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Tight Shell of protein around virus |
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Viruses that acquire an outer lipoprotein coat by "budding" through the host cell membranes |
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messenger RNA is transcribed from viral DNA |
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Cary RNA polymerase, which directs both transcription and replication of RNA genome |
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Reverse Transcriptase Makes DNA out of RNA |
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Plaque forming unit Lyse monolayer (makes hole) |
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Focus Forming Unit Similar to a wart Lose inhibition to growth |
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Live Can infect Both humeral and cellular immunity |
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Dead Can't infect Primarily a humoral response |
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further categorized into subtypes Multiple |
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no subtypes undergo antigenic drift less rapidly than type A Human/Pig |
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results from point mutations creates new influenza virus variants |
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Guillain-Barre's Syndrome |
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(GBS) Nerve damage, polio-like paralysis, and coma Complication of influenza, usually occurs after recovery or immunization |
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Child complication of Influenza or Chicken Pox |
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innactive several strains of A and B |
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Picornaviruses Grow best at 33 degrees C 110 serotypes Can spread: otitis media, sisusitis, pneumonia |
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made way childhood viruses spread Airborn droplets |
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1/3 of "colds" SARS occurs when virus encompasses lower respiratory tract |
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Flu like symptoms 42 human serotypes Can cause pertussis syndrome (sounds like whooping cough) Sign: fever, can cause conjunctivitis May be oncogenic Enduces obesity in animals |
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Respiratory Syncytial virus
Main cause of infant hospitalization |
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Respiratory Syncytial Virus |
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RSV Main cause of infant hospitalization common cause of bronchiolitis and pneumonia |
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Fifth disease/Erythema Infectiosum/Slap Cheek Disease |
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Erythema Infectiosum "Slap Cheek Disease" Grows in stem cells Lacy appearance Can cause Aplastic crisis in people with chronic anemia Can cause Hydrops Fetalis |
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"Chicken Pox" VZV Member of Herpesviridae family Reye's syndrome may occur during recovery May cross placenta and cause fetal damage Given as a live vaccine |
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"Shingles" Caused by chickenpox Virus remians in nerve roots and emerges years later to cause illness More common after 50 |
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Picornaviridae 3 types Vaccine today is inactive |
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Polio Type 1 Major number of epidemics Sometimes causes paralysis |
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Polio Thype II Occurs Sporatically Invariably causes paralysis |
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Polio Type III Usually remains in intestines Can cause paralysis |
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Where does the Polio disease strike? How often does it cause paralysis? |
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Infectious Hepatitis Caused by ingestion of fecal matter Can be acquired from shellfish |
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Serum Hepatitis Caused by contact with infectious blood, semen, and other bodily fluids. Primarily contracted from sexual contact, birth to infected mother. |
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Non A/B hepatitis Most commonly contracted through blood contact. Can be sexually transmitted |
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subunit vaccine contains surface antigen |
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Serious liver disease Needs to piggy back on HBV |
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common illness explosive onset of diarrhea, nausea, vomiting, low-grade fever, cramps, headache, and malaise |
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REO= Respiratory Enteric Orphan Enters Oropharynx by age 16 50-80% have Ab to all 3 types
A cause of Viral Gastroenteritis |
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Common cause HOSPITALIZATION among children. Vomiting and watery diarrhea for 3-8 days |
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Picornaviridae family noroviruses coxsackie viruses echovirus |
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"Norwalk virus" Common on cruise ships |
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Hand Foot Mouth Disease A and B groups cause many conditions Rash on hands, feet, and pharynx vesicles to ulcers, heal without crusting |
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associated with diseases with vesicular lesions |
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Most frequently associated with myocarditis and pleurodynia |
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ECHO= Enteric Cytopathogenic Human Orphan Viable in sewage and water. |
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Tree virus, Mosquito-born viruses West Nile, Dengue fever, Yellow fever |
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Serious symptoms in 1/150 people that contract it. Mild flu-like symptoms in 20% that contract it. No symptoms in 80% that get it. at least 19 mosquitoes types carry it in US |
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Caused by any of 4 related dengue viruses Carried by Aedes mosquitoes Person can be infected by two, if not all four types in lifetime. Fever and near full body Rash |
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Yellow fever virus (flavivirus group) Aedia aegypti Mosquito spread 20% death rate |
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Herpesviridae family Implicated in: African Burkitt's Lymphoma B-cell latency Infectious mononucleosis Berkitt's lymphoma Anaplastic nasopharyngeal carcinoma B-cell lymphomas Downey Cells |
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"Kissing Disease" spread mouth to mouth, fomites, droplets No symptoms in children Epstein Barr is responsible |
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EBV infects B cells establishing latent infections Transformed into immortal, continually dividing cells |
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B-cell lymphoma edemicto Africa and New Guinea |
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Family: Herpesviridae Virus most frequently transmitted to a developing child before birth. Can cause hearing, mental deficiencies If aquired after birth there are few symptoms. Dormant in body for life. Recurrent disease rarely occurs |
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Previously infected people intermittently shed in bodily fluids. |
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Indication of Rabies infection |
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Rhabdoviridae family Highest mortality rate of any human disease Travels up nerve to brain |
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Family Herpesviridae Lipschutz bodies Worst effects are social/mental cold sores, genital herpes is toublesome |
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Cutaneous lesions: confined to skin
Generalized infections: Life threatening. disseminates throughout organs
Encephalitis: (Direct infection of brain tissue, life threatening) |
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100 different strains Cause cutaneous warts on skin, and mucosal warts (genital, oral, and conjunctival) More than 30 STD's 50% of sexually active acquire genital HPV |
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spore - hyphae - mycelium - spores |
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fungi posessing a cell wall |
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Potent carcinogen produced by Aspergillus spp. of mold |
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Causes Tinia versicolor AKAPityriasis vesicolor Normal flora lipophilic yeast |
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trichomycosis or tinea nodosa black growths (pietdra) on hair |
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Three genera of dermatophytes |
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Epidermatophytes Trichophyton Microsporium |
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Dermatomycoses Keratinase enzyme allows to adhere to skin Causes ringworm |
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Causes Hitoplasmosis AKA: Darling's disease, Cave disease, spelunkers disease Endemic in land that drains into ohio and Mississippi rivers Usually flu like, can mimic TB |
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Chicago disease, Gilchrist's disease, North American blasomycosis Lollipop conidium can cause lesions of skin and bones |
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Paracoccidioides brasilienses |
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Paracoccidioidomycosis, South American blastomycosis, LutzSplendore-Almeida disease fungus may grow as yeast in tissues Can cause ulcer like lesions "Ships wheel" formation |
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Coccidioidomycosis AKA San Joaquin Valley Fever, AKA Destert Rheumatism and Posada disease Barrel shaped infectious arthospores Type B blood have greater risk of dissemination |
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Causes: Cryptococcosis AKA Toulosos (yeast) AKA European Blastomycosis AKA BusseBuschke disease
worldwide thanks to dang pigeon droppings May be mistaken for lung cancer Primary cause of fungal meningitis |
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Opportunistic Mycoses Result in: candidiasis, yeast infections, moniliasis, thrush |
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Aspergillus species, especially A. flavus and A. fumigatus |
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cause asperfillosis produces alphatoxin |
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black bread mold Infection requires underlying condition |
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atypical once considdered a protazoa causes a form of pneumonia common cause of death in aids patients |
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