Term
| What receptor do classical hallucinogens exert their effect on? |
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Definition
-5-HT2A receptor, a GPCR that is coupled to Gaq
-these receptors are highly expressed in frontal cortex, where they would be expected to play a major role in cognition, working memory, and sensory processing |
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Term
| What are the two major chemical types of psychedelics? |
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Definition
1. Tryptamines
2. Phenethylamines |
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Term
| What are the effects of "substituting amphetamines?" |
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Definition
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Term
| What is the effect of psychedelics highly dependent on? |
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Definition
-"set": mental expectations
-"setting": environment where drug is taken |
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Term
| Are psychedelics addicting? |
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Definition
| No. Rapid tolerance (tachyphylaxis) develops, where even large doses fail to produce effect; cross tolerance develops |
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Term
| What are the adverse actions of THC? |
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Definition
1. May impair short term memory and cognition - reversible when DC
2. Panic or anxiety attack with very potent marijuana; THC content has increased a lot since the 60s
3. 1/9 of regular users do develop a MODERATE dependency
4. Bronchitis in chronic smokers; same health concerns as tobacco smoke
5. Recent controversy over whether cannabis causes psychosis; recent study shows that "psychosis-prone individuals" were especially likely (24% inc) to develop psychotic symptoms after using cannabis |
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