Term
|
Definition
long term use in RA
use of multiple concurrent NSAIDs in high doses should be avoided |
|
|
Term
|
Definition
optimal approach is controversial
intra-articular injection
low-dose long-term Prednisone with DMARDs
high dose for vasculitis and other serious extra-articular manifestations
abrupt discontinuation dangerous, can cause acute adrenal insufficiency |
|
|
Term
|
Definition
used for RA and other forms of severe chronic arthritis and systemic rheumatic disease
potential for serious toxicity and require regular monitoring
anti-malarials and tetracyclines are least toxic and alkylating agents most toxic |
|
|
Term
|
Definition
anti-malarial
ocular toxicity, rash, GI, hymolytic anemia and neuromyopathy |
|
|
Term
|
Definition
| indigestion, headache, rash, hepatitis, neutropenia |
|
|
Term
|
Definition
folic acid antagonist
rapid flare after withdrawal
CI - renal impairment, pregnancy, alcohol, liver disease |
|
|
Term
|
Definition
GI intolerance, alopecia, hepatitis, infection
CI - pregnancy |
|
|
Term
|
Definition
binds TNF with high affinity
induces neutralizing human antichimeric antibodies
requires use of MTX to maintain efficacy |
|
|
Term
|
Definition
recombinant soluble TNF receptor, binds TNF with high specificity and affinity
does NOT promote neutralizing antibodies
also binds LT-alpha |
|
|
Term
|
Definition
HACA response
impairment of host defenses, can lead to infection (esp histoplasmosis and tuberculosis) and malignancy
CI - SLE, MS |
|
|
Term
| Biologics and Kinase Inhibitors |
|
Definition
anti-CD20 (Rituximab) acts on B cells
CTLA-4-Ig (Abatacept) acts on T cell co-stimulation through CD28
anti-IL-6R (Tocilizumab) acts on IL-6
tofacitinib acts on Jak kinases |
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|
