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Medicinal Chemistry Exam 1
UFCOP
39
Medical
Graduate
09/04/2008
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Term
[image]
 Definition
pKa = 3-5
Term
[image]
 Definition
Alkane
Term
[image]
 Definition
Alkene
Term
[image]
 Definition
Alkyne
Term
[image]
 Definition
Amide
Term
[image]
 Definition
Aryl
Term
[image]
 Definition
Carbamate
Term
[image]
 Definition
Carbonate
Term
[image]
 Definition
Carboxylic Acid
Term
[image]
 Definition
Ester
Term
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 Definition
Imide
Term
[image]
 Definition
Phenol
Term
[image]
 Definition
Phosphate
Term
[image]
 Definition
Phosphoramide
Term
Write out the equation for determining pH given the pKa and concentrations of ionic and protonated species.
 Definition
[image]
Term
[image]
 Definition
Sulfonamide
Term
[image]
 Definition
Thiophenol
Term
[image]
 Definition
Urea
Term
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 Definition

Vinylogous Carboxylic Acid

 

-Defined by the double bond one carbon away from carbonyl group.

Term
[image]
 Definition

1) Basic pKa -1.6

 

2) Acidic pKa 15.7

Term

What is pKa?

[image]

 Definition
Acidic pKa -1
Term

What is the pKa?

[image]

 Definition

Acidic pKa 8-10

 

Weak Acid

Term

What is the pKa?

[image]

 Definition

Acidic pKa 8-10

 

Weak Acid

Term

What is the pKa?

[image]

 Definition

Acidic pKa 8-10

 

Weak Acid

Term

What is the pka?

[image]

 Definition

Acidic pKa 12

 

Weak Acid

Term

What is the pKa?

[image]

 Definition

Acidic pKa 16

 

Neutral

Term

What is the pKa?

[image]

 Definition

Acidic pKa 41

 

Neutral

Term

What is the pKa?

[image]

 Definition
Acidic pKa 50
Term

What is the pKa?

[image]

 Definition

Acidic pKa 15-17

 

Neutral

Term
What are the 6 factors that various functional groups change?
 Definition
1) Solubility
2) Absorption
3) Distribution
4) Binding to Receptors
5) Metabolism
6) Excretion
Term
Going from:
Neutral -> Negative Charge is?

Positive -> Neutral is?
 Definition
Neutral -> Negative (acid)

Positive -> Neutral (base)
Term
In the pH formula what value within the log function goes on top?
 Definition
The deprotonated function. Therefore if the reaction was RNH2 -> RNH3+ then [RNH2] goes on top.
Term
[image]
 Definition
Acidic pKa 40
Term
[image]
 Definition
Basic pKa 3-5
Term
[image]
 Definition
Basic pKa -1
Term
[image]
 Definition
Basic pKa 8-10
Term
[image]
 Definition
Basic pKa -2
Term
[image]
 Definition
Basic pKa -6
Term
[image]
 Definition
Basic pKa -6
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