Term
| Pseudomonas Gen. Features |
|
Definition
Like water.
Semi-obligate aerobes >grow w/o O2 if N present to accept e-.
Opportunistic |
|
|
Term
|
Definition
| Pyocyanin, fluorescin. Grape smell. |
|
|
Term
| Pseudomonas Virulance Factors I |
|
Definition
1. Pili . Adherence to resp. epithelium
2. Poly-sacch. capsule, anti-phagocytotic. Helps attach to trach of CF pts.
3. Exotoxin A: in most clinical isolates. blocks protein synthesis like diptheria |
|
|
Term
| Pseudomonas Virulence Factors II |
|
Definition
4. Exoenzyme S >Ribosylates Ras > cytoskeleton collapse
5. Cytotoxin: Bacterial complement
6. Extracellular proteases, elastase and alkaline protease. > Spread infection/degrade c'.
7. Phospholipase: breakes down cell membranes.
8. Endotoxin >Fever, shock, etc. |
|
|
Term
| Vibrionaceae Gen. Features |
|
Definition
| 1 flagellum. Facultative, oxidase positive, alkalinophilic |
|
|
Term
|
Definition
2 biggest:
cholerae
parahaemolyticus.
Other sp. cause wound infections. |
|
|
Term
|
Definition
| weakly virulent. Prevalent around Ganges, approx 10 cases/yr in US d/t undercooked shellfish. |
|
|
Term
|
Definition
"Rice water" diarrhea (flecks of mucus). No blood or shed cells.
Non-invasive, stays in GI lumen
A-subunit of enterotoxin adp-ribosylates GProtein > increased cAMP, >>>ion xport and water secretion |
|
|
Term
|
Definition
| Massive fluid and electrolyte loss= Hypovolemic shock or metabolic acidosis. |
|
|
Term
|
Definition
Halophilic>live in estuaries. Catch from undercooked oysters/sashimi. 5-92 hr. incubation.
EXPLOSIVE, watery diarrhea.
Kanawaga hemolysin. |
|
|
Term
|
Definition
Highly virulent. Wound infections s/p exposure to contaminated Seawater. OR: septicemia s/p raw oysters.
50% mortality if ABX delayed.
Liver dz predisposes to sepsis |
|
|
Term
| Campylobacter Gen Features |
|
Definition
Gram Neg
Very Motile
Comma shaped
Likes reduced O2.
Major cause of diarrhea. Causes more GI dz than Salmonella and Shigella combined. |
|
|
Term
| Campylobacter Dz features |
|
Definition
Dogs, cats, and food animals have a lot of it.
Get from contaminated meat, milk, water.
Bloody, muco-purulent diarrhea (SI and colon), fever, and abd cramps. a week long. |
|
|
Term
|
Definition
| bacteremia in compromised hosts |
|
|
Term
| Helicobacter pylori Gen features |
|
Definition
Ulcers of stomach and duodenum.
Gram negative, very motile, oxidase positive. Curved (who cares?)
Urease (helps manage low pH)
Non-invasive.
Exotoxin (vacuolating).
Type IV injection of proteins into host cells= increased IL8 (Increased inflammation) >damage |
|
|
Term
|
Definition
| Multi-Abx tx:mixed efficacy. |
|
|
