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Materia Medica
podiatry 2nd year stuff
139
Medical
Professional
10/28/2008

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Term
what is a collodion?
Definition
a drug in an organic solute of ether or ethanol, which dries and leaves a flexible film
Term
what is a solution
Definition
drug in alcohol or water
Term
what is a spirit
Definition
drug in alcohol
Term
what is a tincture
Definition
drug of vegetable origin in water
Term
what is a liniment?
Definition
a liquid or semi liquid applied with friction to unbroken skin
Term
what is the vehicle in a liniment
Definition
soap or alcohol
Term
liniments can contain many active ingredients which have what properties
Definition
soothing, stimulating, analgesic, rubifacient
Term
What situation need caution for the word CREAM
Definition
only to be applied to un broken skin
Term
what is the definintion of a mixture?
Definition
2 or more solids mixed
Term
what is the definition of an emulsion
Definition
2 immiscible liquids stablised into a homogenous mass, with emulsifying agents
Term
what is a feature of buffered solution
Definition
stable to changes in pH ie on skin
Term
what is a poultices
Definition
moistened mass of vegetable material and clay heated before application used to reduce inflammation and pain
Term
what are 2 types of solid preparations
Definition
1. for broken skin (ie an antibiotic powder), 2 for intact skin (eg dusting powders)
Term
why should dusting powders only be used in intact skin?
Definition
because in wounds the dust particles may act as a foreign body, and lead to formation of granulomas and gas gangrene secondary to contamination with clostridium
Term
what is an absorbent?
Definition
take up excretions from the body
Term
what is glycerin primarily used as, and what are its other properties?
Definition
mainly a absorbent... but also highly hygroscopic, emollient, lubricant, anti-septic
Term
what are the properties of Calamine lotion
Definition
an absorbent, made of Zinc carbonate, which is soothing, atringent, and will absorb 1 1/2 times its weight in moisture
Term
Discuss 3 properties of melonin?
Definition
1. highly absorbent acrylic fibre bondeed with a thin polyester film, allows drainage and is non stick, maintains wound moisture
Term
what is a haemostatic?
Definition
an agent that arrests or diminisheds the flow of blood, a styptic
Term
what are some example of a haemostatics?
Definition
FeCl3 (ferric chloride), AgNO3 (silver nitrate), calcium alginate dressings
Term
how do many hameostatics work?
Definition
reduce capillary bleeding time by increasing the contractility and resistance and decreasing the permeability of capillary wall....
Term
what is an analgesic?
Definition
lessen and relieve pain by removing cause (ie inflammation) or by changing response of perception of pain...
Term
what re the classes of analgesics?
Definition
opiates, non-opiates, corticosteroids, NSAIDs
Term
what is an anaesthetic?
Definition
lessen sensitivity to pain by acting directkly on nerve endings. by blocking action potentials
Term
what are 3 types of anaesthetics?
Definition
general, local, topical
Term
what are 2 topical local anaesthetics?
Definition
benzocaine (derivative of cocaine), and chloral hydrate
Term
what is xylocaine?
Definition
a spary/gel or ointment anaesthetic
Term
what are the active ingredient of paraderm plus?
Definition
chlorhexidine gluconate, lignocaine, and bufexamac
Term
what is a paraderm plus?
Definition
anti-septic, anti-inflammatory, and anaesthetic
Term
what does a EMLA patch contain?
Definition
lignocaine, and prilocaine
Term
what are AE of EMLA cream/patches?
Definition
oedema, itching, erythema, burning sensation
Term
when are emla patches applied?
Definition
1 hr before procedure
Term
what are 3 types of anti-inflamatory agents?
Definition
rubificients, heat and cold, NSAIDs, corticosteroids
Term
you would use rubifacients for a chronic inflammation, t or f
Definition
t, this will stimualte blood flow
Term
what does a rubefacient do?
Definition
produces local inflammation when applied to skin. the increased blood flow flushes metablites from areas of chronic inflammation and relieves congestion and stasis
Term
when are rubifacients contraindicated?
Definition
in acute inflammation
Term
rubifacients usually contact what ?
Definition
camphor, menthol, iodine, methyl salicylate, eucalyptus oil, capsaicin
Term
what are 4 mentioned of NSAIDs
Definition
piroxicam (feldene), indomethacin (indospray), diclofenac (voltarin), ibuprofen
Term
what are 2 important c/i or NSAIDs
Definition
GI bleeds, and asprin
Term
how do corticosteroids act?
Definition
on cells to reduce arachidonic nacid and hence prostaglandin production
Term
how do corticosteroids affect other cells?
Definition
decrease monocyte/macrophage activity
Term
what are corticosteroid creams very useful for? when are they c/i?
Definition
dermatitis, eczema....c/i where infection is present...(including fungal)
Term
what do anhydrotics do?
Definition
reduce flow of sweat
Term
which 2 mechs may anhydrotics work?
Definition
cooling, or astringent
Term
what are some examples of a anhydrotic...
Definition
alcohol, aluminium acetate
Term
what are 2 modes of action of astringents?
Definition
1. protein precipitant (shrink cells of mucous membranes, dilute caustics, harden skin) 2 physical astringent (evaporate quickly on skin causing constricton of tissues,m ie evaporation ladss to cooloing)
Term
what are some examples of astringents?
Definition
aluminium, TBCo, cystal violet, AgNO3, Calamine, glycerin
Term
what do emollients do?
Definition
soften and lubricates tissue
Term
what are indications for emollients/
Definition
dermatitis, eczema, congenital icthyosis, dry skin conditions..
Term
when are 2 situations when an emollient is c/i? and what is a problem with emollients?
Definition
hyperhydrosis, infection... the prob is that they can block skin glands , leading to folliculitis
Term
urea, is a what? how does it act?
Definition
keratolytic, which encourgaes absorption and retention of water by strat corneum
Term
what is the use of an anaesthetic?
Definition
surgery, enucleation of painful corns
Term
what is an antipuretic?
Definition
prep that relies itching
Term
what are some example of antipuritics?
Definition
benzocaine, rubifacients, calamine lotion, and withc hazel
Term
discuss use of 20-40% ointment of salicylic acid? and the minimum and maximum return period?
Definition
ID, digital and plantar HD, return min in 4-7 days, maximum 3/52
Term
what strength of salicylic acid is used for VP?
Definition
50,60,70%
Term
at what strength is salicylic acid fungicidal?
Definition
3-5%
Term
discuss solubility of salicylic acid
Definition
colourless cystal soluble in water and alcohol
Term
what is a key point of >10% of salicylic acid?
Definition
whit rubbery coagulum forms, which accumulates, and should be removed to avoid infection
Term
what is an antidote of Silver nitrate?
Definition
NaCl foot bath
Term
when should silver nitrate be avoided?
Definition
open wounds
Term
at <20% what is silver nitrate used for?
Definition
astringent
Term
at >25% what is AgNO3
Definition
(silver nitrate btw) a irritant and caustic
Term
what does a caustic do?
Definition
destroy organic tissue,
Term
how does a keratolytic work? what is a it a subset of?
Definition
break salt linkages between keratin molecules and allow H20 in to cause maceration, they soften rather than destroy str. corneum (a type of keratolytic)
Term
how would silver nitrate be used for Hmolle, HD, nail sulci and heel fissues?
Definition
20-25% sln, applied regularily for less than 2/52
Term
what is the use of 40-50% silver nitrate? how often is it applied?
Definition
deep HD, NVHD, weekly, or every 3-4days to granulation tissue
Term
when is trichloracetic acid used?
Definition
for VP Rx, esp where there is less adipose tissue ie toes as it is gentler
Term
describe 2 ways trichloracetic acid used for VP?
Definition
1. debride callous, and soak lesion with solution, review in 4-14 days
2. apply a crystal to Vp for 30s, and review 4-14 days (stronger action).
Term
what is the antidote for trichloracetic acid
Definition
wash with water
Term
How is glacial Acetic acid used?
Definition
paint on VP, followed by AgNO3, 2-3 applications each visit, pain on HD/NVHD
Term
what is the antedote of Glacial acetic acid?
Definition
water, or bicarbonate soda
Term
what are c/i of an acid?
Definition
at risk, damaged skin, atrophic skin
Term
what is the return for glacial acetic acid?
Definition
min 4 days for VP as weak Rx, 14-12 days for HD
Term
what are C/I of acetone?
Definition
skin breaks, maceration
Term
what is use of acetone?
Definition
skin cleanser that dissolves fats and resins and removes plaster marks...
Term
what cautions should be had with acetone? what is antiodote?
Definition
dont breath in, alcohol
Term
how should acetone be stored?
Definition
17 degrees C, in dark, glass stopper bottles
Term
what is the best concentration of alcohol for antispetic
Definition
70%
Term
C/I alcohol
Definition
open wounds
Term
what is the use of alcohols?
Definition
atringent, antiseptic, solvent, astringent, haemostatic,
Term
what is use of ALUM
Definition
soft corn, hypergranulation, tissue
Term
Aluminium acetate Sln comes as what?
Definition
Burrows Sln, 13% aluminium acetate..
Term
aluminium acetate is diluted at 1:3 for what?
Definition
astringent properties
Term
what concentration is used for hyperaemic stage of erythrema pernio
Definition
1:3 (daily application)
Term
what concentration of aluminium acetate is used for bromidrosis
Definition
1:2
Term
what is return for aluminium acetate?
Definition
bursitis 1-2 days
Term
what is a c/i of aluminium acetate?
Definition
anhydrosis
Term
discuss uses of TBCo.
Definition
1.post op, daily paint for eythrema pernio, daily for fissurs, protect from plaster or abrasions, nail packing, Hmolle, protection from wart treatments
Term
what is the antidote of TBCo? what are C/I
Definition
alcohol. ci= sepsis, weeping wounds
Term
what is use of calamine?
Definition
soothing, astringent, absorbent, antipuritic, rashes, erythema pernio
Term
C/I of calamine?
Definition
anhidrosis, open wounds
Term
what action does camphor have?
Definition
rubefacient, antipuretic, fungicidal, antiseptic, stimulates then numbs nerves
Term
describe the use of Carbon monoxide snow... on VP
Definition
1.debride suurounding callous, 2 apply CO2 to lesion 60 secs with mod pressure, wamr foot bath 5 mins, 60% sal acid for 5-7 days. (note if you dont do steps 3 and 4 a blister will form
Term
C/I CO2
Definition
blister, pain
Term
what are characteristics of coal tar
Definition
black liquid. strong odour,20% coal tar in 70% alcohol
Term
what actions does coal tar have? and what is it used for?
Definition
antiseptic, antipuritic, mild rubifacient, used for psoriasis, eczema, open chill blains
Term
what are the uses of crystal violet?
Definition
antiseptic against Gram +ve microbes, fungicide (1:1000), astringent, needs to be applied frequently
Term
chlorhexidine gluconate.. active against what?
Definition
antispetic, G+ve and G-ve organisms
Term
hydrogen peroxide what is its use?
Definition
antispetic esp against anaerobic bacteria, effervesces violently if septic exudate due to aerobic abcteria enzymes....

also a sleansing agent, softener, styptic
Term
what are c/I of H202
Definition
open wounds, ulcer,
Term
what %age is in ferric chloride sln
Definition
13.9% to 16.1% FeCl3, or strong at 60%
Term
what is the use of ferric chloride?
Definition
styptic, hardens tissue.
Term
describe 3 applications and amount of application of FeCl3
Definition
daily for a week for nail sulci, 2/day for hypergranulation, use a strong soln (60%) no more than 2 times per week for vascular corns
Term
what is a C/I of ferric chloride?
Definition
weeping skin conditions
Term
describe lactic acid...
Definition
mixes with H20, glycerin and alcohol
Term
use of lactic acid?
Definition
keratolytic, 25% lactic acid +25% sal acid for VP - keep dry for several days. return in 7-14 days for review
Term
what is the use of Magnesium sulphate?
Definition
relieve foot strain when used in foot baths, pastes to treat onychia, paronychia, infected cavities, and foreign bodies
Term
how is magnesium sulphate used?
Definition
as Magnoplasm (magnesium sulphate and glycerol paste) applied 5mm thick under dressing and bandage and replace every 12-24 hours
Term
when is magnesium sulphate not used?
Definition
wounds, ulcer
Term
what is the use of eucalyptus
Definition
analgesic, antiseptic, healing agent, rubifacient
Term
what is a problem with chloroxylenol (dettol)
Definition
only active against Gram +ve
Term
what is the success rate of toilnaftate? what is it used for?
Definition
onychomycosis, about 80%
Term
what is tolnaftate commonly called? what is it active against, and not atcive against...
Definition
tinaderm, trichophyton, E floccosum, microsporum not active against candida!!!
Term
what is Daktarin Tincture used for?
Definition
O/M
Term
what is the most efective antifungal? what class is it?
Definition
Terbinafine(lamisil cream), Allylamines
Term
Miconazole is called what and used for what?
Definition
Called Daktarin, and is imidazole antifungal
Term
econazole (ecostatin)is used for what
Definition
tinea
Term
what are 2 oral antifungals?
Definition
terbinafine, itraconazole
Term
what were 2 early oral antifungal
Definition
griseofuluin, Ketoconazole
Term
describe the length of Rx with oral antifungals...
Definition
long (3-6 months)
Term
what are side affects or oral antifungals...
Definition
10% experience... GI disturbances, rashes, pruritis, headaches, dizziness

joint and muscle pain.... also may affect liver function
Term
what is pyrogallol?
Definition
a white toxic crystal phenol used as a photgraphic developer, and to treat certain skin dz. penetrates deeply (a caustic)
Term
calamine is used for what actions?

what are CI?
Definition
sootjhing, astringent, antipruritic, rashes chill blains

CI = anhydrosis, wounds
Term
Ichtammol is used for what purpose?
Definition
mild antispetic, liquifies pus, fissures, applied for subungual breakdown
Term
discuss the use of lactic acid in Vp Rx...
Definition
used at 25% concentration with 25% sall acid, keep dry 7 days and return in 1-2 weeks
Term
what is methyl salicylate used as
Definition
powerful rubifactient, and analgesic
Term
what are hard parrafins used for>
Definition
used in ointment bases to increase melting points
Term
what are liquid paraffin used for/
Definition
poor emollient, used as a vehicle for other meds, and in ointment and cream bases
Term
Discuss the use of Potassium hydroxide in rx of VP
Definition
debride callous, soak foot in warm water 5 mins, dry foot and rub in pellet, immerse foot in water for 2 mins, and dry. debride jelly like VP material. apply Glacial acetic acid to neutralize. return review in 3-7 days
Term
what % is sal acic used for a O/P, return?
Definition
10-15 %, return 7 days
Term
I wish to used sal acid for itsn fungicidal properties... what % useA?
Definition
3-5%
Term
Sal acid appears a good choice for a HD on PMA 3, what % to use and when is the return?
Definition
20-40%. return in a min 4-7 days and a max 3 weeks
Term
what % is phenol used at? what is its use and what is its antidote?
Definition
80%, nail surgery, glycerin!!!
Term
is sal acid a protein precipitant of hydrolyses... (what does this mean?
Definition
hydrolyses, it softens skin!
Term
Name 3 imidazoles
Definition
clotrimazole, econazole, miconazole
Term
disdcuss silver nitrate use on a Hmole
Definition
20%
Term
when is caustic therapy contraindicated?
Definition
open wounds, infection and 'at risk feet'
Term
in caustic therapy, what is used to mask healthy tissue/
Definition
TBCo
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