Term
|
Definition
| Ag recognition, Ag processing, filter/remove foreign particles, & lymphopoiesis |
|
|
Term
T-lymphocytes
type of immunity?
% in PB?
2 populations |
|
Definition
Cell-mediated immunity
60-80% in PB
populations in CD4 (helper) & CD8 suppressor/cytoxic |
|
|
Term
|
Definition
| Fx in humoral immunity production of Ab, Ig on MB, shorter lived of the lymphocytes |
|
|
Term
B-Cell Lymphomas
Clinical Features (4) |
|
Definition
1. lymphadenopathy
2. Night sweats, weight loss
3. May involve BM and PB
4. Variable course |
|
|
Term
| Chronic Lymphocytic Leukemia/SLL |
|
Definition
| Small lymphs in blood, BM, and lymphoid organs. |
|
|
Term
|
Definition
| one is the predominance of lymphs in BM & PB, while the other is primarily lymphocytosis in the lymph nodes and lyphoid organs |
|
|
Term
| Chronic Lymphocytic Leukemia, CLL/SLL |
|
Definition
CS:
Lymphadenopathy, and splenomegaly observed. Transformed to large-cell lymphoma DLBCL aka richter syndrome. >100,000 x 10^9/L WBCs.
Small appearing lymphs.
Susceptibility to infections and ITP |
|
|
Term
| **Diagnostic features of CLL** |
|
Definition
Absolute and Consistent mature lymphocytosis: >5x10^9/L for 3 mos.
Monoclonal B Cell w/ CD5, CD20, CD23*
Typically missing CD10 and FMC7 |
|
|
Term
|
Definition
More agressive that CLL.
>55% of leukemic prolymphs with high WBCs
no CD5 and CD23 like CLL but FMC7, CD20, CD22 present |
|
|
Term
|
Definition
insiduous, BM fibrosis "dry tap" (fibrogenic cytokines), monocytopenia w/ recurrent infections, Strong present of CD22, CD25, CD11c, CD103, but negative for CD5, CD10, CD23 which is in CLL only
RED PULP |
|
|
Term
| SMZL Splenic Marginal Zone Lymphoma |
|
Definition
| Small Lymphs replace splenic white pulp. Villous lymphs, Rare, leukocytosis, average about 35 x 10^9/ul. CD20, CD79a, but missing CD5, CD10, CD23 and CD103 as in HCL |
|
|
Term
| MALT mucosa-associated lymphoid tissue |
|
Definition
| lacks CD5 and CD10 (only in CLL!) but has CD20, CD79a, CD21, CD35 and have t(11;18) |
|
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