Term
| group of closely related basic cyclic nonpeptides with hydrophobic tails (dertergents) |
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Definition
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Term
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Definition
| restricted to gram negative bacteria (cannot penetrate cell wall of gram positive bacteria) |
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Term
| Types of peptide antibiotics from Bacillus brevis |
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Definition
| Linear gramidicins, Gramicidin S |
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Term
| inserts into membrane bilayer as tail to tail dimmers forming ion channel; nonspecific conductance of monovalent cations |
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Definition
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Term
| cyclodecapeptide; exact mechanism of membrane disruption unknown |
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Definition
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Term
| causes hemolytic anemia at therapeutic concentrations, not used systemically, topical use in combination |
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Definition
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Term
| matrix for facilitated diffusion and active transport |
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Definition
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Term
| generally poor because we have similarities with bacterial cell membranes so systemic SE are expansive |
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Definition
| selectivity of membrane-altering antibiotics |
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Term
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Definition
| barrier between cytosol and extracellular space |
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Term
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Definition
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Term
| Polymyxin molecule under physiologic conditions |
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Definition
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Term
| Polymyxins insertion into membrane bilayer |
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Definition
| creates gaps; bactericidal due to cell lysis even in hypertonic media, also adsorb released LPS |
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Term
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Definition
| renally excreted and nephrotoxic, neurotoxicity; almost never used systemically |
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Term
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Definition
| excellent for surface decontamination, many topical applications, parenteral use recently advocated as last resort in MDR gram negative bacteremia |
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Term
| native mixture consisting 80% of gramicidin A |
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Definition
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