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| [image]list all func groups! |
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Linezolid
purely synthetic
[oxazolidenone antibacterial] |
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| This pharmacophore represents what class of drugs[image] |
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| Penicillins & derivatives |
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name the functional groups on this drug?
WHat drug is this anyway?
[image] |
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This Pharmacophore represents which drug class?
[image] |
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Name this compound
[image] |
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| Ageliferin (marine sponge derivative) |
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Magnesium Bromide (MgBr) is used as what type of reagent?
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List in order of least to most reactive aka most to least stable
>>>
Amide, Aldehyde, Carboxylic Acid, Ester, Ketone |
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Definition
1.Carboxylic Acid
2. Amide
3. Ester
4. Ketone
5. Aldehyde |
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Which Compound is found in many drugs?(most stable)
A. Amide
B. Aldehyde
C. Carboxylic Acid
D. Ester
E.Ketone
F. All of them |
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Aromatic, Non-Aromatic, or ANti-Aromatic
[image] |
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Aromatic, Non-Aromatic, or ANti-Aromatic
[image] |
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| Aromatic, Non-Aromatic, or ANti-Aromatic[image] |
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Aromatic, Non-Aromatic, or ANti-Aromatic
[image] |
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Definition
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Aromatic, Non-Aromatic, or ANti-Aromatic
[image] |
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Definition
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Aromatic, Non-Aromatic, or ANti-Aromatic
[image] |
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Which of thes best describes Ciprofloxacins indication/function?
A. ANti-fungal
B. Anti-anginal
C. ANti-malarial
D. Anti-biotic
E. Anti-bacterial |
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Definition
E. Anti-bacterial
Anti bacterials are totally synthetic
Anti Biotics are nature derived |
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Name this compound
[image] |
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Definition
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Name this compound
[image] |
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Definition
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name this compound
[image] |
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Name this compound
[image] |
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This structure is the pharmacophore for 40% of antibiotics. It is termed________
[image] |
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Irreversible Inhibition is characterized by what types of bonds?
(ex: ionic,hydrogen bonds....etc) |
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The process by which a quinoline is converted to a quinolone is known as __________.
ex: [image] |
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Definition
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Name this functional group
[image] |
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Definition
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Name this functional group
[image] |
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Definition
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Name this functional group
[image] |
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Definition
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Name this functional group
[image] |
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Definition
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Name this functional group
[image] |
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Definition
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Name this functional group
[image] |
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Definition
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Name this functional group
[image] |
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Definition
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Name this functional group
[image] |
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Definition
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Name this functional group
[image] |
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Definition
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name this functional group
[image] |
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Definition
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Name this Functional Group
[image] |
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This image depicts a carbapenem.
[image]
They are produced by
A. Bacteria
B. Fungi
C. Humans
D. Fumigation |
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Definition
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Term
Amines that are part of a conjugated system or with an adjacent electron withdrawing group are often___hybridized?
A. sp
B. sp2
C. sp1
D. sp3 |
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Definition
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| Erythromycin demonstrates selective targeting for bacterial______ |
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Definition
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| Solubility, Absorption, Interaction with biological target, metabolism, excretion describe______properties of functional groups. |
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This drug is called ________.
It acts as a topoisomerase inhibitor.
[image] |
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Definition
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| Topotecan is a anticancer agent. It works as a ______________ inhibitor. |
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Definition
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Term
TRUE or FALSE.
Penicillins as well as statins come from fungi. |
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Definition
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Definition
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name this structure
[image] |
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Definition
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Name this structure
[image] |
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Definition
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| [image]Name this structure |
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Definition
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Term
Name this structure
[image] |
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Definition
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Term
Name this structure
[image] |
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Definition
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Name this structure
[image] |
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| Taxol is an anti cancer agent and targets____ |
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Definition
| Microtubules (freezes/stabilizes) |
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Term
| Quinine is an anti malaria agent and targets |
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Definition
Tat2p-mediated tryptophan transport and causes tryptophan starvation |
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Definition
| HMG COA reductase (inhibitors of this enzyme) |
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| Ciprofloxacin inhibits bacterial DNA synthesis and targets__________ |
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Definition
| topoisomerase II (responsible for supercoiling and uncoiling of DNA) |
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Largazole (depicted below) comes from cyanobacteria and targets_________
[image] |
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Definition
Histone Deacetyleases aka HDACs
(Largazole is a Histone Deacetylase Inhibitor) |
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| Sorafenib is a kidney cancer drug that targets_____ |
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Definition
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| Gefitinib(IRESSA) is a cancer drug that targets_______ |
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| Tipranavir treats multi drug resisitant HIV and targets______ |
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Definition
| HIV and CAAX Prenyl Proteases (protease inhibitor) |
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Cephalasporin C is depicted below and targets______
[image] |
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Definition
| Penicillin Binding Proteins PBPs(inhibits cell wall synthesis) |
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Definition
| Streptomycin (it is an aminoglycoside) |
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Definition
| Daptomycin (a lipopeptide antibiotic) |
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Name the functional group
[image] |
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Epothilone A
[anticancer] |
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Definition
| Camptothecin [anticancer] |
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Definition
Halfordinol
[anti-adipogenic activity, obesity] |
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Definition
ondansetron
[nausea from cancer tx] |
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Definition
Rivaroxaban (aka Xarelto)
[blood thinner, irregular heart beat] |
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Definition
Nexium (aka esomeprazole)
[ppi, tx for GERD]
Completely synthetic rx |
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Definition
AMIAS [hypertension, heart failure]
benzimidazole prodrug |
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Term
True or false
Carboxylic acids and Tetrazoles have similar acidities/pKa values |
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Definition
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Term
Replacement or modification of specific pharmacophoric (functional) groups with other groups with similar properties is_____________.
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Definition
Tripelennamine
[1st generation antihistamine,antipruritic] |
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Definition
Methaphenilene
[antihistamine, anticholinergic] |
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Definition
a-tocopherol (aka Vitamin E)
[orally enhances immune system,antioxidant, topically promotes skin health] |
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Definition
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Definition
Isoproterenol
[tx for bradycardia aka slow heart rate, heart block] |
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Definition
Soterenol
[bronchodilator] |
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Definition
Estradiol
[female hormone hormone replacement, menopause] |
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Term
Rx name (this is the trans- version, not cis-)
[image] |
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Definition
Diethylstilbestrol (trans)
{synthetic estrogen}
The trans and cis version are equipotent to estrogen |
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| Acidity can be rationalized if you look at what type of organic structures? |
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Definition
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Definition
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Sulfonamide pKa (R2 is a hydrogen)?
[image] |
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Definition
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Definition
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N-aryl sulfonilamide pKa?
[image] |
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Definition
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Definition
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Alkylcarboxylic acid pKa?
[image] |
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Definition
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Arylcarboxylic acid pKa?
[image] |
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Definition
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Sulfonic Acid pKa?
[image] |
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Definition
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Definition
Irinotecan
[cancer Tx]
Topoisomerase 1 inhibitor |
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Definition
Cefaclor (Ceclor)
2nd generation cephalasporin antibiotic |
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Term
Water solubility is largely dependent on the # of _______'s
you are able to solubilize. They are accounted for by certain functional groups. |
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Definition
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Term
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Definition
Salicylic acid
[Monohydroxybenzoic acid derivative] |
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Term
This molecule may have trouble with dissolution due to _______________________.
[image] |
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Definition
INTRAmolecular hydrogen bonding
[of the carboxylic acid and alcohol]
[image] |
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Term
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Definition
NOVOCAINE
[local anesthetic] |
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Term
Based on pi values a molecule with a log p of 0.3 is _____
while a molecule with a pi value of 0.9 is ________
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Definition
Soluble, insoluble (respectively)
Log p must be less than 0.5 for a molecule to be considered soluble in water. A molecule must have a Log p of less than 5 to have oral bioavailability. |
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Definition
Captopril (Capoten)
[ACE inhibitor,hypertension] |
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Definition
Nadolol (Corgard)
[beta blocker, hypertension] |
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Term
Rx top selling drug of 2014
[image] |
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Definition
Synthroid (Levothyroxine)
[Thyroid hormone replacement]
T4 hormone produced naturally in our bodies
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Definition
Zoloft
[selective serotonin reuptake inhibitor (AKA antidepressant)]
purely synthetic |
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Name functional group
[image] |
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Definition
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Structural group? (HINT: 4)
[image] |
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Definition
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Functional group?
[image] |
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Definition
Piperizine
[It is a core functional group seen in LATUDA] |
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Definition
LATUDA (Lurasidone)
[antipschotic, bipolar depression] |
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Definition
Testosterone
[T deficiency] |
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Term
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Definition
esterone
[estrogenic hormone secreted by the ovary as well as adipose tissue ] |
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Definition
progesterone
[endogenous steroid and progestogen sex hormone] |
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Definition
norethynodrel
[synthetic progestational hormone with actions and uses similar to those of PROGESTERONE] |
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Definition
mestranol
[synthetic steroidal estrogen] |
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Definition
Cortisone
[steroid, antiinflammatory]
NATURAL PRODUCT |
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Definition
Cortisol
[steroid hormone]
NATURAL PRODUCT |
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Definition
PREDNISONE
[synthetic steroid analog, ANTI INFLAMMATORY] |
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Definition
Methicillin
[β-lactam antibiotic of the penicillin class] |
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Term
In med chem we see in reversible reactions/equations that equilibrium lies with the more ________ species.
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Definition
Prostglandin
[lipids involved in injury and illness] |
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Definition
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Definition
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Definition
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| ALcohols hydrogen bond to water which can _______the water solubility |
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Definition
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| Water solubility as described in the monofunctional model says the average functional group can account for about ___carbons |
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Definition
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| Water solubility as described in the polyfunctional model says the average functional group can account for about ___carbons |
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Definition
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Definition
Cytosine
[one of four main bases of DNA] |
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Term
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Definition
pKa = pH +log ([acid]/[base])
pKa = pH +log ([acid]/[base]) |
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Definition
Amobarbital
[sedative barbiturate, tranquilizer] |
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Term
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Definition
Cetirizine (Zyrtec)
[antihistamine] |
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Term
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Definition
Phenylpropanolamine
[stimulant, decongestant, and anorectic] |
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Term
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Definition
crestor (rosuvastatin)
[hyperlipidemia]
synthetic derivative
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Definition
Methadone
[Morphine Derivative]
opiod analgesic/treats pain or opiate withdrawals |
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Term
WHat is the name of the two methyl groups up top?
[image] |
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Definition
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Remember this position!!!!
[image] |
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