Term
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Definition
normal flora protective gm+ mainly opportunistsbreak in skin problem natural/artificial |
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Term
most minor skin infections |
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Definition
Staphylococcus aureus, Streptococcus pyogenes localized systemic- toxin associated |
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Term
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Definition
Staphylococcus, Streptococcus, Pseudomonas, Propionibacteria |
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Term
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Definition
S. aureus- most pathogenic S. epidermis- opportunist/implants S. saprophyticus-opportunist/ uti most staphs penicllin G resistant MRSA- methicillin resistent Staph. aureus resists all penicillins generally catalase pos coagulase- S. aureus-pos Others- neg |
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Term
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Definition
Localized Folliculitis-"pimple", furuncle-"boil", carbuncle. Each deeper and more damage |
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Term
Systemic( Staph infections)(Systemic) |
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Definition
Scalded skin syndrome Toxic shock- fever, vomiting, rash, shock,associated super max tampons |
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Term
Streptococcus > 30 species |
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Definition
5 most important. esp. S. pyogenes, S. agalactiea, S. pneumonia Chains |
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Term
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Definition
Alpha hemolytic-partial digestion, green brown color on blood agar. Beta hemolytic- complete digestion, clearing of red color on blood agar. Gamma reaction- no effect on blood agar, just grows. |
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Term
|
Definition
antiphagocytic: M protein, erythrogenic toxin, DNAse, NADase, Streptokinase Hyaluronidase, leukocidins |
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Term
S. pyogenes most important |
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Definition
Erysipelas: high fever, bright red rash Impetigo: crusted pustules around mouth, especially newborns. Scarlet fever: rash |
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Term
Diagnose: Pharyngitis Swab test |
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Definition
rapid antigen detection test. Quick, not sensitive |
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Term
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Definition
Throat swab overnight on blood agar, look for clearing around colonies (beta hemolysis) Treatment: Penicillin, Erythromycin, Clindamycin |
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Term
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Definition
Gram neg., polar flagella, aeroic, blue green pigment-can secrete into media, grape-like sweet odor |
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Term
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Definition
Mainly opportunist: sick, immunocompromised, burn patients. Very tough. Resists almost all antibiotics. |
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Term
Pseudomonas aeruginosa( May be associated with) |
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Definition
Numerous exotoxins Pneumonia in cystic fibrosis, immunocompromised. Osteomyelitis: via foot wounds- cuts, diabetic ulcers. Goes to bone. Burn wounds. Can lead to fatal sepsis. Urinary tract infections. Especially thru Foley catheters. Endocarditis in IV drug users. |
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Term
Pseudomonas aeruginosa(Treatment) |
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Definition
Several antibiotics at a time. Combination : anti-pseudomonal penicillin-piperacillin and aminoglycoside-gentamycin. Imipenem -broadest antibacterial activity and Aztreonam-magic bullet G- aerobes |
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Term
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Definition
Feeds on sebum-hence most problem during puberty. Causes inflammation, skin scarring |
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Term
Treatment:(Propionibacterium acnes) |
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Definition
Cleanse skin- any number of "soaps". Slow food production- acutane |
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Term
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Definition
Warts human papilloma virus generally benign skin tumors spread direct contact treatment removal freeze burn electrical acid |
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Term
varicella-zoster(Viral Skin Diseases) |
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Definition
part of herpes family one virus two diseases chickenpox shingles |
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Term
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Definition
highly contagious, childhood virus remains latent in nerve cells vaccine used to control odd complication w/ asprin use Reyes syndrome vomiting, brain damage rare now |
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Term
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Definition
reactivation some trigger trauma, immunosuppression, ?? painful lesions rash along sensory nerve trunk, head, eye treatment vaccine acyclovir -soon after outbreak sysmptoms shorten/lessen ?? zoster immune globulin |
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Term
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Definition
cold sores, fever blisters |
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Term
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Definition
respiratory route characteristic koplik spots in throat red spots-bluish/white specks center extremely infectious sotry- 2hrs after infected child leaves waitng room- cold still infect can be deadly kills many n refugee camps |
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Term
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Definition
vaccine MMR measles, mumps, rubella seen uptick because of non-vaccination |
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Term
Fungal diseases(cutaneuous) |
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Definition
hair, nails, outer layer Tinea capitis-head, Tinea pedis-foot ringworm release keratinase raised inflammatory ring, healing center loss hair, flaky skin, crumbly nails |
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Term
Fungal diseases (subcutaneous) |
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Definition
underneath outer layer thru wound sporotrichosis cut in skin soil fungus roses, sphagnum moss may spread via lymph system |
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Term
|
Definition
candidiasis yeast like fungus oral cavity- thrush white coating groin- diaper rash vaginitis |
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Term
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Definition
burrowing mites extreme itching |
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Term
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Definition
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Term
|
Definition
inflammation of conjunctiva outer coating eyeball, inner eyelid Staph, Strep, Neiseseria |
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Term
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Definition
leading cause of preventable blindness |
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|
Term
Chlamydia trachomatis-(Eyes) |
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Definition
infects epithelial cells eye causes hard pustules inner surface eyelid scratches eye when blink control- clean water, control eye seeking flies |
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Term
Keratitis Acanthamoeba-(Eyes) |
|
Definition
esp in contact lens wearers improperly prepared saline solutions Nervous system normally sterile gain access trauma peripheral nerve bloodstream lymphatic system |
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Term
|
Definition
Group A, beta hemolytic most problematic due to subsequent infections.. Group A-refers to Lancefield C carbohydrate type (A-S |
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Term
|
Definition
red swollen tonsils, pharynx, purulent exudate on tonsils, high fever, swollen lymph nodes.rheumatic fever-heart damage. glomerulonephritis-kidney damage |
|
|
Term
Pseudomonas aeruginosa(Also Associated With) |
|
Definition
Osteomyelitis: via foot wounds- cuts, diabetic ulcers. Goes to bone.
Burn wounds. Can lead to fatal sepsis. Urinary tract infections. Especially thru Foley catheters. Endocarditis in IV drug users |
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Term
|
Definition
genital sores clinically same can swap sites Latent in nerve cells trigger trauma, UV, immunosuppression, ?? treatment acyclovir |
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|
Term
infection of CNS(meningitis) |
|
Definition
headache, nausea, vomiting, stiff neck convulsions, coma, death necrosis, clogged bv, edema spinal tap cerebrospinal fluid |
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Term
|
Definition
viral less problem Neisseria meningiditis, 5-40 Streptococcus pneumonia >40 Haemophilus influenzae type B 2mos-5 yrs need to treat promptly penicillin G, Ceftriaxone |
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Term
|
Definition
pregnant women sepsis, bacteremia fetus/baby, elderly, immunosuppressed tillbirths, neurological problems- meningitis, Foodborne Dairy products milk soft cheese Deli meats Can grow at refrigerator temp. |
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Term
|
Definition
gm + endospore forming,deep puncture wounds,secretes toxin neurotoxin spastic paralysis contracts not relax cannot breathe lockjaw |
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Term
|
Definition
vaccination DPT passive immunity tetanus immune globulin active immunity tetanus toxoid vaccine |
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Term
|
Definition
Clostridium botulinum similar to tentanus exotoxin ~90% foodborne ingest toxin smoked fish improper canning vegetables especially non acid >pH4.7 very potent colorless, odorless, tasteless heat sensitive- boiling will inactivate neurotoxin |
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Term
|
Definition
flaccid paralysis no release of acetylcholine never contracts respiratory failure "iron lung" |
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Term
|
Definition
botulism riskfor infants,can survive/grow in intestine prduce toxin |
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Term
|
Definition
humans only known host infecting people for long time ingestion fecal contaminated water |
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Term
|
Definition
salk- fromalin inactivated mainly used now.
sabin- live attenuated not in use problem- reversion vaccinated will shed fully active virus |
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Term
|
Definition
rhabdo virus ss RNA virus Bullet shape, enveloped |
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Term
|
Definition
Bite from an infected animal saliva travels via peripheral nerves to CNS fatal encephalitis takes time incubation weeks to years allows time for vaccination if symptoms appear100% mortality headache, fever, nausea coma death |
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Term
|
Definition
-fear of water
swallowing, thought of swallowing trigger painful pharyngeal muscle spasms. foaming at mouth not want to swallow |
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Term
|
Definition
clean bite hyperimmune rabies serum around bite vaccination- series of shot over time virus grown in human diploid fibroblast cells harvest, inactivate
reservoir skunks, foxes, raccoons, dogs, bats |
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Term
|
Definition
yeast like inhale infected pigeon droppings lungs asymptomatic thru blood to brain |
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Term
|
Definition
headache, confusion, nausea, seizures, coma aids, immunosuppressed at risk. amphotericin B |
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Term
|
Definition
african sleeping sickness Trypanosoma vector TseTse fly progressive disease blood>lymph nodes>CNS sleepcotinually, coma, death organism keeps changing outer glycoprotein coat |
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Term
|
Definition
Naegleria spp. meningo-encephalitis thru nasal passages to brain assoc with swimming in poor water opportunist 95% die w/in week |
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Term
|
Definition
protein animals, humans spongiform encephalopathy,brain encephalitis |
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Term
|
Definition
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Term
|
Definition
bacteria in blood causing an immune response (inflammatory response) in the blood sepsis/septic shock decreased blood pressure, fever, organ failure most often gm - bacillus(have endotoxins) |
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Term
|
Definition
inflammation,esp heart valve Strep throat> rheumatic fever> endocarditis,damaged heart valve more likely have endocarditis, causes clots-called vegetation- to form on valve. |
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Term
|
Definition
rapid onset symptoms shaking, chills, spiking fever hgh fatality rate,damaged or normal heart valve involved S. aureus, S. pyogenes, N. gonnorhea |
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Term
|
Definition
slower onset bacteria piles up on valve, low grade fever, fatigue, anemia involves mainly damaged valves normal bacteria of mouth and throat alpha hemolytic Strep |
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Term
|
Definition
autoimmune comlication of group a beta hemolytic Strep infection may be genetic certain HLA types seen in 75% cases,maybe to M-protein occurs 2-3 wks afer Strep throat fever, arthritis, rash, heart damage |
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|
Term
Brucellosis undulant fever |
|
Definition
cattle, goats, swine,enter via abrasions on skin/mucus membranes,grows inside macrophage variable signs/symptoms, few deaths fever goes in cycles peaks ~40C each evening, B. abortus, cows, erythritol found in calf placenta not human |
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Term
|
Definition
Clostridia spp,soil bacteria easy to get into wounds,grows in damaged/dead/low oxygen areas |
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Term
|
Definition
C. perfringens,pockets of gas in tissue,crackling noise,fatal untreated debridement remove dead tissue surgical maggots amputation penicillin |
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Term
|
Definition
Bites scratches domestic animals, dogs cats, local infection, pneumonia, septicemia |
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Term
Humans> bites/clenched fist injuries |
|
Definition
often worse than animal bite ~5 % require amputation Mouth, S. aureus Bacteroides Fusobacterium septicemia, tissue destruction, infalmmation, swelling |
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Term
|
Definition
gm-, aerobe general contact, scratch, bite papule>rash, swollen lymph nodes, prolonged fever self limiting, rifampin |
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Term
|
Definition
Yersinia pestis,gm- killed large numbers of people vector rat flea, both ill,no rats, no fleas, no plaque (40 day isolation- quarentina> quarentine),painful swollen lymph nodes buboes bubonic plague untreated 50-7-% mortality |
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Term
|
Definition
100% mortality w/in 3 days spread via droplets treated w/antibiotics streptomycin |
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Term
|
Definition
Borrelia burgdorferi vector tick, Ixodes reservoir field mice, other?(deer) nymph stage most involved transmission no person to person, rash at bite site (?50%) bullseye rash,flu-like symptoms longer lasts more damage, harder to treat skin, heart, nerves, joints, eye damage arthritis, encephalopathy, etc antibiotics extended and repeated doses |
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Term
|
Definition
in everybody, Mononucleosis fever, sore throat, swollen neck lymph nodes, enlarged spleen (may rupture) usually self limiting saliva transmission, in children mild in adults more severe.also chronic fatigue syndrome( Burkitts lymphoma)B cell cancer |
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Term
|
Definition
Toxoplasma gondii, sex mature in cat intestines shed in cat feces unlikely in indoor cat fed canned food pregnanacy infect fetus damage, death(Human Fetus) |
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Term
|
Definition
Plasmodium spp, 4 spp,(P. falciparum) most dangerous characteristic schedule ~ every 38-48 hours, depends on species ~ lasts ~6 hours chills, fever, sweats bite>blood>liver>RBC< -rupture RBC at regualr intervals several forms merozoites in rbc sporozoites in liver invades ~30% rbc reanl failure, lung edema, coma, anemia very old, very young at risk death w/treatment 20%< 5 yrs die cerebral malaria vector female anopheles mosquito feeds at night |
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Term
|
Definition
blood flukes millions worldwide heart disease, epilepsy, kidney failure, cirrhosis of liver symptoms -fever, rash, body pains, cough, dysentery larvae>skin>blood>liver/matures> vein-lower/upper intestine or urinary badder veins, stays 30 yrs lays 3500 eggs/day eggs get into intestine/bladder leave body eggs wander into body(triggers immune response)treat praziquntel |
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Term
|
Definition
upper nose, throat middle ear lower arynx trachea, bronchial tubes, alveoli |
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Term
|
Definition
group a beta hemolytic Strp. pyogenes respiratory route resists phagocytosis streptokinins, streptolysins local inflammation,fever,penicillin effective comlications of non treatement rheumatic fever glomerulonephritis |
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Term
|
Definition
common cold,mainly rhinovirus ~113 kinds likes cooler body temp 33-34C upper respiratory epthelium |
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Term
|
Definition
crown of glycoprotein spikes others single rhinovirus sufficient natural immunity short lived fomites/close contact hands>eyes/nose/mouth |
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Term
|
Definition
Mycobacterium tuberculosis acid fast respiratory route long generation time 33hrs sensitive to UV/sunlight resist drying out lasts long time on surface ingested by macrophage forms ball of cells tubercle eventually macrophages in center die caseous center (cheesy) can go dormant 5% reactivate in 1-2 years, 5% reactivation lifetime |
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Term
|
Definition
weight loss, coughing, fatigue log antibiotic treatment 2 drugs 2 years 3-4 drugs 6 months problem w/ compliance causes rise in atibiotic resistance xmdr, extreme multidrug resistance, no drugs work skin test ppd, purified protein derivative "bits of TB Mycobacterium" injected under skin look for immune reaction sensitized T cells w/ 48 hours induration, hard raised red area positive have it had it vaccinated BCG, Bacillus of Calmette and Guerin Quantiferon TB |
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Term
|
Definition
inflammation of lung tissue typical pneumonia Streptococcus pneumoniae atypical Mycolasma, Chlamydia, virus typical/atypical refers to site of infection lobar vs bronchial |
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Term
|
Definition
Streptococcus pneumonia capsule diplococcus fever, chest pain, rustcolored sputum vccine of purified capsular material |
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Term
|
Definition
no cells walls cholesterol in membrane,walking pneumonia primary atypical low grade fever, dry hacking cough, headache tetracycline, erythromycin, quinolones fried egg colonies |
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Term
|
Definition
associatd with birds parrots, parrakeets, pigeons, ducks |
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Term
|
Definition
obligate intracellular parastie 2 forms outside cell, elementary body, tough, infectious form *(inside cell), reticulate body,multiplying form fever headache chills,contact with bird droppings |
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Term
|
Definition
often complication of measles, chicken pox most common cause pneumonia in infants |
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Term
|
Definition
8 pandemics since 1889 kills healthy people RNA virus 8 loosely connected pieces RNA envelope w/glycoprotein spikes Hemagglutinin, helps attach Neuraminidase, helps release several varieties H1N1, H2N1 etc remember *H1N5, bird flu hard to get, deadly *H1N1, swine flu similar to deadly pandemic flu varieties casued by mutations antigenic shift, large changes antigenic drift, small changes |
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Term
|
Definition
hogs> mix deadly RNA parts of duck w/infectious RNA parts of people people flu virus>>> |
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|
Term
duck flu virus(treatment) |
|
Definition
vaccine educated guess of type |
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Term
|
Definition
reservoir mice breathe air contaminated w/ mouse urine/droppings sweep cabin Korean war 2500 infected, 5-10% die 1993 Four corners region of Us 32 of 53 cases died healthy died one case ok morning, respirator afternoon, dead that night mild flu like that progresses> pulmonary edema> death |
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Term
|
Definition
Coccidioides immitis dimorphic soil fungfus spores carried by wind SW US/California chest pains, fever, cough, loss of weight symptoms like TB |
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Term
|
Definition
dental caries,periodontal disease |
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Term
|
Definition
permeable to sugars, not acids sucrose mainly, dental caries, cavities mainly Streptococcus mutans Control clean teth remove food remove plaque flouride |
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Term
|
Definition
gum inflammation and degeneration of structures support teeth |
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Term
|
Definition
inflammation gum bleeding after brushing |
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Term
|
Definition
S. aureus,enterotoxin, heat stable,easy contaminate food via hands esp. cooked food,at risk, due to makeup, handling custards cream pies, ham, poultry,enterotoxin,vomiting, diarrhea, no fever ,symptoms 1-6 hrs later lasts ~8 hrs treatment rehydration |
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Term
|
Definition
invasive bacteria grows,symptoms 12-36 hours later,lasts 1-4 days,cause eat contaminated food, meat and dairy uncooked eggs, poultry contact w/ reptiles/amphibians turtles, snakes, iguana treatment rehydration |
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Term
|
Definition
Vibrio cholerae humans only reservoir infects intestinal mucosa via contaminated food/water cause enterotoxin severe dehydration by gallon death by circulatory collapse treatment rehydration |
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Term
|
Definition
many pathogenic strains "Travelers diarrhea" mild> life threatening dangerous- E. coli 0157:H7 kidney failure hemorrhagic colitis
divide quickly ~15 min mainly ETEC enterotoxigenic E. coli EIEC enteroinvasive E. coli source undercooked beef other apple cidar manure fertilizer prevention cook properly temperature |
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Term
|
Definition
g- microaerophile source chicken cows maure, milk pathogen C. jejeuni fever, cramps, diarrhea recover w/in week complication Guillan Barrre syndrome autoimmune demyelination, paralysis need treat promptly |
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Term
|
Definition
nosocomial Daycare centers mild diarrhea dangerous colitis exotoxin result from extended use broad spectrum antibiotics treat w/ vancomycin, metronidazole |
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Term
|
Definition
fecal/oral 20 million cases US few deaths persists surfaces 3 wks resists chlorine vomiting, diarrhea 2-3 days cruise ships |
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Term
|
Definition
viral gastroenteritis ~ 3m million cases, few deaths 90% children by age 3 infected low grade fever, diarrhea, vomiting ~ 1 week leading cause acute infection/diarrhea/infant mortality |
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Term
|
Definition
4 spp(Species) all non-motile neg lactose ferm, neg H2S production rules out E. coli, Salmonella Human only host fecal/oral preschool, nursing homes never part of normal flora invades intestinal epithelial cells shiga toxin 2 part toxin |
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Term
|
Definition
99% intestinal flora Bacteroidaceae family
Break in intestine/bowel surgery, gunshot grows wild in peritoneal cavity abscesses (mix bacteria/wbc/dead tissue |
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Term
|
Definition
only bateria live in stomach 1993, peptic ulcers antibiotics, antacids |
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Term
|
Definition
inflammation of liver jaundice, yellowing loss liver function partial bkdwn hemoglobin bilirubin several unrelated types Hep A, B, C, D differing severities |
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Term
|
Definition
|
|
Term
|
Definition
Blood, saliva, semen stable on surfaces needles, surgical instruments liver cancer carriers exist prevent w/ vaccine for high risk groups |
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|
Term
|
Definition
clinically inapparent 20yrs liver cancer, cirrhosis via blood contact |
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Term
|
Definition
aflatoxin potent carcinogen infected peanuts |
|
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Term
|
Definition
Giardia lamblia flagellated protozoan infects small intestine prolonged diarrhea weeks resevoir wild animals beavers, cats? dogs?
via contaminated water ingest cysts,resist chlorine, should filter water |
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Term
|
Definition
contaminated water animal wastes,cattle 1993 outbreak,300,000 milwaukee, 4,400 hospitalizations, severe diarrhea via tap water, resists chlorine bkdn sewage treatment filtration Reminder watrborne pathogens 10 min boil effective |
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Term
|
Definition
flatworms roundworms cook properly |
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Term
|
Definition
Dogs. sheep, lick face, ingest eggs humans intermediate host hydatid cyst single round fluid filled balloon size grapefruit,location problem brain, liver, lungs surgical removal difficult cysts breaks dangerous anaphylactic shock |
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Term
|
Definition
urinary bladder, upper urinary tract Sterile |
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|
Term
|
Definition
lactobacilli, produce lactic acid, acidic pH |
|
|
Term
|
Definition
small resident microflora |
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|
Term
|
Definition
normally sterile - due to acidity and washing action |
|
|
Term
Urinary System Infections |
|
Definition
usually opportunistic Factors: Disorders of the nervous system Diabetes,Obstruction of urine flow Closeness of intestinal gram neg bacteria
especially in females |
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|
Term
Infections usually cause inflammation |
|
Definition
ureteritis- inflammation of the urethra cystitis- urinary bladder ureteritis- ureter pyelonephritis-kidneys glomerulonephritis- kidneys |
|
|
Term
Infections are usually nosocomial |
|
Definition
particularly E. coli rule of thumb for presence of infection >100,000 bact/ml urine or 1000 bact/ml of a single type or 100 bact./ml ofcoliforms |
|
|
Term
|
Definition
more common in females due to short urethra dysuria- painful urination
pyuria- leukocytes in the urine organisms: E. coli, Staph saprophyticus |
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|
Term
|
Definition
Brights Disease- Kidney Damage Inflammation of the glomeruli Immune complex disease often sequel to beta hemolytic Strep. pyogenes Produces- fever, high blood pressure, protein/RBC in urine |
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Term
|
Definition
most disease transmitted by sexual activity most cured with antibiotics |
|
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Term
|
Definition
- gm neg Neisseria gonnorrhea in females often asymptomatic Attach to mucosal cells by fimbrae/pili
Complications-endocarditis, meningitis, arthritis, sterility infected mother- baby becomes blind |
|
|
Term
Non-gonococcal Urethritis |
|
Definition
60 cause by Chlamydia trachomatis others mycoplasma 40 acquired thru sexual activity Usually mild/asymptomatic Sterility may occur |
|
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Term
|
Definition
spirochaete, Trponema pallidum several stages to the disease. Primary-chancre. Secondary-rash, Tertiary-gumma |
|
|
Term
|
Definition
Tests: VDRL- Venereal disease research laboratory-a slide flocculation test RPR- rapid plasma reagin test(body to presence of spirochaete
look for reagin type antibodies
IgE produced against particular lipid produced as response to tissue damage
Get false positives, need confirmatory test
Other test: Flourescent treponemal antibody absorption test
Look for ab in serum.
mix serum with avirulent strain T. pallidum
then add flourescent tagged anti-antibody, look for glowing organisms)
Both tests similar, both indirect: |
|
|
Term
|
Definition
infects many species- man to fungus over 90 types usually latent in nerve cells
no effective treatment, no cure |
|
|
Term
|
Definition
Oral herpes Type I: cold sore. fever blister |
|
|
Term
|
Definition
small number of cases locations and types switch painful lesions
very infective
variable reoccurrence
Acyclovir- somewhat effective
- reduces number, duration of attacks
Can be problem for fetus
can cross placental barrier
can get it from the birth canal
do C-section |
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|
Term
|
Definition
papilloma virus can be sexually transmitted |
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