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Microbal Mechanisms of Pathogenicity
BYU MMBIO 221 Dr. Erickson
62
Microbiology
Undergraduate 1
10/30/2010

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Term
superantigens
Definition
provoke intense immune response. T cells produce too many cytokines. you hurt yourself. TSS, staph antigens.
Term
diptheria toxin
Definition
inhibits protein synthesis. A-B toxin. diptheriae only produces toxin when infected by phage.
Term
erythrogenic toxins
Definition
strep. pyogenes synthesizes 3 types of cytotoxins that are superantigens that damage the plasma membranes of blood caililaries. Scarlet fever caused by strep. pyogenes
Term
botulinum toxin
Definition
Clostridium botulinum. A-B toxin
Term
tetanus toxin
Definition
A-B toxin binds to nervous system controlling skeletal muscles causeing contractions
Term
Vibrio Enterotoxin
Definition
vibrio cholerae A-B binds to epithelial cells, causeing them to secrete large amounts of fluids and electrolytes. causes diarrhea and vomiting. E. Coli can produce a similar toxin
Term
Staphlococcal Enterotoxin
Definition
staph aureus produces a superantigen in the intestines.
Term
DIC
Definition
caused by endotoxins. causes blood clots.
Term
study chart pg. 438
Definition
Term
lacrimal apparatus
Definition
system that protects the eyes by flushing them
Term
sebum
Definition
prevents hair from drying, protective layer over the skin
Term
leukocytes
Definition
white blood cells
Term
granulocytes
Definition
type of white blood cells that have large granules. Neutrophils, basophils, eosinphils.
Term
neutrophil
Definition
stain in neutral dye, active in initial stage of infection. they can leave teh blood, enter an infected tissue, and destroy microbes.
Term
basophils
Definition
stain in basic dye. release histamine for inflammation in allergic responses.
Term
Eosinophils
Definition
stain with acidic dye called eosin. produces toxic proteins that fight parasites such as helminths. they can also leave the blood.
Term
agranulocytes
Definition
have granules, but you can't see them. 3 types: monocytes, dendritic cells, lymphocytes
Term
monocytes
Definition
not actively phagocytic until they leave the blood and mature into macrophages
Term
dendritic cells
Definition
found on skin, mucous membranes, thymus, lymph nodes. phagocytosis and initiating adaptive immune response (communicates with T and B cells)
Term
Lymphocytes
Definition
include natural killer cells, T cells, and B cells.
Term
natural killer (NK) cells
Definition
hunt and kill infected cells using toxic stuff stored in granules. example of toxic stuff: perforin creates channel in membrane causeing cytolysis, granymes cause cells to self destruct
Term
leukocytosis
Definition
increase of white blood cells in response to infection
Term
differential white blood cell count
Definition
percentage of kinds of white blood cells
Term
platelets
Definition
blood clotting
Term
fixed macrophages/ histiocytes
Definition
resident in certain tissues and organs of the body. all have different names. the other kind of macrophages wander.
Term
mononuclear phogocytic system
Definition
all the macrophages of the body
Term
chemotaxis
Definition
attraction of phagocytes to mircobes
Term
opsonization
Definition
coating process that promotes phagocytosis
Term
phagolysosome
Definition
fusion of phagosome (membrane formed around microbe when it is brought into the macrophage) with a lysosome
Term
lysosome
Definition
hydrolyzes peptidoglycan
Term
inflammation
Definition
redness, pain, heat, swelling, sometimes loss of function. acute (shoret but severe) or chronic (long but not as bad)
Term
vasodilation
Definition
dilation of blood vessels, increasing blood flow to damaged areas and is resonsible for redness and heat associated with inflammation
Term
edema
Definition
accumulation of fluid
Term
chemicals released by damaged cells in response to injury
Definition
histamine, kinins, prostaglandins, leukotrienes
Term
Complement system
Definition
destroys microbes by 1: cytolysis 2:inflammation 3:phagocytosis
Term
opsonization
Definition
coating microbe to enhance phagocytosis. makes it easier for phagocyte to bind to a microbe.
Term
MAC membrane attack complex
Definition
C5b- C9 in the complement system. causes cytolysis
Term
C3 convertase
Definition
Term
C3
Definition
C3a:binds to mast cells with C5a and cause them to relase histamine and other chemicals that increase blood vessel permeability during inflammation. this happens because they release histine.
C3b: binds to microbe, causing opsonization
Term
classical pathway
Definition
antibodies attach to antigens. C1 binds to antibodies, starts cascade.
Term
alternative pathway
Definition
B,D,P factors are surface proteins that bind to C3.
Term
Lectin pathway
Definition
lectin binds to mannoose, working as an opsonin and activating C2 and C4, which cascades to C3.
Term
interferons
Definition
type of cytokine. interfere with viral replication. alpha and beta (causes uninfected cells to synthesize AVPs), gamma (causes macrophages to produce nitric oxide that appears to kill bacteria).
Term
AVPs (antiviral proteins)
Definition
disrupt viral multiplication
Term
iron-binding proteins
Definition
Lactoferrin, transferrin, ferritin, hemoglobin
Term
AMPs (antimicrobial peptides)
Definition
attract dendritic cells, kill microbes, recruit mast cells. broad spectrum of activity.
Term
perforin/ granzyme
Definition
pore-forming protein that lets granzyme into the cell. granzyme then apoptosizes (chops up the DNA) of the cell.
Term
T Cytotoxic cells (CD8+ T cells)
Definition
matures into CTL (cyutotoxic T lymphocyte) that destroys cells on contact using perforin and granzymes.
Term
T Regulatory cells
Definition
stop T cells from reacting against self. maintains tolerance.
Term
T helper cells
Definition
activated when come into contact with APC. produce cytokines and activates all cells related to cell-mediated immunity: mactophages, T cytotoxic cells, and NKs.
Term
Dendritic cells
Definition
primary APCs to induce immune responses by T cells.
Term
Macrophages
Definition
cell eaters. activated by ingesting antigenic material or by cytokines made by helper T cells. activated macrophages are better phagocytes adn APCs. notable: eat cancer cells.
Term
Natural Killer Cells (NKs)
Definition
don't have to be activated by antigen. kill cells that don't display MHC class I slef-antigens
Term
cytokines
Definition
chemical messengers. soluble proteins or glycoproteins produced by immune cells in response to a stimulus. communicate between white blood cells.
Term
chemokines
Definition
cytokines that bring leukocytes into area of infection important for inflammation
Term
tumor necrosis factor
Definition
TNF- alpha. targets tumor cells. factor in inflammatory responses
Term
cytokine storm
Definition
harmful overproduction of cytokines caused by a feedback loop.
Term
Humoral immunity
Definition
B cells. targets free circulating patogens using antibodies
Term
cellular immunity
Definition
t cells- targets infected cells, or intracellular pathogens. mostly uses specialized phagocytic or NK cells
Term
B cells
Definition
lymphocytes that mature in bone marrow. involved in humoral immunity. produces Antibodies. mature into plasma cells that make antibodies or memory cells.
Term
T cells
Definition
lymphocytes that mature in the thymus. involved in cellular immunity.
Term
antibodies
Definition
stem (Fc region)and V region on tips of the Y. V region binds to epitope, Fc region binds to host cell or complement.
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