shed fully active virus
Term
Rabies
Definition
rhabdo virus
ss RNA virus
Bullet shape, enveloped
Term
rabies(cont)
Definition
Bite from an infected animal saliva
travels via peripheral nerves to CNS
fatal encephalitis takes time
incubation weeks to years
allows time for vaccination
if symptoms appear100% mortality
headache, fever, nausea
coma death
Term
Rabies(Hydrophobia)
Definition
-fear of water

swallowing, thought of swallowing
trigger painful pharyngeal muscle spasms.
foaming at mouth not want to swallow
Term
Rabies (Treatment)
Definition
clean bite
hyperimmune rabies serum around bite
vaccination- series of shot over time
virus grown in human diploid fibroblast cells harvest, inactivate

reservoir
skunks, foxes, raccoons, dogs, bats
Term
Cryptococcus
Definition
yeast like
inhale infected pigeon droppings
lungs asymptomatic
thru blood to brain
Term
meningoencephalitis
Definition
headache, confusion, nausea, seizures, coma
aids, immunosuppressed at risk.
amphotericin B
Term
Protozoal
Definition
african sleeping sickness
Trypanosoma
vector TseTse fly
progressive disease
blood>lymph nodes>CNS
sleepcotinually, coma, death
organism keeps changing outer glycoprotein coat
Term
Amoeba
Definition
Naegleria spp.
meningo-encephalitis
thru nasal passages to brain
assoc with swimming in poor water
opportunist
95% die w/in week
Term
Prions
Definition
protein
animals, humans
spongiform encephalopathy,brain
encephalitis
Term
bacteremia
Definition
bacteria appear in blood
Term
septicemia
Definition
bacteria in blood causing an immune response (inflammatory response) in the blood
sepsis/septic shock
decreased blood pressure, fever, organ failure
most often gm - bacillus(have endotoxins)
Term
Bacterial endocarditis
Definition
inflammation,esp heart valve
Strep throat> rheumatic fever> endocarditis,damaged heart valve
more likely have endocarditis, causes clots-called vegetation- to form on valve.
Term
acute endocarditis
Definition
rapid onset symptoms
shaking, chills, spiking fever
hgh fatality rate,damaged or normal heart valve involved
S. aureus, S. pyogenes, N. gonnorhea
Term
subacute endocarditis
Definition
slower onset bacteria piles up on valve, low grade fever, fatigue, anemia
involves mainly damaged valves
normal bacteria of mouth and throat
alpha hemolytic Strep
Term
Rheumatic fever
Definition
autoimmune comlication of group a beta hemolytic Strep infection may be genetic certain HLA types
seen in 75% cases,maybe to M-protein

occurs 2-3 wks afer Strep throat
fever, arthritis, rash, heart damage
Term
Brucellosis undulant fever
Definition
cattle, goats, swine,enter via abrasions on skin/mucus membranes,grows inside macrophage
variable signs/symptoms, few deaths
fever goes in cycles peaks ~40C each evening, B. abortus, cows, erythritol
found in calf placenta not human
Term
gangrene
Definition
Clostridia spp,soil bacteria easy to get into wounds,grows in damaged/dead/low oxygen areas
Term
gas gangrene
Definition
C. perfringens,pockets of gas in tissue,crackling noise,fatal untreated
debridement remove dead tissue
surgical
maggots
amputation
penicillin
Term
Pasteurella multocida
Definition
Bites scratches
domestic animals, dogs cats, local infection, pneumonia, septicemia
Term
Humans> bites/clenched fist injuries
Definition
often worse than animal bite
~5 % require amputation
Mouth, S. aureus Bacteroides
Fusobacterium septicemia, tissue destruction, infalmmation, swelling
Term
cat scratch fever
Definition
gm-, aerobe
general contact, scratch, bite
papule>rash, swollen lymph nodes, prolonged fever
self limiting, rifampin
Term
plague
Definition
Yersinia pestis,gm-
killed large numbers of people
vector rat flea, both ill,no rats, no fleas, no plaque
(40 day isolation- quarentina> quarentine),painful swollen lymph nodes
buboes
bubonic plague
untreated
50-7-% mortality
Term
pneumonic plague
Definition
100% mortality w/in 3 days
spread via droplets
treated w/antibiotics
streptomycin
Term
Lyme disease
Definition
Borrelia burgdorferi
vector tick, Ixodes
reservoir
field mice, other?(deer)
nymph stage most involved transmission
no person to person, rash at bite site (?50%)
bullseye rash,flu-like symptoms
longer lasts more damage, harder to treat skin, heart, nerves, joints, eye damage arthritis, encephalopathy, etc
antibiotics extended and repeated doses
Term
Epstein Barr virus
Definition
in everybody, Mononucleosis
fever, sore throat, swollen neck lymph nodes, enlarged spleen (may rupture) usually self limiting
saliva transmission, in children mild
in adults more severe.also chronic fatigue syndrome( Burkitts lymphoma)B cell cancer
Term
Toxoplasmosis
Definition
Toxoplasma gondii, sex mature in cat intestines shed in cat feces
unlikely in indoor cat fed canned food
pregnanacy infect fetus damage, death(Human Fetus)
Term
malaria
Definition
Plasmodium spp, 4 spp,(P. falciparum) most dangerous
characteristic schedule
~ every 38-48 hours, depends on species
~ lasts ~6 hours chills, fever, sweats
bite>blood>liver>RBC<
-rupture RBC at regualr intervals
several forms merozoites in rbc
sporozoites in liver
invades ~30% rbc
reanl failure, lung edema, coma, anemia
very old, very young at risk death
w/treatment 20%< 5 yrs die cerebral malaria

vector
female anopheles mosquito
feeds at night
Term
schistosomiasis
Definition
blood flukes
millions worldwide
heart disease, epilepsy, kidney failure, cirrhosis of liver
symptoms
-fever, rash, body pains, cough, dysentery

larvae>skin>blood>liver/matures> vein-lower/upper intestine or urinary badder veins, stays 30 yrs
lays 3500 eggs/day
eggs get into intestine/bladder leave body
eggs wander into body(triggers immune response)treat praziquntel
Term
respiratory
Definition
upper
nose, throat middle ear
lower
arynx trachea, bronchial tubes, alveoli
Term
Strep throat
Definition
group a beta hemolytic
Strp. pyogenes
respiratory route
resists phagocytosis
streptokinins, streptolysins
local inflammation,fever,penicillin effective
comlications of non treatement
rheumatic fever
glomerulonephritis
Term
rhinovirus
Definition
common cold,mainly rhinovirus
~113 kinds
likes cooler body temp
33-34C
upper respiratory epthelium
Term
corona virus
Definition
crown of glycoprotein spikes
others

single rhinovirus sufficient
natural immunity short lived
fomites/close contact
hands>eyes/nose/mouth
Term
tuberculosis
Definition
Mycobacterium tuberculosis
acid fast
respiratory route
long generation time
33hrs
sensitive to UV/sunlight
resist drying out
lasts long time on surface
ingested by macrophage
forms ball of cells
tubercle
eventually macrophages in center die
caseous center (cheesy)
can go dormant
5% reactivate in 1-2 years, 5% reactivation lifetime
Term
tuberculosis (typical)
Definition
weight loss, coughing, fatigue
log antibiotic treatment
2 drugs 2 years
3-4 drugs 6 months
problem w/ compliance
causes rise in atibiotic resistance
xmdr, extreme multidrug resistance, no drugs work
skin test
ppd, purified protein derivative
"bits of TB Mycobacterium" injected under skin
look for immune reaction
sensitized T cells
w/ 48 hours
induration, hard raised red area
positive
have it
had it
vaccinated
BCG, Bacillus of Calmette and Guerin
Quantiferon TB
Term
Bacterial pneumonias
Definition
inflammation of lung tissue
typical pneumonia
Streptococcus pneumoniae
atypical
Mycolasma, Chlamydia, virus

typical/atypical refers to site of infection
lobar vs bronchial
Term
pneumococcal pneumonia
Definition
Streptococcus pneumonia
capsule
diplococcus
fever, chest pain, rustcolored sputum
vccine of purified capsular material
Term
Mycoplasma pneumonia
Definition
no cells walls
cholesterol in membrane,walking pneumonia
primary atypical
low grade fever, dry hacking cough, headache
tetracycline, erythromycin, quinolones
fried egg colonies
Term
Psittacosis
Definition
associatd with birds
parrots, parrakeets, pigeons, ducks
Term
Chlamydia psittaci
Definition
obligate intracellular parastie
2 forms
outside cell, elementary body, tough, infectious form
*(inside cell), reticulate body,multiplying form
fever headache chills,contact with bird droppings
Term
viral pneumonia
Definition
often complication of measles, chicken pox
most common cause pneumonia in infants
Term
Influenza
Definition
8 pandemics since 1889
kills healthy people
RNA virus
8 loosely connected pieces RNA
envelope w/glycoprotein spikes
Hemagglutinin, helps attach
Neuraminidase, helps release
several varieties
H1N1, H2N1 etc
remember
*H1N5, bird flu hard to get, deadly
*H1N1, swine flu similar to deadly pandemic flu varieties casued by mutations
antigenic shift, large changes
antigenic drift, small changes
Term
duck flu virus
Definition
hogs> mix deadly RNA parts of duck w/infectious RNA parts of people
people flu virus>>>
Term
duck flu virus(treatment)
Definition
vaccine
educated guess of type
Term
Hanta virus
Definition
reservoir mice
breathe air contaminated w/ mouse urine/droppings
sweep cabin
Korean war
2500 infected, 5-10% die
1993 Four corners region of Us
32 of 53 cases died
healthy died
one case ok morning, respirator afternoon, dead that night
mild flu like that progresses> pulmonary edema> death
Term
Coccidiomycosis
Definition
Coccidioides immitis
dimorphic
soil fungfus
spores carried by wind
SW US/California
chest pains, fever, cough, loss of weight
symptoms like TB
Term
Mouth
Definition
dental caries,periodontal disease
Term
plaque
Definition
permeable to sugars, not acids
sucrose mainly, dental caries, cavities
mainly Streptococcus mutans
Control
clean teth
remove food
remove plaque
flouride
Term
Periodontal disease
Definition
gum inflammation and degeneration of structures support teeth
Term
Porphyromonas gingivalis
Definition
inflammation
gum bleeding after brushing
Term
Staphyolococcal
Definition
S. aureus,enterotoxin, heat stable,easy contaminate food via hands
esp. cooked food,at risk, due to makeup, handling custards cream pies, ham, poultry,enterotoxin,vomiting, diarrhea, no fever ,symptoms
1-6 hrs later
lasts ~8 hrs
treatment
rehydration
Term
Salmonellosis
Definition
invasive bacteria grows,symptoms
12-36 hours later,lasts 1-4 days,cause
eat contaminated food, meat and dairy
uncooked eggs, poultry
contact w/ reptiles/amphibians
turtles, snakes, iguana

treatment
rehydration
Term
Cholera
Definition
Vibrio cholerae
humans only reservoir
infects intestinal mucosa
via contaminated food/water

cause
enterotoxin
severe dehydration
by gallon
death by circulatory collapse

treatment
rehydration
Term
E. coli
Definition
many pathogenic strains
"Travelers diarrhea"
mild> life threatening
dangerous- E. coli 0157:H7
kidney failure
hemorrhagic colitis

divide quickly
~15 min

mainly
ETEC enterotoxigenic E. coli
EIEC enteroinvasive E. coli

source
undercooked beef
other
apple cidar
manure fertilizer

prevention
cook properly
temperature
Term
Campylobacter
Definition
g-
microaerophile

source
chicken
cows
maure, milk

pathogen
C. jejeuni
fever, cramps, diarrhea
recover w/in week
complication
Guillan Barrre syndrome
autoimmune
demyelination, paralysis
need treat promptly
Term
Clostridium difficile
Definition
nosocomial
Daycare centers

mild diarrhea
dangerous colitis

exotoxin
result from extended use broad spectrum antibiotics
treat w/ vancomycin, metronidazole
Term
Norovirus
Definition
fecal/oral
20 million cases US
few deaths

persists surfaces
3 wks
resists chlorine

vomiting, diarrhea
2-3 days

cruise ships
Term
Rotavirus
Definition
viral gastroenteritis
~ 3m million cases, few deaths
90% children by age 3 infected
low grade fever, diarrhea, vomiting
~ 1 week

leading cause acute infection/diarrhea/infant mortality
Term
Shigella
Definition
4 spp(Species)
all non-motile
neg lactose ferm, neg H2S production
rules out E. coli, Salmonella

Human only host
fecal/oral
preschool, nursing homes
never part of normal flora

invades intestinal epithelial cells
shiga toxin
2 part toxin
Term
Bacteroides fragilis
Definition
99% intestinal flora Bacteroidaceae family

Break in intestine/bowel
surgery, gunshot
grows wild in peritoneal cavity
abscesses (mix bacteria/wbc/dead tissue
Term
Helicobacter pylori
Definition
only bateria live in stomach
1993, peptic ulcers
antibiotics, antacids
Term
Hepatitis
Definition
inflammation of liver
jaundice, yellowing
loss liver function
partial bkdwn hemoglobin
bilirubin
several unrelated types
Hep A, B, C, D
differing severities
Term
Hep A least nasty
Definition
fecal oral
strawberries?
Term
Hep B
Definition
Blood, saliva, semen
stable on surfaces
needles, surgical instruments
liver cancer
carriers exist
prevent w/ vaccine for high risk groups
Term
Hep C
Definition
clinically inapparent
20yrs
liver cancer, cirrhosis
via blood contact
Term
Aspergillus flavus
Definition
aflatoxin
potent carcinogen
infected peanuts
Term
Protozoal
Definition
Giardia lamblia
flagellated protozoan
infects small intestine
prolonged diarrhea
weeks

resevoir
wild animals
beavers, cats? dogs?

via contaminated water
ingest cysts,resist chlorine, should filter water
Term
Cryptosporidiosis
Definition
contaminated water
animal wastes,cattle
1993 outbreak,300,000 milwaukee, 4,400 hospitalizations, severe diarrhea
via tap water, resists chlorine
bkdn sewage treatment filtration

Reminder watrborne pathogens
10 min boil effective
Term
Helminths
Definition
flatworms
roundworms

cook properly
Term
Echinococcus granulosus
Definition
Dogs. sheep, lick face, ingest eggs
humans intermediate host
hydatid cyst
single round fluid filled balloon
size grapefruit,location problem
brain, liver, lungs

surgical removal difficult
cysts breaks
dangerous anaphylactic shock
Term
Excretory
Definition
urinary bladder, upper urinary tract
Sterile
Term
Vaginal microflora
Definition
lactobacilli, produce lactic acid, acidic pH
Term
Female urethra
Definition
small resident microflora
Term
Male urethra
Definition
normally sterile
- due to acidity and washing action
Term
Urinary System Infections
Definition
usually opportunistic
Factors: Disorders of the nervous system
Diabetes,Obstruction of urine flow
Closeness of intestinal gram neg bacteria

especially in females
Term
Infections usually cause inflammation
Definition
ureteritis- inflammation of the urethra
cystitis- urinary bladder
ureteritis- ureter
pyelonephritis-kidneys
glomerulonephritis- kidneys
Term
Infections are usually nosocomial
Definition
particularly E. coli
rule of thumb for presence of infection
>100,000 bact/ml urine
or 1000 bact/ml of a single type
or 100 bact./ml ofcoliforms
Term
Cystitis:
Definition
more common in females
due to short urethra
dysuria- painful urination

pyuria- leukocytes in the urine
organisms: E. coli, Staph saprophyticus
Term
Glomerulonephritis
Definition
Brights Disease- Kidney Damage
Inflammation of the glomeruli
Immune complex disease
often sequel to beta hemolytic Strep. pyogenes
Produces- fever, high blood pressure, protein/RBC in urine
Term
Reproductive System
Definition
most disease transmitted by sexual activity
most cured with antibiotics
Term
Gonorrhea
Definition
- gm neg Neisseria gonnorrhea
in females often asymptomatic
Attach to mucosal cells by fimbrae/pili

Complications-endocarditis, meningitis, arthritis, sterility
infected mother- baby becomes blind
Term
Non-gonococcal Urethritis
Definition
60 cause by Chlamydia trachomatis
others mycoplasma
40 acquired thru sexual activity
Usually mild/asymptomatic
Sterility may occur
Term
Syphillis
Definition
spirochaete, Trponema pallidum
several stages to the disease. Primary-chancre. Secondary-rash, Tertiary-gumma
Term
Syphillis(Test)
Definition
Tests: VDRL- Venereal disease research laboratory-a slide flocculation test
RPR- rapid plasma reagin test(body to presence of spirochaete

look for reagin type antibodies

IgE produced against particular lipid produced as response to tissue damage

Get false positives, need confirmatory test

Other test: Flourescent treponemal antibody absorption test

Look for ab in serum.

mix serum with avirulent strain T. pallidum

then add flourescent tagged anti-antibody, look for glowing organisms)


Both tests similar, both indirect:
Term
Viral(Herpes)
Definition
infects many species- man to fungus
over 90 types
usually latent in nerve cells

no effective treatment, no cure
Term
Herpes- Greek for creep
Definition
Oral herpes Type I: cold sore. fever blister
Term
Genital herpes Type II
Definition
small number of cases locations and types switch
painful lesions

very infective

variable reoccurrence

Acyclovir- somewhat effective

- reduces number, duration of attacks

Can be problem for fetus

can cross placental barrier

can get it from the birth canal

do C-section
Term
Genital Warts
Definition
papilloma virus
can be sexually transmitted
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