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Martin
Somatosensory; Mechanoreception
39
Medical
Graduate
03/13/2011

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Term
Glasgow coma scale
Definition
verbal response, motor response and eye opening are graded.. the higher score the better prognosis
90% less than or equal to 8 are in coma
Greater than or equal to 9 not in coma

8 is the critical score
Less than or equal to 8 at 6 hours - 50% die

9-11 = moderate severity

Greater than or equal to 12 = minor injury
Term
ICP curve
Definition
there is a point when compensatory mechanisms begin to fail and pressure rises rapidly
Term
elevated ICP, what is major concern?
Definition
compression of blood vessels and lack of oxygen being delivered to brain
Term
Intracranial Perfusion Pressure
Definition
[mean arterial pressure -ICP] needs to be adequate 40 mmHg, more important than ICP
Term
Cushing's reflex
Definition
when BP is elevated, bradychardia, pulse pressure widens; oxygen receptor in medulla are reflexively connected to BP regulation and this forces BP to rise when brain is hypoxic; at the same time heart rate will decrease because baroreceptors will register high BP and tell heart to slow down, widened pulse pressure
Term
pulse pressure
Definition
difference between diastolic and systolic pressure
Term
cerebral perfusion pressure
Definition
mean arterial pressure - ICP
greater than 40 mmHg; < 40 mmHg can lead to ischemia
Term
cytotoxic edema --> vasogenic edema --> cytotoxic edema
Definition
cells are expanding in brain and this causes increased intracranial pressure --> leads to vasogenic edema --> positive feedback loop
Term
ICP elevation can be detected by...
Definition
fundoscopic exam, lumbar puncture (monometer), pressure transducers
Term
receptor embryological development
Definition
can be from nervous tissue
can be from epithelial tissue
Term
Sherrington's classification
Definition
proprioceptor
exteroceptors -- surface stimulation
interoceptor -- internal environment (pH, O2)
telreceptors -- distance stimulation
Term
Clinical classification
Definition
visceral -- organs
deep -- proprioception
special sensory --
cutaneous --skin
Term
what determines an adequate stimulus?
Definition
embryological origin
receptor specialization
evolutionary refinement
Term
what is the most sensitive receptor?
second most sensitive?
Definition
auditory receptors
visual receptors
low sensory threshhold
Term
what senses are not so sensitive?
Definition
pressure receptors, high sensory threshold
Term
visible spectrum
Definition
the range of wavelengths of light that can elicit a change in vision receptors without destroying it
Term
convergence vs divergence
Definition
convergence -->when multiple cells converge in one cell
divergence -->when a single cells send information to many cells
Term
properties of stimulus; qualitative, quantitative, temporal and spatial
Definition
amplitude
temporal patterns
spatial patterns
complexity
Term
redundancy
Definition
multiple sensory receptors in an area that carries the same information
Term
receptive field
Definition
the size of area which corresponds to the stimulation of a single afferent fiber
Term
how do receptive fields for second order neurons compare to first order neurons
Definition
larger because of convergence
Term
how do receptive fields for second order neurons compare to first order neurons?
Definition
larger because of convergence
Term
how is a receptive field for cells in the cochlea measured?
Definition
cycles per second
Term
how is the receptive field for lateral geniculate measured?
Definition
outside area of response
Term
single cells in the temporal lobe that can recognize a single face
Definition
represents convergence of many neurons on a single neuron
Term
receptive fields vary in size and density
Definition
it is difficult to perceive small stimulus (tick on thigh versus hand) in some areas due to large receptive fields and lack of overlap
Term
place coding
Definition
brain localizes based on which pathway stimulus is imported on; if pathways change, due to cell destruction, for instance, place coding can be lost or rearranged; inherent in organization of fibers; e.g. rearrangement of cells in thalamus can change ability to localize; e.g. the sound of particular music can elicit visual perception
Term
frequency coding
Definition
rate of firing itself is interpreted by the brain as a particular stimulus
Term
fast adapting
Definition
phasic receptors; just a few initial firings; pacinian and meissner's
Term
slow adapting
Definition
tonic receptors; continuous firing; merkel's discs and ruffini's are slow adapting
Term
how does habituation occur?
Definition
the cortex decides that repeated stimulus is unnecessary
Term
feature extraction often occurs on the same or different pathways?
Definition
different qualities are sent on different pathways... is often determined by ecological niche
Term
Weber-Fechner law
Definition
physical properties of stimulus are not encoded linearly, but are logarithmic. There is a maximum response at which stimulus can increase, but response will stop increasing
Term
Ecological Niche
Definition
sensitive to stimulus features that are important for survival
Term
receptive field of a joint receptor is measured in what unit?
Definition
degrees... firing rate changes as angle of joint changes.. adequate stimulus is at 80 degrees for some joint receptors and higher for others (this allows place coding, different angles stimulate receptors of different thresholds)
Term
sensory filtering
Definition
some info is blocked from being encoded at all and is often determined by ecological niche; ignoring what is not significant
Term
somesthesia
Definition
deep touch, discriminative touch (hapsis), crude touch, vibration, itch
nocioception, temperature, kinesthesia
Term
are itch and pain of the same functional modality?
Definition
no... they are not sent on the same pathways. GRPR (gastrin releasing peptide receptor) itch receptor expressed in lamina 1 2nd order cell bodies
Term
what two types of afferent fibers do muscle spindles have?
Definition
Ia and II
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