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MCAT Biology 05: Endocrine System
Vocabulary & concepts
30
Medical
Not Applicable
05/22/2009

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Cards

Term
Exocrine gland
Definition
Gland that releases enzymes in the external environment through ducts (e.g. sweat, mucous, digestive glands)
Term
Endocrine glands
Definition
Glands that release hormones directly into body fluids (e.g. pancreas)
Term
What are the three classes of hormones?
Definition

  1. Peptide
  2. Steroid
  3. Tyrosine derivatives

Term
How are peptide hormones produced?
Definition

  1. RER (preprohormone)
  2. ER lumen-cleavage (prohormone)
  3. Transported to Golgi
  4. Cleavage & further modification
  5. Packaged into secretory vesicle

Term

 

What hormones are secreted by the anterior pituitary?

 

Definition

  1. hGH
  2. ACTH
  3. TSH
  4. FSH
  5. LH
  6. Prolactin

Term
hGH
Definition

  1. Human growth hormone
  2. Peptide
  3. Stimulates growth in almost all cells

 

Term
ACTH
Definition

 

  1. Adrenocorticotropin
  2. Peptide
  3. Stimulates the adrenal cortex to release glucocorticoids (stress hormones) via secondary messenger system (cAMP)

 

Term
TSH
Definition

  1. Thyroid-stimulating hormone
  2. Peptide
  3. Stimulates thyroid to release T3 & T4 via secondary messenger system (cAMP)
  4. T3 & T4-exert negative feedback on TSH release

Term

 

Prolactin

 

Definition

  1. Peptide
  2. Promotes lactation

Term
What hormones are secreted by the posterior pituitary?
Definition

  1. ADH (vasopressin)
  2. Oxytocin

Term
What hormones are secreted by the adrenal cortex?
Definition

  1. Cortisol
  2. Aldosterone

Term
Aldosterone
Definition

  1. Steroid (mineral corticoid)
  2. Collecting duct-increase Na/Cl reabsorption & K/H secretion
  3. Increases blood pressure (indirect)

Term
Cortisol
Definition

  1. Steroid (glucocorticoid)
  2. Stimulates gluconeogenesis in the liver (glucose & glycogen synthesis from amino acids, glycerol, and/or lactic acid)
  3. Increases blood sugar

Term
What hormones are secreted by the adrenal medulla?
Definition

  1. Epinephrine
  2. Norepinephrine

Term
T3/T4
Definition

  1. Tyrosine derivatives
  2. Increase basal metabolic rate

Term
Calcitonin
Definition

 

  1. Peptide
  2. Decreases osteoclast activity and number
  3. Slightly decreases blood calcium

 

Term
Insulin
Definition

 

  1. Peptide-produced by β-cells
  2. Net effect-decrease blood glucose
  3. Uptake of carbs (glycogen in liver and muscles)
  4. Uptake of fatty acids (adipose tissue)
  5. Uptake of amino acids (protein in all cells)

 

Term

 

Glucagon

 

Definition

  1. Peptide-released by α-cells
  2. Net effect-raise blood glucose
  3. Stimulates glycogenolysis and gluconeogenesis in liver

Term
PTH
Definition

  1. Parathyroid hormone
  2. Peptide
  3. Increases blood calcium
  4. Increases osteocyte absorption of calcium and phosphate from bone
  5. Stimulates osteoclast proliferation

Term
Where is sperm produced?
Definition

 

Seminiferous tubules

 

Term
Leydig cells
Definition

  1. Stimulated by LH
  2. Release testosterone

Term
Sertoli cells
Definition

  1. Stimulated by FSH
  2. Surround & nurture spermatocytes and spermatids

Term
How does sperm mature?
Definition

  1. Spermatogonia (2n)
  2. Onset of puberty & meiosis I-primary spermatocyte
  3. Meiosis II-secondary spermatocyte
  4. Spermatid
  5. Spermatozoa

Term
How does sperm leave the body?
Definition

  1. Epididymus-maturation
  2. Vas deferens
  3. Urethra
  4. Ejaculation

Term
How does an oocyte mature?
Definition

  1. At birth-primary oocytes
  2. Puberty-FSH stimulates growth of granulosa cells around the primary oocyte
  3. Primary follicle-cells secrete zona pellucida around egg
  4. Secondary follicle-theca cells grow around follicle
    1. LH-stimulates theca cells to secrete androgen
    2. Estradiol-converted by granulosa cells & secreted into blood
  5. Luteal surge-hi estradiol increases LH
  6. Ovulation-secondary oocyte released and swept into Fallopian tube
  7. Corpus luteum-follicle remains that secrete estradiol and progesterone
  8. Corpus albicans-degradation within two weeks w/o pregnancy

Term
Fertilization
Definition

  1. Sperm entry
  2. Oocyte-undergoes second meiotic division to become ovum
  3. Fertilization-fusion of sperm nuclei with ovum to form zygote 
  4. Cleavage-morula formation (8 totipotent cells)
  5. Blastocyst formation
  6. Implantation into uterus

Term
HCG
Definition

  1. Human chorionic gonadotropin
  2. Prevents degeneration of the corpus luteum
  3. Maintains estrogen and progesterone secretions

Term
What is the difference between differentiation and determination?
Definition

  1. Determination-cellular commitment to a specialized developmental path
  2. Differentiation-cellular specialization that occurs at the end of development

Term
Gastrula
Definition

 

  1. Formation by gastrulation
  2. Germ layers
    1. Ectoderm-outer coverings of the body; nervous system; sense organs
    2. Endoderm-lining of the digestive tract & much of liver and pancrease
    3. Mesoderm-everything in-between (e.g. muscle, bone)

 

Term
Neurula
Definition

  1. Formed by neurulation
  2. Neural plate formation-notochord-induced (mesoderm)

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