Shared Flashcard Set

Details

Microbiology Final T/F
true/false questions from past exams
203
Science
Graduate
06/09/2008

Additional Science Flashcards

 


 

Cards

Term
M protein is an important virulence factor of Streptococcus pyogenes that inhibits phagocytosis.
Definition
True
Term
Acute glumerulonephritis occurs approximately 1-4 weeks following primary infection.
Definition
True
Term
Treatment of acute glomerulonephritis with penicillin is ineffective
Definition

True

Term

Escherichia coli is one of the most common causes of urinary tract infections in women.

Definition
True
Term
Eshcerichia coli is one of the most common causes of neonatal meningitis and sepsis
Definition
True
Term
Eshcerichia coli is one of the most common causes of food poisoning
Definition
False
Term

Eshcerichia coli is one of the most common causes of nosocomial infections

Definition
True
Term
Typhoid fever is caused by Salmonella typhi which is normal flora in many animals, especially poultry.
Definition

False

Term
The causatative agent in typhoid fever survives phagocytosis in the gut and can be isolated from blood cultures of infected individual
Definition
True
Term
During chronic infection of typhoid fever, the causative agent persistently colonizes the gall bladder.
Definition
True
Term
The causative agent in typhoid fever is most commonly transmitted by contaminated food and water
Definition
True
Term
Vaccine(s) are available for typhoid fever and recommended for traverlers who plan to visit endemic areas.
Definition
Term
Mycoplasma pneumoniae is one of the most common causes of atypical pneumonia in young adults, especailly in closed communities (i.e. boarding schools, military camps, prisons)
Definition
True
Term

Infection of Mycoplasma pneumoniae does not result in life-long protective immunity.

Definition
True
Term
Mycoplasma pneumoniae is commonly transmitted from environmental water aerosol sources, such as air conditioners and water-cooling towers associated with larger buildings.
Definition
False
Term
Since Mycoplasma pneumoniae lacks a cell wall, penicillin is ineffective for treatment
Definition
True
Term
In common causes of meningitis in young adults, treatment with antibiotic as soon as possible is recommended because it is fatal more than 50% of the time if left untreated.
Definition
True
Term
The most common bacteria that cause minigitis are all members of the normal flora.
Definition
True
Term
Meningitis is a serious infectino because macrophages can not cross the blood brain barrier to cobat the infection
Definition
False
Term
Many meningitis infections can be treated with bacteriostatic antibiotics, but meningitis requires the use of bacteriocidal antibiotics.
Definition
True
Term
Aspergillus species are environmetnal fungi that grow in the soil as molds and in infected lung tissue as spherules.
Definition
False
Term
Cryptococcus neoformans is an environmental yeast that can cause meningitis in both immunocompetent and immunocompromised individuals
Definition
True
Term
Dermatophytes are opportunistic environmental molds that can cause serious systemic infection in patients with AIDS
Definition
False.
Term
Rhizopus and Mucor, environmetnal molds that can contaminate cereals and nuts, produce aflatoxins which have been associated with hepatoma
Definition
False
Term

Histoplasma capsulatum is a dimorphic fungi which grows as a mold in the soil of the eastern and midwestern USA

Definition

True

Term
Most people who live in the endemic areas have been infected by Histoplasma capsulatum
Definition
True
Term
Histoplasma capsulatum can produce tuberculosis-like lesions in the lungs and like mycobacterium tuberculosis it can survive phagocytosis and grow withing macrophages
Definition
True
Term
Histoplasma capsulatum produces a large polysaccharide capsule, which is an important virulence factor
Definition
False
Term
Histoplasma capsulatum is transmitted by the inhalation of air-borne conidia spores
Definition
True
Term
Coccidioides immitis is a dimorphic fungi which grows as a mold in the soild of the Central valley of California, the southwestern US, and Mexico
Definition
True
Term

Most people who are exposed to Coccidiodes immitis have asymptomatic infections

Definition
True
Term

Systemic infections with Coccidiodes immitis usually occurs first in the lungs and may disseminate to other tissues, including the meninges and skin

Definition
True
Term
Inhalation of respiratory droplets from asymptomatic carriers is a common mode of transmission in coccidiodomycosis
Definition
False
Term
Severe disseminated infections of coccidiodomycosis are commonly treated with amphotericin B
Definition
True
Term

A gram negative rod shows up in a patient's blood sample who has bloody diarrhea as a symptom, what is the most likely cause of this?

Definition
Salmonella enterica
Term
A coinfection of N. gonorrhoeae and C. trachomatis is uncommon
Definition
False
Term

Penicillin G is the drug of choice for treating infection by either N. gonorrhoeae or C. trachomatis.

Definition
False
Term
Chlamydial infection is more prevalent in the US than gonoccocal infection
Definition
True
Term

RPR and VDRL tests are rapid inexpensive screening tests that detect syphilis antibodies that fortitously cross-react with cardiolipin

Definition
True
Term
When performing the RPR and VDRL tests, false negative syphilis results sometiems occur if the antibody titer is high
Definition
True
Term
In latent syphilis the RPR, VDRL, and FTA-ABS tests are all positive
Definition
True
Term
Specific treponemal tests, like the FTA-ABS, that directly measure antibody to Treponema pallidum are used to confirm false negative RPR and VDRL results in syphillis
Definition
False
Term
The RPR and VDRL tests can be used to monitor treatment success or failure in syphillis since the titer of antibody decreases with successful treatment
Definition
True
Term
Due to the introudtion of the Group B streptococcal capsular polysaccharide vaccine the incidence of meningitis in neonates and infants has decreased significantly in the last 10 years.
Definition
False
Term
Presently the majority of acute meningitis cases are caused by Haemophilis influenzae
Definition
False
Term
Septicemia rarely precedes meningitis
Definition
False
Term
Bordetella pertussis is a common cause of meningitis in young infants
Definition
False
Term
Haemophilus influenzae is normal flora of the gastrointestinal tract and was the most common cause of meningitis in neonates prior to the introduction of the capsular polysaccharide vaccine
Definition
False
Term
The vaccine for Haemophilus influenzae is effective only against Haemophilus influenzae type b
Definition

True

Term

Haemophilus influenzae is a common cause of otitis media (ear infection) of young children

Definition
True
Term
Haemophilus influenzae requires both X & V factors for growth and diagnosis frequently depends on isolation and culture
Definition
True
Term
Rifampin can be used for prophylaxis of Haemophilus influenzae in close contacts of the ill
Definition
True
Term
In ringworm, the characteristic erythema and vesicles of ringworm results from hypersensitivity reactions to fungal metabolites
Definition
True
Term

In ringworm, hyphal cells are present only in the stratum corneum and do not penetrate the basal layers of the epithelium

Definition
True
Term
In ringworm, dermatophytes that cause ringworm grow only as hyphae, they are incapable of growth in the yeast form
Definition
True
Term
In ringworm, when serious secondary bacterial infection is present, antifungal therapy to eliminate the predisposing ringworm infection should be initiated first
Definition
False
Term
Ringworm can be acquired by exposure to shed skin scales from infected humans and other animals
Definition
True
Term
In oral thrus, the causative fungus is considered normal flora of the mouth and vaginal tract
Definition
true
Term
In oral thrush, the causative fungus grows as a budding yeast that forms pseudohyphae when it invades tissue
Definition
True
Term
In oral thrush, a positive skin test indicates the presence of chronic infection.
Definition
False
Term
Nystatin and ketoconazole are commonly used to treat oral thrus
Definition
True
Term

All of the following are risk factors for Candida albicans infections: diabetes, broad spectrum antibiotic usage, HIV infection, pregnancy

Definition
True
Term

Active immunization against Clostridium with toxoid vaccines is available to both tetanus and botulism, but not gas gangrene

Definition

False

Term
Clostridium botulinum, tetani, and perfingens are all associated with wound infections, but only botulinum is associated with food poisoning
Definition
False
Term
Clostridium botulinum and tetani are usually suceptible to penicillin, but perfingens is not
Definition
False
Term
Clostridium botulinum, tetani, and perfingens all produce exotoxins
Definition
True
Term
Corynebacterium diphtheriae is a pleomorphic Gram-positive rod
Definition
True
Term
cornebacterium diphtheriae is normal flora of the human upper respiratory tract
Definition
True
Term
The primary clinical symptoms of diphtheria are mediated by exotoxin
Definition
True
Term
The DPT vaccine is used to simultaneously immunize individuals against diphtheria, pneumonia, and tetanus
Definition
Term
Vaccination against diphtheria is extremely effective in that there are usually very few (<10cases/year) in the US
Definition
True
Term

During Hepatitis A virus infection, there are multiple serotypes, therefore reinfection is common

Definition
False
Term

During Hepatitis A virus infection, it is highly contagious because it is present at high titers in the blood of infected individuals

Definition
False
Term

During Hepatitis A virus infection, no effective vaccine is presently available

Definition
False
Term

During Hepatitis A virus infection, virus is shed into the feces and infected individuals for approximately two weeks prior to the appearance of clinical symptoms.

Definition
True
Term
HIV is a simple retrovirus, in that it lacks "accessory" genes that are commonly present in complex retroviruses
Definition
False
Term
A few individuals who have chemokine receptors (CCR-5) on their T-lymphocytes appear to be resistant to HIV infection
Definition
False
Term

Reverse transcriptase mediates HIV viral integration into the host cell chromosome

Definition
False
Term
Since HIV has a low mutation rate only a few "variant" viral particles are produced during years of chronic infection
Definition

False

Term
Regarding HPV, paillomaviruses are non-enveloped DNA viruses
Definition

True

Term
Specific genotypes of HPV are associated with infection of specific tissues
Definition
True
Term
Frogs and reptiles are reservoirs for papillomaviruses that cause human warts
Definition
False
Term
Specific genotypes of HPV are associated with malignant transformation (cancer) whereas other genotypes are not associated with malignancy
Definition
True
Term
Only DNA viruses have been associated with oncogenesis, since integration of viral DNA is required for malignant transformation
Definition
False
Term
Oncogenes are unique genes found only in viruses
Definition
False
Term
Most oncogenes encode gene products that suppress cell proliferation
Definition
False
Term
The rate of cervical cancer is low in the USA because HPV infection is uncommon
Definition
False
Term
HPV infection is probably necessary for carcinoma, but insufficient (by itself), to cause malignant transformation
Definition
True
Term
The E6 and E7 proteins of HPV inactivate host molecules (p53 and RB) that regulate the rate of cellular proliferation
Definition
True
Term
Smoking is an imporant co-factor associated with HPV-induced cervical cancer
Definition

True

Term

Most individuals who become infected with HBV resolve their primary infection and develop lifelong immunity

Definition
True
Term
Most individuals who become persistently infected with HBV become asymptomatic cariers and serve as a reservoir for transmission to others
Definition
True
Term
Chronic hepatitis as a result of HBV infectionis a long term risk factors for the development of hepatocellular carcinoma
Definition
True
Term
Recombivax, a live attenuated vaccine is available to prevent HBV infection
Definition
False
Term

Although it is a DNA virus, HBV utilizes a virally-encoded reverse transcriptase in its lifecycle

Definition
True
Term
Detection of HBsAg (hepatitis B surface antigen) in the lood is an important diagnostic indicator of infection
Definition
True
Term

most of the liver damage seen in chronic HBV infection is due to the direct cytopathic effect of the virus on hepatocytes

Definition

False

Term
Neonates of mothers with chronic HBV infection should be given both HBIG and active immunization
Definition
True
Term
HCV infection is frequently asymptomatic
Definition
True
Term
HCV infection is primarily transmitted by exposure to infected blood
Definition
True
Term
Chronic infectiono with HCV occurs infrequently (<5%) following primary infection
Definition
False
Term
HCV infection is the leading cause of liver transplants in the US
Definition
True
Term
Presently, there is no vaccine to prevent HCV infection
Definition
True
Term

Infleunza viruses are non-enveloped RNA viruses

Definition

False

Term
Most influenza pandemics are caused by influenza B virus
Definition
False
Term
Rimantidine can be used as a prophylactic agent to limit the spread of influenza A virus in closed populations, such as nursing homes
Definition
True
Term
Neuramidase spikes on the surface of influenza virus mediate its initial attachment and entry into host cells
Definition
False
Term
Influenza A virus undergoes major antigenic changes (shifts) in its capside proteins, which allows the virus to evade existing immunity in the population
Definition
False
Term

Antigenic drift results from teh accumulation of point mutations in the RNA sequence of the viral genome

Definition
True
Term
Antigenic shift results from homologous recombination of the nonsegmented RNA genome
Definition
True
Term
Antigenic shift results from homologous recombination of the nonsegmented RNA genome
Definition

False

Term
Antigenic shift usually occurs when a single host cell is co-infected with an influenza Group A and an influenza Group B strain of virus
Definition
False
Term
Most emerging diseases are caused by "new" pathogens (eg. microbes that have not previously infected humans)
Definition

False

Term
Increased international travel is a significant factor contributing to the emergence/reemergence of some infectious diseases
Definition
True
Term
Changes in weather, human demographics, and land use can all contribute to the emergence of infectious diseases
Definition
true
Term
Failure to maintain adequate vaccination programs can result in the reemergence of infectious diseases
Definition

True

Term
The acquisition of antibiotic resistance can lead to the reemergence of infectious diseases
Definition
True
Term
Most individuals who are colonized with H pylori do not develop gastric ulcers
Definition
True
Term
There is an association between H pylori infection and gastric carcinoma
Definition
True
Term
Antacids are effective in treating duodenal ulcers because they neutralize the excess acid produced by H pylori
Definition

False

Term
H pylori is primarily transmitted person to person
Definition
True
Term
Although H pylori frequently causes bleeding into the gastrointestinal tract, it does not cause septicemia or disseminated disease
Definition
True
Term

Negative polarity RNA viruses found in spinal fluid requires entry of the nucleus in order to replicate in infected cells

Definition
false
Term

Negative polarity RNA viruses found in spinal fluid requires conversion of its genome into double-stranded DNA in order to produce viral proteins for replication in infected cells

Definition
false
Term

Negative polarity RNA viruses found in spinal fluid requires RNA-dependent RNA polymerase in its core in order to replicate itself in infected cells

Definition
True
Term

Negative polarity RNA viruses found in spinal fluid requires encoding of an aspartyl protease in its genome in order to replicate itself in infected cells

Definition
False
Term

Negative polarity RNA viruses found in spinal fluid requires enveloped characteristic transmitted by respiratory droplets in order to replicate itself in infected cells

Definition

False

Term

-azole drugs can treat actinomycosis

Definition
False
Term
-azole drugs can treat histoplasmosis
Definition
True
Term
-azole drugs can treat cryptococcosis
Definition
True
Term

Secondary syphilis

can be cultured in vitro from the site of damage

Definition
False
Term
rheumatic fever

can be cultured in vitro from the site of damage

Definition
False
Term
glomerulonephritis

can be cultured in vitro from the site of damage

Definition
False
Term
viral hepatitis caused by HCV

can be cultured in vitro from the site of damage

Definition
False
Term
The influenza vaccine is a trivalent vaccine that contains two influenza A strains and one influenza B strain
Definition
True
Term

Re-immunization of the infleunza vaccine is recommended each year since a new vaccine is usually formulated each year to combat antigenic variation of influenza virus

Definition

True

Term
Adults usually receive the live-attenuated "whole virus" vaccine, whereas children usually receive the killed "split virus" vaccine
Definition
False
Term
High titers of antibody to hemagglutinin is the primary protective result of influenza immuniztion
Definition
True
Term
The influenza vaccine is currently recommended for anyone who wants it
Definition
True
Term

Prions are unique infectious agents that do not contain RNA or DNA

Definition
True
Term
Prions are thought to be acquired by ingestion/eating
Definition
True
Term
The brain is the primary site of pathological damage in prion-mediated diseases
Definition
True
Term
Immunopathogenic mechanisms account for most of thee tissue damage observed in prion-mediated diseases
Definition

False

Term
Mad Cow Disease is thought to be a prion-mediated disease
Definition

True

Term
RSV is an enveloped RNA virus
Definition

True

Term
RSV is the most common cause of bronchiolitis and pneumonia in infants
Definition
True
Term
RSV commonly causes nosocomial outbreaks
Definition
True
Term
In serious cases, passive immunization can reduce the severity and duration of disease
Definition
False
Term
Human herpes virus type 8 establishes latent infection in B cells, is the most common cause of infectious mononucleosis in the US, and is associated with cancer in Africa and China
Definition

False

Term
Cytomegalovirus establishes latent infection in B cells, is the most common cause of infectious mononucleosis in the US, and is associated with cancer in Africa and China
Definition
False
Term
Papillomavirus establishes latent infection in B cells, is the most common cause of infectious mononucleosis in the US, and is associated with cancer in Africa and China
Definition

False

Term
Hepatitis B virus establishes latent infection in B cells, is the most common cause of infectious mononucleosis in the US, and is associated with cancer in Africa and China
Definition
False
Term
Epstein-Barr virus establishes latent infection in B cells, is the most common cause of infectious mononucleosis in the US, and is associated with cancer in Africa and China
Definition
True
Term
HSV-2 is a large enveloped DNA virus
Definition
True
Term
HSV-2 can be inactivated by soap and water
Definition
True
Term

In HSV-2, life-long colonization occurs following primary infection

Definition
True
Term

Delivery by C-section, from mothers with active HSV-2 infection , is an option used to prevent severe disseminated infections in newborns

Definition
True
Term
Treatment with ganciclovir can limit the severity and duration of vesicular lesions associated with reactivation
Definition
False
Term
The presence of alpha-hemolytic streptococi in the throat is a predisposing factor for pneumonia
Definition
False
Term

viral respiratory tract infection is a predisposing factor for pneumonia

Definition

True

Term
Alcoholism is a predisposing factor for pneumonia
Definition
True
Term
HIV infection is a predisposing factor for pneumonia
Definition

True

Term
hospitilizationis a predisposing factor for pneumonia
Definition

True

Term

Inhibition of HIV viral attachment to host cell receptors is a likely chemotherapeutic agent to combat HIV

Definition
True
Term

Inhibition of viral reverse trancriptase activity is a likely chemotherapeutic agent to combat HIV infection

Definition
True
Term
Inhibition of host ribosome binding and translation of viral encoded mRNA is a likely chemotherapeutic agent to combat HIV infection
Definition

False

Term
Inhibition of viral aspartyl-protease activity is a likely chemotherapeutic agent to combat HIV infection
Definition
True
Term
Inhibition of viral maturation mechanisms (core/capsid self-assembly) is a likely chemotherapeutic agent to combat HIV infection
Definition
True
Term

What is

  • transmitted by saila, breast milk, blood urine, and sex?
  • may cross the placenta and is the #1 cause of birth defects in the US
  • May cause retinitis in severely immunocompromised patients
  1. respiratory syncytial virus
  2. herpes simplex virus type 2
  3. cytomegalovirus
  4. human immunodeficiency virus
Definition

3. cytomegalovirus

Term

The spirochete that causes Lyme disease is transmitted to humans by infected ticks

Definition

True

Term
Flue-like symptoms and a rash on the palms of the hands and soles of the feet are initial symptoms of Lyme Disease
Definition
False
Term
Arthritis is a common manifestation of untreated Lyme Disease
Definition
True
Term

The incidence of Lyme Disease is probably vastly overdiagnosed

Definition
True
Term
Hepatitis B virus is transmitted by sexual contact
Definition
True
Term

Treponema pallidum is transmitted by sexual contact

Definition
True
Term
Papillomavirus is transmitted by sexual contact
Definition
True
Term
Herpes simplex type 2 is transmitted by sexual contact
Definition
True
Term
Peole in isolated communities such as prisons are likely reservoirs for antigenic shift variants of influenza virus that cause pandemics
Definition

False

Term
Pigs and chickens are likely reservoirs for antigenic shift variants of influenza virus that cause pandemics
Definition

True

Term
Immunocompromised individuals are likely reservoirs for antigenic shift variants of influenza virus that cause pandemics
Definition
False
Term

Multinucleated cells or syncytia are observed in several viral infections because certain viruses stimulate host cell nuclear replication, but inhibit cell division

Definition

False

Term
Multinucleated cells or syncytia are observed in several viral infections because some viral infections induce nuclear budding and cytoplasmic enlargement of host cell
Definition
false
Term
Multinucleated cells or syncytia are observed in several viral infections because when host cells become immortalized by viruses they frequently grow larger
Definition

false

Term
Multinucleated cells or syncytia are observed in several viral infections because virally encoded fusion proteins on the surface of infected host cells cause them to fuse together
Definition
True
Term

Multinucleated cells or syncytia are observed in several viral infections because viral oncogenes up-regulate the cyell cycle and cause uncontrolled host cell growth

Definition
False
Term
Proteins on the surface of viral particles mediate attachment of the virus to specific receptors on the surface of host cells
Definition
True
Term
The viral capsid disintegrates after viral particles enter the nucleus where translation of the viral genome takes place
Definition
False
Term
Some viruses have an outer envelope composed of viral proteins and phospholipids derived from host cell membranes
Definition
True
Term
Some viruses have surface proteins that can cause fusion of virally infected host cells
Definition
Term
Rhinoviruses are small non-enveloped viruses with an RNA genome
Definition
True
Term

Rhinoviruses are transmitted by hand-tohand contact as well as by respiratory aerosols

Definition

True

Term
Atypical pneumonia is a common complication of Rhinovirus infection in neonates
Definition
False
Term
One reason that there is no vaccine for the "common cold" is that there are more than 100 serotypes of Rhinovirus
Definition
True
Term
Rhinovirus is a picovirus
Definition
True
Term

Poliovirus is a picornavirus

Definition
True
Term
Hepatitis A is a picorna virus
Definition
True
Term

Which of the following is leaset likey to be transmitted either in utero or at birth?

 

  1. Herpes simplex virus type 2
  2. Measles virus
  3. Hepatitis B virus
  4. Human immunodeficiency virus
  5. Cytomegaly virus
Definition
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