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Metabolic Cooperation of Tissues
Medical School Biochem
27
Biochemistry
Graduate
09/28/2011

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Term
All tissues use which fuel as the major fuel for energy?
Definition
Glucose
Term
Glucose not immediately used for energy is first stored as?
Definition
Glycogen
Term
Excess dietary glucose (beyond energy need and reserve stores) in the liver is converted into what?
Definition
Triglycerides
Term
The liver degrades amino acids into what products?
Definition
Urea and Pyruvate
Term
What is Urea?
Definition
Urea is physiologically safe nitrogen formed as by product from the metabolism of nitrogen containing compounds. It is excreted by the kidneys
Term
What is BUN?
Definition
Blood Urea Nitrogen. It is a measure of the amount of ammonia (as urea) in serum blood.
Term
What is an abnormally elevated BUN indicative of?
Definition
Renal dysfunction
Term
What is abnormally depressed levels of BUN indicative of?
Definition
Hepatic dysfunction
Term
What is the name of the metabolic process in the liver resposible for the degradation of Amino Acids?
Definition
Ureagenesis
Term
What is the first step of converting Glucose into ATP?
Definition
Glycolysis, 10 enzymes are involved
Term
What is the second step in converting glucose to ATP?
Definition
Pyruvate decarboxylation. 3 enzyme step that predominantely features Pyruvate Dehydrogenase (PDH)
Term
What is the third step in the conversion of Glucose to ATP?
Definition
Krebs Cycle (Citric Acid cycle)
Term
What sort of metabolic process do cells with no mitochondria use to generate energy?
Definition
Anaerobic Glycolysis
Term
What are the products of Anaerobic Glycolysis?
Definition
Lactate and ATP
Term
What is the critical enzyme for conversion of Pyruvate into Lactate?
Definition
Lactate Dehydrogenase (LDH)
Term
How is the lactate product of Anaerobic metabolism handled by the body?
Definition
Lactate is metabolized in the liver into pyruvate using LDH
Term
What happens to ingested dietary triglycerides?
Definition
Packaged in Chylomicrons and then sent to adipose tissue for processing
Term
What is the process by which excess glucose is converted into Triglycerides in the liver?
Definition
Excess glucose does not enter the krebs cycle but instead undergoes fatty acid synthesis and lipogenesis
Term
What is lipogenesis?
Definition
The process by which fatty acids are converted into triglycerides. Requires phosphorylated glycerol
Term
How do lipoproteins (such as VLDL and Cholymicrons) traverse the cell membrane and enter adipose tissues?
Definition
with the enzyme Lipoprotein lipase. This enzyme both works as a glycerol hydrolase and works with membrane transport proteins
Term
Triglycerides produced from the liver are packaged in what?
Definition
VLDL, very low density lipoproteins
Term
Why must VLDL and Cholymicrons undergo lipogenesis in adipose tissue?
Definition
The triglycerides in VLDL and Cholymicrons are converted into fatty acids by lipoprotein lipase
Term
Where does the phosphorylated glycerol for lipogenesis in adipose tissue come from?
Definition
Glycerol-P is generated during glycolysis in adipose tissue
Term
Where does phosphorylated glycerol come from in Lipogenesis in the liver?
Definition
Glycerol product from the action of lipoprotein lipase is uptaken and phosphorylated in the liver
Term
What enzyme phosphorylated Glycerol in the liver?
Definition
Glycerol Kinase
Term
What is the process by which glucose is stored in livers and muscles? What is the product?
Definition
The process is glycogenesis and the product is glycogen
Term
What amino acids can not be degraded in the liver? What happens to them?
Definition
Leu, Ile, and Val. This branched chain amino acids are degraded in muscles into Acetyl CoA (which then enters the Krebs cycle)
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