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MCB 63 midterm
Basic Cell Anatomy
18
Biology
Not Applicable
07/20/2007

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Term
Cell membrane of neurons
Definition
•Cell membrane is made of cholesterol
•Membrane is composed of lipids (fats)
•Protein structures -> transfer information, act as catalysts, etc.
•Enzymes are proteins
•Proteins embedded in the membrane act as channels to allow ions to get across liquid membrane
•Foreign body can only get across the membrane if it acts like a lipid (like dissolves like) -> isolates interior of the cell
Term
[K+] of neurons
Definition
•[K+] is very large inside the cell
•K+ has an affinity for amino acids inside the cell (exposes more negative charge)
Term
[Na+] of neurons
Definition
•[Na+] is higher outside the cell
•Na+ is angry -> negative charge across membrane
•Na+ can get into the cell if it carries glucose (glucose molecules can’t get across the membrane alone)
•Sodium potassium pumps monitor the concentrations of Na+ and K+ by pulling Na+ back out of the cell as soon as it gets in
Term
Sodium-Potassium Pumps
Definition
pumps located in the cell membrane that monitor [Na+] and [K+] by pulling Na+ out of the cell body once it gets in
Term
Resting potential
Definition
usually -90 to -70 mV ; everything is cool inside the cell
Term
Action potential
Definition
change in voltage across the cell: Na+ slips in and opens enough doors to allow a flux of Na+ ions --> the cell becomes more positive; K+ begins to exit the cell, making it even more positive
Term
nodes of Ranvier
Definition
an area between myelin sheaths, coated with everything necessary to rejuvenate action potential
Term
Axon Hillock
Definition
Area of the neuron where the action potential begins
Term
oligodendroglial cells
Definition
neuroglia that create myelin sheath in the central nervous system
Term
saltatory conduction
Definition
information jumping from one node to the next
Term
Multiple Sclerosis (MS)
Definition
death of myelin in random spots along the nervous system. Results in slower conduction of signals throughout the nervous system and --> no signals to and from the brain
Term
ALS
Definition
Amyotrophic lateral sclerosis - pattern loss of fine motor control, followed by loss of gross motor control --> victims functionally become trapped inside their own bodies
Term
synaptic cleft
Definition
space between pre- and post-synaptic elements, found in mammals
Term
GABA
Definition
gamma-aminobutyric acid, a major inhibitory neurotransmitter
Term
Glutamate
Definition
A major excitatory neurotransmitter
Term
Properties of the synapse
Definition
•Mammals always have a synaptic cleft; invertebrates have direct connection btwn pre- and post-synaptic elements
•Cleft allows flexibility
•Vesicles store molecules called neurotransmitters
•Voltage sensitive calcium channels in the axon terminal open up in response to change in voltage
•Calcium causes vesicles to fuse with presynaptic membrane; neurotransmitters are emptied into the synaptic cleft
•Protein receptors on postsynaptic membrane -> triggers action potential
Term
Repolarization
Definition
When the natural resting polarization is restored to a neuron after an action potential.
Term
Hyperpolarization
Definition
When the membrane potential of the neuron dips lower than its resting potential because excess K+ is leaving the cell.
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