Term
| What's the make up of Parvoviridae |
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Definition
1. ssDNA 2. Icosahedral nucleocapsid 3. Nonenveloped |
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Term
| How does Parvovirus causes the slapped face appearance |
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Definition
| Deposit of immune complexes |
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Term
| How does parovirus cause anemia? |
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Definition
| Lyses precursor cells in the bone marrow |
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Term
| Name the two cancer viruses |
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Definition
1. Papillomavirus (HPV) 2. Polyomavirus (JC) |
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Term
| HPV is the cause of the common _____ |
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Definition
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Term
| The common or flat wart is transmitted by |
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Definition
| a break in the skin allowing the virus to enter |
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Term
| Describe epdiermodysplasia veruciformis |
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Definition
| wart leading to malignant conversion due to exposure to the sun |
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Term
| Genital warts is caused by? |
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Definition
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Term
| Genital wart can convert to _____ |
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Definition
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Term
| which HPV strains convert to carcinoma |
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Definition
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Term
| Which protein product of HPV binds to p53 |
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Definition
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Term
| what's the function for p53 |
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Definition
| induce expression of WAF 1 and causes cell cycle arrestz by inhibiting cyclins and cdks |
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Term
| HPV E7 binds to ____ which is a negative regulator of cell growth |
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Definition
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Term
| What's the make up of HPV, what other virus shares it |
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Definition
1. dsDNA circular 2. Icosahedral nucleocapsid Polymavirus |
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Term
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Definition
| Progressive Multifocal Leukoencephalopathy |
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Term
| A JC virus non-productive infection is due to |
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Definition
| Insufficent Large T antigen so viral replication cannot take place |
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Term
| the middle T antigen of JC virus resembles |
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Definition
| growth factor receptor and allows the cell to proliferate w/out Growth factor |
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Term
| What does Large T antigen from polyomarius do? |
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Definition
| Binds & activates p53 & RB |
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Term
| what are the symptoms of Progressive mulifocal leukoencephalopathy |
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Definition
1. Ataxia 2. Abnormalities of motor funciton, speech & sensation 3. Leads to dementia and death |
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Term
| Where does JC virus infect |
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Definition
| myelinating oligodendrocytes in white matter |
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Term
| Which virus causes Subacute Sclerosing Panencephalitis |
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Definition
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Term
| What are the symptoms of Subactue Sclerosing Panencephalitis |
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Definition
1. Gradual progressing psychological degeneration 2. personality changes 3. Seizures 4. Uncontrollable movements 5. Leads to dementia & death |
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Term
| What's at risk for developing Subactue Sclerosing Panencephalitis |
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Definition
| Measles before 2 and latient in the CNS for 6-15 years |
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Term
| Prions cause which disease |
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Definition
|
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Term
| what are the symptoms of CJD |
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Definition
1. Ataxia 2. Neurological signs as alterations in hearing, speech, visions that lead to dementia |
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Term
| What's the diagnosis of CJD |
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Definition
| Protease resistance prion |
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Term
| What are the known transmissions of CJD |
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Definition
1. Cornea transplants 2. GH from cadavers that had CJD 3. Consume contaminated meat 4. Rare inherited form |
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Term
| What's the pathogenesis behind CJD |
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Definition
| Noraml alpha helix changes conformation to beta pleated sheets |
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Term
| The beta pleated sheets of CJD infects by linking _______ _____ bonds and form ______ |
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Definition
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Term
| ___ is the first protein made in Adenovirus gene expression, it binds to ______ |
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Definition
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Term
| Adenovirus protein ___ binds to p53 |
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Definition
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Term
| 3 proteins are involved in adenovirus replication |
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Definition
TP acts as a primer adDBP is a DNA binding protein AdDNA poly is a DNA dependent polymerase |
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Term
| Adenovirus is latent in the ______ ____ and has _______ potential |
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Definition
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Term
| Name the 4 clincial presentations of adenovirus |
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Definition
Respiratory tract infection Conjunctivitis Hemoohagic cystitis: infants gastroenteritis |
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Term
| What's a complication of respiratory adenovirus infection |
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Definition
|
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Term
| Name the 3 modes of transmission of adenovirus |
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Definition
1. Fecal oral 2. Hand to eye 3. Respiration |
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Term
| What's the classic shape of Orthopoxvirus (smallpox) |
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Definition
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Term
| Small pox replication occurs in the _____, but gene expression & replication occurs in the ______ |
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Definition
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Term
| Describe gene repolication in small pox |
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Definition
Self priming leads to formation of high M.W concatemers which are cleaved and repaired to make the viral genome |
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Term
| Describe the assembly phase of smallpox |
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Definition
| Occurs in the cytoskeleton, comet tails form through the cytoplasm to the cell surface |
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Term
| What is the clinical manifestation of Small pox |
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Definition
| Pustular rash most common on the extremities, fever and respiratory symptoms |
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Term
| monkeypox is more common in |
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Definition
|
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Term
| What's the symptoms of monkey pox |
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Definition
| Pustular rash, fever and respiratory symptoms and differs from smallpox with lymph node swelling |
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Term
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Definition
1. Herpes simplex virus 1 & 2 2. Varicella Zoster 3. Cytomegalovirus 4. Epstein Barr |
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Term
| Which proteins are similar in HSV 1 & 2 and which ones are different |
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Definition
| D is identical and G is different |
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Term
| HSV codes for _______ _____ that makes it suspectible to Acyclovir and gancicgvir |
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Definition
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Term
| What does Acyclovir and Gancicgvir target |
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Definition
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Term
| HSV 1 infectious appear _____ the waist and HSV2 infections appear ____ the waist |
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Definition
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Term
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Definition
Gingvostomatitis (mouth ulcers) Keratoconjunctivitis (uclers on the eyes) Herpes labialis (cold sore) Temporal lobe encephalitis |
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Term
| Extercellular protein 47 in herpes blocks |
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Definition
| antigen presentation, it's the reason why it's latent |
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Term
| Where does HSV1 hide out in? How about HSV2 |
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Definition
| Trigeminal ganglia & Sacral ganglia |
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Term
| Why is Acyclovir important in women? |
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Definition
| worry and stress and trigger reactive HSV II |
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Term
| CMV is the most common viral cause of ______ _______ in the U.S. |
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Definition
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Term
| Name the TORCHES organisms that can cross the placenta |
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Definition
1. Toxoplasmosis 2. Rubella 3. Cytomegalovirus 4. Herpies, HIV 5. Syphilis |
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Term
| What's congential cytomegalic inclusion disease |
|
Definition
| Caused by CMV, it's disease of the newborn associated w/ CMV |
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Term
| A infant w/ congenital cytomegalic inclusion diseasee would present w/ |
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Definition
1. Mental retardation 2. Hearing loss 3. Mental defects |
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Term
| Give the symptoms of CMV induced Atypical Infectious Mono. |
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Definition
1. Swollen lymph nodes 2. fever 3. Tiredness 4. Differs from mono by absence of sore throat |
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Term
| the gold standard for diagnosising CMV is the |
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Definition
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Term
| What's the treatment for CMV |
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Definition
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Term
| owl body intranuclear inclusions are associated w/ |
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Definition
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Term
| Varicella-zoster viruse cause _____ by primary infection and _____ in recurrent form |
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Definition
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Term
| Give the characteristics of chickenpox |
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Definition
1. Flu like 2. lesion on the trunk, skin |
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Term
| Where does the latient form of varicella zoster hide out |
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Definition
|
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Term
| What's the difference in chicken pox infection and shingles |
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Definition
| Shingles lesions are on a dermatome |
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Term
| Name the varicella zoster virus vaccine |
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Definition
| Oka vaccine, live attenuated |
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Term
| Give the symptoms of mononucleosis |
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Definition
1. Tiredness 2. Sore throat 3. Swollen lymph nodes 4. Fever |
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Term
| What's the cause of the symptoms for mono |
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Definition
| Over reaction of the immune system to EBV infected B cells |
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|
Term
| Epstein Barr Virus infections B cells via |
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Definition
|
|
Term
| name the 2 onca genes in EBV |
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Definition
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Term
| LMP1 activates ___ receptor |
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Definition
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Term
| LMP2 constitutive activates |
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Definition
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Term
| The ____ ____ test diagnosis EBV |
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Definition
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Term
| Brukitts lymphoma requries 2 hits one from ___ and the other in c-myc (translocation in __ + _) |
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Definition
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Term
| The incidence of Hodgkins disease is higher in people who had __ |
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Definition
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