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MEMBRANE STRUCTURE AND FUNCTION
BIO 311C
34
Biology
Undergraduate 1
05/11/2013

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Term
Fluid Mosaic Model
Definition

fluid = lipids

mosaic = large diversity of proteins

Term
Membrane Fluidity
Definition

Depends on temperature: increase T -> increase fluidity

 

Depends on lipid composition: 

increase cholesterol -> decrease fluidity

increase Cis C=C -> increase fluidity

increase length of FA -> decrease fluidity

Term
Lateral Movement
Definition
constantly bobbing from left to right
Term
Flip-flop movement
Definition
flip from one layer of phospholipid bilayer to another, rare
Term
Membrane Proteins
Definition

Diverse Functions: transport, enzymatic activity, communication, cell-cell recognition, attachment

 

Two classes: integral membrane proteins, peripheral membrane proteins

Term
Integral Membrane Proteins
Definition
Integrated into membrane, can be transmembrane
Term
Transmembrane Proteins
Definition
integral proteins that reach all the way across a membrane
Term
Peripheral Membrane Proteins
Definition
outside surface of membrane, not embedded, loosely bound to surface
Term
Membrane Carbohydrates
Definition

short, branched chains of sugars attached to lipids or proteins

 

Consist of: glycolipids, glycoproteins

 

Function: cell-cell recognition

 

only found in PM, always on outside of the cell, sugars are pointing out

Term
Membrane Sidedness
Definition
Distinct inside and outside faces: cytosolic or extracellular
Term
Membrane Functions
Definition
cell communication, cell recognition, cell adhesion, metabolic functions, regulation of movement in/out
Term
Membrane Permeability
Definition
selectively permeable due to structure, traffic across membrane depends on the lipid bilayer and transport proteins
Term
Lipid Bilayer
Definition

2 layers of phospholipids with hydrophobic core 

 

allow nonpolar substances to pass through cell

Term
Transport Proteins
Definition
polar adn charged ions adn molecules
Term
Carrier Proteins
Definition
transport molecules by changing shape
Term
Channel Proteins
Definition
hollow tube that transports molecules
Term
Passive Transport
Definition

diffusion of a substance across a membrane with no energy investment

 

exergonic

 

move down the gradient

Term
Diffusion
Definition

passive transport

 

the tendency of a substance to move down its gradient form more concentrated to less concentrated

Term
Simple Diffusion
Definition
unaided diffusion through the phospholipid bilayer, no transport proteins involved
Term
Facilitated Diffusion
Definition

speed up movement of hydrophilic molecules across membranes, require transport proteins

 

how we move charged and polar substances

Term
Osmosis
Definition

diffusion of water across a selectively permeable membrane

 

diffuses from low solute concentration to high concentration

Term
Water Balance of Cells
Definition
water movement important for cell structure and funciton
Term
Tonicity
Definition
the ability of a surrounding solution to cause a cell to gain or lose water
Term
Isotonic
Definition
solute and solvent are equally distributed
Term
Hypotonic
Definition

solution that has more solute than solvent

 

Ex) more salt than water

Term
Hypertonic
Definition

more solvent than solute

 

Ex) more water than salt

Term
Active Transport
Definition

use energy to move up the gradient

 

requires carrier proteins

 

 

Term
Primary Active Transport
Definition

Direct

 

ATP is direct energy source

 

use ion pumps

Term

Ion Pumps

 

Definition

Na-K and H pumps

 

contribute to membrane potential, voltage difference across a memrane

Term
Electrochemical Gradient
Definition
spatial variation of both electrical potential and chemical concentration across a membrane
Term
Secondary Active Transport
Definition

Indirect or co-transport

 

gradient is direct energy source

 

couples the diffusion of one substance to the active transport of another substance

Term
Bulk Transport
Definition
transport of large molecules or many molecules across membranes via vesicle formation and fusion
Term
Exocytosis
Definition
release of molecules out of the cell by the fusion of vesicles with the plasma membrane
Term
Endocytosis
Definition
the uptake of molecules by the formation of intracellular vesicles form the plasma membrane
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