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Definition
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Definition
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Definition
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Definition
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Definition
Lyme disease Borrelia burgdorferi |
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Term
Downey cell (atypical lymphocyte) |
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Definition
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Definition
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Definition
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Definition
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Definition
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Definition
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Term
Rash on hands/feet spreads to trunk |
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Definition
Rocky Mountain spotted fever (Rickettsia rickettsii) |
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Term
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Definition
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Term
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Definition
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Safety-pin (bipolar) staining |
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Definition
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Term
Sausage-shaped gametocyte |
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Definition
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Term
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Definition
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Term
Rash on trunk that goes outwards |
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Definition
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Definition
Relapsing fever: Borrelia recurrentis |
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Definition
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Definition
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Definition
Leishmania Bartonella bacilliformis |
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Term
Broad-based budding yeast |
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Definition
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Term
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Definition
Corynebacterium diphtheriae |
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Term
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Definition
Haemophilus influenza type B |
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Definition
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Definition
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Term
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Definition
Old name for Tuberculosis |
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Term
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Definition
Mycobacterium tuberculosis |
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Term
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Definition
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Term
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Definition
Pneumocystis jiroveci (PCP) |
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Term
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Definition
Herpes virus causing pharyngitis, Epstein-Barr virus: heterophile positive; Cytomegalovirus: heterophile negative |
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Term
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Definition
Allergic aspergillosis/hypersensitivity pneumonitis, Thermophilic Actinoyces spp.; Acute damage by cytokines, type III HSR, may be type IV also |
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Term
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Definition
Aspergillosis (aspergilloma) |
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Term
Grape-like smell in culture |
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Definition
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Term
Green sputum in cystic fibrosis patient |
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Definition
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Term
Grows on chocolate agar, not on blood agar |
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Definition
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Term
Heterophile antibody-positive |
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Definition
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Term
Kidney bean-shaped diplococci |
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Definition
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Term
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Definition
Measles – paramyxovirus, negative sense, ssRNA, enveloped helical |
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Term
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Definition
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Term
Many PMNs in sputum, no organisms seen |
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Definition
Atypical pneumonia: M. pneumonia, |
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Term
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Definition
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Term
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Definition
Acinetobater, Bordatella, Burkholderia, Legionella, Moraxella, Pseudomonas |
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Term
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Definition
CMV: heterophile negative |
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Term
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Definition
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Term
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Definition
Paracoccidioides brasiliensis |
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Term
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Definition
Francisella tularensis, buffered charcoal yeast agar, cysteine glucose blood agar |
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Term
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Definition
Streptococcus pneumonia, Paragonimus westermani (lung fluke) – sputum will also have parasitic eggs |
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Term
Anaplasma phagocytophilum |
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Definition
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Term
|
Definition
Black legged tick (Ixodes tick) |
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Term
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Definition
•Vector: tick: Ixodes scapularis |
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Term
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Definition
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Definition
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Definition
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Definition
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Definition
•Vector: human body louse and fleas |
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Term
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Definition
•Vector: Rocky mounted wood tick (D. andersoni) |
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Term
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Definition
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Term
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Definition
Vector: reduviid (triatomine) bugs, aka kissing-bug |
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Term
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Definition
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Term
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Definition
•Vector Aedis aegypti mosquito |
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Term
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Definition
Flea transmit it to prairie dogs and rodents |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
Crimean-Congo hemorrhagic fever |
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Definition
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Term
|
Definition
Vector: black legged deer tick |
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Term
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Definition
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Term
Japanese encephalitis virus |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
St. Louis encephalitis virus |
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Definition
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Term
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Definition
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Term
|
Definition
•Vector: body louse (humans in over crowded situations) |
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Term
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Definition
Cryptosporidiosis (C. parvum), Cyclospora cayetanensis (NOT common) |
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Term
Elliptical Acid fast oocyst |
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Definition
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Term
Barrel shaped (football shaped) eggs with plugged ends |
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Definition
Whipworm: Trichuris trichiura |
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Term
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Definition
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Term
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Definition
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Term
Chronic diarrhea in AIDS patient |
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Definition
Cryptosporidiosis (C. parvum) |
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Term
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Definition
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Term
Colorless colonies on SMAC agar |
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Definition
Enterohemorrhagic E. coli (EHEC) |
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Term
|
Definition
S. typhi,, Clostridium botulinum |
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Term
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Definition
Pork Tapeworm: Taenia solium |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
Listeria monocytogenes, Yersinia enterocolitica |
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Term
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Definition
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Term
|
Definition
Enterohemorrhagic E. coli (EHEC), Shigella |
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Term
|
Definition
Echinococcus granulosus, E. multilocularis |
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Term
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Definition
Tropheryma whippelii, Giardia lamblia, Isospora belli, Giant Intestinal Fluke: Fasciolopsis buski |
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Term
|
Definition
Enterohemorrhagic E. coli (EHEC) |
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Term
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Definition
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Term
|
Definition
Fish Tapeworm: Diphyllobothrium latum |
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Term
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Definition
Enteroinvasive E. coli (ETEC) |
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Term
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Definition
Cestodes: Tapeworms, Trematodes: Fluke |
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Term
Oval-shaped eggs with lateral spine |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
Whipworm: Trichuris trichiura |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
|
Definition
Pinworm: Enterobius vermicularis |
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Term
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Definition
Anisakiasis: Anisakis simplex |
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Term
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Definition
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Term
Reptiles: turtles (snakes, lizards) |
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Definition
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Term
Gas gangrene. Bronze colored blisters |
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Definition
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Term
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Definition
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Term
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Definition
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Term
knobby-coated, oval-shaped, bile-stained Eggs |
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Definition
Roundworm: Ascaris lumbricoides |
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Term
Broad-based budding yeast |
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Definition
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|
Term
|
Definition
Group B strep or listeria |
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Term
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Definition
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Term
|
Definition
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Term
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Definition
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Term
Grows on chocolate agar, not on blood agar |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
Kidney-bean shaped diplococci |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
Sausage-shaped gametocyte |
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Definition
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|
Term
|
Definition
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Term
Temporal lobe encephalitis |
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
Weakly acid fast branching rods |
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
Staphylococcus saprophyticus |
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Term
|
Definition
Deposits of IgG along GBM |
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Term
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Definition
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|
Term
|
Definition
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|
Term
Uncomplicated hematuria in young boy |
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
Secondary syphilis (treponema pallidum) |
|
|
Term
|
Definition
Secondary syphilis (treponema pallidum) |
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Term
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Definition
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|
Term
Dew drops on a rose petal |
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Definition
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|
Term
|
Definition
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|
Term
Frothy, yellowish-green discharge |
|
Definition
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|
Term
|
Definition
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|
Term
Hutchinson teeth (notched incisors) |
|
Definition
Congenital syphilis (treponema pallidum) |
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Term
Growth on chocolate, not on blood |
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Definition
|
|
Term
Kidney-bean shaped diplococci |
|
Definition
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|
Term
|
Definition
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|
Term
Many PMNs, no organisms on Gram stain |
|
Definition
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|
Term
|
Definition
Congenital syphilis (treponema pallidum) |
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Term
|
Definition
Congenital syphilis (treponema pallidum) |
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Term
|
Definition
Congenital syphilis (treponema pallidum) |
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Term
|
Definition
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|
Term
|
Definition
Congenital syphilis (treponema pallidum) |
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Term
|
Definition
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|
Term
Thin, gray adherent discharge |
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Definition
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|
Term
|
Definition
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|
Term
|
Definition
Bacterial vaginosis or trichomoniasis |
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|
Term
Adenovirus, type of vaccine |
|
Definition
|
|
Term
Bacillus anthracis, type of vaccine |
|
Definition
|
|
Term
Bordetella pertussis, type of vaccine |
|
Definition
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|
Term
Clostridium tetani, type of vaccine |
|
Definition
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|
Term
Corynebacterium diphtheriae, type of vaccine |
|
Definition
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|
Term
Haemophilus influenzae, type of vaccine |
|
Definition
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|
Term
Hepatitis A virus, type of vaccine |
|
Definition
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|
Term
Hepatitis B virus, type of vaccine |
|
Definition
|
|
Term
Human Papilloma virus, type of vaccine |
|
Definition
|
|
Term
Influenza virus, type of vaccine |
|
Definition
|
|
Term
Measles virus, type of vaccine |
|
Definition
|
|
Term
Mumps virus, type of vaccine |
|
Definition
|
|
Term
Mycobacterium tuberculosis, type of vaccine |
|
Definition
|
|
Term
Neisseria meningitidis, type of vaccine |
|
Definition
Conjugated and polysaccharide but mostly conjugated |
|
|
Term
Poliovirus, type of vaccine |
|
Definition
Sabin – live, attenuated, Salk – killed |
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|
Term
Rabies virus, type of vaccine |
|
Definition
|
|
Term
Rotavirus, type of vaccine |
|
Definition
|
|
Term
Rubella virus, type of vaccine |
|
Definition
|
|
Term
Smallpox, type of vaccine |
|
Definition
|
|
Term
Streptococcus pneumoniae, type of vaccine |
|
Definition
Polysaccharide vaccine with no conjugated protein (capsule) |
|
|
Term
Varicella Zoster virus, type of vaccine |
|
Definition
|
|
Term
Yellow fever virus, type of vaccine |
|
Definition
|
|
Term
Japanese encephalitis virus, type of vaccine |
|
Definition
|
|
Term
Rickettsia prowazekii, type of vaccine |
|
Definition
|
|
Term
Salmonella typhi, type of vaccine |
|
Definition
|
|
Term
Tick-borne encephalitis virus, type of vaccine |
|
Definition
|
|
Term
Vibrio cholera, type of vaccine |
|
Definition
Killed, inactivated whole cell |
|
|
Term
Yersinia pestis, type of vaccine |
|
Definition
|
|
Term
|
Definition
|
|
Term
Bipolar staining Gram-negative rod |
|
Definition
|
|
Term
Broad-based budding yeast |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Step Pyogenes or Staph Aureus |
|
|
Term
|
Definition
Staph Aureus or Step Pyogenes |
|
|
Term
|
Definition
|
|
Term
|
Definition
Measles = Paramyxovirus Infection |
|
|
Term
|
Definition
|
|
Term
Papular/pustular rash with different stages |
|
Definition
|
|
Term
Pustular rash all in same stage |
|
Definition
Smallpox – variola major and minor |
|
|
Term
Rash on hands/feet spreads to trunk |
|
Definition
|
|
Term
Rash starts behind ears, spreads down body |
|
Definition
German Measles = Toga virus |
|
|
Term
|
Definition
Chagas…this is the Chigoma on the face |
|
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Term
|
Definition
|
|
Term
|
Definition
Scarlet Fever = Strep Progenes |
|
|
Term
|
Definition
|
|
Term
|
Definition
Pityriasis versicolor, Malassezia furfur = asexual form |
|
|
Term
|
Definition
|
|
Term
|
Definition
Bacillus Antracis = Anthrax |
|
|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
Gastric MALT B-cell lymphomas |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
Hemolytic uremic syndrome |
|
Definition
|
|
Term
|
Definition
Strongyloides stercoralis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
Primary hepatocellular carcinoma |
|
Definition
|
|
Term
|
Definition
Chlamydia, C. jejuni, salmonella, shigella, yersinia |
|
|
Term
|
Definition
|
|
Term
Waterhouse-Friedrichsen syndrome |
|
Definition
|
|
Term
|
Definition
|
|
Term
X-linked lymphoproliferative disease |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Strep. Pneumo, strep viridans |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
Blood agar: CAMP positive |
|
Definition
Group B strep or listeria |
|
|
Term
|
Definition
|
|
Term
Buffered charcoal yeast extract agar |
|
Definition
|
|
Term
|
Definition
Haemophilus and Neisseria |
|
|
Term
|
Definition
|
|
Term
|
Definition
Gram – bacteria that ferment lactose |
|
|
Term
|
Definition
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|
Term
|
Definition
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
Thiosulfate citrate bile salts sucrose agar |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
Eosin Methylene Blue (EMB) agar |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Determines level of O2 requirement |
|
|
Term
Triple Sugar Iron (TSI) agar |
|
Definition
Differentiate enterics based on reducing sulfur and fermenting carbohydrates |
|
|
Term
Xylose-Lysine-Deoxycholate (XLD) agar |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
T cell, B cell, Expressed in: Acute lymphoblastic leukemia, cutaneous T cell lymphoma, Expressed on CLL |
|
|
Term
|
Definition
CTL, Uses: Quantify cytotoxic T cells (Tc), Def in: Familial CD8 deficiency; |
|
|
Term
|
Definition
|
|
Term
|
Definition
Pre B cells, mature B cells, follicular DC, Signal transducer on B cells. Expressed on CLL |
|
|
Term
|
Definition
Pre B Cells, Mature B cells, Chain of the CR2 co-receptor. Expressed on CLL |
|
|
Term
|
Definition
B cell (EBV receptor) ; , Follicular DC, Receptor for complement component C3d; part of Bcell coreceptor w/ CD19 |
|
|
Term
|
Definition
T cells; Co-receptor on T cells that binds B7 |
|
|
Term
|
Definition
|
|
Term
|
Definition
T cells. Def in Hyper IgM syndrome |
|
|
Term
|
Definition
|
|
Term
|
Definition
Platelets (glycoprotein IIIa) |
|
|
Term
|
Definition
Cell distribution: B cells, monocytes. Function: Regulates T cell activation. Clinical use/notes: Ligand for CD 28 and CD152 |
|
|
Term
|
Definition
Subset of B cells. Function: Regulates T cell activation. Clinical use/notes: Ligand for CD28 and CD152 |
|
|
Term
|
Definition
B cells, macrophages, dendritic cells. Function: Promotes isotype switching. Clinical use/notes: Binds CD 154; co-receptor on B cells |
|
|
Term
|
Definition
NK cells, macrophages, PMN, Function: FcγR; phagocytosis; ADCC, Uses: Quantify NK cells |
|
|
Term
|
Definition
T helper cells, Function: Co-receptor for MHC II, Uses: Quantify Th cells, receptor for HIV |
|
|
Term
Virulence factor and MOA for: Acute glomerulonephritis (GABHS- M12 strains) |
|
Definition
Virulence factor: M protein, MOA: Disruption of complement binding to immune complex (disrupts c3b)à decreases removal of complex |
|
|
Term
Virulence factor and MOA for: Botulism |
|
Definition
Botulinum toxins: Affect peripheral cholinergic synapses by blocking the NMJ and inhibiting the release of NT (AcH) àprevents contraction/flaccid paralysis |
|
|
Term
Virulence factor and MOA for: Cholera |
|
Definition
Cholera toxin (heat labile): Permanently activates Gs --> increases cAMP |
|
|
Term
Virulence factor and MOA for: Diphtheria |
|
Definition
Diphtheria toxin (heat labile): Inactivates EFàInhibits eukaryotic protein synthesis |
|
|
Term
Virulence factor and MOA for: Escherichia coli meningitis |
|
Definition
K1 (capsular) antigen; Antiphagocytic |
|
|
Term
Virulence factor and MOA for: Escherichia coli UTI |
|
Definition
Pili: Adherence to urethral mucosa |
|
|
Term
Virulence factor and MOA for: Gas gangrene |
|
Definition
Alpha-toxin (lecithinase ): Breaks down lipids in cell membranes --> cell death |
|
|
Term
Virulence factor and MOA for: Gonorrhea |
|
Definition
Pili (antigenic): Enhance attachment to host epithelium and mucosal surfaces. Antigen shuffling allow variation of pili over time |
|
|
Term
Virulence factor and MOA for: Gram-negative septic shock |
|
Definition
LPS; Increased immune response --> cytokine storm |
|
|
Term
Virulence factor and MOA for: Klebsiella pneumoniae |
|
Definition
|
|
Term
Virulence factor and MOA for: Pneumococcal pneumonia/meningitis |
|
Definition
|
|
Term
Virulence factor and MOA for: Peptic ulcers (H. Pylori) |
|
Definition
Urease: Cleaves urea à Produces ammonia ions (NH3) that neutralize stomach acid in the vicinity of the organism. MOA: Cleaves urea à Produces ammonia ions (NH3) that neutralize stomach acid in the vicinity of the organism |
|
|
Term
Virulence factor and MOA for: Pseudomonal pneumonia |
|
Definition
|
|
Term
Virulence factor and MOA for: Pseudomonal wound infection |
|
Definition
Pseudimonal toxin: Similar to diphtheria toxin (interferes with EF2) |
|
|
Term
Virulence factor and MOA for: Rheumatic fever (GABHS) |
|
Definition
M protein: Body makes Ab against strep but they happen to cross react and bind to the heart tissue |
|
|
Term
Virulence factor and MOA for: Scalded skin syndrome |
|
Definition
Exfoliative toxin (ET): Superantigen that attacks the intercellular adhesive of the stratum granulosumàmarked epithelial desquamation |
|
|
Term
Virulence factor and MOA for: Scarlet fever |
|
Definition
Erythrogenic toxin (acquired this toxin by lysogeny – bacterial phage (virus that infects bacteria)). Responsible for fever and rash |
|
|
Term
Virulence factor and MOA for: Staphylococcal food poisoning (aur) |
|
Definition
enterotoxin; Induces cAMP |
|
|
Term
Virulence factor and MOA for: Strep throat |
|
Definition
M protein; antiphagocytic |
|
|
Term
Virulence factor and MOA for: Tetanus |
|
Definition
Virulence factor: Tetanus toxin (tetanospasmin). MOA of toxin: Very potent. Stops release of NT GABA, glycine and excitatory NTàdangerous overactivity in mm from smallest stimuli |
|
|
Term
Toxic shock syndrome (S. Aureus) |
|
Definition
Virulence factor: Superantigen exotoxin. MOA of Toxin has affinity for the T cell receptor/MHC Class 2 antigen complex à stimulates an enhanced T lymphocyte responseàT cell activation causes large amount of T cell cytokine release à TSS |
|
|
Term
Virulence factor and MOA for: Whooping cough (B. Pertussis) |
|
Definition
Virulence factor: Pertussis Toxin (PT). MOA Catalyzes the ADP ribosylation of the alpha-I subunit of the G protein à inactivates Gi à increases cAMP |
|
|
Term
Virulence factor and MOA for: Meningococcal meningitis |
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Definition
1. polysaccharide capsule (only in N. Meningitis NOT GC): antiphagocytic. 13 serogroups (A,B,C,Y, W135 most common). We don’t have a vaccine for B so you can get meningitis even with the vaccine. 2. LOS- lipooligosaccharide (no O antigen) - endotoxin: causes immune response (cytokine storm). 3. Pili: Attachment to nasopharyngeal mucosa |
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Term
Virulence factor and MOA for: Tuberculosis |
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Definition
Facultative intracellular Virulence dependent on ability to survive and grow in host cells. Makes no toxins but when engulfed by macrophages, bacterial sulfolipids inhibit the fusion of phagocytic vesicles with lysosomes. MOA Inhibits fusion of phagosome/lysosome. |
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Term
Virulence factor and MOA for: Traveler’s diarrhea (ETEC) |
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Definition
Enterotoxins: 1. Heat stabile toxin (ST) --> causes increase in cellular cGMP. 2. Heat labile toxin (LT)- essentially identical to cholera toxin which --> causes increase in cellular cAMP MOA: Prolonged hypersecretion of chloride ions and water by the intestinal mucosal cells and inhibits the reabsorption of Naàhyperosmotic diarrhea |
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Term
Virulence factor and MOA for: Shigellosis |
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Definition
1. Shiga toxin: inhibit protein synthesis by interfering with 60s (like EHEC). 2. Invasion of intestinal mucosa via actin polymerization --. Propel themselves |
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Term
Virulence factor and MOA for: Pseudomembranous colitis |
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Definition
2 toxic polypeptides: 1. enterotoxin A: damages mucosa. 2. Cytotoxin B: kills the cells |
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Term
Virulence factor and MOA for: Meningococcal septic shock , (N. Meningitis) |
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Definition
LOS: Increased immune response --> cytokine storm |
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Term
Virulence factor and MOA for: Listeriosis |
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Definition
1. Facultative intracellular: Escapes phagosome before lysosome/phagosome fusion. 2. Listeriolysin O hemolysin: Lyses phagocytic vacuoles/damages membranes |
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Term
Virulence factor and MOA for: Anthrax (B. Anthracis) |
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Definition
Virulence factors are: 1. Anthrax Toxin has both (A) – LF --- lethal factor and -- EF — edema factor as well as (B) - PA – protective Ag 2. Glutamic acid Capsule MOA of Virulence factor 1: anthrax toxin – increases intracellular cAMP --> severe edema (widened mediastinum, etc. ). MOA of virulence factor 2: antiphagocytic |
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Term
Virulence factor and MOA for: Hemolytic uremic syndrome (0157:H7)- EHEC |
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Definition
Shiga-like toxin (Verotoxin ): Inhibits protein synthesis by interfering with 60s ribosomes (like Shigella toxin) |
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Term
Virulence factor and MOA for: Bacillus cereus food poisoning |
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Definition
Virulence factors: 1. Emetic Heat Stabile enterotoxin and 2. Diarrheal Enterotoxin (heat labile). MOA for VF's: 1. causes nausea, vomiting, abdominal cramps, 2. increases cAMP |
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