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Micobiology GU
Micobiology GU Dr Hada Dr Mayi
172
Microbiology
Graduate
04/24/2011

Additional Microbiology Flashcards

 


 

Cards

Term
Produces maintains and transports sperm cells
Definition
Male reproductive system
Term
Defense of male reproductive system
Definition
flushing of urine
Term
Produces eggs in a 28 day cycle
Definition
Female reproductive system
Term
Mucus
Definition
Defense of female reproductive system
Term
Acidic pH of vagina
Definition
Defense of female reproductive system
Term
SIgA
Definition
Defense of female reproductive system
Term
Flushing action of urine
Definition
Defense of urinary tract
Term
Shedding of epithelial cells lining the urinary tract
Definition
Defense of urinary tract
Term
Acidity of urine
Definition
Defense of urinary tract
Term
Lysozyme and lactoferrin in urine
Definition
Defense of urinary tract
Term
SIgA
Definition
Defense of urinary tract
Term
Normal biota of the male urethra and genital tract
Definition
Nonhemolytic Streptococci
Term
Normal biota of the male urethra and genital tract
Definition
Staphylococci
Term
Normal biota of the male urethra and genital tract
Definition
Corynebacteria
Term
Normal biota of the male urethra and genital tract
Definition
Lactobacillus
Term
Only anatomic areas of normal flora of the female genital tract
Definition
Anterior urethra and vagina
Term
Flora of the vagina depends on these factors
Definition
Age, pH, hormonal levels
Term
Greatly influences normal flora of the vagina
Definition
Estrogen
Term
In utero, the fetal vagina contains these bacteria
Definition
None
Term
How does a new born vagina acquire normal flora
Definition
Hands of caregivers, infants feces
Term
In the first six weeks of life estrogens are present in the infant vagina, what normal flora predominates
Definition
Lactobacillus
Term
In the absence of estrogen (pre puberty years) this bacteria is present as normal flora of the vagina
Definition
Staphylococci
Term
In the absence of estrogen (pre puberty years) this bacteria is present as normal flora of the vagina
Definition
Streptococci
Term
In the absence of estrogen (pre puberty years) this bacteria is present as normal flora of the vagina
Definition
Enterobacteriaceae
Term
After menarche (in the presence of estrogen) the vagina is dominated by this normal flora
Definition
Lactobacillus
Term
After menarche (in the presence of estrogen) the vagina is dominated by this normal flora
Definition
Gram (+) and gram (-) anaerobes and facultative anaerobes
Term
After menopause (absence of estrogen) this bacteria decreases in numbers
Definition
Lactobacillus
Term
May lead to UTI's in the anterior urethra of a female
Definition
Lactobacillus
Term
May lead to UTI's in the anterior urethra of a female
Definition
Streptococci
Term
May lead to UTI's in the anterior urethra of a female
Definition
Staphylococci
Term
May lead to UTI's in the anterior urethra of a female due to fecal spread
Definition
Enterobacteriaceae
Term
May lead to UTI's in the anterior urethra of a female due to fecal spread
Definition
Enterococcus
Term
UTI infecting the bladder
Definition
Cystitis
Term
UTI infecting the kidney
Definition
pyelonephritis
Term
UTI infecting the urethra
Definition
Urethritis
Term
UTI leading to a burning pain with urination
Definition
dysuria
Term
Cloudy urine is consistent with presence of
Definition
WBC
Term
Orange urine is consistent with presence of
Definition
RBC
Term
Back pain is consistent with a UTI infecting this organ
Definition
Kidney
Term
If pyelonephritis is inadequately treated it can lead to
Definition
Septicemia
Term
Most common causative agent of UTI
Definition
Escherichia coli
Term
Catalase (+) causative agent of UTI
Definition
Staphylococcus saprophyticus
Term
Urease (+) causative agent of UTI, member of Enterobacteriaceae
Definition
Proteus mirabilis
Term
Community acquired UTIs are usually a result of this form of transmission
Definition
Endogenous
Term
UTIs are more common in women than men do to this anatomical feature of the urethra
Definition
Shorter length of female urethra
Term
UTIs are more common in women than men do to the location of these anatomical structures
Definition
Close proximity of anus and urethral opening
Term
Recurrent UTIs in some women are do to E coli invading deeper tissues of the urinary tract allowing for this
Definition
Avoidance of antibiotics
Term
Most common nosocomial infection
Definition
UTI
Term
Treatment for UTI includes antibiotics plus ____ to control burning and urgency
Definition
Pyridium
Term
Bacteria causing Weils disease
Definition
Leptospira interrogans
Term
Long Gram -, spirochetes with hooked ends
Definition
Leptospira interrogans
Term
Invasion is via mucosa or broken skin, there is no lesion at site of entry, may lead to severe systemic disease
Definition
Leptospira interrogans
Term
Generalized infection may lead to systemic infection including: renal and hepatic failure, extensive vasculitis, myocarditis, and death. Invasion of CNS leads to meningitis
Definition
Leptospira interrogans
Term
Symptoms including fever with relapses, Jaundice may occur in severe cases with renal failure being the most common cause of death
Definition
Leptospira interrogans
Term
Worldwide zoonotic disease with a variety of hosts. Rodents (mainly rats) can shed the bacteria their entire lives through urine
Definition
Leptospira interrogans
Term
In the US rats, dogs, farm animals are the major source of human infection. Bacteria are discharged through urine and transmitted to humans via infected soil, water, and food
Definition
Leptospira interrogans
Term
Organisms can survive for months in water or wet soils, no person to person transmission has been documented
Definition
Leptospira interrogans
Term
Culture and microscopy are insensitive, main form of diagnosis is through microscopic agglutination using the patients serum and live bacteria
Definition
Leptospira interrogans
Term
Treatment includes antibiotics, there is a vaccine available but only targets specific strains used primarily for the military
Definition
Leptospira interrogans
Term
Vaginal itching, burning, inflammation
Definition
Vaginitis
Term
Vaginal itching, burning, discharge
Definition
Vaginosis
Term
Most common cause of vaginosis
Definition
BV
Term
Gram +, but appears gram -
Definition
Gardnerella vaginalis
Term
Increased prevalence indicates a role in BV but not a sole etiologic agent
Definition
Gardnerella vaginalis
Term
Gram +, thought to maintain acidic pH by metabolism of glucose
Definition
Lactobacillus crispatus, Lactobacillus jensenii
Term
In females with BV these bacteria are replaced by Gardnerella vaginalis and other anaerobic flora
Definition
Lactobacillus crispatus, Lactobacillus jensenii
Term
No gram reaction, higher incidence in women with BV
Definition
Mycoplasma hominis
Term
Gram +, obligate anaerobe, very high incidence in women with BV
Definition
Mobiluncus
Term
Gram -, obligate anaerobe, higher incidence in women with BV
Definition
Fusobacterium
Term
This bacteria uses lactic acid production (low pH) and production of H2O2 (high oxidation-reduction) to inhibit overgrowth of less desirable anaerobic vaginal flora from causing vaginosis
Definition
Lactobacillus
Term
Product of Mobiluncas causing irritation of the mucus membranes
Definition
Malic acid
Term
Amines, malic acid, endotoxin, collagenases, proteases play a role in causing
Definition
BV
Term
This virulence factor of Mobiluncus and Gardnerella vaginalis increases with increasing pH
Definition
Adherence
Term
Not considered a sexually transmitted disease but is more common in women that are sexually active
Definition
BV
Term
Clinical diagnosis includes Vaginal fluid with pH>4.5, homogenous adherent discharge, fishy odor on 10% K (due to metabolic products), clue cells (obscure borders)
Definition
BV
Term
Gram stain diagnosis based on quantization of large gram + bacilli
Definition
Lactobacillus
Term
Gram stain diagnosis based on quantization of smaller gram -
Definition
Gardnerella
Term
Complications include pelvic inflammatory disease, adverse outcome of pregnancy (preterm birth, premature rupture of membranes, postpartum endometritis, cellulitis
Definition
BV
Term
Treatment includes metronidazole (PO, cream, lactate gel), clindamycin (cream),
Definition
BV
Term
Bacterial infection usually from intestinal tract, may be a consequence of a UTI
Definition
Acute prostatitis
Term
Often bacterial infection, sometimes not, cases do not respond to antibiotics and are thought to be of mixed populations of bacteria in biofilms
Definition
Chronic prostatitis
Term
Symptoms include pain: pelvic, back, genital, ejaculation. Frequent urge to urinate, blood in urine,
Definition
Prostatitis
Term
Gram -, cocci poses fimbriae and capsules
Definition
Neisseria gonorrhea
Term
Diplococci within PMNs, adjacent flattened ends
Definition
Neisseria gonorrhea
Term
Facultative anaerobe susceptible to environmental conditions. Fastidious, enhanced growth at high CO2, thayer martin medium
Definition
Neisseria gonorrhea
Term
Fimbriae for adherence, antigenic variation, and promotion of endocytosis
Definition
Neisseria gonorrhea
Term
Contain IgA protease that cleaves IgA on mucosal surfaces
Definition
Neisseria gonorrhea
Term
Outer membrane contains Lipooligosaccharide (LOS)
Definition
Neisseria gonorrhea
Term
This virulence factor of Neisseria gonorrhea elicits an inflammatory response causing purulent discharge
Definition
Neisseria gonorrhea
Term
Lack of immunity leads to repeat infections due to phase variation
Definition
Neisseria gonorrhea
Term
Primary sites of infection include: urethra in ment, urethra and cervix in women. Men are more symptomatic than women
Definition
Neisseria gonorrhea
Term
In males clinical symptoms include burning on urination and yellow purulent discharge. Complications may occur but are uncommon
Definition
Neisseria gonorrhea
Term
In females clinical symptoms include burning or frequent urination, vaginal discharge, abdominal pain. Infection can spread externally to the rectum in about 1/2 the cases. Major complication is PID leading
Definition
Neisseria gonorrhea
Term
Opthalmia neonatorumthis occuring through passage of infected birth canal, rationale for mixed antibiotic prophalxis for newborns
Definition
Neisseria gonorrhea
Term
One of the most frequently reported diseases in the US and 2nd most common cause of venereal disease
Definition
Neisseria gonorrhea
Term
Almost always sexually transmitted with humans being the only reservoir
Definition
Neisseria gonorrhea
Term
One of the more common cause of purulent arthritis in adults (mainly women)
Definition
Neisseria gonorrhea
Term
Very low percentage of cases (mainly women) develop arthritis dermatitis syndrome which includes arthritis and dermatitis of the wrists, elbows and ankles
Definition
Neisseria gonorrhea
Term
Gram stain conclusive for male purulent material. In females cervical secretions not conclusive, need to do either ELISA or PCR for confirmation
Definition
Neisseria gonorrhea
Term
Used for testing antibiotic sensitivity of Neisseria gonorrhea
Definition
Neisseria gonorrhea
Term
Disadvantage of using this type up test is no antibiogram
Definition
NAAT
Term
May be resistant to penicillin or tetracycline
Definition
Neisseria gonorrhea
Term
Very small gram -, contains LPS but little peptidoglycan
Definition
Chlamydiaceae
Term
Obligate intracellular parasite, development occurs in 3 phases
Definition
Chlamydiaceae
Term
Infection of mucosa membranes through small abrasions, may lead to granuloma formation
Definition
Chlamydia trachomatis
Term
Most females are asymptomatic, however, manifestation includes mucopurulent cervicitis and PID
Definition
Chlamydia trachomatis
Term
PID more severe than N gonorrhoeae
Definition
Chlamydia trachomatis
Term
In males most genital infections are symptomatic, manifestation includes mucopurulent urethritis
Definition
Chlamydia trachomatis
Term
Manifestation leads to proctitis
Definition
Chlamydia trachomatis
Term
Bacteria causing lymphogranuloma venereum
Definition
Chlamydia trachomatis
Term
Primary lesion at site of infection is usually overlooked by it is small, and heals rapidly. Later manifestation includes painful enlargement of lymph nodes draining site of infection (usually inguinal)
Definition
Lymphogranuloma venereum
Term
Neonatal conjunctivitis from exposure at birth as well as infant pneumonia
Definition
Chlamydia trachomatis
Term
Most common bacterial disease
Definition
Chlamydia trachomatis
Term
Most common sexually transmitted disease
Definition
Chlamydia trachomatis
Term
Most common cause of epididymitis in sexually active men
Definition
Chlamydia trachomatis, Neisseria gonorrhoeae
Term
Chlamydia trachomatis disease epidemic to Africa, asia, and S america.
Definition
Lymphogranuloma venereum
Term
Most common form of neonatal conjunctivitis in the US
Definition
Chlamydia trachomatis
Term
Gold standard for diagnosis of Chlamydia trachomatis, however, is starting to be replaced by molecular diagnosis
Definition
Culture
Term
Urine samples of Chlamydia trachomatis can be used for this test if purulent discharge is not available
Definition
NAAT
Term
Treatment includes agents that are taken up by host cells effectively
Definition
Chlamydia trachomatis
Term
Gram -, but lacks a true cell wall
Definition
Ureaplasma urealyticum, Mycoplasma genitalium
Term
Cause GI infections (urethritis in men) that are nongonnoccocal and nonchlamydial
Definition
Ureaplasma urealyticum, Mycoplasma genitalium
Term
In women, known to cause chorioamnionitis and postpartum fever
Definition
Ureaplasma urealyticum, Mycoplasma genitalium
Term
Diagnosis is usually not done
Definition
Ureaplasma urealyticum, Mycoplasma genitalium
Term
If urethritis persists after doxycycline treatment, treat with azithromycin
Definition
Ureaplasma urealyticum, Mycoplasma genitalium
Term
Gram -, spirochete, helically coiled, long corkscrew-shaped
Definition
Treponema pallidum
Term
Too thin too observe with light microscope
Definition
Treponema pallidum
Term
Periplasmic flagella allow corkscrew movement
Definition
Treponema pallidum
Term
Microaerophile, long generation time contributing to long incubation
Definition
Treponema pallidum
Term
Can infect almost every tissue in the body making it a great imitator
Definition
Treponema pallidum
Term
Painless slow evolving chronic granulomas disease
Definition
Syphilis
Term
Causative agent of syphilis
Definition
Treponema pallidum
Term
Fluctuates between short symptomatic and long asymptomatic stages
Definition
Syphilis
Term
Impedes access to bacterial antigens when coated with fibronectin which protects against phagocytosis
Definition
Treponema pallidum
Term
Long incubation, invasion through mucus membrane or abrasion in skin, dissemination via lymphatics or blood
Definition
Treponema pallidum
Term
This bacteria causes progression of disease that manifests in 3 clinical stages: primary, secondary, tertiary. The disease can go into a latent stage
Definition
Treponema pallidum
Term
This stage of syphilis is characterized by a hard chancre with painless regional lymph node enlargement. There are no other systemic signs and the majority of patients may not know they have the disease
Definition
Primary
Term
This stage of syphilis is characterized by several alternating relapses. Hallmark is a rash commonly on the palms and soles. Condylomata may occur on the mucous membranes
Definition
Secondary
Term
Stage of syphilis classified as the first 4 years between secondary and tertiary stages
Definition
Early latency
Term
Stage of syphilis classified as 4-40 year period between secondary and tertiary stages
Definition
Late latency
Term
Stage of syphilis that progresses slowly painless granulomas of the skin and bones develop known as gummas
Definition
Tertiary
Term
Congenital disease via transplacental infection. Manifestations include: interstitial keratitis, notched incisors, CN 8 deafness
Definition
Syphilis
Term
Primary stage is a risk factor for HIV
Definition
Syphilis
Term
Cannot be cultured in vitro, can be grown on tissue culture at reduced O2
Definition
Treponema pallidum
Term
Bacteria can be observed in lesion material using dark field microscopy for those patients with primary chancre, secondary lesions, and congenital infections
Definition
Treponema pallidum
Term
Wasserman Ab are specific for
Definition
Cariolipin
Term
If positive wasserman Ab suspect this bacteria
Definition
Treponema pallidum
Term
VDRL, RPR are tests for
Definition
Wasserman Ab
Term
This test is used to confrim nontreponemal tests
Definition
FTA-Ab
Term
Treatment for early stages of syphilis
Definition
Benzathine penicillin
Term
Used to treat late and congenital stages of sypihlis
Definition
Penicillin G
Term
Due to the slow growth of this bacteria, treatment needs to be prolonged for it to be effective
Definition
Treponema pallidum
Term
Sexually transmitted infection characterized by painful sores in the genital area
Definition
Chancroid
Term
Similar to primary syphilis however a painful ulcer develops known as chancroid
Definition
Haemophilus ducrey
Term
Family of HSV1 and HSV2
Definition
Herpesviridae
Term
Genome and structure of HSV1 and HSV2
Definition
dsDNA, enveloped
Term
Viral infection can be lytic or latent usually a result of direct inoculation of the: eyes, respiratory, mouth, genitals, and anus
Definition
HSV1, HSV2
Term
For fast results do PCR of DNA, virus can be obtained from vesicles but not crusted lesions. Tzanck smear shows epidermal multi-nucleated cells and eosinophilic intranuclear inclusions
Definition
HSV1, HSV2
Term
Active lesions of this virus should be cared for away from high risk group including: burn patients, eczema, neonates, immunocomprimised
Definition
HSV1, HSV2
Term
Treatment for HSV1 or HSV2 in immunocomprimised
Definition
Acyclovir
Term
What is used to treat herpes keratitis
Definition
Trifluridine
Term
Family HPV belongs to
Definition
Papovaviridae
Term
Genome and structure of HPV
Definition
dsDNA, naked
Term
Virus causing warts know as papillomas
Definition
HPV
Term
Genital warts from this virus rarely cause discomfort or pain but may lead to cancer of the genitals, anus, mouth, and URT
Definition
HPV
Term
These serotypes are in the vaccine for HPV
Definition
6,11,16,18
Term
HPV squamous cell with a larger irregular nucleus appear rounded and in clumps
Definition
Koilocytotic
Term
Visible warts typically do not cause cancer from this virus. hard to detect warts may be made more visible by using vinegar
Definition
HPV
Term
If pap smear is inconclusive, follow up test is a ___ DNA test for this virus
Definition
HPV
Term
The most common STD
Definition
HPV
Term
Asymptomatic shedding promotes transmission usually through direct contact, warts may spread through auto inoculation and fomties
Definition
HPV
Term
HPV treatment for immunocompromised
Definition
Cidofovir
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