Term
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Definition
Glucocorticoid replacement; Weak Anti-inflammatory
Use: Replacement therapy for adrenal insufficiency
Other Drugs: Cortisone (Cortone) - converted to active hydrocortisone in the liver; 80% of effects of hydrocortisone |
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Term
| Fludrocortisone (generic) |
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Definition
Mineral corticoid replacement; Anti-inflammatory
Mechanism: Oral synthetic adrenocortical steroid (mineralcorticoid and glucocorticoid activity); similar to aldosterone
Use: glucocorticoid replacement therapity in adrenocortical insufficiency; salt losing adrenogenital syndrome |
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Term
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Definition
Anti-inflammatory
Mechanism: converted to prednisolone in liver to be active
High anti-inflammatory effects with minor salt retaining effects
Other drugs: Prednisolone (Delta-Cortef®)
Fluticasone (Flovent®, Flonase®)
Budesonide (Pulmicort®)
Clobetasol (Temovate®)
Clocortolone (Cloderm®)
Mometasone (Nasonex®)
Desonide (Desowen®)
Fluocinonide (Lidex®)
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Term
| Aminoglutethimide (Cytadren) |
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Definition
Glucocorticoid
Mechanism: inhibits conversion of cholesterol to pregnenolone, inhibiting all steroid synthesis
Use: Cushings syndrom; metastatic breast and prostate CA
Adverse: inhibits estrogen synth, and testosterone synthesis to a lesser degree |
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Term
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Definition
Glucocorticoid
Mechanism: inhibits 17a-hydroxylase, inhibit androgens and cortisol synth; eventually inhibits all steroid synthesis
Use: Cushings, most effective steroid biosynthesis in pts with cushings |
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Term
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Definition
Glucocorticoid
Mechanism: Relatively selective inhibitor of 11a-1-hydroxylase, the terminal enzyme in cortisol synthesis; sustains aldosterone functions;
Use: tests adrenal function and short term symptoms while determining cushing syndrome |
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Term
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Definition
Glucocorticoid
Mechanism: Adrenocorticolytic, causes selective atrophy of the zona fasciculata/reticularis of the adrenal gland; binds mitochondrial proteins and inhibits synthesis of corticosteoroids
use: Primary adrenal carcinoma; cushings |
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Term
| Mifepristone (RU 486, Mifeprix®) |
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Definition
Glucocorticoid
Mechanism: powerful antagonist of progesteron receptors and glucocorticoid receptors at higher doses
Use: induce abortion; inoperable pts with ectopic ACTH secretion or adrenal carcinoma who have failed to respond to other therapies |
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Term
| Spironolactone (Aldactone®) |
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Definition
Mineralcorticoid
Mechanism: K sparing diuretic, competes with aldosterone for binding sites
Use: HTN, hyperaldosteronism (primary), decrease hirsuism in women, treat ascites from cirrhosis |
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