Shared Flashcard Set

Details

Medical Terminology
n/a
20
Pharmacology
Graduate
01/19/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Synergistic drug interaction
Definition
Occurs when two drugs result in an increased effect more than just the addition of both
Term
Pharmacodynamic drug interaction
Definition
Drugs that interact at a common receptor site or that have additive or inhibitory effectors due to actions at different sites in an organ
Term
Drug-drug interaction
Definition
Whenever one drug affects the pharmacokinetics, pharmacodynamics, efficacy, or toxicity of another drug
Term
Poor metabolizer
Definition
A person who metabolizes a certain drug–the rate of which is related to the metabolizing cytochrome P-450 enzyme–slower than others
Term
Object drug
Definition
The drug affected by the drug interaction
Term
Precipitant drug
Definition
The drug causing the drug interaction
Term
Antagonistic drug interaction
Definition
Occurs when one drug lessens the effects of another
Term
Cytochrome P450
Definition
Refers to a set of enzymes that metabolize numerous substrates via oxidation (Phase I reaction)
Term
Pharmacokinetic drug interaction
Definition
Occurs when one drug alters the rate or extent of absorption, distribution, metabolism, or excretion of another drug; the result may be and increase or decrease in concentration of drug at the site of action
Term
Cytochrome P450 inducer
Definition
An inducer increases the metabolism of a substrate resulting in a decreased level or effect of the substrate
Term
Pharmacogenetics
Definition
Study of genetic cause of individual variations in drug response
Term
Pharmacogenomics
Definition
…more broadly involves genome-wide analysis of the genetic determinant of drug efficacy and toxicity; includes the use of genomic technologies
Term
Mutation
Definition
A variation in DNA sequence present in <1% of the population
Term
Genetic polymorphism
Definition
A variation in DNA sequence present in ≥ 1% of the population
Term
SNP
Definition
A single nucleotide polymorphism
Term
Synonymous SNP
Definition
Occurs when a nucleotide change occurs yet the resultant amino acid is unchanged
Term
Non synonymous SNP
Definition
Occurs when a nucleotide change occurs and there is a resultant amino acid change which can affect to efficacy and/or toxicity of a drug
Term
Allele
Definition
One of the variant forma of a gene at a particular location on a chromosome
Term
Genotype
Definition
The two alleles that any individual has
Term
Phenotype
Definition
The clinical presentation of an individual with a particular genotype
Supporting users have an ad free experience!