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med surge 1, exam 3
Cardiac
115
Organic Chemistry
Undergraduate 3
11/05/2011

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Term
Blood pressure =
Definition
Cardiac output x peripheral resistance
Term
Cardiac output =
Definition
Heart rate x stroke volume
Term
Normal, prehypertention, stage 1, stage 2
Definition
N: <120/<80, pre: 120-139/80-90, stage 1: 140-159/ 90-99, stage 2: >160/>100
Term
Primary HTN (aka essential)
Definition
no known cause associated risk, over age of 60, family hx obesity, innactivity hyper lipid, aa, smoking, stress.
Term
Secondary HTN
Definition
associated with kidney disease, adrenal gland, steroids, estrogen, brain tumors
Term
Complications of HTN
Definition
CVD, PVD, Renal Disease.
Term
HTN treatment rule of 3's MDBP
Definition
3: months, drugs, behaviors, partners.
Term
Use multiple drugs to treat HTN if:
Definition
AA, BP 20/10 above the goal, Standing BP above the goal in pt over 65, not at goal after 3 months.
Term
Thiazide diuretic, name, action
Definition
Hydroclorothiazide, Prevent sodium and water re- absorption in the kidney, K waster.
Term
Loop name/action
Definition
Lasix, decrease NA re-absorbtion,K wasting.
Term
Potassium sparing Diuretic name/ action
Definition
Sprironolactone, Retain K, not as potent.
Term
S/S of decreased K?
Definition
Weak, cramping, palpitations, N/V, Constipation, polydypsea, polyurea, LOC changes.
Term
Hyperkalemia s/s
Definition
bradycardia, ecg changes, weakness, tingling, paralysis.
Term
Action of ace, end in?
Definition
blosck conversion of angio 1 to angio 2, angio 2 is a vasoconstrictor, leads to vasodilation. PRILS.
Term
ADRs, testing, teaching ace?
Definition
Check electrolytes, BUN and Creatinine before and 1 week after starting. Cough, HypoTN, Hyper K, and acute renal failure.
Term
Arbs stand for, names?
Definition
Angiotension 2 recpetor blockers, Hozar and losartin.
Term
Calcium channel blockers name and action
Definition
Cardizem, Kalim, block calcium channels, peripheral vasodilation.
Term
Ace ADR
Definition
HyperKalemia, cough, hypotention.
Term
Monitor in Ace
Definition
Monitor lites and liver/kidney (creatinine)
Term
Calcium channel blockers teaching
Definition
Avoid with Grapefruit juice.
Term
tekturna
Definition
renin inhibitor for lowering BP.
Term
centrally acting drugs for HTN
Definition
Catapress
Term
nitrates
Definition
indure, minipress, isobid, nirtopress, nitropresside.
Term
Stable plaques
Definition
Cholestoral core
Term
Unstable plaques
Definition
fatty core, break off
Term
before cholestrol test
Definition
npo 8-10 hrs
Term
Total chol under
Definition
200
Term
statins do what to ldl and hdl
Definition
lovers ldl nothing for hdl
Term
high trig you can add what?
Definition
nicotinic acids: fibrinic acid or niacin
Term
Zetia
Definition
combo drug, inhibits cholesterol in the intestines.
Term
adrs of statins
Definition
muscle cramos, abd discomfort, liver injury
Term
nicotinic acids adr
Definition
eat with food, puritis, flushing, gout
Term
contractily
Definition
depends on movement of electrolites, ability of the heart to contract
Term
automatisity
Definition
ability to spontaneously depolerize
Term
excitability
Definition
ability of cell to depolarize, respond to stimuli
Term
conductivity
Definition
ability to transfer energy from one cell to another
Term
refractory
Definition
cell resting
Term
Ejection fraction
Definition
amount of blood pump out at end of diastole. usually around 50%
Term
marker dependent on preload
Definition
BNP, released by ventricals with increased filling pressure.
Term
what can BNP be used to distinguish
Definition
lung vs heart problems
Term
BNP moderate and severe
Definition
50 mod, 100 severe
Term
decrease afterload
Definition
vaso dialate
Term
homocytine
Definition
protien from animal products
Term
Stroke volume
Definition
amount of blood ejected by the left ventricle on each contraction.
Term
Pulse pressure
Definition
difference between systolic and diastolic, should be 30-40
Term
PR interval prolonged means what? What could cause
Definition
Impluse took longer to get from Sa to Av, electolyte imbalance (hypoK, hypocalc?) drugs
Term
Isoelectic
Definition
waves look the same
Term
PR time normal
Definition
.12-.2 seconds
Term
QRS time normal
Definition
less than .12, greater than 4
Term
QT interval normal?
Definition
.32-.40
Term
Little blocks on ecg worth how much time
Definition
.04
Term
Big blocks on ECG worth how much time
Definition
.20 sec
Term
Normal (sa node) hr
Definition
60-100
Term
PR interval should be
Definition
0.12 < PR < 0.20
before the QRS, regular and go up not down (on lead 2)
Term
Class IA
Definition
Moderately slow conduction, prolong repolarization, prolong QT interval
slows heart rate. Pronestyl, quinadine
Term
class 1a drugs are for what?
Definition
pvc and atrial tachy/flutter/fib
Term
Class 1B:
Definition
Shorten repolarization
Lidocaine!
Term
class 1b for what? ADRs
Definition
pvc’s vtac vfib, CNS confusion, slurring, fine line between therapudic or toxic
Term
Class 1C drugs, for what?
Definition
vtac vfib pvc tamba core- blocks, bradycardai, makes heart failure worse
Term
Class II Drugs, does what, examples, adrs
Definition
Control dysrhythmias associated with increased rates by decreasing heart rate and conduction velocity, beta blockers. Olols! Bradycarida, broncho spasm and insomnia.
Term
Class III Drugs, action, drug, adrs
Definition
: Lengthen the absolute refractory period and prolong repolarization, Ameoderon (DA ONE) tacy dysrhythmias. Hpot, brady, makes some dysrethmias worse, liver tox, photo sensitivities
Term
Class IV Drugs, adrs,
Definition
Calcium channel blockers which decrease the action of the SA and AV nodes, , diltiazem varapamil, brady, hpot, worse heart failure, cause blocks.
Term
other drugs for heart ryhthm issues
Definition
Digoxin
Atropine
Term
Atropine affects hr how?
Definition
increases heart rate
Term
Digoxin, what's it do, adrs, s/s of tox
Definition
decreased hr, increases force of contraction. Controls rate of resp. for atrial fib and flutter. Narrow safe dosage range, look it up and look at the s/s of over. Action is potentiated in hypokalemia
Term
dig toxisity S/s
Definition
Changes in LOC, palpitations, vision changes, edema, increased urine output
Term
Vagal manuver?
Definition
Bare down, stimulate Av and SA nodes
Term
Cardio version (use for)
Definition
synchronized with pt own heart rate. Rebooting compy. Vtach with a pulse
Term
Defibrillation how it works, when use
Definition
not synchronized, pulseless
Term
Sinus Dysrhythmia
Definition
The sinus node remains the pacemaker of the heart but there is an increase or decrease in the rate outside of the normal ranges
Term
Sinus Tachycardia
Definition
Stimulation of the sympathetic nervous system or inhibition of the parasympathetic secondary to activity, pain, drugs, fever….
Term
Sinus Bradycardia
Definition
Stimulation of parasympathetic or vagal stimulation, MI, drugs, exercise
Term
Premature Atrial Complexes, causes?
Definition
Irritable atrial tissue allows something other than the SA node to become the pacemaker
Shape is different, occurs early, can be hidden, stress, anxiety, caffeine, nicotine, usually asymptomatic. No treatment needed unless secondary to heart failure.
Term
Atrial Flutter looks like? caused by?
Definition
Rapid atrial depolarization at 250-400/minute (lots of “P” waves)
, saw tooth, Valve, hyper thyroid, paracardidits
Term
Atrial Fibrillation, looks like, caused by?
Definition
Rapid atrial impulses from multiple sources at a rate of 350-600/minute (no distinct “P” waves), , thromi, cardio myopathy
Term
Premature Ventricular Complex looks like? Cause
Definition
Irritable ventricular cells, assume the role of pacemaker. Can be unifocal or multifocal
Depolarization occurs in a less efficient manner QRS complex is wider, different in appearance, and early
caffine, age, ischemia, electrolytes
Term
Ventricular Tachycardia, looks like?
Definition
Irritable venticular cells firing at 140-180/minute
May be intermittent or sustained, may produce a pulse or be pulseless
Patient may be stable or compromised
Term
Ventricular Fibrillation
Definition
Chaos in the ventricles with multiple irritable foci. Can be “coarse” or “fine” but no identifiable wave forms
No actual ventricular contraction therefore no cardiac output, no pulse, fatal if untreated
Term
Nitrates dilate venous or arterial
Definition
cornerstone of treatment, dilates the venous system, higher dose dilates the arteries
Term
Labs of MI
Definition
Troponin T and I, CK-MB, Myoglobin, D-Dimer
Term
Troponin T and I
Definition
myocardial muscle enzyme, indicates damage to cardiac muscle. Can see and detect in 3-4 hours, peaks in 24 hours and last 1-3 weeks.
Term
CK-MB
Definition
Predictable course over three days
Peaks 24 hours after chest pain
Two subforms increase sensitivity of diagnostic tests
detect 4-8 hours after
Term
Myoglobin
Definition
Earliest marker with rapid decline, 1-3 hours lasts 24
Term
D-dimer
Definition
- end product of thrombis formation and break down. Good to Dx risk, unstable plaque, CAD
Term
ECG CHANGES IN Myocardial Infarct
Definition
ST segment elevation: Temporary (returns to normal in 1-6 weeks)
T wave inversion: Temporary(1-2 weeks)
Abnormal Q wave: Permanent(wider than .04 greater than 1/3 the height of the qrs. Happens within 3 weeks of MI)
Term
ECG changes in angina
Definition
Normal unless during anginal episode
Variations (changes in ST or T wave conversion
Term
Electron Beam Computed Tomography
Definition
detects calcium in the coronary arteries- dx for aterosclerosis.
Term
Stress Test
Definition
Exercise Tolerance v Pharmacological Stress
- dx, then see how the interventions have worked. Avoid Smoking, ETOH, and maybe cardiac meds on the day of test. Treadmill, bike, walk increase speed and resistance until up to the max desired HR, or until you get problems.
In people who are less mobile- they can get a medication induced stress test, dabutamine or adenosine.
After monitor till normal or admit you.
Term
Myocardial Perfusion Imaging
Definition
Thallium scan
- radio isotope injected, uptake by cardiac muscle, areas that don’t show uptake indicate ischemia or cell death. In combo with stress test, or before or after they do a stent.
Term
Pain management for MI
Definition
Nitroglycerine
Morphine
Aspirin
Term
Perfusion drugs
Definition
Fibrinolytics
Glycoprotein IIb/IIIa Inhibitors
Aspirin
Heparin
Term
Fibrinolytics, drugs, when give, don't give to?
Definition
target the fibrin compontent- tpa, rediplace. Have to be given within 6 hours of symprtoms. Contraindicated in recent major urgery or trauma, having a hemorragic strok, known bleeding disorder, malignent hypertention, pregnant, closed head injuries.
Term
Surgical Procedures for mi?
Definition
Percutaneous Transluminal Coronary Angioplasty
Coronary Artery Bypass Grafting
Term
Phase one of cardiac rehab
Definition
from MI till discharge. Promote rest, ensure limited mobility, gradualy then ambulate up to 3 times a day
Term
Phase 2 cardiac rehab
Definition
two 4 weeks to 6 months after discharge at home, increasing mobiliy
Term
phase 3 cardiac rehab
Definition
after 6 months, maintaining walking and exercising
Term
Left sided heart failure
Definition
think about what is up and down stream, up- lungs (not getting enough to the lungs) pulmonary symptoms, decrease in cardiac output
Term
right sided hf
Definition
Edema, venous congestion. May not have pulmonary symptoms. Increase in central venous pressure.
Term
High Output Failure
Definition
cardiac output normal, but heart fails from increased demand. Like in sepsis
Term
S/s of left sided failure
Definition
cough, pulmonary edema pink frothy spewtum, base crackles moving up, noct. Dyp, and orthopnea
Term
S/s of right sided
Definition
decrease in CO loce, weakness, chest pain. Mostly upstream problems, edema, gi symp, N/V, liver failure, Jugular vine distention. Acites.
Term
Afterload reducing drugs
Definition
ACE inhibitors
ARBs
Human B-Type Natriuretics
Term
Preload Reducers
Definition
Diuretics
Venous vasodilators (nitrates)
Term
Contractility enhancers
Definition
Digitalis
Beta-adrenergic drugs
Term
3 things that influence the amount of damage
Definition
amount of anaerobic metabolism, collateral circulation, workload on the heart
Term
3 ECG changes after MI
Definition
inverted T wave (last 1-2 weeks) elevated ST interval (1-6 weeks) Q wave is 1/3 or over .4 the length of the QRS complex.
Term
Qt length
Definition
.32-.4
Term
Pt/inr
Definition
prothrombin time- measures values Coumadine 2-3x
Term
ptt
Definition
partial prothrombin time, heparin, 1.5-2 x
Term
Mitral Stenosis sounds symptoms
Definition
Left, then right, sided heart failure symptoms
Diastolic murmur at the apex
Term
Mitral Insufficiency or Regurgitation
, cause
Definition
Rheumatic heart disease primary cause
Back flow from the ventricle to the atria
Left, then right, sided failure
High pitched systolic murmur, possible S3
Term
Mitral Valve Prolapse
Definition
Often asymptomatic, common (5-10%)
Systolic click or murrmer
Term
Aortic Stenosis
Definition
Increase in afterload and left sided failure
CO becomes fixed and unable to meet demand
Harsh systolic crescendo/decrescendo murmur
Term
Aortic Regurgitation
Definition
Reflux from aorta to ventricle
Left sided failure develops
Decrescendo diasltolic murmur
Term
Dig theraputic levels
Definition
.5-.8
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