Term
| Anaplastic large cell lymphoma |
|
Definition
|
|
Term
Burkitt lymphoma
(3 translocations possible) |
|
Definition
t(8;14) 8-c-MYC, 14-IgH
t(2;8) 2-kappa, 8-c-MYC
t(8;22) 8c-MYC, 22-lambda |
|
|
Term
| Chronic myelogenous leukemia |
|
Definition
t(9;22) 9-ABL, 22-BCR
(fusion protein with tyrosine kinase activity) |
|
|
Term
Diffuse large B-cell lymphoma
(2 possible translocations) |
|
Definition
Bcl-6 (chr 3) translocation - 30%
t(14;18) involving BCL-2 - 10% - 20% |
|
|
Term
|
Definition
| t(14;18) 14-IgH, 18-BCL-2 |
|
|
Term
|
Definition
| t(11;14) 11-cyclin D1, 14-IgH |
|
|
Term
|
Definition
|
|
Term
Acute lymphoblastic leukemia/lymphom (B-cell)
2 Good
2 Bad |
|
Definition
Good
Hyperdiploidy
t(12;21)
Bad
t(9;22)
Translocations involving 11q23 (MLL gene) |
|
|
Term
Acute myelogenous leukemia
2 Good
2 Intermediate
1 Bad |
|
Definition
Good
t(8;21)
inv(16)
Intermediate (APML)
t(15;17) 15-PML (promyelocytic leukemia)
17-RAR-alpha
Bad
t(11q23;v) |
|
|
Term
| Alveolar soft part sarcoma |
|
Definition
|
|
Term
Breast Carcinoma
BRCA1
BRCA1
Low grade ductal/lobular carcinoma |
|
Definition
BRCA1 (17q21)
BRCA2 (13q12.3)
16q LOH |
|
|
Term
Clear cell sarcoma
aka Malignant melanoma of soft parts |
|
Definition
|
|
Term
Colorectal carcinogenesis
Mucosa at risk
Adenomas
Invasive carcinoma |
|
Definition
Mucosa at risk
APC (5q21), loss of DNA methyl groups,
beta-catenin, MSH2
Adenomas
K-ras (12p12), SMADs, p53 (17p13), LOH at 18q21
Invasive carcinoma
Telomerase |
|
|
Term
|
Definition
|
|
Term
| Desmoplastic round small cell tumor |
|
Definition
|
|
Term
| Dermatofibrosarcoma protuberans |
|
Definition
|
|
Term
| Endometrial adenocarcinoma |
|
Definition
Type 1: MSI, PTEN, K-ras, beta-catenin
Type 2: p53 overexpression |
|
|
Term
|
Definition
t(11;22)(q24;q12) 11FLI1, 22-EWS
t(21;22) 21-ERG, 22-EWS
t7;22) 7-ETV1, 22-EWS |
|
|
Term
| Extraskeletal myxoid chondrosarcoma |
|
Definition
|
|
Term
| Gastrointestinal stromal tumor |
|
Definition
Most: c-KIT mutation
Some: platelet derived growth factor receptor-alpha mutation |
|
|
Term
|
Definition
|
|
Term
| Liposarcoma (myxoid/round cell type) |
|
Definition
|
|
Term
Melanoma
(Dysplastic nevus syndrome /
Heritable melanoma syndrome) |
|
Definition
|
|
