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benefits one, other doesn't care (skin) |
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host is harmed, organism benefits |
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proteins secreted out of organism --> very specific to organs |
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Neurotoxins Cytotoxins entertoxins |
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Definition
nerves cells secretion -> GI tract |
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Definition
LPS Layer (gram -) designed to have a full body shut down as organism is destroyed, it releases harmful toxins |
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Exo: toxic in minutes Endo: toxic in high doses |
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Exo: specific to a cell type (blood,liver, nerves) Endo: Systemic: fever, inflammation, whole body shut down |
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Exo: small proteins Endo: LPS of cell wall (gram -) |
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Heat Denatured at 60 degrees C |
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Exo: Can be comverted to toxoid (vaccine) Endo: cannot be converted to toxoid (no vaccine) |
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Exo: yes: stimulates antitoxins Endo: no: doesnt stimulate antitoxins |
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Exo: Usually not Endo: Yes-classic sign of full body shut down |
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Exo: Secreted from live cell Endo: Released by cell via shredding or during lysis |
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Exo: few gram+ and gram- Endo: All gram- bc LPS layer |
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Any chemical used in the treatment, relief, or prophylaxis of a disease. |
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Definition
use of drug to PREVENT imminent infection of a person at risk |
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Antimicrobial Chemotherapy |
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Definition
The use of chemotherapeutic drugs to CONTROL INFECTION |
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Definition
term for any antimicrobial drug, regardless of its origin |
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Definition
substances produced by the natural metabolic processes of some m.organisms that can INHIBIT or DESTROY other m.organisms |
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natural drugs that were chemically modified |
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drugs made with chemicals only in a lab |
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targeting certain organisms, effective mainly on gram+ bacteria |
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Definition
gram+ and gram- bacteria works on a wide variety |
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use of heat to eliminate organisms in solutions |
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kill/destroy all microbial life |
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reduce organism on inanimate objects to safe levels |
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kill/destroy organism on body surface/skin |
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dissolves proteins/muscle |
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death of body cells/cell death |
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dissolves connective tissue |
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destroys white blood cells |
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3 mechanisms organisms use to Avoid the defenses or immune response of host cells |
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Definition
1. Avoid phagocytosis--dont allow to be eatten by using the actin tail to attach to the microorganims 2. get eatten--do this by hiding in the White blood cells 3. change outer appearance--host cell will not be able to recognize or identify organism |
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3 ways to "side step", prevent the drug/antibiotic from killing organism |
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Definition
1. Make enzymes to destroy the drug 2. Change membrane receptors making it so the drug cannot attach to the microbe 3. Pumps can be used to pump drug in then right back out |
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4 factors to consider when choosing a chemical control method |
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Definition
1. temp and pH 2. the # of microorganisms 3. concentration of agent 4. how the chemical agent works |
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Definition
Personal contact, food, water ex: salmonella and e.coli |
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Transmission: Blood and wounds |
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Definition
injection drug use, injuries, surgeries, needle pricks, transfusions ex: AIDS and hepatitis B |
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Transmission: sexual transmissions |
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Definition
genital-genital genital-oral genital-anal ex: HIV and herpes |
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clostrinium tetani--whole body spasms clostrinium botulism--flaccid paralysis |
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staphylococcus aureus--wounds escherichia coli--diarrhea |
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amanita phalloides--GI tract problems Streptococcus pyogenes--scarlet fever/red rash |
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phenol--denatures proteins hydrogen peroxide--cleans wounds chlorine--kills pathogens in water |
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pasturization--decreases # of heat sensitive microorganisms autoclaving--destroys endospores, sterilizes ojects(lab glassware) Incineration--oxidizes cell components with flaming |
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Definition
filteration of liquid--(pore size)used to make beer and wine filteration of air--HEPA filters |
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Definition
environment when a microorganism lives and allows for it to replicate or maintain |
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actively participating in a pathogens life cycle, serving as a site for multiplication and completing the life cycle ex: mosquito carrying malaria |
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an animal that transports an infectious agent, but is not personally affected by it. ex: housefly whose feet have been contaminated with feces |
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