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Metabolic Fuels and Dietary components
UC MED 2015
81
Medical
Graduate
10/17/2011

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Term
compounds that have no use or value in the human body and maybe toxic
Definition
xenobiotic compunds
Term
pattern of central obesity is called?
Definition
apple shaped
Term
Easy! the major fuels we obtain from our diet is...
Definition
carbohydrates, proteins, and fats
Term
What are some of the major users of our ATP?
Definition
Biosynthesis, Detoxification, Muscle contraction, Active Ion transport, and Thermogenesis
Term
Oxidation of fuels to generate ATP
Definition
respiration
Term
carbohydrates are normally converted to
Definition
glucose
Term
fat is processed to
Definition
fatty acids
Term
protein is processed to
Definition
amino acids
Term
pathways that break molecules down
Definition
catabolic
Term
pathways that build molecules
Definition
anabolic
Term
the amount of energy required to raise the temperature of 1 liter (L) of water 1 degree Celsius (1°C).
Definition
1 Calorie (1kcal)
Term
oxidative pathways are catabolic or anabolic?
Definition
catabolic
Term
The major carbohydrates in our diets...
Definition
starch, sucrose, lactose, fructose, and glucose
Term
storage form of carbohydrates in plants is
Definition
polysaccaride starch
Term
Two examples of disaccharides
Definition
sucrose (table sugar) and lactose (milk sugar)
Term
Two examples of monosaccharides
Definition
glucose and fructose
Term
Oxidation of carbohydrates to CO2 and H2O in the body produces approximately...
Definition
4kcal/g
Term
The complete oxidation of proteins to CO2, H2O, and NH4+in the body yields approximately...
Definition
4 kcal/g
Term
The complete oxidation of triacylglycerols to CO2 and H2O in the body releases approximately
Definition
9 kcal/g
Term
ethanol (CH3CH2OH) is oxidized to CO2and H2O in the body and yields approximately ...
Definition
7 kcal/g
Term
The average 70-kg man has approximately ___ kg stored triacylglycerol,which accounts for approximately _____% of his total stored calories
Definition
15 kg
85%
Term
Why is fat such a good storer of energy?
Definition
It has a lot of energy per g and and contains little water unlike other sources of energy
Term
Liver glycogen is important for?
Definition
used to maintain blood glucoselevels between meals,which is necessary for optimal functioning of the nervous system.
Term
Daily energy expenditure (DEE)
Definition
includes the energy to support our basal metabolism (basal metabolic rate [BMR] or resting metabolic rate [RMR]) and our physical activity, plus the energy required to process the food we eat (diet-induced thermogenesis [DIT]).
Term
a measure of the energy required to maintain life: the functioning of the lungs,kidneys and brain,the pumping of the heart,the maintenance of ionic gradients across membranes,the reactions of biochemical pathways, etc.
Definition
resting metabolic rate
Term
Factors that affect Basal Metabolic Rate
Definition
Gender(males greater than females), body temp (higher with fever), environmental temp(higher in cold) , thyroid status (increased in hyperthyroidism), pregnancy and lactation (increasing factors), and age (decrease with age)
Term
The essential fatty acids are...
Definition
linolenic acid are supplied by dietary plant oils,and eicosapentaenoic acid (EPA)and docosahexaenoic acid (DHA) are supplied in fish oils. They are the precursors of the eicosanoids (a set of hormone like molecules that are secreted by cells in small quantities and have numerous important effects on neighboring cells). Theeicosanoids include the prostaglandins, thromboxanes, leukotrienes, and other related compounds
Term
The 9 essential a.a.(can't be made by our body)
Definition
lysine, isoleucine, leucine, threonine, valine, tryptophan, phenylalanine, methionine, and histidine
Term
What are the free fates of free amino acids?
Definition
1)used to make proteins
2)serve as precursors for synthesis of essential nitrogen-containing compounds (e.g., heme, DNA, RNA)
3) are oxidized as fuel to yield energy.
Term
DISEASE- Kwashiorkor
Definition
characterized bymarked hypoalbuminemia (low levels of albumin in the blood), anemia, edema (buildup of fluids in the interstitial spaces), pot belly, lossof hair, and other signs of tissue injury
Term
MEDICAL TERM- Maramus
Definition
prolonged protein and calorie malnutrition, particularly in young children. Children with marasmus usually do not develop edema.
Term
Vit C
Definition
Common Sources: Citrus fruits, potatoes, peppers, broccoli, spinach, and strawberries

Deficiency disease: Scurvy: defective collagen formation leading to subcutaneous hemorrhage, aching bones, joints, and muscle in adults, rigid position and pain in infants
Term
Thiamin
Definition
Source: Enriched cereals and breads, unrefined grains, pork, legumes, seeds, and nuts

Deficiency disease: Beri-Beri- wet (edema), anorexia, weight loss, apathy, decrease in short term memory, confusion, irritability, muscle weakness, and enlarged heart
Term
Riboflavin
Definition
Common sources: Dairy products, fortified cereals, meats, poultry, fish, and legumes

Deficiency Disease- Ariboflavinosis-sore throat, hyperemia, edema of oral mucosal membranes, cheilosis, angular stomatis, glossitis, magenta tongue, seborrheic dermatitis, normochromic normocylic anemia
Term
Niacin
Definition
Sources: chicken, beef, fish, enriched cereals, whole grains, and most foods

Deficiency Disease- Pellagra: pigmented rash in areas exposed to sunlight; vomiting, constipation, and diarrhea; bright red tongue, neurologic symptoms
Term
Vit B6 (pyridoxine)
Definition
Sources: chicken fish pork, eggs, fortified cereals, unmilled rice, oats, starchy vegetables, noncitrus fruits, peanuts, and walnuts
Deficiency Disease- Seborrheic dermatitis, microcytic anemia, epileptiform convulsions; depression and confusion
Term
Folate
Definition
Sources: Citrus fruits, dark green veggies, fortified cereals, breads, and legumes

Deficiency Disease- Impaired cell division and growth, MEGALOBASTIC ANEMIA, neural tube defects
Term
Vit B12
Definition
Sources: Animal products

Deficiency Disease- MEGALOBASTIC ANEMIA, neurological symptoms
Term
Biotin
Definition
Source- liver, egg yolk

Deficiency disease- conjunctivitis, CNS abnormalities, glossitis, alopecia; dry, scaly dermatitis
Term
Pantothenic acid
Definition
Source: Wide distribution in foods, esp. animal tissues, whole grain cereals, and legumes

Deficiency Disease- irritability and restlessness; fatigue, apathy, malaise; gastrointestinal symptoms and neurological symptoms
Term
Choline
Definition
Source- milk, liver, eggs, and peanuts

Deficiency disease- liver damage
Term
What are the fat soluble vits?
Definition
Vit A, K, D, E
Term
Vit A
Definition
Sources: Carrots, dark green and leafy veggies, sweet potatoes, squash, and broccoli

Deficiency Disease- Night blindness; XEROPHTHALMIA; keratinization of epithelium in gastrointestinal, respiratory, and genitourinary tracts, skin becomes dry and scaly
Term
Vit K
Definition
Sources: green leafy veggies, cabbage family, bacterial flora of intestine

Deficiency Disease- Defective blood coagulation, hemorrhagic anemia of the newborn
Term
Vit D
Definition
Sources; Fortified milk, exposure to sunlight

Deficiency disease- Rickets (in children); inadequate bone mineralization (osteomalacia)
Term
Vit E
Definition
Sources: Veggies oils, margarine, wheat germ, nuts, green leafy veggies

Deficiency disease- muscular dystrophy and neurologic abnormalities
Term
What are the water soluble vitamins?
Definition
Vit C, Thiamin, Riboflavin, Niacin, B6, B12, Folate, Biotin, Pantothenic acid, and Choline
Term
In the process of respiration,fuels most often undergo which one of the following fates?
Definition
They are oxidized to generate ATP
Term
The recommended total fat intake is
Definition
less than 35% of your total calories (worthless if you eat too much)
Term
The caloric content per gram of fuel is best represented by
Definition
It is the amount of energy that can be obtained from oxidation of the fuel
Term
The resting metabolic rate is best explained by
Definition
t is equivalent to the caloric requirement of our major organs and resting muscle.
Term
Less than ____g of sodium should be ingested daily, which is equivalent to _____g of table salt
Definition
2.3g of sodium
or
4.5g of table salt
Term
After a meal, glucose is _______ and then if not needed immediately it will be stored as _________.
Definition
oxidized
glycogen- in the liver or muscle
Term
The liver packages triacylglycerols as...
Definition
very-low-density lipoproteins (VLDL)- can be stored in adipose tissue
Term
What are the 3 fates of glucose?
Definition
1) Oxidation- energy
2) synthesis- many compounds
3) storage- glycogen or TAG
Term
What are the 3 fates of amino acids?
Definition
1) protein synthesis
2) oxidation- energy
3) synthesis of nitrogen containing compounds
Term
What are the 3 fates of fats?
Definition
1) storage- TAG
2) synthesis- membrane lipids
3) oxidation- energy
Term
What are the "hgealthy" values for waist circumfrence of mean and women?
Definition
men <40 in
women <35in
Term
What enzyme type cleaves dietary proteins?
Definition
proteases
Term
What protease is found in the stomach?
Definition
pepsin
Term
What protease is found in the stomach?
Definition
pepsin
Term
What proteases work in the lumen of the intestine and where are they secreted from?
Definition
trypsin, chymotrypsin, elastase, and the carboxypeptidases(TCEC)- secreted by the pancreas
Term
What proteases are associated with the intestinal epithelial cells complete the conversion of dietary proteins to amino acids?
Definition
Aminopeptidases and di- and tripeptidases
Term
Amino acids are absorbed into the ___________ and released into the __________.
Definition
intestinal epithelial cells
hepatic portal vein
Term
The triacylglyecerols are...(for digestion)
Definition
emulsified in the intestine by bile salts
Term
Bile salts are synthesized and stored where?
Definition
synthesized- liver
stored-gall bladder
Term
CoA ( Coenzyme A) which makes the acetyl group more active is a cofactor derived from which vitamin?
Definition
pantothenate
Term
What is a major precursor of neurotransmitters,the chemicals that convey electrical impulses (as ion gradients)between neurons?
Definition
glucose
Term
Since they lack mitochondria, this is the only fuel source in RBCs?
Definition
glucose, anaerobic glycolysis occurs in RBCs and lactate is formed
Term
What two types of lipoproteins are produced in the fed state?
Definition
1) chylomicrons- large lipoprotein particles that consist of triglycerides (85-92%), phospholipids (6-12%), cholesterol (1-3%) and proteins (1-2%). They transport dietary lipids from the intestines to other locations in the body
2) VLDL- functions as the body's internal transport mechanism for lipids
Term
In the fasting state, liver glycogen is degraded by?
Definition
glycogenolysis- supplies glucose to the blood
Term
What is the process called that mobilizes adipose triacylglycerols to release fatty acids and glycerols into the blood?
Definition
lipolysis
Term
As the length of the dast increase, what is used for the major source of fuel?
Definition
fatty acids
Term
During fasting state, the liver produces glucose from both...
Definition
1) glycolysis
2) gluconeogenesis
Term
What are the major sources of carbon for gluconeogenesis?
Definition
1) lactate
2) amino acids
3) glycerol
Term
When the carbon of amino acids is converted to glucose, what happens to the nitrogen?
Definition
It is converted to urea.
Term
A fast for 3 or more days means we are in the...
Definition
starved state
Term
What happens in the starved state?
Definition
Muscles continue to use fatty acids for energy, but they use less ketone bodies. With an increased amount of ketone bodies in the blood, the brain will begin to use them for energy. Protein is preserved, to help keep us alive for long as possible.
Term
What are the three levels of protein malnutrition and how does the BMI rate them?
Definition
I- BMI 17.0-18.4
II- BMI 16.0-16.9
III- BMI < 16.0
Term
Can the liver oxidize ketone bodies?
Definition
No
Term
What two proteins secreted by the liver are measured to test for malnutrition?
Definition
serum- albumin and transferrin
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