Term
|
Definition
1. Blocks Penicillin binding proteins
2. Blocks cross linking (transpeptidation)
3. Activates autolytic enzymes |
|
|
Term
| 4 Penicillinase Resistant drugs and compare to penicillin |
|
Definition
Dicloxacillin
Nafcillin
Methicillin
Oxacillin
Narrow spectrum/Bulkier R group |
|
|
Term
| 2 Aminopenicillins and compare to penicillin |
|
Definition
Ampicillin (IV) and Amoxicillin (oral)
Wider spectrum |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| 4 Antipseudomonal Penicillins |
|
Definition
Pipercillin
Azlocillin
Carbenicillin
Ticarcillin |
|
|
Term
Ticarcillin give with
Pipercillin given with |
|
Definition
Claculanic acid
Tazobactum |
|
|
Term
| What are the antiseudomonals used in combonation with |
|
Definition
|
|
Term
| Spectrum of Aminopenicillins |
|
Definition
HELPSS
H. flu
E. coli
Listeria
Proteus
Salmonella
Shigella |
|
|
Term
Spectrum changes between generations of cephalosporons
Name bacteria uses for 1st and 2nd gens |
|
Definition
1st generation better against G positive
Later generations better against G negative
1. PEcK
Proteus
E. coli
Klebsiella
2. HENS PEcK
H. flu
Enterobactor
Neisseria
Serratia |
|
|
Term
| name 2 1st generation cephalosporins |
|
Definition
PHatZO
cePHalexin
cefaZolin |
|
|
Term
| name 3 2nd generation cephalosporins |
|
Definition
FACKing FOX is FURry
ceFAClor
ceFOXitin
ceFURoxime |
|
|
Term
| name some 3rd generation cephalosporins |
|
Definition
anything with a "T"
ceftriaxone
cefotaxime
ceftazidine
cefdiner
cefixime |
|
|
Term
| 4th gen cephalosporin and use |
|
Definition
|
|
Term
| What Don't 3rd gen cephalosporins treat |
|
Definition
1. Listeria
2. Atypicals: chlamydia/mycoplasma
3. Methicillin Resistant
4. Enterrococcus
Special:
Neisseria- ceftriaxone
Pseudomonas-ceftazidime |
|
|
Term
| MOA of Monobactums and what are they synergistic with |
|
Definition
Binds PBP3 inhibiting cell wall synthesis
synergistic with aminoglycosides |
|
|
Term
|
Definition
| Cilistatin to reduce renal breakdown |
|
|
Term
|
Definition
| In the hospital in severe cases. spectrum covers almost all bacteria except MRSA and Mycoplasma |
|
|
Term
|
Definition
| Inhibits cell wall mucopeptide formation by binding D-ala D-ala |
|
|
Term
|
Definition
MRSA
enterococci
clostridium difficile |
|
|
Term
|
Definition
Bacteriocidal of the 30S
1. misreading of the mRNA
2. inhibiting initiation complex |
|
|
Term
|
Definition
Gentomycin
Neomycin
Amikarin
Tobramycin
Sterptomycin |
|
|
Term
| Aminoglycosides are ineffective against |
|
Definition
| Anearobes because they use an oxygen uptake transporter |
|
|
Term
Uses:
Neomycin
Tobramycin
Streptomycin |
|
Definition
Neomycin-skin
Tobramycin-Pseudomonas
Streptomycin- TB (2 line), Plague, Tuleremia |
|
|
Term
|
Definition
Bacteriostatic of 30s
1. prevents attachment of aminoacyl-tRNA
2. chelates cations |
|
|
Term
USES of Tetracyclines
1. Doxycycline
2. Minocycline
3. Demeclocycline
Name any other uses |
|
Definition
1. Doxy: prostatitis
2. Mino: Meningococceal
3. Deme: SIADH
Lyme disease
H. pylori
M. pneumonia
Rickettsia
Chlamydia
B. henselae |
|
|
Term
|
Definition
Bacteriostatic
1. Blocks translocation @ the 50s subunit |
|
|
Term
|
Definition
Atypical Pneumonias
1. Legionella
2. M. avium
3. Chlamydia
B. henselea |
|
|
Term
|
Definition
Bacteriostatic:
Inhibits peptidyltransferase of ATP->AMP |
|
|
Term
|
Definition
Meningitis, G+, G-, anearobes
Pregnancy with RMSF |
|
|
Term
|
Definition
clindamycin and Lincomycin
Bacteriostatic:
1. Blocks Translocation of 50s subunit |
|
|
Term
|
Definition
| Anaerobes: B. fragilis and C. perfringens |
|
|
Term
|
Definition
| inhibit PABA dihydropteroate synthetase |
|
|
Term
|
Definition
| inhibits dihydrofolate reductase |
|
|
Term
| Why do you give Azythromycin in HIV |
|
Definition
|
|
Term
|
Definition
Nocardia asteroides
Sulfasalazine->UC and RA
Sulfadiazine-> Burns and T. gondi |
|
|
Term
|
Definition
| Bacteriocidal inhibits DNA gyrase 2 and Topoisomerase 4 |
|
|
Term
|
Definition
Gonorrhea
Chlamydia
UTI
Diarrhea |
|
|
Term
| Drug used in surgery prophylaxis |
|
Definition
|
|
Term
| Gram negative rod infection with Penicillin allergy |
|
Definition
|
|
Term
| Used to wipe out gut flora with liver failure |
|
Definition
|
|
Term
| What two drugs have very similar spectrums |
|
Definition
|
|
Term
| Dind divalent cations and decrease absorption |
|
Definition
|
|
Term
| Only macrolid that is good for pregnancy and does not inhibit P450 |
|
Definition
|
|
Term
| Which Antibiotics are lipid soluble |
|
Definition
Nafcillin
Cefoperazone, Ceftriaxone
Doxycycline
Chloramphenicol |
|
|
Term
| Resistance in Penicillins - 3 ways |
|
Definition
1. Beta lactamases which cleave the beta lactam ring
2. change PBP (MRSA)
3. change in porins (gram -) |
|
|
Term
| Resistance to Aminoglycosides |
|
Definition
| Enzymes that inactivate the drugs via conjugation rxn that transfers acetyl, phophoryl, or adenylyl groups |
|
|
Term
| Resistance to Macrolids and Clindamycin |
|
Definition
| Formation of methyl transferases that inhibit drug binding sites on the 50s subunit |
|
|
Term
| Resistance to tetracyclines and -azoles |
|
Definition
| Drug being pumped out of cell |
|
|
Term
| 2 antibiotics which cause phototoxicity |
|
Definition
| Sulfonamides and tetracyclines |
|
|
Term
|
Definition
| Hypersensitivity reaction |
|
|
Term
|
Definition
| Inhibits formation of initiation complex of 50s |
|
|
Term
|
Definition
| Binds to 50s ribosomes subunit prevents the interaction w/ acceptor site and stimulates its dissociation |
|
|
Term
| Causes Intersitital Nephritis |
|
Definition
|
|
Term
| What is a Jarish-Herxheimer Rxn |
|
Definition
| When penicillin is given in syphilis, all syphilis toxins released at the same time |
|
|
Term
|
Definition
Cefoteton, cefopearazone (3rd gens)
Metrondiazole |
|
|
Term
|
Definition
Nephrotoxic
Ototoxic
Tetratogenic |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Gray baby and bone marrow suppression |
|
Definition
|
|
Term
|
Definition
Macrolids
Flouroquinolones |
|
|
Term
| Stimulates motolin and causes acute jaundice (cholestatic) |
|
Definition
|
|
Term
| Causes pseudomonas colitis |
|
Definition
Clindamycin
Ampicillin
3rd gen cephalosporins |
|
|
Term
|
Definition
|
|
Term
| Name the SE of Sulfonamides (5) |
|
Definition
1. Crystaluria
2. Kernicterus
3. Phototoxic
4. Steven Johnson
5. G6PD |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Free radicle metabolites in the bacterial cell damaging DNA |
|
|
Term
|
Definition
Giardia
Entamoeba
Trichomonas
Gardnerella vaginalis
C. Difficile (colitis)
H. pylori |
|
|
Term
|
Definition
| Decrease synthesis of Mycolic acids and needs bacteria catalase |
|
|
Term
| Only drug that can be used solo for M. tuberculosis |
|
Definition
|
|
Term
|
Definition
Neurotoxic
Hepatotoxic->hepatitis
Lupus like
Sideroblastic anemia |
|
|
Term
|
Definition
| inhibit DNA dependent RNA polymerase |
|
|
Term
| Causes Red fluids and is hepatotoxic |
|
Definition
|
|
Term
| Causes Optic neuropathy->loss of red/green color |
|
Definition
|
|
Term
|
Definition
| Activated by bacteria pyrazinamidase and decreases mycolic acid. Used for TB engulfed by macrophages |
|
|
Term
|
Definition
| decrease carbohydrate polymerization of mycobacterium cell wall. Blocks arabinosyltransferase |
|
|
Term
| increase porphyrin synthesis and not CI in pregnancy |
|
Definition
|
|
Term
| Depolarization of cell membrane |
|
Definition
|
|
Term
| What drug for Leprosy colors tissue red |
|
Definition
|
|
Term
|
Definition
1. Rifampin
2. Dapsone
3. Clofazimine |
|
|
Term
Drugs used for Staph aureus
1st line
2nd line
resistant |
|
Definition
1st: Nafcillin/Oxacillin
2: Quinopristine/Dalfopristine
Resistance: Vancomycin |
|
|
Term
|
Definition
1st line Ampicillin/aminoglycoside
Allergy: Macrolide |
|
|
Term
|
Definition
Meningitis: 3rd gen cephalosporin
pneumonia: macrolide |
|
|
Term
|
Definition
| 1. Penicillin/aminoglycoside |
|
|
Term
|
Definition
1. Vancomycin
2. Daptomycin |
|
|
Term
|
Definition
| 1.Ciproflaxacin/Doxycycline |
|
|
Term
|
Definition
| 1. Metronidazole/Penicillin/Diazepam (antispasmic) |
|
|
Term
|
Definition
| 1. Metronidazole/Vancomycin |
|
|
Term
|
Definition
|
|
Term
|
Definition
Erythromycin
Aminoglycoside for endocarditis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Drugs: Francisella Tularemia |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Flouroquinolone/azithromycin |
|
|
Term
| Drugs: Bordetella pertusis |
|
Definition
| Macrolids @ cararrhal stage |
|
|
Term
|
Definition
|
|
Term
|
Definition
3rd gen ceph
Aminoglycosies |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
