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Definition
| Chemical agents that cause changes at the base pair level in DNA. |
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Definition
| When one or more DNA base pairs are lost |
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Term
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Definition
| Radiation caused by ultraviolet rays, X-rays, or gamma rays. They cause mutations in the chromosome in the form of deletions and translocations. |
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Term
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Definition
the process by which we analyze the combination of traits in a
generation. We can use the combination of traits determine whether two genes are linked or
not. If the genes are linked, it will be rare for recombination to happen between them. Therefore,
these genes will be inherited together. When the distance between two genes are located
farther apart there is a greater chance of recombination then ther is when
two genes are closer together. |
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Term
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Definition
| Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus. |
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Term
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Definition
Cloning a gene based simply on knowing its position in the genome without any idea of the function of that gene.
The overall strategy of positional cloning is to map the location of a human disease gene by linkage analysis and to then use the mapped location on the chromosome to clone (or copy) the gene. |
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Term
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Definition
This is where you have a marker on each chromosome and you try to
test which chromosome contains your gene. You look for linkage between your gene and one of
these markers. When you find a marker linked to your gene, you know your gene is on the same
chromosome as that marker. |
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Term
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Definition
A technique to identify the gene & its
sequence so that you can sub-clone it.
you start with a specific function such as learning
but
then We screen through a
large pool of mutants to find one that has a loss of function such as learning. You identify and segregate the mutant and then subclone it. |
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