Term
What are three agents that cause infections of the integument? |
|
Definition
Propionibacterium acnes
Staph aureus
Strep pyogenes |
|
|
Term
Which agent is the predominant ANAEROBIC member of the normal skin flora? What type of rod is it? |
|
Definition
Propionibacterium acnes
Gram positive diptheroid |
|
|
Term
What are the three normal flora of the skin? |
|
Definition
-Propionibacterium acnes
-diphtheroids
-coagulase negative staph |
|
|
Term
Which class can be described as "short Gram positive bacilli, like 'Chinese letters?'
|
|
Definition
|
|
Term
What is the most common skin disease? |
|
Definition
|
|
Term
What population does Acne Vulgaris normally occur in?
What is it initially caused by?*
The overgrowth of which agent causes inflammatory Acne Vulgaris? |
|
Definition
-adolescent population
-alteration in sebaceous physiological processes
-propionibacterium acnes |
|
|
Term
In the absence of P. Acnes, what is formed from:
increased sebum production after puberty
or
follicular canals plugged due to altered physiology? |
|
Definition
|
|
Term
In the non-infectious process of acne, what two things can cause canal/duct blockage? |
|
Definition
Keratinization
Desquamation |
|
|
Term
What non-inflammatory structure may microcomedones evolve into? |
|
Definition
Comedones; open or closed surface pores |
|
|
Term
What is not present in the non-inflammatory manifestation of acne? |
|
Definition
there is no P. Acnes present |
|
|
Term
What is a closed comedeone?
What is an open comedone? What is the common misconception about open comedones? |
|
Definition
"White head"
"Black head'
-the "black" part is not dirt, rather melanin, which results in pigmentation |
|
|
Term
What are the four main goals of treatment for acne vulgaris? |
|
Definition
-antikeratinizing
-inhibit sebum production
-anti p. acnes
-anti-inflammatory |
|
|
Term
How long may intermittent treatment of Acne vulgaris take? |
|
Definition
|
|
Term
Name 5 treatments for acne vulgaris that inhibit P. Acnes |
|
Definition
Salicylic acid
Retinoic Acid
Azelaic Acid
Benzoyl Peroxide
Antibiotics |
|
|
Term
Which three antibiotics are anti-P acnes? |
|
Definition
erythromycin
clindamycin
doxycycline |
|
|
Term
Name 4 non-abrasive compounds in medicating cleansing OTC's for acne vulgaris: |
|
Definition
-Topical Vitamin A
-Topical Vitamin C
-Low does retinol
-Alpha hydroxy acid |
|
|
Term
What three treatments can you use for severe acne? |
|
Definition
-systemic antibiotics
-corticosteroids
-estrogens, anti-androgens, spironolactone |
|
|
Term
What are the four most harmful actions you can do if you have acne? |
|
Definition
-Frequent, non-medicated vigorous cleansing
-abrasive cleaning
-restricted diet
-squeezing pimples (can lead to inflammatory response) |
|
|
Term
Is Acne curable? Is the treatment duration less than or more than 6 months? |
|
Definition
|
|
Term
Which agent of the integument can be described as Gram-positive cocci
forms pairs, short chains, grape-like clusters
produces coagulase? |
|
Definition
|
|
Term
The manifestations of Staph Aureus can be grouped into which two groups? |
|
Definition
Non-toxin mediated and toxin mediated |
|
|
Term
Folliculitis, Furuncles, Carbuncles, and Epidermis impetigo
fall under which classification of manifestations of staph aureus integument infection? |
|
Definition
Non-toxin mediated diseases |
|
|
Term
What is "cured" defined as in HCV?
Because it is so expensive and difficult, what are the three criteria for treatment of HCV? |
|
Definition
-persistent loss of HCV RNA in blood during long-term follow-up
-persistent elevation of aminotransferases, quantitative HCV RNA, severe histologic changes on liver biopsy |
|
|
Term
What are the two transmissions for HAV? Which are the major vehicles? |
|
Definition
-Fecal-oral and person-to-person transmission are possible (fecal-oral is bigger)
-food and water are major vehicles |
|
|
Term
Which immunoglobulin in HAV indicates lifelong immunity? |
|
Definition
|
|
Term
Which immunoglobulin in HAV is generally present 5-10 days before symptoms and last for under 6 months? What can this be useful for? |
|
Definition
IgM; It can be useful for diagnosing HAV. |
|
|
Term
What are HavRix and Twinrix? Who are they recommended for? |
|
Definition
Killed vaccine for hepatitis A virus; recommended for children and international travelers |
|
|
Term
|
Definition
-underdeveloped countriess mostly in S.E./central asia |
|
|
Term
Fulminant hepatitis E with liver failure is found very rarely (1%) EXCEPT in which population? |
|
Definition
Pregnant women in their third trimester (25%) |
|
|
Term
What is the treatment for HEV? |
|
Definition
Supportive treatment only |
|
|
Term
What "kind" of virus is HIV? What does it have multiple of? |
|
Definition
it is a retrovirus and has multiple serotypes |
|
|
Term
How long is the incubation period for HIV? |
|
Definition
|
|
Term
What does M-tropic strain of HIV infect? |
|
Definition
Infects macrophages/primary T lymphocytes |
|
|
Term
What does M-tropic strain indicate? |
|
Definition
|
|
Term
What does the T-tropic strain of HIV indicate? |
|
Definition
It indicates that the patient will progress to AIDS rapidly and a steep decline in T-helper cells. |
|
|
Term
Viral genome for HIV:
RNA -->DNA?
or
DNA--> RNA? |
|
Definition
|
|
Term
In HIV, what 2 things convert ssRNA into ssDNA? |
|
Definition
-reverse transcriptase (66)
-ribonuclease H |
|
|
Term
What is an important distinction that occurs when HIV ssRNA is converted to ssDNA? Why does this occur? |
|
Definition
Many replication (base pair) errors occur because reverse transcriptase has no proofreading. |
|
|
Term
Some drugs that target reverse transcriptase also target what? |
|
Definition
DNA-dependent polymerase in mitochondria; (big effect on normal replication) |
|
|
Term
Once infected with HIV, how long does a person remain infected? How long must he/she be treated for? |
|
Definition
A person remains infected for life and treatment must be lifelong. |
|
|
Term
In acute phase of infection, where does HIV primarily replicate? |
|
Definition
|
|
Term
After three weeks of infection of HIV, what noticeable endoscopic change will occur? |
|
Definition
there will be no more T cells in the GIT |
|
|
Term
Where does the human immune system battle HIV virus in the body? What happens with a few years? |
|
Definition
lymph nodes (T cells and HIV virion die); eventually, the virus overwhelms the immune system and progresses to AIDS |
|
|
Term
After all the T-cells are gone from the gut, what is activiated? |
|
Definition
a chronic, generalized/systemic immune activation |
|
|
Term
What is one of the strongest predictors for progression from HIV infection to AIDS and which may be the main cause of CD4 depletion? |
|
Definition
the strong chronic, systemic immune activation |
|
|
Term
What is the CD4 count for AIDS? |
|
Definition
|
|
Term
What is defined as a "slowly progressive demyelinating disease with neuronal loss of the CNS?" |
|
Definition
HAD: HIV-associated dementia |
|
|
Term
What is the worst risk factor for HAD? |
|
Definition
|
|
Term
What does HIV affect in the CNS? What doesn't HIV affect in the CNS? |
|
Definition
It affects: monocytes, macrophages, and microglia cells.
It does not affect: neurons or oligodendrocytes |
|
|
Term
What are the results of HIV infection in the CNS (2) |
|
Definition
-diffuse or focal myelin pallor of white matter (demyelination)
-neuronal loss |
|
|
Term
What is defined as: neurocognitive impairment demonstrated by cognitive testing but are asymptomatic in their daily life? |
|
Definition
Asymptomatic neurocgnitive impairment (ANI) |
|
|
Term
What is defined as when the patient has impairments causing mild disturbance of ADL's?
(difficulties in concentration, attention, memory) What does this progress from? |
|
Definition
HIV-associated mild neurocognitive disorder (MND)
This progresses from ANI |
|
|
Term
What is the full progression of CNS disease via HIV? |
|
Definition
|
|
Term
What are the most common feature of HAD? |
|
Definition
cognitive changes (forgetfulness, confusion, loss of memory) |
|
|
Term
Which two diagnostic tests detect HIV-specific antibodies? Problem with this test? |
|
Definition
EIA; western blot. Must wait until immune response ("window of no positive serology") |
|
|
Term
Which viral antigen must be tested for all blood donors? What are they testing for? |
|
Definition
p24 antigen; tests for HIV, especially when "window" period of no antibodies |
|
|
Term
What are the four strategies to prolong survival in those with HIV? |
|
Definition
-antiretroviral therapy
-P. carinii prophylaxis
-M. Avium prophylaxis
-care by a physician with HIV-care experience |
|
|
Term
What happens if you stop reverse transcriptase? Which drug type does this? |
|
Definition
you stop any new virus from infecting person's cells; RTI's and NNRTI's do this (Reverse-transcriptase inhibitors and non-nucleoside reverse transcriptase inhibitors)
Ex: neveripine; loviride |
|
|
Term
What do protease inhibitors do? Name three examples. |
|
Definition
Stop maturation of virus. Virus is made, but not infectious.
saquinavir; indinavir; amprenavir |
|
|
Term
|
Definition
inhibits HIV-1 co-receptor CCR5 |
|
|
Term
What does Isentres (Raltegravir) do? |
|
Definition
|
|
Term
Is HIV monotherapy efficacious long term? Why or why not? (2 reasons) |
|
Definition
It is NOT efficacious long term because you get resistance and because of the high mutation rate of the virus. |
|
|
Term
What is are the results of RTI's(NRTI's)? |
|
Definition
-blocks production of viral DNA and inhibits further DNA synthesis via CHAIN TERMINATION |
|
|
Term
|
Definition
-it attaches to viral reverse transcriptase to block its function and it will block the further prodcution of viral DNA. |
|
|
Term
Does the latent virus DNA get killed by antiviral therapy? Why or why not? |
|
Definition
No because it is already in the human genome. |
|
|
Term
What does HAART stand for? What does it consist of? |
|
Definition
Highly active Antiretroviral Therapy: multiple drugs used for treatment of HIV; Old definition is 2 RTI's and something else; now it can be two NRTI's plus something else. |
|
|
Term
What are the three caveats of HAART? |
|
Definition
-does not prevent all new infections of susceptible cells
-does not kill latent virus (NO CURE!!); latent infected T-cells are the major reservoir
-patient is still infectious via sexual contact |
|
|
Term
What are two reasons why HAART must be adhered to faithfully? |
|
Definition
-drug resistance is a significant problem
-latently infected T cells are the major reservoir. If HAART is stopped prematurely, latent cells will become active and progress to AIDS |
|
|
Term
What are two reasons why CD4 count increases rapidly with HAART? |
|
Definition
-initial redistribution of memory T cells
-slow repopulation of naive cells |
|
|
Term
It must be noted that HIV therapy causes a lot of :__________. This is why it is important to know when to start therapy. |
|
Definition
|
|
Term
During primary infection, what 2 types of cells does EBV virus infect? After resolution of primary infection, EBV is a latent-persisent infection where? |
|
Definition
epithelia cells and resting B cells; peripheral blood/memory B lymphocytes |
|
|
Term
During latency, where can Epstein-Barr virus occur due to a lytic infection after B cells spread to oropharynx? |
|
Definition
|
|
Term
If there are non-sense antibodies present in the body, what is the probably agent? |
|
Definition
|
|
Term
What type of antigen is EBV? |
|
Definition
tyoe 1 T-INdependent antigen |
|
|
Term
What are the two more unusual manifestations of EBV?
|
|
Definition
splenomegaly
heptaomegaly |
|
|
Term
Why is there a splenomegaly in EBV? |
|
Definition
The spleen is the major organ for B cells in the body, and in Epstein-Barr disease, there is a huge proliferation of B cells. |
|
|
Term
What are three complications with EBV? |
|
Definition
lymphomas
hairy leukoplakia
multiple sclerosis |
|
|
Term
What drug do you never give if someone has infectious mono due to EBV? |
|
Definition
|
|
Term
Treatment for EBV: What kind of treatment?
Ampicillin?
acetominophen?
acyclovir?
corticosteroids? |
|
Definition
supportive;
No ampicillin, acyclovir, corticosteroids.
YES to acetominophen. |
|
|
Term
Four ways of CMV transmission? |
|
Definition
-secretions
-blood transfusion
-vertical transmission
-organ transplant recipients
(if immunosuppressed, CMV = fatal) |
|
|
Term
Which agent is the most common cause of congenital infection? |
|
Definition
|
|
Term
Which agent are CMV manifestations very similar to? |
|
Definition
EBV (but CMV is much more prevalent) |
|
|
Term
Are non-toxin mediated diseases contagious? What does that mean if a person is exposed? |
|
Definition
All are contagious which means that a person exposed to infection will be colonized with the virulent strain, but not necessarily develop the disease. |
|
|
Term
Which four types of agents cause cellulitis? |
|
Definition
1. Gram-positive cocci (pyogenes, aureus, pneumoniae)
2. Gram-negative rods
3. Atypical mycobacteria (necrotizing skin lesions)
4. Fungal agents |
|
|
Term
Exposure to what predisposes a person to cellulitis and often involves bacteremia? (mycobacterium or vibrio) |
|
Definition
exposure to fresh or seawater |
|
|
Term
Which epidemiologic factor predisposes a person to cellulitis and involves the agents Pasteurella and Capnocytophaga? |
|
Definition
Animal (cat/dog) scratches or bites |
|
|
Term
Infections in areas adjacent to the oral cavity/in oral secretions predisposes people to cellulitis caused by which agent? |
|
Definition
|
|
Term
In cellulitis epidemiology, which etiology causes infections that occur within 72 hours of surgery? (2) |
|
Definition
1. gram positive cocci
2. C. perfringens |
|
|
Term
In cellulitis epidemiology, which etiology causes infections that occur between 10-->30 days? |
|
Definition
gram-negative rods (facultative anaerobes)
gram-positive cocci |
|
|
Term
In cellulitis epidemiology, which etiology causes infections that occur between 2-3 months post-operative? |
|
Definition
diphtheroides
coagulase negative staph |
|
|
Term
Describe the manifestation of the local infection of cellulitis. |
|
Definition
-inflammation: erythema, pain, edema, warmth, NEVER sharply dermarcated |
|
|
Term
What treatment must be done for cellulitis? |
|
Definition
|
|
Term
As far as the epidemiology of anthrax, what type of disease is it? And what are the primary hosts? |
|
Definition
Enzootic disease of *herbivores such as sheep, goats, cattle, etc. |
|
|
Term
What is formed by bacillus anthracis that can survive for years in the soil? |
|
Definition
|
|
Term
Which type of anthrax accounts for 95% of human cases? |
|
Definition
|
|
Term
In cutaneous anthrax, how does death occur? (2 reasons) |
|
Definition
Death is due to both a Toxemia and a Bacteremia. |
|
|
Term
Which disease caused by P. aeruginosa must you make sure not to confuse with anthrax? |
|
Definition
|
|
Term
What is the etiologic agent of erysipelas? What is another name for erysipelas? |
|
Definition
Group A Strep; St. anthony's fire |
|
|
Term
What precedes erysipelas? |
|
Definition
URT or skin infection caused by GAS |
|
|
Term
Erysipelas is similar to cellulitis except that: |
|
Definition
-the illness begins with systemic signs and an erythema forms that is : bright red and indurated that IS SHARPLY DEMARCATED |
|
|
Term
Sole reservoir for smallpox? |
|
Definition
|
|
Term
How is smallpox virus passed? (2) |
|
Definition
-respiratory secretions
-contact with lesions |
|
|
Term
4 complications of smallpox? |
|
Definition
-variola keratitis
-encephalitis
-cellulitis
-secondary bacterial infection |
|
|
Term
DNA polymerase inhibitor that is used in the treatment of smallpox? |
|
Definition
|
|
Term
Which stage of smallpox is described as:
after exposure to the virus, this period is when people do not have any symptoms and feel fine. This period averages 12-14 days and people are not contagious.
|
|
Definition
|
|
Term
Which stage of smallpox is described as:
first symptoms include fever, malaise, head/body aches. fever is usually very high and people are too sick to carry on ADL's. This stage my last 2-4 days. |
|
Definition
|
|
Term
Which stage of smallpox is the most contagious? |
|
Definition
|
|
Term
Where does the early rash begin in smallpox? Within 24 hours, what happens to the rash? What happens to fever? |
|
Definition
It begins on the tongue and in the mouth; In 24 hours, the rash spreads to all parts of the body; The fever falls down and the patient may feel better. |
|
|
Term
Which stage of smallpox is described as: the raised bumps become sharply raisd, usually round and firm to touch as if there is a small object under the skin. Like BB pellets under the skin. |
|
Definition
|
|
Term
What happens after pustules develop in smallpox? What happens after scab phase in smallpox? When is the patient no longer contagious? |
|
Definition
they form scabs; scars are formed. The patient is no longer contagious once all the scabs have fallen off. |
|
|
Term
Which areas of the body do most lesions of smallpox end up spreading to? |
|
Definition
|
|
Term
What is the seasonal occurrence of chicken pox? |
|
Definition
|
|
Term
Where is the virus located in varicella and zoster? |
|
Definition
The virus is located in the lesions; know that the lesions are contagious. |
|
|
Term
Where do lesions first develop in chickenpox? |
|
Definition
They first develop on the head/scalp and spread to trunk |
|
|
Term
What is the most common agent of secondary infection that causes the hospitalization of children with varicella? |
|
Definition
Secondary infection by GAS or staph aureus |
|
|
Term
What does a zoster-infected pt. manifest with? |
|
Definition
VARICELLA! (chickenpox) not ZOSTER (shingles) |
|
|
Term
What age group does herpes zoster occur in? what types of children does this occur in? |
|
Definition
adults above 60 years old; immunocompromised children |
|
|
Term
|
Definition
Recrudescence of VZV due to waning cellular immunity |
|
|
Term
Manifestations of herpes zoster: |
|
Definition
ASYMMETRICAL maculopapular crusting rash FOLLOWS DERMATOME or cranial nerve distribution; SEVERE PAIN |
|
|
Term
What are three complications of herpes zoster? |
|
Definition
-opthalmic/otic zoster
-postherpetic neuralgia (severe burning pain from non-noxious stimuli; very debilitating)
-acute peripheral facial palsy: paralysis |
|
|
Term
What must you NOT give for treatment of varicella in children? Why? |
|
Definition
NEVER give aspirin because of Reye's syndrome. |
|
|
Term
What antiviral therapy for varicella is recommended only for people at high risk for severe disease? |
|
Definition
|
|
Term
Which antiviral therapies are used for zoster within 72 hours of onset of rash? |
|
Definition
Acyclovir, famciclovir, valacyclovir |
|
|
Term
What type of vaccine is Varivax and what is it used for? |
|
Definition
Varivax ia a live attenuated vaccine for the prevention of varicella |
|
|
Term
After administration of Varivax, can children manifest with varicella? what is the difference? |
|
Definition
Children can manifest with with EXTREMELY MILD varicella and no significant sequelae occur. |
|
|
Term
Name two contraindications for Varivax vaccine: |
|
Definition
-pregnant women
-immunocompromised children |
|
|
Term
What is the agent for erythema infectiosum? |
|
Definition
|
|
Term
Name two other diseases caused by Parvovirus B19? |
|
Definition
Arthropathy and Aplastic Crisis |
|
|
Term
Treatment of diseases caused by Parvovirus B19? |
|
Definition
-supportive only
-antipyretics, analgesics, and NSAIDS
-transfusion for those with aplastic crisis |
|
|
Term
Name a risk factor for aplastic crisis: |
|
Definition
immunosuppressed pt. at risk for anemia, chronic bone failure |
|
|
Term
What is HHV-6 and HHV-7 closely related to? |
|
Definition
|
|
Term
What are the agents for exanthem subitum? |
|
Definition
|
|
Term
primary mode of transmission for HHV-6 and HHV-7? |
|
Definition
|
|
Term
Agent frequently responsible for first febrile illness in 6-12 months of age? |
|
Definition
|
|
Term
HHV-8 is associated with all forms of what complication (particularly in underdeveloped countries)? |
|
Definition
|
|
Term
Agent for which 100% of infected persons are seropositive for? What will cause reactivation of this virus? |
|
Definition
HHV-6; immunosuppression will reactivate virus |
|
|
Term
What is the agent of pityriasis rosa? |
|
Definition
|
|
Term
What is the usual progression of exanthem subitum? |
|
Definition
High fever then defervescence, then rash |
|
|
Term
Main reason for spinal taps of little children? Why? |
|
Definition
High fever with no rash; spinal tap done to check for aspetic meningitis |
|
|
Term
What class of virus does mumps, measles, and rubella fall under? |
|
Definition
|
|
Term
Age group most infected for measles? Seasonality for measles? portal of entry? primary attack rate for measles (% of infected that manifest Dx)? |
|
Definition
-children <5
-winter-spring
-upper respiratory tract
->90% attack rate |
|
|
Term
Leading causes of death in children 1-5 in developing countries as complications of measles? |
|
Definition
|
|
Term
What occurs 10-12 days after infection of measles and 3-4 days before exanthem/enanthem? |
|
Definition
PRODROME:
coryza
unproductive cough
conjunctivitis with photophobia
|
|
|
Term
Is the rash for measles symmetrical or asymmetrical? opposite as which disease? |
|
Definition
Measles rash are symmetrical whereas herpes zoster is asymmetrical |
|
|
Term
Can measles cross the placenta? |
|
Definition
|
|
Term
|
Definition
supportive: vitamin A;
gamma globulin for immunocompromised (6 days after exposure) |
|
|
Term
Prevention of measles: who do you not administer vaccine to? |
|
Definition
live, attenuated MMR. Don't administer to pregnant women! |
|
|
Term
Two other names for rubella? |
|
Definition
|
|
Term
Primary age groups for rubella?; seasonality?; Is rubella just as infectious or less infectious than chickenpox and measles?; What populations are at risk? |
|
Definition
adolescents, young adults; winter and spring; rubella is less infectious, meaning there are asymptomatic infections that occur; immigrants from developing countries and continental Europe |
|
|
Term
Prodromal symptoms present in rubella? |
|
Definition
Prodromal symptoms are minimal/absent; fever is low-grade in rubella vs. high grade in rubeola; arthralgia appears like when caused by human parvovirus B19 |
|
|
Term
Complication of Rubella?; most critical timing for this complication?; consequences? |
|
Definition
CRS: congenital rubella syndrome; first trimester of maternal pregnancy; teratogenicity and birth defects |
|
|
Term
Lab diagnoses for newborn uses what test? what does each letter stand for? What is measured? |
|
Definition
STRCH test:
syphilis
toxoplasmosis
rubella
CMV
herpes
IgM in cord blood is measured |
|
|
Term
|
Definition
DO NOT TREAT WITH IMMUNOGLOBULIN. Based on risks physicians may actually suggest therapeutic abortion. |
|
|
Term
What test do you use before or during pregnancy to determine maternal immune status for rubella? |
|
Definition
|
|
Term
Name three diseases that are superficial mycoses: |
|
Definition
Pityriasis Versicolor; Black or white piedra; Tinea Nigrans |
|
|
Term
Agent for pityriasis versicolor? Who is most affected?; clinical manifestations? (3) |
|
Definition
Malassezia furfur; young adults;
-brown colored patches/lesions on chest abdomen or back
-Pityrosporum folliculitis (acne like pustules on upper trunk/arms)
-Dandruff; seborrhic dermatitis |
|
|
Term
Treatment of pityriasis versicolor? |
|
Definition
Antifungal (ketoconazole or ciclopirox)
1% selenium sulfide ointment or shampoo (selsun blue) |
|
|
Term
Agent of black piedra? white piedra? |
|
Definition
Black: piedra hortai
White: trichosporon beigelii |
|
|
Term
What is formed on external hairshaft? |
|
Definition
Ectothrix is formed, which is a sheath of arthrospores |
|
|
Term
Although there are no symptoms for black or white piedra, what does white piedra resemble?; Therapy? |
|
Definition
Nits/lice; cut off or shave infected hair |
|
|
Term
Agent for Tinea Nigrans?; 95% of this happens in what age group? Which gender does it predominate in? |
|
Definition
Hortaea Werneckii; persons under 18 years old; 75% female |
|
|
Term
Where does the black/brown mottled macules form in tinea nigrans? Treatment? |
|
Definition
It forms on the palm or plamer surface of fingers; keratinolytic agents |
|
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Term
Most common fungal agent for dermatophytoses? (ringworm); what does it infect? Other two agents for dermatophytoses? |
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Definition
trichophyton; hair, skin and nails; epidermophyton and microsporum |
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Term
Pt. risk factors for pityriasis versicolor and dematophytoses? |
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Definition
malnutrition, antibiotics, low epithelial cell turnover rate, hyperridosis |
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Term
Hair, skin, and nails share what common quality? |
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Definition
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Term
"Tinea" indicates what disease? |
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Definition
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Term
Agent for dermatophytic onychomycosis? |
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Definition
Tinea unguium; nails crumble |
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Term
Any fungal infection of skin, nails, or hair caused by a fungi other than a dermatophyte is caused by?; three forms? name of diseases? |
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Definition
candida alblicans; yeast, pseudohyphae; hyphae; dermatomycoses |
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Term
How to treat cutaneous candidosis? |
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Definition
1% crystal violet; nystatin, amphotericin B, ketoconazole (systemic) |
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Term
Which agent infects gardners and lumberjacks?; clinical manifestations?; how to treat? |
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Definition
Sporothrix schenckii; painless chronic infections with nodular lesions along lymphatics; itraconazole/amphotericin B; apply heat 4x a day |
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Term
What must be done to determine etiology of hepatitis before any treatment is initiated? |
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Definition
blood tests must be done before any treatment! |
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Term
Three forms of chronic hepatitis (cirrhosis/liver cancer)? |
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Definition
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Term
Two characteristics about the incubation period of viral hepatitis? Why can hepatitis transmission be hard to control? |
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Definition
can be prolonged
is highly variable
-patient is infectious before Signs and Symptoms occur |
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Term
what follows the prodrome phase of hepatitis? do prodromal symptoms continue? High levels of what produce dark urine and clay stool? |
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Definition
after prodrome phase, there is icteric phase. Yes, prodromal symptoms continue; bilirubin |
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Term
What happens during convalescent phase of hepatitis? |
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Definition
disappearnce of jaundice; fatigue may still persist |
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Term
Which two hepatitis viruses do vaccines exist for A person immune to HBV is also immune to? |
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Definition
Hep. B virus and Hep. A virus; HDV |
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Term
What is HBV also known as? Production of which antigen anitbody results in complete recovery from HBV infection and immunity from future infection? What is this called? |
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Definition
serum hepatitis; production of SURFACE antigen antibody causes "neutralizing immunity" |
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Term
Which antigen of HBV cannot be detected by clinical kits and does not result in neutralizing immunity? |
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Definition
Core antigen HBcAg (vs. HbsAg) |
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Term
Three types of antigen of HBV? |
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Definition
HBsAg (surface)
HBcAg (core)
HBeAg (soluble) |
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Term
Which antigen of HBV has the ability to infect others? |
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Definition
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Term
Transmission of HBV? Most important route of transmission? Two other routes of transmission? |
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Definition
SSS: serum, saliva, and semen; sexual contact esp. homosexuals. percutaneous (needle stick/IVDU) and perinatally |
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Term
Nearly all of which groups will develop chronic infection if they have Hep B? What will 15-25% of patients die from? |
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Definition
infants and young children; cirrhosis/carcinoma |
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Term
The "natural history" for chronic HBV infection can be divided into which four phases? |
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Definition
immune tolerance
immune clearance
inactive surface Ag carrier state
reactivation |
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Term
immune tolerance phase of chronic HBV occurs in patients infected when? persistently normal levels of what? |
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Definition
patients infected at birth or early childhood; ALT |
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Term
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Definition
PEG-interferon-@2a; antiviral drugs such as lamivudine, adefovir dipivoxil, entecavir |
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Term
Passive immunization for HBV occurs via which vaccine? Active immunization is recommended for who? where do you inject active vaccine in adults? |
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Definition
HBVIG; all children in the US (engerix; tiwnrix) deltoid muscle in adults |
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Term
What do you administer to infants born to infected mothers with HBV? |
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Definition
administer BOTH:
HBIG and HBV vaccine |
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Term
What does HDV need to replicate?; HDV causes greatest morbidity by how? |
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Definition
HBV!; increasing severity and accelerating pace of chronic HBV infection (cirrhosis/liver cancer) |
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Term
What is the most efficient mode of transmission for HDV? |
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Definition
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Term
If HDV is present, what MUST be present? |
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Definition
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Term
Presence of which antibodies to delta antigen helps diagnose HDV?; how to prevent HDV? |
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Definition
IgG; treat HBV via pre/post-exposure prophylaxis |
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Term
Whereas HCV and HDV are RNA viruses, what kind of genome does HBV have? |
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Definition
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Term
What is the single most common reason for liver transplants? |
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Definition
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Term
What accounts for the most of cases of chronic hepatits (70%) and many cases of ESLD in the US? |
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Definition
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Term
Which ages are affected in HCV? Where is peak incidence? |
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Definition
ALL ages are affected; peak incidence is 20-39 |
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Term
In HCV, the rapid accumulation of ______ in the _______ region of the envelope allows the virus to escape ______ ________ by the host. This leads to chronic infection |
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Definition
MUTATIONS; HYPERVARIABLE; IMMUNE SURVEILLANCE |
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Term
Three biggest risk factors of HCV? |
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Definition
IVDU
repeated transfusions
tattoos/piercings |
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Term
Chronic liver disease occurs at a high rate (70% of asymptomatic; 85-100% of symptomatic) for which type of hepatitis? |
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Definition
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Term
Appearance of what after 5-12 weeks after onset of hepatitis C will diagnose HCV? Presence of what and for how long differentiates acute vs. chronic HCV? |
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Definition
-appearance of anti-HCV Ab's
-presence of liver enzymes >6 months |
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Term
Treatment of HCV: (problematic) |
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Definition
PEG-interferon-@ and ribavirin.
Very expensive, exteremly difficult to tolerate |
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Term
What type of virus is HAV (RNA/DNA)? Which populations are at risk for HAV? Main transmission for HAV? |
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Definition
RNA virus; day-care center workers, closed populations, oyster-eaters; fecal/oral transmission with food and water as major vehicle (person-to-person may occur) |
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Term
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Definition
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Term
HIV binds to human cells via which two glycoproteins? |
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Definition
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Term
What is the agent for infectious mononucleosis?
What is the manifestation of IM in early childhood?
Who primarily manifests with IM in the industrialized world? |
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Definition
1. EBV aka HHV-4
2. SUBCLINICAL manifestation in early childhood
3. primary infection occurs in adolsecsents and adults |
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Term
If "Downey Cells" are found in blood, what is the likely virus? |
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Definition
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Term
Which agent is responsible for causing a seropositive marking in nearly 100% of all adults? |
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Definition
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Term
What do CID and SNHL stand for, and what disease are they associated with? |
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Definition
CID: cytomegalic inclusion disease
SNHL: bilaterla sensorineural hearing loss
CMV! |
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Term
What does a child with CMV at birth manifest with? |
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Definition
jaundice
blood clotting
petechial rash
pneumonia(resp. distress)
chorioretinitis of the eye
seizures (microencephaly)
lethargy
motor disability |
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Term
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Definition
Death is common in days to weeks later; survivors have significant sequelae |
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Term
Number one infection of infancy in the first 3 months? |
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Definition
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Term
Four manifestations of CMV in AIDS pt.? |
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Definition
pnemonia
retinitis
encephalitis
gastroenteritis |
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Term
If you have a "negative" on which test, should you expect CMV-IM? What shape of cells would you expect to find? |
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Definition
Negative heterophile-agglutination test; "owl-eye" cells |
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Term
Treatment of CMV? Treatment of CMV retinitis in AIDS patients? |
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Definition
Ganciclovir
Foscarnet
Cidofovir **acyclovir resistant
-Formivirsen |
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Term
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Definition
CMVIG (esp. for transplant pt.)
Vaccine: orphan drug = phosphoprotein 65; glycoprotein B |
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