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Microbiology Exam 4
Chapter 24- Wond and deep tissue infections
32
Microbiology
10th Grade
03/26/2012

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Term
Cellulitus
Definition
An acute, spreading infection of the skin that extends into the subcutaneous tissues. Usually S. aureus or S. pyogenes
Term
What are the symptoms of Cellulitus?
Definition
local pain, redness, swelling, and tenderness.
Term
Periorbital or facial cellulitus is often referred to as what?
Definition
Haemophilus influenzae
Term
A wound is what?
Definition
A type of injury in which the skin is torn, cut, or punctured (open wound), or where blunt force trauma causes a contusion (closed wound).
Term
Whether a wound becomes infected depends on what?
Definition
number of pathogens, virulence of pathogens, status of the host defenses, and presence of foreign material.
Term
Usually S. aureus, from extension of a wound infection or hematogenous. Difficult to treat.
Definition
Infection of the bone
Term
Bacteria adhere to joint and grow synovial fluid. Usually S. aureus, steptococci and N. gonorrhoeae
Definition
Arthritis; joint infection
Term
What are the five types of wounds?
Definition
Burn, Incised (cut with sharp object), puncture, laceration (torn tissue), and contusion (crush).
Term
Wounds can be caused by what?
Definition
Wounds are breaks in skin (except contusion) causes by trauma, burns, surgery, or bites.
Term
Pathogenisis of wound infections
Definition
usually can heal quickly without infection, if they don't, can form assesses.
Term
Wound can also result from what?
Definition
Poor circulation without trauma. IE: Diabetes.
Term
A closed cavity of living and dead microorganisms and phagocytic cells (pus).
Definition
Abscess
Term
What are some characteristics of Abscess?
Definition
Anaerobic, low pH, no blood flow to bring oxygen. Impossible to treat with antibiotics alone.
Term
What are the 3 steps for wound repair?
Definition
1. Bleeding stops by clotting
2. Fibroblasts enter, form collagen and granulation tissue
3. Wound pulls together and filler from bottom up, unless abscess forms.
Term
What are the four parts of wound treatment?
Definition
Debridement; remove all material and dead/dying tissue.
Cover wound after granulation is completed.
Restore circulation if compromised.
Drain abscesses surgically if present.
Term
Infection of wounds depend on what several factors? If factors present then what?
Definition
Wounds expose tissue receptors (collagen, fibrin, etc)
Foreign material is preventing healing
Microbial contamination
Size of wound
Circulation
Abscess formation
-- no amount of antibiotics will prevent infection.
Term
Diabetic Wounds
Definition
Often found on feet due to poor circulation and loss of feeling. Increases trauma and reduces defense again infection.
Term
How are diabetic wound prevented?
Definition
Good foot car, glycemic control, sometime revascularization.
Term
Surgical Site Wounds/ Infections
Definition
May be deep, extending into organ spaces.
Usually from damaged tissues, may result in dehiscenese. (incision does not heal closed, swelling pulls sutures back open)
Term
Anaerobic Wound Infections
Definition
Low oxygen in tissue because of tissue crushing. Anaerobic bacteria present, causing tissue destruction, and gangrene.

Contusions may allow endogenous anaerobes from GI tract to enter and live in wound.
Term
Staphylococcus aureus
Definition
most common wound pathogen, pyogenic (produces lots of purulence), produces many toxins and invasins, lots of inflammation, redness, fever, and pain.
Term
Pseudomonas aeruginosa
Definition
Strictly aerobe (never found in abscesses)Normally found in soil and water. Infects burn and some surgical wounds. Causes endotoxin shock.

Treated with sulver sulfadiazine ointment
Term
Coagulase negative staphylococci
Definition
Usually S. epidermidis. Not as virulent as Sapthylococcus auereus but more common and likes to stick to plastic. Can cause small superficial suture infections.
Term
Streptococcus pyogenes
Definition
Many toxins and spreading factors, invasive, spreads in between the tissue layers.
Term
Streptococcus pyogenes causes what?
Definition
necrotizing faciitis (spreads along the fascia) and myositis ("felsh-eating infection" of muscle")
Term
Treatment of Streptococcus pyogenes?
Definition
Surgically removing all infected tissue.
Term
Clostridium tetani
Definition
Found in soil, traumation wound introduces endospores, they germinate in the wound making tetanospasmin toxin causing muscle spasms; tetanis.

Prevent by vaccination against tetanostoxin.
Term
Gangrene
Definition
Exogenous GI tract anaerobes. Mostly Clostridum perfringens. Toxins quickly spread, kill the tissue and form gas.

Treatment=amputation. Anti-biotic are not enough.
Term
Pasteurella multocida is the pathogen for what type of bite wound?
Definition
Dogs and cats
Term
Bartonella hensellae is the pathogen for what type of bite wound?
Definition
Kittens
Term
Streptobacillus moniliformis is the pathogen for what type of bite wound?
Definition
Rates
Term
Fungal wound infections
Definition
Sporotrichosis. Found normally in soil, gardeners and farmers get infections on hands from puncture wounds. Slow, chronic infection that follows the lymphatics up from the wound.
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