Term
| antimicrobials that block cell wall synthesis by inhibitions of peptidoglycan cross-linking |
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Definition
penicillin
methicillin
ampicilin
piperacillin
cephalosporins
aztreonam
imipenen |
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Term
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Definition
bind penicillin-binding proteins
block transpeptidase x-linking of peptidoglycan
activate autolytic enzymes
gram+ organisms and syphili |
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Term
penicillin
tox and resistance |
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Definition
hypersensitivity rxns, hemolytic anemia
resistance from beta-lactamases cleaving beta-lactam ring |
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Term
| beta-lactamase inhibitors |
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Definition
added to penicillin antibiotics to protect the antibiotic from destruction by beta-lactamase/penicillinase
clavulanic acid
sulbactam
tazobactam |
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Term
|
Definition
beta-lactam drugs that inhibit cell wall synthesis but are less susceptible to penicillinases
bactericidal |
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Term
cephalosporins
uses - by generation |
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Definition
1st gen: gram + cocci
2nd gen: gram + cocci
3rd gen: serious gram (-)
ceftriaxone
4th gen: increased activity against pseudomonas and gram +
cefepime |
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Term
|
Definition
hypersensitivity rxns
vitamin K deficiency
increases nephrotoxicity of aminoglycosides
disulfram-like rxn with ethanol |
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