Term
Current understanding of Mental Illness
focuses on a _______ |
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Definition
Holistic Understanding
-MI is complicated and disorder occurs at multiple levels |
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Term
6 ways mental illness can be defined |
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Definition
- evolutionary perspective
- statistical persepctive (deviance)
- pragmatic (whatever professionals treat)
- skeptical antipsychiatry view (ppl diagnose to get ride of bad behavior)
- value view (determined by social norms)
- harmful dysfunction model
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Term
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Definition
- model used to define mental illness
Wakefield (1992) |
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Term
Current mental illness defintion |
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Definition
Harmful Distress
Distress discovered by self-report (subjective) and behavioral observations |
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Term
Problems associated w/ current MI definition (7) |
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Definition
- says nothing about cause/etiology
- bad inter-rater reliab: inconsistent & biased reporting, temporarily unstablity w/in the person
- comorbidity between disorders
- limited predictive validity
- limited relation to tx
- definitions are arbitrary and hard to measure
- biased by culture
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Term
Holistic understanding of MI (6 levels) |
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Definition
- cultural/social (opportunities)
- interpersonal/environmental (reinforcement)
- mental
- organ (hypofrontality)
- cellular/molecular (serotinergic)
- genetic/epigentic (5-HTTLPR)
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Term
Examples of mental level phenomenon
associated with MI |
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Definition
- Metacognitive beliefs
- basic neurocognition, motivation, affect
- autonomic or basic functions
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Term
Reasons holistic understanding of MI is
better than previous definitions (7) |
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Definition
- help thoerize and test models of etiology (etiology)
- object & performance-based assessments (inter-rater reli)
- isolates more specific unit of analysis (comorbidity)
- identifies core neurodevelopmental or vulnerability features (predictive valid)
- new entry points for tx (tx relation)
- objective, ratio based measures (arbirtrary)
- quanitify influences of various sources (culture)
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Term
Issues with Holistic approach to MI (5) |
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Definition
Issues with conceptual overlay, not a public policy
- where is bx and self-report, critical for diagnosis?
- creates confusion, who is the expert to tx and R?
- how does causality work (each level effects each other)
- one path to MI from simple to broad? (equifinality/multifinality)
- social & professional issues: what level do you diagnose & tx, insurance, legal responsibility?
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Term
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Definition
- cities became center of civilization
- large populations of indigent ppl w/ mental illness
- gov't charged with their car
- Islamic culture: scientific wave created scientific method
- Asylums
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Term
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Definition
Asylums: a natural laboratory
-superintendents were medical doctors trained in experimental science
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Term
Organizations for professionals
caring for the mentally ill |
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Definition
-1st called Association of Medical Superintendents of American Institutions for the Insane (AMSAII): changed to American Psychiatric Association |
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Term
Plan for running an asylum |
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Definition
Thomas Kirkbride
Pennsylvania Hospital for the Insane
"Kirkbride" Plan-privacy, socialization, sun, air
-stoped blaming individual |
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Term
19th century understanding of
psychopathology: summary |
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Definition
-recognition that organs of the nervous system are related to MI
-recognition that clearly defined exogenous agents can cause MI |
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Term
20th century treatments (3)
(non pharmacological) |
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Definition
1908: Antibiotic for synphilis
1953: Psychosurgeries (lobotomy)
1938: ECT (based on faulse observation that schizo & epilepsy don't co-occur & correct observation that epilepsy are euthymic post-seizure) |
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Term
Invention of Chlorpromazine |
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Definition
1952: chlorpromazine (AP), started as anesthetic for surgery, sedetive effect used in schizo but found the calming effects (putatively) occur above and beyond the sedative side effects
1955: Impiramine (AD), Tricyclic 5-HT reuptake inhibitor made psychosis worse but helped depression
1957: Benzodiazepine (Tranquilizer), muscle relaxation and helped fear/anxiety. Improved neg affect w/ lots of disorders (psychosis, OCD, trauma, and addicts) |
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Term
What chlorpromazine showed |
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Definition
Extrogenous chemicals can alter neurochemistry
to alter MI |
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Term
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Definition
Effect of drugs: 93% of state inpatient beds were lost
1955: community mental healthy study act enacted by congress to get info on effects of deinstitutionalization
1965-Community Mental Health Act: grants to establish local community mental health |
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Term
Effect of Community Mental Health Act (5) |
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Definition
Grants to states for local community mental health centers
- inpatient tx for emergencies
- outpatient tx
- partial hospitalization programs
- emergency/crisis tx
- consultation/education
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Term
Where have patients gone? |
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Definition
Forensic system
7.5-15% of ppl incaracerated have severe MI |
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Term
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Definition
Emil Kraepelin: founder of modern psychiatry
- Assumption that MI was biological in nature
- categorical system (≈20 diagnoses)
- seperated dementia praecox from manic depression
- don't know cause but know the symptoms
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Term
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Definition
dementia praecox: persistent & psychotic symtpoms and deteriorating state
manic depression: intermittent psychotic symptoms and erratic course
(1st time these had been split, psychotic by nature meaning symptoms had to with a seapartion from the body |
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Term
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Definition
-continuum or spectrum w/ broad categories
(Freud example)
- Healthy: efffective for handling anxiety, well functioning w/ work or love
- neurosis: ineffective for handling anxiety, problems w/ work or love
- psychosis: ineffective for keeping engaged w/ reality, considerable problems w/ work or love
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Term
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Definition
continuum in population (e.g. Eysenck)
- Neuroticism: tendency to experience negative emotions
- extroversion: tendency to enjoy positive events
- psychoticism: vulnerability to reality disturbances
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Term
Examples of each broad type of taxonomies |
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Definition
- Categorical
- Hierarchical
- psychodynamic systems
- coping strategies/ defense mechanisms
- hybrid DSM systems
- Dimensional
- symptom-based assessments
- Big 5
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Term
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Definition
first in 1900
most recent 1999
Chapter 5: mental & Behavioral Disorders |
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Term
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Definition
- Category checklist for DSM is very clearly defined algorithms, ICD is less clear
- ICD gives more room for clinician interpretation
- ICD has less behaviorally ranked symptoms
- DSM has x our of y symptoms in z categories (not this detailed in ICD)
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Term
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Definition
- Emphasized hierarchical approach
- viewed psychopathology as dimensional, but w/ distinct categories
- Diagnoses meant as a guideline
- Categories mainly descriptive in nature
- based on APA's psychoanalytic orientation
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Term
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Definition
- improved compatibility w/ ICD
- Shift from psycho-analysis to psychodynamic thought
- focus on fit between personality & environment
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Term
3 problems associated with the DSM-II |
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Definition
- DSM-II drifted from behavioral & medical sciences and allienated psychiatry from science
- Efficency: Post WWII lots of mental health professionals (most not psychiatrists or trained in psycho-analysis) were seeing patients
- Legal: Diagnoses were not defensible in court
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Term
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Definition
Spitzer & Fleiss (1975) created Kappa to show DSM-II was crap
Kappa=(Po-Pc)/(1-Pc)
Interpreting Kappa for dichotomous decisions
% agreement= 100, Kappa = 1.00
% agreement= 75, Kappa = .5
% agreement= 50, Kappa = 0
% agreement= 25, Kappa = -.5
% agreement= 0, Kappa = 1.00 |
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Term
Interpretive guidelines for Kappa |
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Definition
Greater than .90 = uniformly high
.6-.9 = only satisfactory
.4-.75 = no better than fair
less than .4 = poor |
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Term
Fixing the theoretical bias |
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Definition
- Changes made from DSM-II to III
- steer away from psychoanalytic to be more consistent w/ larger med and bx science
- limited use of psychoanalytic terms (neurosis, moved these disorders to Axis II)
- criteria focus on "atheoretical behavior"
- symptoms: maladies reported by patient
- signs: maladies detected by clinicians
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Term
Issue with fixing the theoretical bias |
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Definition
Many claim biased on a medical orientation: assumption that problem bxs reflect underlying biological abnormalities |
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Term
Fixing the issue of clearer criteria |
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Definition
Fixed from DSM-II to III
The Feigner Criteria: Behavioral-based criteria for 14 disorders developed |
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Term
Fixing the issue of standardizing the clinical interview |
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Definition
Changes made from DSM-II to III
- Schedule for affective disorders and schizophrenia (SADS)
- semi-structured clinical interview for the DSM-III (SCAD)
- diagnostic interview schedule (DIS)
- mini-international neuropsychiatric interview (MINI)
- composite international diagnostic interview (CIDI)
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Term
Evaluating structured interviews |
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Definition
Kappa: >.7 = good
.5-.7=fair
<.5=poor
SCID=most of Axis 1 in fair to good range but differed a lot between sites (Williams, 1992)
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Term
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Definition
Multi-axial system
- axis I: mental illness
- axis I: stable metnal illness
- III: medical
- IV: psychosocial & environmental factors
- V: GAF
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Term
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Definition
40= highest if you have psychotic symptoms
20=highest if you have suicidal ideations
10=highest if suicidal |
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Term
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Definition
III (1980): homosexuality deleted
IV (1994): clinical significant criteria included for 1/2 of disorders
-empirically baed: 3 step review process
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Term
Personality diagnositc system |
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Definition
Hierarchical bc they are somewhat stable
[image]
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Term
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Definition
-individual cognitive, affective and other genetic characteristics that contribute to a relatively stable set of behaviors
-thought to occur through social learning, genetics, and environmental factors |
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Term
Defense mechanism- hierarchical example |
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Definition
- Adaptive Coping Strategies: Level 4
- ways of dealing w/ stress, satisfactory to self & others
- Neurotic Coping Strategies: Level 3
- manipulate emotive & cog processes w/in the ind, when used chronically not adaptive
- Immature or Borderline Coping Strategies: Level 2
- manipulate cog and emotive processes b/ individuals instead of wihin an ind
- Psychotic Coping Strategies: Level 1
- distortion of reality to cope
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Term
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Definition
Hierarchical defense mechanisms
Adaptive Coping strategies
- Altruism
-sublination: indirect expression of instincts w/out adverse consequences or displeasure
-suppression: temporary loss of painful emotion
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Term
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Definition
hierarchical defense mechanisms
Neurotic Coping Strategies
-repression: awareness lost but emotion retained
-intellectualization: awareness retained but emotion lost
-dissociation: both awareness and emotion lost
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Term
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Definition
hierarchical defense mechanism
immature or borderline coping strategies
-projection: external attribution of internal psych processes
-passive aggression: implicit aggression w/ intent of changing others behavior
-acting out: instinctive expression (toward another) to avoid awareness of cog or emotive process |
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Term
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Definition
Hierarchical defense mechanism
Psychotic coping strategies
-Projection: external attribution of internal psych processes and out of touch with reality
-denial: frank rejection of reality |
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Term
evaluating defense mechanisms |
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Definition
-hierarchical defense mechanisms in the DSM-IV
-followed really successful adults and assessed defense mechanism levels
-DSM-IV was decently reliable
-if clinicians are given disorders and told to sort and resort them you come up w/ an outline of where disorders fit from broad to more narrow (hierarchical) |
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Term
Other hierarchical diagnostic system
(not defense mechanisms) |
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Definition
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Term
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Definition
Dimensional approach
- Neuroticism: enduring tendency to have neg emotions
- extraversion: end tend to have positive emotions, especially w/ social relations
- opennesses to experience: end tend to show creativity and ingenuity
- agreeableness: end tend to be pleasent and accommodating in social situations
- conscientiousness: end tend to act w/ ones conscience
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Term
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Definition
-FFM more reliable but validity worked into DSM bc of impairment criteria
But.. FFM is valid in that it converges w/ DSM
-psychometric methods can be used to assess FFM but not w/ DSM |
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Term
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Definition
Genotype:molecular level, genetics Phenotype: physical characteristics reflecting genotype & environment (can see w/ naked eye)subtle stable phenotypes that directly reflect the genotype (boimarkers, vulnerability markers, intermediate phenotypes) e.g. cog ability, facial asymetry, eye tracking Mutations: changes to DNA sequence from radiation, UV light, chemicals, viruses, or copy errors Epigenetics: Basic DNA sequence stays the same but changes in how genes are expressed Endophenotype: |
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Term
Identifying the endophenotypes |
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Definition
1. associated w/ illness 2. heritable 3. stable trait, present regardless of if symptoms are present 4. within families, illness & endophenotypes co-occur 5. found in unaffected biological family members (e.g. mem impairment in mono twins of schizo even if twin doesn't have schizo) |
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Term
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Definition
-Peak means categorical, flast means dimensional |
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Term
Taxometric graph properties |
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Definition
Y axis is variability of a characteristic and X axis is another characteristic (both indicators of the same group)
Peak in the middle means more variability here because people from both groups are present, flat ends because it is all one group or the other |
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Term
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Definition
Taxometric approach take 1 indicator, stratify it, and calculate the covariant w/ the other 2 measures as a function of the first measure |
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Term
Taxometric important terms |
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Definition
Fallible indicators: tangible measures of whatever you are trying to figure out is categorical/dimensional Latent structure: dimensional vs. categorical taxonic: aka categorical taxon rate: estimate of the group membership |
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Term
Ways to estimate taxometrics |
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Definition
Mean Above Minus Below A Cut (MAMBAC): 2 dimensional indicator
Maximum Covariance (MAXCOV): 3 dimensional indicators Maximum Eigenvalue (MaxEig): 3 dimensional indicators
1 scale you can do factor analysis and use subscales as diff indicators |
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Term
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Definition
Paul Meehl -determine if schizophrenia is a discrete entity or a dimensional quality within a population |
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Term
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Definition
Study of what is upon people -correlations between variables in large samples |
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Term
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Definition
Incidence: # of new cases in a defined period of time Point Prevalence: # of cases at as specific moment Period Prevalence: # of cases during a defined period of time Relative Risk: prob of an event occurring in one group compared to probability of it occurring in another group Odds Ratio: odds of en event occurring in one group compared to odds of it occurring in another group |
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Term
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Definition
Rr=(# in group1 with disease/total # in group1) / (# in group2 with disease/total# in group 2)
e.g. 200 smokers, 50 have cancer: 200 nonsmokers, 10 get cancer Rr= (50/200)/(10/200)=.25/.05=5 |
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Term
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Definition
Rr is 5 times that of developing cancer if you are a smoker (easier to understand) |
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Term
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Definition
Or=(# in group1 with disease/# in grp1 without disease)/(# in grp2 with disease/# in grp2 without disease)
e.g. 200 smokers, 50 cancer: 200non, 10 cancer Or=(50/150)/(10/190)=6.6 |
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Term
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Definition
You are 6.6 times more likely to develop cancer if you are a smoker compared to a nonsmoker (better mathetmatically) |
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Term
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Definition
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Term
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Definition
Financial (direct: cost associated w/ tx or basic needs that can’t be met, Indirect: loss of productivity) Mortality: deaths associated w/ a specific cause in a defined period of time per 1,000 Morbidity: incidence or prevalence rates
Disability adjusted life years = (years of life lost + years lived in disability)/total years |
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Term
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Definition
Measure of the strength of a relationship between variables -descriptive, no inferential (does not increase with n)
Cohen’s = (M1-M2)/Pooled SDs |
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Term
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Definition
Negligible = 0-.19 Small = .2-.49 Medium = .5-.79 Large = .8* |
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Term
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Definition
Negligible = 0-.09 Small = .1-.29 Medium = .3-.49 Large = .5* |
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Term
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Definition
ECA: epidemiology LCS: comorbidity CATIE: schizophrenia |
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Term
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Definition
ECA: Epidemiological Catchments Area Study NIMH funded
Gave Diagnostic Interview Schedule for the DSM-III to lots of people across multiple cites (1 year apart) -lots of stuff written based on this data |
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Term
Lifetime prevalence of MI |
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Definition
ECA found w/in 1 year over 33% of general population met diagnostic criteria for some disorder |
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Term
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Definition
NCS: national comorbidity survey NIMH funded Composite international diagnostic interview administered twice (1 year apart) Prevelance study
Found 50% lifetime prevalence and 30% year long period prevalence |
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Term
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Definition
NCSR: replicated using structured clinical interview for DSM-IV Any disorder occurred about 50% (lifetime) 2 or more comorbid 28% 3 or more comorbid 17% |
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Term
Treatment of MI across time |
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Definition
Trend of increases in treatment Still not enough, especially w/ severe MI |
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Term
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Definition
World Health Organization Started in 1948 in Geneva as part of NATO
Mission: “attainment by all peoples of the highest possible level of health” -each year focus on one area of interest and do comprehensive R in that area (2001=mental health) |
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Term
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Definition
Global Burden of Disease Study WHO: first worldwide epidemiological project DALY statistic formulated from world wide data Study is completed annually |
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Term
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Definition
Disability adjusted life years One DALY = one year of life lost or life disabled Weighted towards mid adult (most productive years) |
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Term
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Definition
European Study on the Epidemiology of Mental Disorders -CIDI interviews to a lot of people in 8 countries (U.S. had highest prevalence of any disorder and only about 50% were getting treatment)
YLD=years of healthy life lost to disability |
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Term
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Definition
-epidemiological methods are relatively well-established -challenges involve data procurement, which has improved w/ globalization, improved population racking & tech advances -MI is quite common -MI is quite costly to societies -TX is underutilized, especially by those who need it most |
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Term
Behavioral Genetics- Family Study |
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Definition
2 groups -ill probands (person w/ illness)/family -control proband/family
Procedure: determine % of family who develop illness analysis: compare rates of illness between 2 groups |
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Term
Behavioral Genetics- Adoption studies |
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Definition
2 groups: -probands from ill relatives raised by adopted family -probands from ill relatives raised by biological family Procedure: determine % of proband who develop illness Analysis: compare rates of proband illness, higher illness rates in bio group supports genetic omponent |
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Term
Behavioral Genetics - Twin studies |
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Definition
Concordance (twins w/ at least 1 afflicted relative)
Pairwise: # of twins that are both ill/total twins |
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Term
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Definition
A+C+E=1 provides contribution of genetics, common and unique environment |
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Term
Calculating genetic contribution |
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Definition
A or h2: additive genetics = 2*(rmz-rdz) C: common environment = rmz-A D: unique environment = 1-rmz |
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Term
Methods in molecular genetics |
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Definition
Forward genetics: identify "mutant" or abnormal genes and liking them to endophenotypes of phenotypes (linkage studies)
Reverse genetics: inducing "knockout gene"-deletion of a specific gene and linking them to endophenotypes and phenotypes (animal analogue studies) |
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Term
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Definition
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Term
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Definition
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Term
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Definition
autonomic muscle, sensory & REM |
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Term
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Definition
getting ready for action (amphetamine) |
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Term
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Definition
involuntary motor activity, reward |
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Term
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Definition
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Term
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Definition
pain reduction & pleasure |
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Term
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Definition
1. production in dendrites 2. transmitter release 3. number of receptors 4. reuptake 5. processing of used transmitter 6. neuromodulators |
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Term
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Definition
Hindbrain: cerebellum, pons, medulla oblongata midbrain:relays, substantia nigra, basal ganglia forebrain: thalamus hypothalamus, limbic, cerebrum |
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Term
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Definition
Hippocampus: consolidation of memories parahippocampal gyrus: spatial mem dentate gyrus: new memories Amygdala: emotion, memory, arousal hypothalamus: four Fs Septa nuclei: reward Nucleus accumbens: reward, pleasure, addiction |
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Term
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Definition
Cingulate cortex: bridges limbic & cortex (awareness, conflict monitoring, comparing internal/external stimuli) Temporal: auditory processing center Posterior: sensory info, spatial Occipital: visual processing Frontal: higher order cognition, planning |
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Term
Anterior vs. posterior cingulate cortex |
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Definition
anterior: error and conflict monitoring, effortful decision making
posterior: episodic mem retrieval, evaluating outcomes |
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Term
dorsolateral vs orbitofrontal |
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Definition
dorsolateral: motor planning, organization & regulation, WM
orbitofrontal: affective value of reinforcers, decision making, expectancy, planning to reward and punishment |
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Term
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Definition
Event Related potentials: responses to an external or internal stimuli EEG (oddball paradigm- response to unpredictable stimuli) |
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Term
Waves of interest to psychopathology |
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Definition
P300-parietal region occurring 300ms after stimulus onset- implicit info processing
N400-semantic integration, mag increases w/ more effort
P50-responds to second of identical stimuli, sensory gating |
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Term
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Definition
differential activation of R vs L cortical regions
R frontal cortical: avoidance bx, negative affect L: approach bx, extroversion, pos affect |
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Term
Single Photon emission computer tomography |
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Definition
3-d images of metabolism using exogenous radio-isotopes |
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Term
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Definition
blood floow good spatial, bad temporal |
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Term
Function Near Infra Red (fNIR) |
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Definition
similar to fMRI, poorer resolution, better portability |
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Term
peripheral NS measurement |
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Definition
Cardiovascular activity pupilometrics: increased mental effort/awareness galvanic skin conductance startle response |
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Term
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Definition
strength of reaction to unexpected stimuli
Information processing: prepulse inhibition, warning stimuli to inhibit response to following response)
Affective modulation of startle response: magnitude of response is modified by affective state (scared easily when relaxed) |
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Term
Problem w/ multiple measurement |
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Definition
Chapman & Chapman, 1973 0saying grps differ on one measure but not another suggests differnetial deficit is not always true -the difference could be due to the sensitivity of tests |
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Term
higher-order cognitive processes |
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Definition
Social Cognition:encoding, retrieval, processing, motivated bx related to same species interaction
schematic organization:association of concepts w/in LTM that forms beliefs
Meta-cognition: insight, self-awareness of ones own cognitions |
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Term
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Definition
Higher-order cog processes
-fundamental attribution: state explains self, trait explains others -optimism bias -self-serving bias: claim responsibility for success -just world bias -hindsight bias -confirmation bias -rosy retrospection |
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Term
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Definition
Higher-order cog process
Awareness regarding one's mental illness, need for tx, consequences of bx |
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Term
measurement of implicit attitudes |
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Definition
Subjective-based interviewer-based behaviora: objective assessments
methods adopted from cog sciences (e.g. implicit attitudes test) |
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