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microbial pathogenesis I
ONU med micro r-anderson
50
Microbiology
Undergraduate 2
09/22/2011

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Cards

Term
steps of pathogenesis
Definition
entry, attachment, avoid host defenses or overcome host defenses, damage, exit
Term
transmission
Definition
movement of pathogen from its reservoir to an uninfected host
Term
reservoir
Definition
where a pathogen survives and multiples until it can enter a new host
Term
types of reservoirs
Definition
animals, humans, environment (soil and water)
Term
human reservoirs serve as ___ to microbes
Definition
nutrient source for survival and multiplication of pathogen
Term
asymptomatic
Definition
shows no signs of disease
Term
symptomatic
Definition
shows signs of disease
Term
examples of human only reservoirs
Definition
pertussis, measles, gonorrhea, cold, HIV
Term
reasons why human only microbes stay in humans
Definition
very sensitive to environmental changes or only attach to human tissues
Term
animal reservoirs
Definition
primary site of survival and multiplication is animals
Term
zoonoses
Definition
animal reservoirs
Term
examples of animal reservoir microbes
Definition
rabies, HPS, lyme
Term
HPS stands for ___
Definition
hantavirus pulmonary syndrome
Term
animal reservoirs can attach to ___ and ___
Definition
both human and animal tissues
Term
environmental reservoirs
Definition
soil and water
Term
soil reservoir examples
Definition
tetanus Clostridium tetani
diarrhea Bacillus cereus
Term
water reservoir examples
Definition
cholera Vibrio cholerae
typhoid fever Salmonella typhi
Term
characteristic of all environmental reservoir microbes
Definition
versatile pathogens that can survive and replicate under a variety of conditions
Term
factors influencing transmission
Definition
number of microbes, source of microbes, portal of entry, microbial genetic factors
Term
ID50
Definition
Infectious dose for 50% of people
Term
virulent
Definition
ability to cause disease
Term
Number of microbes as factor for transmission
Definition
infectious dose varies with microbe and host factor
Term
source of microbes as factor for transmission
Definition
microbes adapts to host making transmission from animal to human more difficult
Term
portal of entry as factor for transmission
Definition
determines cell receptors to which microbes may respond
Term
microbial genetic factors as factor of transmisison
Definition
some strains of microbes are more virulent than others
Term
portal of entry def.
Definition
opening/surface that have contact with environment
Term
types of modes of transmission
Definition
horizontal and vertical
Term
horizontal transmission
Definition
from reservoir (human, animal, environment) to host
Term
types of horizontal transmission
Definition
contact, common vehicle, vector
Term
types of contact transmission
Definition
direct, indirect, droplet
Term
types of common vehicle transmission
Definition
water-borne, food-borne, airborne
Term
types o vector transmission
Definition
mechanical and biological
Term
direct contact transmission
Definition
physical contact, fluid exchange or parenteral route
Term
parental route
Definition
breaks the integrity of the skin or mucous membrane
Term
indirect contact transmission
Definition
through fomites
Term
fomites
Definition
nonliving intermediate carries pathogen to new host
Term
droplet transmission
Definition
mucous droplets transmit pathogen
Term
distance traveled by droplet transmission
Definition
<1 meter
Term
contagiousness of droplet transmission
Definition
highly contagious
Term
water contaminated by
Definition
fecal material
Term
waterborne pathogen most common in...
Definition
undeveloped countries
Term
waterborne pathogens common where in developed countries?
Definition
toddles from failure to wash hands before food prep
Term
food borne transmission
Definition
pathogen contaminates uncooked or improperly cooked foods
Term
airborne transmission pathogen characteristics
Definition
pathogen resists drying and temperature changes, travels >1 meter, and most contagious
Term
mechanical transmission
Definition
something carries pathogen on/in body (flies and shellfish)
Term
biological transmission
Definition
pathogen lives/replicates in an arthropod
Term
types of vertical transmission
Definition
during development, during birth, after birth
Term
during development transmission
Definition
pathogen must cross maternal-placental barrier
Term
during birth transmission
Definition
child encounters pathogen while passing though vagina
Term
after birth transmission
Definition
child receives pathogen through breast milk
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