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MCDB 1B
Lectures 8, 9 & 10
33
Biology
Undergraduate 2
02/10/2009

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Term
simple neuron network
Definition
sensory neuron connected to a motor neuron connected to a muscle cell
Term
neurons
Definition

specialized cells of the nervous system that recieve, encode and transmit information

-neurons + glial cells make up the nervous system

-composed of four regions - cell body, dendrites, axon, and axon terminals

 

Term
sensory cells
Definition
recieve information and convert or transduce it into electrical signals
Term
effectors
Definition

-muscles and glands

-recieve signals communicated from the nervous system to cause behavioral or physiological response

Term
ganglia
Definition

cluster of neurons

-frequently one pair of ganglia is larger and more central in an organism and is given the designation "brain"

Term
CNS - central nervous system
Definition

In vertebrates, most of the cells of the nervous
system are found in the brain and the spinal cord,
which together are called the central nervous
system

-information is transmitted to the CNS via sensory cells and from the CNS to effectors via neurons

Term
PNS - peripheral nervous system
Definition
Neurons and supporting cells found outside the
CNS
Term
cell body
Definition
contains the nucleus and most of the cells organelles
Term
dendrites
Definition
projections from the cell body that bring
information from other neurons or sensory cells
to the cell body
Term
axon
Definition

carries information away from the cell body

-conduct information to target cells (other neurons, muscle cells, or gland cells)

 

Term
axon terminal
Definition

located at the end of the axon, it has many fine nerve endings

-the axon terminal is positions very close to the target cell

-nerve impulses cause the release of neurotransmitters (chemical messengers) into the synapse

Term
membrane potential
Definition

the difference in voltage across the plasma membrane  of a neuron

-of a resting axon is about -60 miliVolts mV

Term
resting potential
Definition
the voltage difference in an unstimulated neuron
Term
ion pumps
Definition

use energy to move ions against their concentration gradient

-the major ion pump in neural membranes is the sodium–potassium pump (Na+/K+ ATPase), which expels Na+ ions from the cell, exchanging
them for K+ ions from outside the cell

-This keeps the concentration of K+ greater inside
the cell than outside

Term
ion channels
Definition
are pores formed by proteins in the
lipid bilayer that selectively allow ions to pass
through.
Term
potassium equilibrium
potential
Definition
the
tendency of K+ ions to diffuse into the cell is
equal to their tendency to diffuse out
Term
depolarized
Definition
When the inside of a neuron becomes less
negative in comparison to its resting condition
Term
hyperpolarized
Definition
when the inside of a neuron becomes
more negative in comparison to its resting
condition
Term
Nerve impulses
Definition
are action potentials that travel along
axons.
Term
action potential
Definition

-a sudden and major change in
membrane potential that lasts for about 1–2 milliseconds at speeds up to 100 meter per second

-During an action potential, the voltage changes from the resting potential of –60 mV to +50 mV, then rapidly returns to the resting potential

-primarily caused by voltage-gated sodium channels

-travel faster in large-diameter axons
than in small-diameter axons and are self regenerating

Term
refractory period
Definition
the time when
a plasma membrane cannot propagate an action
potential
Term
Patch clamping
Definition
allows single ion channels to be studied
Term
swhann cells
Definition
to increase the diameter of the axon, the axon is wrapped with myelin sheath
Term
myelin
Definition
electrically insulates the axon (charged ions
cannot cross the regions of the axon that are
wrapped in myelin)
Term
nodes of Ranvier
Definition
ion channels are clustered here in between myelin sheath
Term
saltatory
conduction
Definition
When an action potential fires at one node of
Ranvier, it jumps to the next over the myelin sheaths
Term
Multiple Sclerosis (MS)
Definition

-Gradual destruction of myelin

-autoimmune disease that affects the central nervous system (CNS)

-no cure

Term
synapse
Definition
A synapse is an axon terminal that contains many
vesicles filled with chemical messenger molecules
know as neurotransmitters
Term
Acetylcholine
Definition

-is the neurotransmitter used by all vertebrate motor neurons

-released when the vesicles fuse with the presynaptic membrane and moves into the narrow space called the synaptic cleft

Term
excitatory
Definition
If a postsynaptic neuron responds to chemical
stimulation by depolarizing, the synapse is
excitatory.
Term
inhibitory
Definition

If the postsynaptic neuron hyperpolarizes, the
synapse is inhibitory

-(GABA) and glycine are most common

Term
Spacial summation
Definition

adds up the simultaneous
influences of synapses at different sites on the
postsynaptic cell

-"several synapses fire at the sime time"

Term
Temporal summation
Definition

adds up postsynaptic
potentials generated at the same site in a rapid
sequence.

-"same synapse fires rapidly"

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