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Definition
| Smallest DNA virus with ssDNA genome and naked icosahedral capsid |
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| Can only infect growing cells because cannot induce cell to enter S phase. Entirely dependent on host cell machinery |
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| Two genera that can infect humans: erythrovirus B19 and dependovirus |
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| Enters via respiration and disseminates in blood to cause erythema, rash, pruritus, arthralgia, and erythroid aplasia; can cause spontaneous abortion in pregnant females but is not teratogenic. |
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| Directly kills erythrocyte precursors and causes febrile exanthema (fifth disease) |
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| Infection of the fetus of a seronegative mother can result in anemia and congestive heart failure due to RBC destruction |
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Definition
| Can be used as vectors in gene therapy. Latently infect non-dividing cells without causing disease and have a specific site of integration |
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Definition
| Includes papillomaviruses and polyomaviruses |
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Definition
| dsDNA genome in small icosahedral capsid. Can cause lysis or oncogenci transformation by binding to p53 and Rb and transforming cells not permissive to replication |
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Definition
| Produce two anti-tumor suppressing proteins, E6 and E7, that bind to p53 and Rb. Sexual transmission, produces warts due to rise of dermal papillae |
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Definition
| Different serotypes affect different areas. Protein-based vaccine to prevent cervical cancer, precancerous/dysplastic lesions, and genital warts |
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| BK and JC only cause disease in immunosuppressed. They enter the RT, multiply and disseminate to the kidney where they become latent. Oncogenic in animals (SV40) mediated by T-antigen |
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Definition
| In IC patients, it spreads to the urinary tract, causing hemorrhagic cystitis |
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Definition
| Goes to the CNS and causes multifocal leukoencephalopathy (PML) like prions |
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Definition
| Linear dsDNA in a naked icosahedral capsid containing fibers at its vertices. Both the capsid and fibers are cytotoxic and produce E1A and E1B, which bind to Rb and p53 |
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Definition
| Cause lytic, persistent, or latent infections as well as adenoid tumors in animals. |
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Definition
| Spread by aerosol or fecal-oral, enter and spread to gut. Cause conjunctivitis, pharyngitis, and gastroenteritis. Hepatitis and meningoencephalitis in IC, children and BMT recipients at risk for acute hemorrhagic cystitis |
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Definition
| Infect mucoepithelial cells, replicate in permissive cells, latent in lymphoid tissue. Live attenuated vaccine for two serotypes reserved for military recruits |
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